William A Greenberg

Summary

Affiliation: Diversa Corporation
Country: USA

Publications

  1. pmc Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
    William A Greenberg
    Diversa Corporation, 4955 Directors Place, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:5788-93. 2004
  2. ncbi request reprint An enzyme library approach to biocatalysis: development of nitrilases for enantioselective production of carboxylic acid derivatives
    Grace DeSantis
    Diversa Corporation, 4955 Directors Place, San Diego, California 92121, USA
    J Am Chem Soc 124:9024-5. 2002
  3. ncbi request reprint Cycloaddition of delta2-thiazolines and acyl ketenes under acidic conditions results in bicyclic 1,3-oxazinones and not 6-acylpenams as earlier reported
    Nils Pemberton
    Organic Chemistry and Inorganic Chemistry, Umea University, S 901 87 Umea, Sweden
    Org Lett 7:1019-21. 2005
  4. ncbi request reprint D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols
    Masakazu Sugiyama
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:14811-7. 2007

Collaborators

  • Grace DeSantis
  • Dan E Robertson
  • Masakazu Sugiyama
  • Nils Pemberton
  • Lisa J Whalen
  • Zhangyong Hong
  • Chi Huey Wong
  • Pi Hui Liang
  • Stephen M Dean
  • Michael D Levin
  • Fredrik Almqvist
  • Zuolin Zhu
  • Hans Emtenas
  • Dan Boström
  • Peter J Domaille

Detail Information

Publications4

  1. pmc Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
    William A Greenberg
    Diversa Corporation, 4955 Directors Place, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:5788-93. 2004
    ..9% and diastereomeric excess at 96.6%. In addition, down-stream chemical steps have been developed to convert the enzymatic product efficiently to versatile intermediates applicable to preparation of atorvastatin and rosuvastatin...
  2. ncbi request reprint An enzyme library approach to biocatalysis: development of nitrilases for enantioselective production of carboxylic acid derivatives
    Grace DeSantis
    Diversa Corporation, 4955 Directors Place, San Diego, California 92121, USA
    J Am Chem Soc 124:9024-5. 2002
    ..The first enzymes are reported that effect this transformation to furnish the (R)-4-cyano-3-hydroxybutyric acid which is a precursor to the blockbuster drug Lipitor...
  3. ncbi request reprint Cycloaddition of delta2-thiazolines and acyl ketenes under acidic conditions results in bicyclic 1,3-oxazinones and not 6-acylpenams as earlier reported
    Nils Pemberton
    Organic Chemistry and Inorganic Chemistry, Umea University, S 901 87 Umea, Sweden
    Org Lett 7:1019-21. 2005
    ..Thus, we report new data showing that instead of acyl beta-lactams, the optically active isomers 3R,9R-1,3-oxazinones 3a-g are obtained stereoselectively in 38-93% yields...
  4. ncbi request reprint D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols
    Masakazu Sugiyama
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:14811-7. 2007
    ..Facile access to these compounds makes them attractive core structures for further inhibitor optimization...