Research Topics
Genomes and GenesSpecies | G H KijakSummaryAffiliation: Division of Retrovirology Country: USA Publications
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Detail Information
Publications
Lost in translation: implications of HIV-1 codon usage for immune escape and drug resistanceGustavo H Kijak
Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD 20850, USA
AIDS Rev 6:54-60. 2004..Quasi-synonymy conditions HIV-1 and, potentially, other rapidly evolving organisms in their exploration of the mutational space...
Variable contexts and levels of hypermutation in HIV-1 proviral genomes recovered from primary peripheral blood mononuclear cellsGustavo H Kijak
Henry M Jackson Foundation for the Advancement of Military Medicine US Military HIV Research Program, 1600 East Gude Drive, Rockville, Maryland 20850, USA
Virology 376:101-11. 2008..These data suggest considerable complexity in the interplay of host restriction and viral defense during HIV-1 infection...
Development and application of a high-throughput HIV type 1 genotyping assay to identify CRF02_AG in West/West Central AfricaGustavo H Kijak
The Henry M Jackson Foundation, Rockville, Maryland 20850, USA
AIDS Res Hum Retroviruses 20:521-30. 2004..Together with other regional genotyping assays MHAcrf02 will contribute to the development of a global picture of HIV-1 diversity and geographic distribution, providing a strong foundation for intervention, including vaccine development...
Distinguishing molecular forms of HIV-1 in Asia with a high-throughput, fluorescent genotyping assay, MHAbce v.2Gustavo H Kijak
Henry M Jackson Foundation for the Advancement of Military Medicine US Military HIV Research Program, Rockville, MD 20850, USA
Virology 358:178-91. 2007..MHAbce v.2, with an area of application including China, India, Southeast Asia, and the Pacific Rim, can be used to develop a comprehensive and detailed picture of this important component of the HIV/AIDS pandemic...
HyperPack: a software package for the study of levels, contexts, and patterns of APOBEC-mediated hypermutation in HIVGustavo H Kijak
U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD 20850, USA
AIDS Res Hum Retroviruses 23:554-7. 2007..HyperPack is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/hyperpack/...
RecDraw: a software package for the representation of HIV-1 recombinant structuresGustavo H Kijak
US Military HIV Research Program, Rockville, Maryland 20850, USA
AIDS Res Hum Retroviruses 26:1317-21. 2010..RecDraw is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/research.php?ServiceID = 5&SubServiceID = 6 ...
HLA class I allele and haplotype diversity in Ugandans supports the presence of a major east African genetic clusterG H Kijak
Division of Retrovirology, US Military HIV Research Program Henry M Jackson Foundation, Rockville, MD 20850, USA
Tissue Antigens 73:262-9. 2009..The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines...
High-throughput genotyping of KIR2DL2/L3, KIR3DL1/S1, and their HLA class I ligands using real-time PCRR N Koehler
Division of Retrovirology, US Military HIV Research Program Henry M Jackson Foundation, Rockville, MD 20850, USA
Tissue Antigens 74:73-80. 2009..The application of this platform will further clarify the nature and impact of the KIR-HLA epistatic interaction on disease course in large global population-based studies...
Identification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern ThailandSodsai Tovanabutra
US Military HIV Research Program, Rockville, Maryland 20850, USA
AIDS Res Hum Retroviruses 23:829-33. 2007..More comprehensive HIV-1 prevention and treatment programs in IDU can help to limit the growing complexity of HIV-1 strains in Thailand...
Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, TanzaniaRebecca N Koehler
US Military HIV Research Program, Henry M Jackson Foundation, Rockville, Maryland 20850, USA
J Infect Dis 202:1562-6. 2010..This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection...
Socio-demographic and drug use factors associated with HIV-1 recombinants and dual infections in Northern Thai drug users: associations of risk with genetic complexityG H Kijak
US Military HIV Research Program, Henry M Jackson Foundation, Rockville, MD 20850, USA
Drug Alcohol Depend 116:24-30. 2011..In this study we aim to investigate the socio demographic factors associated with an increasing level of genetic diversity among HIV strains in a population of drug-users in Northern Thailand...
High-throughput high-resolution class I HLA genotyping in East AfricaRebecca N Koehler
United States Military HIV Research Program Henry M Jackson Foundation, Rockville, Maryland, USA
PLoS ONE 5:e10751. 2010..The availability of genotyping tools with this capacity will be extremely useful in the identification of correlates of immune protection and the evaluation of candidate vaccine efficacy...
Origin of human immunodeficiency virus type 1 quasispecies emerging after antiretroviral treatment interruption in patients with therapeutic failureGustavo H Kijak
National Reference Center for AIDS, Department of Microbiology, School of Medicine, University of Buenos Aires, Argentina
J Virol 76:7000-9. 2002..This study demonstrates the important role that the reemergence of quasispecies plays in HIV-1 population dynamics and points out the difficulties that may be found when recycling ARV therapies with patients with treatment failure...
