Mary A Marovich

Summary

Affiliation: Division of Retrovirology
Country: USA

Publications

  1. ncbi request reprint Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    J Infect Dis 186:1242-52. 2002
  2. ncbi request reprint ALVAC-HIV vaccines: clinical trial experience focusing on progress in vaccine development
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    Expert Rev Vaccines 3:S99-104. 2004
  3. pmc A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells
    Michael A Eller
    U S Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 6:e24254. 2011
  4. ncbi request reprint Leishmaniasis recidivans recurrence after 43 years: a clinical and immunologic report after successful treatment
    M A Marovich
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Clin Infect Dis 33:1076-9. 2001
  5. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
  6. ncbi request reprint Human dendritic cells as targets of dengue virus infection
    M Marovich
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Investig Dermatol Symp Proc 6:219-24. 2001
  7. pmc Role of dendritic cells in antibody-dependent enhancement of dengue virus infection
    Kobporn Boonnak
    Department of Medicine, Uniformed Services University of the Health Sciences, Division of Retrovirology, Department of Vaccine R and D, Walter Reed Army Institute of Research, 13 Taft Ct, Suite 200, Rockville, MD 20850, USA
    J Virol 82:3939-51. 2008
  8. pmc Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens
    Silvia Ratto-Kim
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    PLoS ONE 7:e45840. 2012
  9. pmc Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection
    Kobporn Boonnak
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20850, USA
    J Virol 85:1671-83. 2011
  10. pmc Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
    Jeffrey R Currier
    United States Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 5:e13983. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    J Infect Dis 186:1242-52. 2002
    ..These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers...
  2. ncbi request reprint ALVAC-HIV vaccines: clinical trial experience focusing on progress in vaccine development
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    Expert Rev Vaccines 3:S99-104. 2004
    ..All of these observations have important implications for the future of HIV vaccines and need to be considered in the design of the next generation of products...
  3. pmc A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells
    Michael A Eller
    U S Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 6:e24254. 2011
    ..We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conventional intramuscular or intradermal injections of the vaccine alone...
  4. ncbi request reprint Leishmaniasis recidivans recurrence after 43 years: a clinical and immunologic report after successful treatment
    M A Marovich
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Clin Infect Dis 33:1076-9. 2001
    ..Combination therapy with intralesional sodium stibogluconate and oral itraconazole was successful and immunologic data suggest that both CD4(+) and CD8(+) T cell subsets had roles in this disease process...
  5. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  6. ncbi request reprint Human dendritic cells as targets of dengue virus infection
    M Marovich
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Investig Dermatol Symp Proc 6:219-24. 2001
    ..Immature dendritic cells exposed to dengue virus produce TNF-alpha protein. Some of these immature dendritic cells undergo TNF-alpha mediated maturation as a consequence of exposure to the dengue virus...
  7. pmc Role of dendritic cells in antibody-dependent enhancement of dengue virus infection
    Kobporn Boonnak
    Department of Medicine, Uniformed Services University of the Health Sciences, Division of Retrovirology, Department of Vaccine R and D, Walter Reed Army Institute of Research, 13 Taft Ct, Suite 200, Rockville, MD 20850, USA
    J Virol 82:3939-51. 2008
    ..Studying the cellular targets of DV infection and their susceptibility to ADE will aid our understanding of complex disease and contribute to the field of vaccine development...
  8. pmc Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens
    Silvia Ratto-Kim
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    PLoS ONE 7:e45840. 2012
    ..This study supports the rationale for testing heterologous prime-boost regimens in humans...
  9. pmc Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection
    Kobporn Boonnak
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20850, USA
    J Virol 85:1671-83. 2011
    ..Our data suggest that ADE effects are cell type specific, are influenced by host genetics, and, depending on relative infection rates, may further contribute to the complexity of DV pathogenesis...
  10. pmc Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
    Jeffrey R Currier
    United States Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 5:e13983. 2010
    ..The HIV sequences were derived from circulating recombinant form CRF01_AE, which predominates in Thailand. The objective was to evaluate safety and immunogenicity of MVA-CMDR in human volunteers in the US and Thailand...
  11. pmc Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccines
    Patricia L Earl
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA
    Vaccine 27:5885-95. 2009
    ..The MVA/CMDR vaccine candidate expressing CRF01_AE genes has elicited HIV-specific T-cell responses in two independent Phase I clinical trials. Further testing of the other rMVA is warranted...
  12. doi request reprint Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infection
    Michael A Eller
    U S Military HIV Research Program, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Acquir Immune Defic Syndr 61:9-18. 2012
    ..To study the possible role of T cells associated with better outcome, we examined CD4 and CD8 T-cell responses against HIV-1 and cytomegalovirus (CMV) in Ugandans infected with subtype A HIV-1...
  13. pmc Human FcγRII cytoplasmic domains differentially influence antibody-mediated dengue virus infection
    Kobporn Boonnak
    Division of Retrovirology, Henry M Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Immunol 190:5659-65. 2013
    ....
  14. pmc Peptide impurities in commercial synthetic peptides and their implications for vaccine trial assessment
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    Clin Vaccine Immunol 15:267-76. 2008
    ..We propose a simple schema of biological QA/QC protocols to augment the standard biochemical QA/QC analyses as a means to circumvent this and other problems that can affect cellular immune-based assay outcome and interpretation...
  15. doi request reprint Mitigation of variation observed in a peripheral blood mononuclear cell (PBMC) based HIV-1 neutralization assay by donor cell pooling
    Lindsay Wieczorek
    Military HIV Research Program, Silver Spring, MD, USA Henry M Jackson Foundation, Bethesda, MD, USA
    Virology 447:240-8. 2013
    ....
  16. pmc Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoire
    Nicholas J Steers
    Henry Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, Maryland 20850, USA
    J Virol 85:1541-53. 2011
    ..These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells...
  17. pmc Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motif
    Michael A Eller
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    J Virol 85:4802-11. 2011
    ..These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif...
  18. pmc Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applications
    Jeffrey R Currier
    US Military HIV Research Program MHRP, Rockville, MD, USA
    J Transl Med 9:212. 2011
    ..Assessment of potential HIV strain coverage by candidate T cell-based vaccines (whether natural sequence or computationally optimized products) is now a critical component in interpreting candidate vaccine suitability...
  19. pmc Differential effects of dengue virus on infected and bystander dendritic cells
    Dupeh R Palmer
    Department of Viral Diseases, Walter Reed Army Institute of Research, Naval Research Center, Silver Spring, Maryland, USA
    J Virol 79:2432-9. 2005
    ..Taken together, these results constitute an immune evasion strategy used by DV that directly impairs antigen-presenting cell function by maturation blockade and induction of apoptosis...
  20. pmc A randomized controlled trial of local heat therapy versus intravenous sodium stibogluconate for the treatment of cutaneous Leishmania major infection
    Naomi E Aronson
    Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    PLoS Negl Trop Dis 4:e628. 2010
    ..Cutaneous Leishmania major has affected many travelers including military personnel in Iraq and Afghanistan. Optimal treatment for this localized infection has not been defined, but interestingly the parasite is thermosensitive...
  21. ncbi request reprint An immunocytometric assay based on dengue infection via DC-SIGN permits rapid measurement of anti-dengue neutralizing antibodies
    Nicole C Martin
    Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Virol Methods 134:74-85. 2006
    ..Importantly, serotype-specific neutralizing activity against recently isolated dengue strains with less heterotypic cross-neutralization than laboratory adapted viruses was also demonstrated...
  22. pmc Identification of germinal center B cells in blood from HIV-infected drug-naive individuals in Central Africa
    Lydie Beniguel
    CGIMAP EA3064, Faculte de Medecine, Université Jean Monnet, 15 Rue A Paré 42023, Saint Etienne Cedex 2, France
    Clin Dev Immunol 11:23-7. 2004
    ..It may impact the management of HIV infection in countries with limited access to HIV drugs and urges consideration for implementation of therapeutic vaccines...
  23. pmc Specific antibody production by blood B cells is retained in late stage drug-naïve HIV-infected Africans
    Lydie Beniguel
    GIMAP EA3064, Faculte de Medecine, université J Monnet, St Etienne, France
    Clin Dev Immunol 11:121-7. 2004
    ....