Research Topics
| Jeffrey R CurrierSummaryAffiliation: Division of Retrovirology Country: USA Publications
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Detail Information
Publications
A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assaysJeffrey R Currier
The US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20851, USA
J Immunol Methods 260:157-72. 2002..The size, shape and appearance of the spots produced using this peptide panel provided a standard for the establishment of acceptance criteria of spots for the evaluation of ELISPOT plates using an automated reader system...
Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applicationsJeffrey R Currier
US Military HIV Research Program MHRP, Rockville, MD, USA
J Transl Med 9:212. 2011..Assessment of potential HIV strain coverage by candidate T cell-based vaccines (whether natural sequence or computationally optimized products) is now a critical component in interpreting candidate vaccine suitability...
CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: use of multiple peptide sets increases the detectable breadth of the CTL responseJeffrey R Currier
The US Military HIV Research Program, Rockville, MD 20850, USA
BMC Immunol 7:8. 2006..While considerable effort has been focused upon mapping and defining immunodominant CTL epitopes in HIV-1 subtype B and subtype C infections, few epitope mapping studies have focused upon subtype A...- Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected EthiopiansJeffrey R Currier
The U S Military HIV Research Program, Rockville, Maryland 20850, USA
AIDS Res Hum Retroviruses 21:239-45. 2005..Efforts to optimize the cross-reactivity of vaccine-induced CD8 T cells may need to focus on the relative immunogenicity of minor sequence variation... - Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidateJeffrey R Currier
United States Military HIV Research Program, Rockville, Maryland, United States of America
PLoS ONE 5:e13983. 2010..The HIV sequences were derived from circulating recombinant form CRF01_AE, which predominates in Thailand. The objective was to evaluate safety and immunogenicity of MVA-CMDR in human volunteers in the US and Thailand... - Detection of high frequencies of HIV-1 cross-subtype reactive CD8 T lymphocytes in the peripheral blood of HIV-1-infected KenyansJeffrey R Currier
US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20850, USA
AIDS 17:2149-57. 2003..To quantitate rapidly the frequency of HIV-1 subtype-specific and broadly HIV-1 cross-subtype-reactive CD8 T cells in the peripheral blood of HIV-1-infected individuals from a geographical region of multiple subtype endemicity... - Peptide impurities in commercial synthetic peptides and their implications for vaccine trial assessmentJeffrey R Currier
U S Military HIV Research Program, Rockville, Maryland 20850, USA
Clin Vaccine Immunol 15:267-76. 2008..We propose a simple schema of biological QA/QC protocols to augment the standard biochemical QA/QC analyses as a means to circumvent this and other problems that can affect cellular immune-based assay outcome and interpretation... - Comprehensive screening for human immunodeficiency virus type 1 subtype-specific CD8 cytotoxic T lymphocytes and definition of degenerate epitopes restricted by HLA-A0207 and -C(W)0304 allelesJeffrey R Currier
U S Military HIV Research Program, Rockville, Maryland 20850, USA
J Virol 76:4971-86. 2002..These findings provide biological validation of HLA supertypes in HIV-1 CTL recognition and support earlier studies of cross-subtype CTL responses during HIV-1 infection... - HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responsesNicholas J Steers
United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
PLoS ONE 7:e42579. 2012..Preliminary immunological data from the RV144 phase III trial indicated that the immune responses were biased towards the Env antigen with a dominant CD4+ T-cell response... - A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cellsMichael A Eller
U S Military HIV Research Program, Rockville, Maryland, United States of America
PLoS ONE 6:e24254. 2011..We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conventional intramuscular or intradermal injections of the vaccine alone... 
Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infectionMichael A Eller
U S Military HIV Research Program, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
J Acquir Immune Defic Syndr 61:9-18. 2012..To study the possible role of T cells associated with better outcome, we examined CD4 and CD8 T-cell responses against HIV-1 and cytomegalovirus (CMV) in Ugandans infected with subtype A HIV-1...- Lost in translation: implications of HIV-1 codon usage for immune escape and drug resistanceGustavo H Kijak
Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD 20850, USA
AIDS Rev 6:54-60. 2004..Quasi-synonymy conditions HIV-1 and, potentially, other rapidly evolving organisms in their exploration of the mutational space... - HIV-1 MN Env 15-mer peptides better detect HIV-1 specific CD8 T cell responses compared with consensus subtypes B and M group 15-mer peptidesAlleluiah Rutebemberwa
Henry M Jackson Foundation and the US Military HIV Research Program, Rockville, Maryland 20850, USA
AIDS 19:1165-72. 2005..To compare the ability of three Env (15-mer) peptide sets derived from the HIV-1 MN, the subtype B consensus, and the group M consensus to detect HIV-1 specific interferon (IFN)-gamma responses in HIV-1 subtype B infected subjects... - Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoireNicholas J Steers
Henry Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, Maryland 20850, USA
J Virol 85:1541-53. 2011..These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells... - Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cellsMary A Marovich
Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
J Infect Dis 186:1242-52. 2002..These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers... - Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimensSilvia Ratto-Kim
United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
PLoS ONE 7:e45840. 2012..This study supports the rationale for testing heterologous prime-boost regimens in humans... - High-throughput high-resolution class I HLA genotyping in East AfricaRebecca N Koehler
United States Military HIV Research Program Henry M Jackson Foundation, Rockville, Maryland, USA
PLoS ONE 5:e10751. 2010..The availability of genotyping tools with this capacity will be extremely useful in the identification of correlates of immune protection and the evaluation of candidate vaccine efficacy... - Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motifMichael A Eller
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
J Virol 85:4802-11. 2011..These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif... - A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infectionChristof Geldmacher
Mbeya Medical Research Programme, Referral Hospital, Mbeya, Tanzania
J Virol 81:13809-15. 2007..0001) and subdominant in the hierarchy of Gag-specific responses. The present study indicates that chronic exposure of the human immune system to high levels of HIV viremia is a determinant of virus-specific CD8 T-cell loss... - CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patientsChristof Geldmacher
Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
J Virol 81:2440-8. 2007..36; P = 0.0016). Particularly, recognition of multiple epitopes within two regions of Gag (amino acids [aa] 1 to 75 and aa 248 to 500) was associated with the maintenance of a low steady-state viremia, even years after acute infection... - HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected EthiopiansGuido Ferrari
Duke University, Durham, NC, USA
Hum Immunol 65:648-59. 2004..These data represent the first report of correlating HLA phenotype and HIV-specific cell-mediated immune responses among infected Ethiopians and may be useful in designing cytotoxic T lymphocyte-inducing vaccines for this part of Africa... - In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtypeChristof Geldmacher
Mbeya Medical Research Program, Referral Hospital, Mbeya, Tanzania
AIDS 21:135-43. 2007..This study was designed to assess whether the Gag- and Nef-specific T-cell response is biased towards recognizing the infecting subtype... - Circulating and unique recombinant forms of HIV type 1 containing subsubtype A2Unchalee Visawapoka
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
AIDS Res Hum Retroviruses 22:695-702. 2006..Monitoring of A2-containing recombinants and subtype C strains, both relatively rare in Kenya, may be informative in the course of cohort development and evaluation of candidate vaccines...