Jeffrey R Currier

Summary

Affiliation: Division of Retrovirology
Country: USA

Publications

  1. ncbi A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays
    Jeffrey R Currier
    The US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20851, USA
    J Immunol Methods 260:157-72. 2002
  2. pmc Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applications
    Jeffrey R Currier
    US Military HIV Research Program MHRP, Rockville, MD, USA
    J Transl Med 9:212. 2011
  3. pmc Peptide impurities in commercial synthetic peptides and their implications for vaccine trial assessment
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    Clin Vaccine Immunol 15:267-76. 2008
  4. pmc Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
    Jeffrey R Currier
    United States Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 5:e13983. 2010
  5. pmc CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: use of multiple peptide sets increases the detectable breadth of the CTL response
    Jeffrey R Currier
    The US Military HIV Research Program, Rockville, MD 20850, USA
    BMC Immunol 7:8. 2006
  6. ncbi Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians
    Jeffrey R Currier
    The U S Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 21:239-45. 2005
  7. ncbi Detection of high frequencies of HIV-1 cross-subtype reactive CD8 T lymphocytes in the peripheral blood of HIV-1-infected Kenyans
    Jeffrey R Currier
    US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20850, USA
    AIDS 17:2149-57. 2003
  8. pmc Comprehensive screening for human immunodeficiency virus type 1 subtype-specific CD8 cytotoxic T lymphocytes and definition of degenerate epitopes restricted by HLA-A0207 and -C(W)0304 alleles
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    J Virol 76:4971-86. 2002
  9. pmc HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e42579. 2012
  10. pmc Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens
    Silvia Ratto-Kim
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    PLoS ONE 7:e45840. 2012

Collaborators

Detail Information

Publications24

  1. ncbi A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays
    Jeffrey R Currier
    The US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20851, USA
    J Immunol Methods 260:157-72. 2002
    ..The size, shape and appearance of the spots produced using this peptide panel provided a standard for the establishment of acceptance criteria of spots for the evaluation of ELISPOT plates using an automated reader system...
  2. pmc Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applications
    Jeffrey R Currier
    US Military HIV Research Program MHRP, Rockville, MD, USA
    J Transl Med 9:212. 2011
    ..Assessment of potential HIV strain coverage by candidate T cell-based vaccines (whether natural sequence or computationally optimized products) is now a critical component in interpreting candidate vaccine suitability...
  3. pmc Peptide impurities in commercial synthetic peptides and their implications for vaccine trial assessment
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    Clin Vaccine Immunol 15:267-76. 2008
    ..We propose a simple schema of biological QA/QC protocols to augment the standard biochemical QA/QC analyses as a means to circumvent this and other problems that can affect cellular immune-based assay outcome and interpretation...
  4. pmc Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
    Jeffrey R Currier
    United States Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 5:e13983. 2010
    ..The HIV sequences were derived from circulating recombinant form CRF01_AE, which predominates in Thailand. The objective was to evaluate safety and immunogenicity of MVA-CMDR in human volunteers in the US and Thailand...
  5. pmc CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: use of multiple peptide sets increases the detectable breadth of the CTL response
    Jeffrey R Currier
    The US Military HIV Research Program, Rockville, MD 20850, USA
    BMC Immunol 7:8. 2006
    ..While considerable effort has been focused upon mapping and defining immunodominant CTL epitopes in HIV-1 subtype B and subtype C infections, few epitope mapping studies have focused upon subtype A...
  6. ncbi Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians
    Jeffrey R Currier
    The U S Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 21:239-45. 2005
    ..Efforts to optimize the cross-reactivity of vaccine-induced CD8 T cells may need to focus on the relative immunogenicity of minor sequence variation...
  7. ncbi Detection of high frequencies of HIV-1 cross-subtype reactive CD8 T lymphocytes in the peripheral blood of HIV-1-infected Kenyans
    Jeffrey R Currier
    US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20850, USA
    AIDS 17:2149-57. 2003
    ..To quantitate rapidly the frequency of HIV-1 subtype-specific and broadly HIV-1 cross-subtype-reactive CD8 T cells in the peripheral blood of HIV-1-infected individuals from a geographical region of multiple subtype endemicity...
  8. pmc Comprehensive screening for human immunodeficiency virus type 1 subtype-specific CD8 cytotoxic T lymphocytes and definition of degenerate epitopes restricted by HLA-A0207 and -C(W)0304 alleles
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    J Virol 76:4971-86. 2002
    ..These findings provide biological validation of HLA supertypes in HIV-1 CTL recognition and support earlier studies of cross-subtype CTL responses during HIV-1 infection...
  9. pmc HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e42579. 2012
    ..Preliminary immunological data from the RV144 phase III trial indicated that the immune responses were biased towards the Env antigen with a dominant CD4+ T-cell response...
  10. pmc Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens
    Silvia Ratto-Kim
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    PLoS ONE 7:e45840. 2012
    ..This study supports the rationale for testing heterologous prime-boost regimens in humans...
  11. ncbi Designing the epitope flanking regions for optimal generation of CTL epitopes
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Rockledge, MD 20852, USA
    Vaccine 32:3509-16. 2014
    ..These results highlight the importance of flanking regions in promoting efficient antigen processing and presentation. This concept can have important implications in vaccine design and development strategies. ..
  12. pmc A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells
    Michael A Eller
    U S Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 6:e24254. 2011
    ..We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conventional intramuscular or intradermal injections of the vaccine alone...
  13. doi Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infection
    Michael A Eller
    U S Military HIV Research Program, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Acquir Immune Defic Syndr 61:9-18. 2012
    ..To study the possible role of T cells associated with better outcome, we examined CD4 and CD8 T-cell responses against HIV-1 and cytomegalovirus (CMV) in Ugandans infected with subtype A HIV-1...
  14. ncbi Lost in translation: implications of HIV-1 codon usage for immune escape and drug resistance
    Gustavo H Kijak
    Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD 20850, USA
    AIDS Rev 6:54-60. 2004
    ..Quasi-synonymy conditions HIV-1 and, potentially, other rapidly evolving organisms in their exploration of the mutational space...
  15. ncbi HIV-1 MN Env 15-mer peptides better detect HIV-1 specific CD8 T cell responses compared with consensus subtypes B and M group 15-mer peptides
    Alleluiah Rutebemberwa
    Henry M Jackson Foundation and the US Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS 19:1165-72. 2005
    ..To compare the ability of three Env (15-mer) peptide sets derived from the HIV-1 MN, the subtype B consensus, and the group M consensus to detect HIV-1 specific interferon (IFN)-gamma responses in HIV-1 subtype B infected subjects...
  16. ncbi Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    J Infect Dis 186:1242-52. 2002
    ..These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers...
  17. pmc Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoire
    Nicholas J Steers
    Henry Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, Maryland 20850, USA
    J Virol 85:1541-53. 2011
    ..These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells...
  18. pmc High-throughput high-resolution class I HLA genotyping in East Africa
    Rebecca N Koehler
    United States Military HIV Research Program Henry M Jackson Foundation, Rockville, Maryland, USA
    PLoS ONE 5:e10751. 2010
    ..The availability of genotyping tools with this capacity will be extremely useful in the identification of correlates of immune protection and the evaluation of candidate vaccine efficacy...
  19. pmc Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motif
    Michael A Eller
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    J Virol 85:4802-11. 2011
    ..These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif...
  20. ncbi HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians
    Guido Ferrari
    Duke University, Durham, NC, USA
    Hum Immunol 65:648-59. 2004
    ..These data represent the first report of correlating HLA phenotype and HIV-specific cell-mediated immune responses among infected Ethiopians and may be useful in designing cytotoxic T lymphocyte-inducing vaccines for this part of Africa...
  21. pmc CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
    Christof Geldmacher
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 81:2440-8. 2007
    ..36; P = 0.0016). Particularly, recognition of multiple epitopes within two regions of Gag (amino acids [aa] 1 to 75 and aa 248 to 500) was associated with the maintenance of a low steady-state viremia, even years after acute infection...
  22. ncbi In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype
    Christof Geldmacher
    Mbeya Medical Research Program, Referral Hospital, Mbeya, Tanzania
    AIDS 21:135-43. 2007
    ..This study was designed to assess whether the Gag- and Nef-specific T-cell response is biased towards recognizing the infecting subtype...
  23. pmc A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection
    Christof Geldmacher
    Mbeya Medical Research Programme, Referral Hospital, Mbeya, Tanzania
    J Virol 81:13809-15. 2007
    ..0001) and subdominant in the hierarchy of Gag-specific responses. The present study indicates that chronic exposure of the human immune system to high levels of HIV viremia is a determinant of virus-specific CD8 T-cell loss...
  24. ncbi Circulating and unique recombinant forms of HIV type 1 containing subsubtype A2
    Unchalee Visawapoka
    Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    AIDS Res Hum Retroviruses 22:695-702. 2006
    ..Monitoring of A2-containing recombinants and subtype C strains, both relatively rare in Kenya, may be informative in the course of cohort development and evaluation of candidate vaccines...