David Lo

Summary

Affiliation: Digital Gene Technologies
Country: USA

Publications

  1. ncbi request reprint TOGA analysis of gene expression to accelerate target development
    D Lo
    Department of Integrative Biology, Digital Gene Technologies, Inc, 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharm Sci 14:191-6. 2001
  2. ncbi request reprint Exploiting immune surveillance mechanisms in mucosal vaccine development
    David Lo
    Digital Gene Technologies, Inc, 11149 North Torrey Pines Road, Suite 2302, La Jolla, CA 92037, USA
    Expert Opin Biol Ther 4:397-406. 2004
  3. ncbi request reprint Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA 92037, USA
    Int Immunol 16:91-9. 2004
  4. ncbi request reprint Peptidoglycan recognition protein expression in mouse Peyer's Patch follicle associated epithelium suggests functional specialization
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA, USA
    Cell Immunol 224:8-16. 2003
  5. ncbi request reprint Open system gene expression profiling and identification of novel genes for targeted vaccine delivery
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA 92037, USA
    Expert Rev Vaccines 1:95-100. 2002
  6. ncbi request reprint Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling
    David Lo
    Digital Gene Technologies, Inc, 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
    Adv Drug Deliv Rev 54:1213-23. 2002
  7. ncbi request reprint Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR
    Ron S Broide
    Neurome, Inc, 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1000:211-22. 2004
  8. pmc Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice
    Antonio Currais
    The Salk Institute for Biological Studies, Laboratory of Cellular Neurobiology, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Aging Cell 11:1017-26. 2012
  9. pmc Antigen presentation by keratinocytes directs autoimmune skin disease
    Lian Fan
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:3386-91. 2003
  10. ncbi request reprint CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity
    Maria P Lemos
    Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
    J Immunol 171:5077-84. 2003

Collaborators

  • Ron S Broide
  • Terri M Laufer
  • MITCHELL E KRONENBERG
  • HILDE MC CHEROUTRE
  • Dirk Elewaut
  • Antonio Currais
  • Lian Fan
  • Allison B Goldfine
  • John Spence
  • Mary E Pauza
  • Maria P Lemos
  • Hiral Gami
  • Mary Elizabeth Patti
  • Kazuaki Yoshikawa
  • Amy Warren
  • Maura Costello
  • Michio Niinobe
  • Jose Jimenez-Chillaron
  • Sarah Crunkhorn
  • Edwin J Landaker
  • Tiebing Liang
  • Tatiana Foroud
  • Lucinda Carr
  • Tricia Patterson
  • Brian S Anobile
  • Jing He
  • Cathleen M Dobbs
  • Kathryn Haskins
  • Steven Wagner
  • Brenda J Bradley
  • Brian W Busser
  • Traci Q Lifsted
  • Mohamed Oukka

Detail Information

Publications14

  1. ncbi request reprint TOGA analysis of gene expression to accelerate target development
    D Lo
    Department of Integrative Biology, Digital Gene Technologies, Inc, 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharm Sci 14:191-6. 2001
    ..These studies will quickly lead to identification of genes critical to specific biological and clinical processes, accelerating the development of new targets and therapies...
  2. ncbi request reprint Exploiting immune surveillance mechanisms in mucosal vaccine development
    David Lo
    Digital Gene Technologies, Inc, 11149 North Torrey Pines Road, Suite 2302, La Jolla, CA 92037, USA
    Expert Opin Biol Ther 4:397-406. 2004
    ..Ongoing research is identifying genes that may be critical to triggering mucosal immunity; an understanding of their role in discrimination may lead to the development of new vaccines...
  3. ncbi request reprint Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA 92037, USA
    Int Immunol 16:91-9. 2004
    ....
  4. ncbi request reprint Peptidoglycan recognition protein expression in mouse Peyer's Patch follicle associated epithelium suggests functional specialization
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA, USA
    Cell Immunol 224:8-16. 2003
    ....
  5. ncbi request reprint Open system gene expression profiling and identification of novel genes for targeted vaccine delivery
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA 92037, USA
    Expert Rev Vaccines 1:95-100. 2002
    ..These receptors will be ideal for targeted delivery of new synthetic vaccines. In addition, gene expression profiling will provide important new information on the biology of the M-cell and mucosal immune mechanisms...
  6. ncbi request reprint Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling
    David Lo
    Digital Gene Technologies, Inc, 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
    Adv Drug Deliv Rev 54:1213-23. 2002
    ..The power of this gene profiling approach also suggests application to other systems, such as the response to metabolic changes or drug treatments...
  7. ncbi request reprint Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR
    Ron S Broide
    Neurome, Inc, 11149 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1000:211-22. 2004
    ..These results support the accuracy of the SQuISH protocol for determining relative mRNA levels in the brain...
  8. pmc Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice
    Antonio Currais
    The Salk Institute for Biological Studies, Laboratory of Cellular Neurobiology, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Aging Cell 11:1017-26. 2012
    ..These data suggest that aberrant glucose metabolism potentiates the aging phenotype in old mice and contributes to early stage central nervous system pathology in younger animals...
  9. pmc Antigen presentation by keratinocytes directs autoimmune skin disease
    Lian Fan
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:3386-91. 2003
    ..Disease can be induced by skin inflammation but not solely by activation of T cells. Thus, cutaneous immunopathology can be directed through antigen presentation by tissue-resident keratinocytes to autoreactive TCR Tg CD4(+) cells...
  10. ncbi request reprint CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity
    Maria P Lemos
    Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
    J Immunol 171:5077-84. 2003
    ..These findings indicate that DCs are not only key initiators of the primary response, but provide all of the necessary cognate interactions to control CD4(+) T cell fate during the primary immune response...
  11. ncbi request reprint T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes
    Mary E Pauza
    Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Diabetes 53:978-88. 2004
    ..Thus, the generation of 6.9TCR transgenic mice provides a model of autoimmune diabetes whereby controlled expression of an endogenous polymorphic autoantigen effectively determines disease development...
  12. ncbi request reprint Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research
    John Spence
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Addict Biol 10:47-51. 2005
    ..By evaluating differences in gene expression for linkage to a quantitative trait, this combined approach was implemented to identify alpha-synuclein, a candidate gene for alcohol preference...
  13. pmc NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells
    Dirk Elewaut
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 197:1623-33. 2003
    ....
  14. ncbi request reprint Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue
    Allison B Goldfine
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:640-50. 2006
    ..These data suggest that changes in necdin and E2F4 expression after rosiglitazone exposure in humans are associated with altered adipocyte differentiation and may contribute to improved insulin sensitivity in humans treated with TZDs...