Research Topics
Genomes and Genes | Morgane RollandSummaryAffiliation: Division of Retrovirology Country: USA Publications
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Publications
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2Morgane Rolland
US Military HIV Research Program, Silver Spring, Maryland 20910, USA
Nature 490:417-20. 2012....- Evaluating immune correlates in HIV type 1 vaccine efficacy trials: what RV144 may provideMorgane Rolland
MHRP HJF, Rockville, Maryland 20850, USA
AIDS Res Hum Retroviruses 28:400-4. 2012..Here we describe how researchers can determine the correlates of immune protection for an HIV/AIDS vaccine, particularly in the context of the RV144 trial, and we discuss the terminology used to describe correlates and surrogates... - Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequencesMorgane Rolland
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 6:e17969. 2011..Furthermore, since peptides were not recognized based on their frequency in the population, it remains unclear by which mechanisms variability-inclusive antigens (i.e., constructs enriched with frequent variants) expand CTL recognition... - Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteinsMorgane Rolland
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 2:e823. 2007..One hypothesis is that similarities between HIV and human proteins influence the host immune response, i.e., resemblance between viral and host peptides could preclude reactivity against certain HIV epitopes... - Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trialMorgane Rolland
Department of Microbiology, University of Washington, Seattle, Washington, USA
Nat Med 17:366-71. 2011..These results represent what is to our knowledge the first evidence of selective pressure from vaccine-induced T cell responses on HIV-1 infection in humans... - Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteinsMorgane Rolland
Department of Microbiology SC 42, University of Washington, Seattle, WA 98195 8070, USA
J Virol 81:8507-14. 2007.... - Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loadsMorgane Rolland
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 3:e1424. 2008..e., the intrinsic ability to present fewer, more or specific viral epitopes, could affect clinical markers of disease progression... - Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responsesYi Liu
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
J Infect Dis 200:1825-33. 2009..However, some studies have shown preferential or similar targeting of variable versus conserved epitopes during primary infection... - MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral loadHolly Janes
Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 7:e43396. 2012..We linked the viral sequence data with immune response and acute viral load data to explore mechanisms for and consequences of the observed sieve effect... - Coping with viral diversity in HIV vaccine designDavid C Nickle
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS Comput Biol 3:e75. 2007..These immunogens should elicit immune responses against high-frequency viral strains as well as against most mutant forms of the virus... - HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral loadChristine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 82:6434-46. 2008.... - Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processesJoshua T Herbeck
Department of Microbiology, SC 42, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
J Virol 85:7523-34. 2011..Furthermore, the diversity of HIV strains coupled with complex and individual-specific patterns of CTL escape did not reveal shared sequence characteristics of acute infection that could be harnessed for vaccine design... - HIV-1 group M conserved elements vaccineMorgane Rolland
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS Pathog 3:e157. 2007 
HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative CapacityMorgane Rolland
Department of Microbiology, University of Washington, Seattle, Washington, USA
J Virol 87:5461-7. 2013....
Viral evolution and escape during primary human immunodeficiency virus-1 infection: implications for vaccine designJames I Mullins
aDepartments of Microbiology and Medicine, University of Washington School of Medicine, Seattle, WA, 98195 8070, USA bPartners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin HIV AIDS 3:60-6. 2008....