Research Topics
| George A DiamondSummaryCountry: USA Publications
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Detail Information
Publications
Rosiglitazone and cardiovascular riskSanjay Kaul
Division of Cardiology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Curr Atheroscler Rep 10:398-404. 2008..We conclude that the data showing the increased risk for myocardial infarction and death from cardiovascular disease for diabetic patients taking rosiglitazone are inconclusive...
COURAGE under fire: on the management of stable coronary diseaseGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA
J Am Coll Cardiol 50:1604-9. 2007..We herein reevaluate the evidence with regard to each of these points, and conclude that COURAGE indeed provides relevant new information to assist the practitioner in the appropriate management of patients with stable coronary disease...
Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular deathGeorge A Diamond
Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Ann Intern Med 147:578-81. 2007..We conclude that the risk for myocardial infarction and death from cardiovascular disease for diabetic patients taking rosiglitazone is uncertain: Neither increased nor decreased risk is established...
Screen testing cardiovascular prevention in asymptomatic diabetic patientsGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA
J Am Coll Cardiol 49:1915-7. 2007..This analysis shows that unconditional treatment is the dominant strategy, costing 24% less ($3.2 billion) and preventing 25% more (16,800) atherosclerotic events annually on a national basis...
The things to come of SHAPE: cost and effectiveness of cardiovascular preventionGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Am J Cardiol 99:1013-5. 2007..In conclusion, greater attention should be paid to improving the population-wide delivery of and long-term adherence to proven preventive therapy than to the identification of "high-risk" treatment targets...
An orwellian discourse on the meaning and measurement of noninferiorityGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA
Am J Cardiol 99:284-7. 2007..In conclusion, the resultant probabilistic measures thereby render the meaning of noninferiority more transparent and clinically relevant...
From here to eternity: a unified kinetic model for the pathophysiology of atherosclerotic eventsGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, Calif, USA
Am J Med 120:5-11. 2007....
Bayesian classification of clinical practice guidelinesGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Arch Intern Med 169:1431-5. 2009..We conclude that this quantitative schema has the potential to improve the quality and cost of evidence-based clinical management...
Hazardous to your health: kinetic foundations of risk stratification and therapeutic triageGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, and David Geffen School of Medicine, University of California, Los Angeles, USA
Am J Med 119:275.e1-6. 2006..Clinical risk stratification nevertheless relies only on the former...
Prior convictions: Bayesian approaches to the analysis and interpretation of clinical megatrialsGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, and the School of Medicine, University of California, Los Angeles, California, USA
J Am Coll Cardiol 43:1929-39. 2004..Accordingly, the Bayesian approach should be employed more widely in the design, analysis, and interpretation of clinical megatrials...
Making sense of noninferiority: a clinical and statistical perspective on its application to cardiovascular clinical trialsSanjay Kaul
Division of Cardiology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
Prog Cardiovasc Dis 49:284-99. 2007....
As time goes by: current status and future directions in the controversy over stentingSanjay Kaul
Division of Cardiology, Cedars Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
J Am Coll Cardiol 50:128-37. 2007....
The JUPITER trial: myth or reality?Ryan P Morrissey
Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Curr Atheroscler Rep 13:413-21. 2011..Given these limitations, the attendant societal health policy implications remain largely unknown...
Current status and future trends in drug-eluting stentsSanjay Kaul
Division of Cardiology, Cedars-Sinai Medical Center and the David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
Am Heart Hosp J 5:165-8. 2007
Statins in acute coronary syndromes: do the guideline recommendations match the evidence?Ryan P Morrissey
Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 54:1425-33. 2009..On the basis of these observations, and despite a compelling pathophysiologic rationale, the justification for current Class I, Level of Evidence: A recommendation for statin therapy in patients with ACS remains open to question...
Trials and tribulations of non-inferiority: the ximelagatran experienceSanjay Kaul
Division of Cardiology, Cedars Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
J Am Coll Cardiol 46:1986-95. 2005..Such determinations of non-inferiority are highly dependent on the underlying assumptions, and graphical sensitivity analyses make this dependence explicit...
Role of clopidogrel in managing atherothrombotic cardiovascular diseaseShervin Eshaghian
Cedars Sinai Medical Center and the David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
Ann Intern Med 146:434-41. 2007....
Narrative review: drug-eluting stents for the management of restenosis: a critical appraisal of the evidenceRoderick Tung
Cedars-Sinai Medical Center, David Geffen School of Medicine, and University of California, Los Angeles, Los Angeles, California 90048, USA
Ann Intern Med 144:913-9. 2006....
Good enough: a primer on the analysis and interpretation of noninferiority trialsSanjay Kaul
Division of Cardiology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
Ann Intern Med 145:62-9. 2006....
Continuous probabilistic prediction of angiographically significant coronary artery disease using electron beam tomographyMatthew J Budoff
Division of Cardiology, Harbor UCLA Research and Education Institute, Torrance, Calif 90502 2064, USA
Circulation 105:1791-6. 2002..Such a model could greatly facilitate clinical triage in symptomatic patients with no known CAD...
On reporting of effect size in randomized clinical trialsGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center and University of California, Los Angeles, California, USA
Am J Cardiol 111:613-7. 2013..In conclusion, our results have shown that composite measures of effect size communicate the clinical importance of trial results better than do conventional assessments of risk reduction and statistical significance...
By desperate appliance relieved? On the clinical relevance of risk stratification to therapeutic decision-makingGeorge A Diamond
Division of Cardiology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California
Am J Cardiol 109:919-23. 2012..Instead, risk stratification guidelines specific to a particular disease and a particular treatment should be founded on prospective empiric validation...
Trial and error. How to avoid commonly encountered limitations of published clinical trialsSanjay Kaul
Division of Cardiology, Cedars Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles, California 90048 1804, USA
J Am Coll Cardiol 55:415-27. 2010..Accordingly, this review highlights these limitations using numerous examples of published clinical trials and describes ways to overcome these limitations, thereby improving the interpretability of research findings...
Dronedarone for atrial fibrillation have we expanded the antiarrhythmic armamentarium?David Singh
Division of Cardiology, Cedars Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
J Am Coll Cardiol 55:1569-76. 2010..We conclude that the available data support the use of dronedarone in select patient populations as a second- or third-line agent...
Prospective validation of a quantitative method for differentiating ischemic versus nonischemic cardiomyopathy by technetium-99m sestamibi myocardial perfusion single-photon emission computed tomographySiu Sun Yao
Division of Cardiology, St Luke s Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York 10019, USA
Clin Cardiol 27:615-20. 2004..Quantitative analysis of perfusion patterns among patients with LV dysfunction offers an opportunity for developing criteria to differentiate ischemic from nonischemic cardiomyopathy...
Rosiglitazone and cardiovascular riskGeorge A Diamond
N Engl J Med 357:938-9; author reply 939-40. 2007
Prevention and treatment: a tale of two strategiesGeorge A Diamond
J Am Coll Cardiol 51:46-8. 2008
The disconnect between practice guidelines and clinical practice--stressed outGeorge A Diamond
JAMA 300:1817-9. 2008
Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 1: diagnosis of stable ischemia and ischemic heart diseaseCarl J Pepine
Circulation 109:e44-6. 2004
Predicting cardiovascular events with coronary calcium scoringWilliam S Weintraub
N Engl J Med 358:1394-6. 2008
DTCA for PTCA--crossing the line in consumer health education?William E Boden
Division of Cardiovascular Medicine, University at Buffalo Schools of Medicine and Public Health, and Buffalo General Hospital, Buffalo, NY, USA
N Engl J Med 358:2197-200. 2008
