Morgane Rolland

Summary

Affiliation: Division of Retrovirology
Country: USA

Publications

  1. pmc HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacity
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    J Virol 87:5461-7. 2013
  2. pmc Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
    Morgane Rolland
    US Military HIV Research Program, Silver Spring, Maryland 20910, USA
    Nature 490:417-20. 2012
  3. pmc Evaluating immune correlates in HIV type 1 vaccine efficacy trials: what RV144 may provide
    Morgane Rolland
    MHRP HJF, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 28:400-4. 2012
  4. pmc Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e17969. 2011
  5. pmc Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Nat Med 17:366-71. 2011
  6. pmc Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 2:e823. 2007
  7. pmc Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteins
    Morgane Rolland
    Department of Microbiology SC 42, University of Washington, Seattle, WA 98195 8070, USA
    J Virol 81:8507-14. 2007
  8. pmc Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads
    Morgane Rolland
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 3:e1424. 2008
  9. pmc Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses
    Erinn C Lanxon-Cookson
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98105 8070, United States
    J Virol Methods 194:7-13. 2013
  10. pmc Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 200:1825-33. 2009

Detail Information

Publications18

  1. pmc HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacity
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    J Virol 87:5461-7. 2013
    ....
  2. pmc Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
    Morgane Rolland
    US Military HIV Research Program, Silver Spring, Maryland 20910, USA
    Nature 490:417-20. 2012
    ....
  3. pmc Evaluating immune correlates in HIV type 1 vaccine efficacy trials: what RV144 may provide
    Morgane Rolland
    MHRP HJF, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 28:400-4. 2012
    ..Here we describe how researchers can determine the correlates of immune protection for an HIV/AIDS vaccine, particularly in the context of the RV144 trial, and we discuss the terminology used to describe correlates and surrogates...
  4. pmc Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e17969. 2011
    ..Furthermore, since peptides were not recognized based on their frequency in the population, it remains unclear by which mechanisms variability-inclusive antigens (i.e., constructs enriched with frequent variants) expand CTL recognition...
  5. pmc Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Nat Med 17:366-71. 2011
    ..These results represent what is to our knowledge the first evidence of selective pressure from vaccine-induced T cell responses on HIV-1 infection in humans...
  6. pmc Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 2:e823. 2007
    ..One hypothesis is that similarities between HIV and human proteins influence the host immune response, i.e., resemblance between viral and host peptides could preclude reactivity against certain HIV epitopes...
  7. pmc Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteins
    Morgane Rolland
    Department of Microbiology SC 42, University of Washington, Seattle, WA 98195 8070, USA
    J Virol 81:8507-14. 2007
    ....
  8. pmc Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads
    Morgane Rolland
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 3:e1424. 2008
    ..e., the intrinsic ability to present fewer, more or specific viral epitopes, could affect clinical markers of disease progression...
  9. pmc Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses
    Erinn C Lanxon-Cookson
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98105 8070, United States
    J Virol Methods 194:7-13. 2013
    ..005, a consistent ratio of mutant: parental viruses (70:30), and a multipoint [1+s 4,7] algorithm that uses data points within the logarithmic phase of viral growth for assessing fitness differences. ..
  10. pmc Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 200:1825-33. 2009
    ..However, some studies have shown preferential or similar targeting of variable versus conserved epitopes during primary infection...
  11. pmc HIV-1 group M conserved elements vaccine
    Morgane Rolland
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Pathog 3:e157. 2007
  12. pmc Sieve analysis in HIV-1 vaccine efficacy trials
    Paul T Edlefsen
    Statistical Center for HIV Aids Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Curr Opin HIV AIDS 8:432-6. 2013
    ..Statistical and sequence analysis methods provide opportunities to mine the mechanisms behind the effect of an HIV vaccine...
  13. pmc Fitness costs of mutations at the HIV-1 capsid hexamerization interface
    Siriphan Manocheewa
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e66065. 2013
    ..These functionally constrained sites provide potential targets for novel HIV drug development and vaccine immunogen design...
  14. pmc MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load
    Holly Janes
    Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e43396. 2012
    ..We linked the viral sequence data with immune response and acute viral load data to explore mechanisms for and consequences of the observed sieve effect...
  15. pmc HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 82:6434-46. 2008
    ....
  16. pmc Coping with viral diversity in HIV vaccine design
    David C Nickle
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Comput Biol 3:e75. 2007
    ..These immunogens should elicit immune responses against high-frequency viral strains as well as against most mutant forms of the virus...
  17. pmc Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processes
    Joshua T Herbeck
    Department of Microbiology, SC 42, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    J Virol 85:7523-34. 2011
    ..Furthermore, the diversity of HIV strains coupled with complex and individual-specific patterns of CTL escape did not reveal shared sequence characteristics of acute infection that could be harnessed for vaccine design...
  18. ncbi request reprint Viral evolution and escape during primary human immunodeficiency virus-1 infection: implications for vaccine design
    James I Mullins
    aDepartments of Microbiology and Medicine, University of Washington School of Medicine, Seattle, WA, 98195 8070, USA bPartners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 3:60-6. 2008
    ....