Ian A Sigal

Summary

Affiliation: Devers Eye Institute
Country: USA

Publications

  1. ncbi request reprint Finite element modeling of optic nerve head biomechanics
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, 5 King s College Road, University of Toronto, Toronto, Ontario M5S 3G8, Canada
    Invest Ophthalmol Vis Sci 45:4378-87. 2004
  2. ncbi request reprint Factors influencing optic nerve head biomechanics
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 46:4189-99. 2005
  3. pmc Morphing methods to parameterize specimen-specific finite element model geometries
    Ian A Sigal
    Ocular Biomechanics Laboratory, Devers Eye Institute, 1225 ME 2nd Ave, Portland, OR 97232, USA
    J Biomech 43:254-62. 2010
  4. doi request reprint Mesh-morphing algorithms for specimen-specific finite element modeling
    Ian A Sigal
    Orthopaedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    J Biomech 41:1381-9. 2008
  5. doi request reprint Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
    Biomech Model Mechanobiol 8:85-98. 2009
  6. doi request reprint Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
    Biomech Model Mechanobiol 8:99-109. 2009
  7. pmc Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:345-63. 2011
  8. pmc Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
    Invest Ophthalmol Vis Sci 50:5785-99. 2009
  9. pmc Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 52:7109-21. 2011
  10. doi request reprint Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma
    Richard E Norman
    Mechanical and Industrial Engineering, University of Toronto, 5 King s College Rd, Toronto, Ontario M5S 3G8, Canada
    Exp Eye Res 93:4-12. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Finite element modeling of optic nerve head biomechanics
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, 5 King s College Road, University of Toronto, Toronto, Ontario M5S 3G8, Canada
    Invest Ophthalmol Vis Sci 45:4378-87. 2004
    ..The goal of this study was to characterize the biomechanics of the optic nerve head using computer modeling techniques...
  2. ncbi request reprint Factors influencing optic nerve head biomechanics
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 46:4189-99. 2005
    ..This was a systematic analysis in which finite element methods were used to determine which anatomic and biomechanical factors most influenced the biomechanical response of the ONH to acute changes in IOP...
  3. pmc Morphing methods to parameterize specimen-specific finite element model geometries
    Ian A Sigal
    Ocular Biomechanics Laboratory, Devers Eye Institute, 1225 ME 2nd Ave, Portland, OR 97232, USA
    J Biomech 43:254-62. 2010
    ..Morphing techniques provide an exciting new possibility for the analysis of the biomechanical role of shape, independently or in interaction with loading and material properties...
  4. doi request reprint Mesh-morphing algorithms for specimen-specific finite element modeling
    Ian A Sigal
    Orthopaedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    J Biomech 41:1381-9. 2008
    ....
  5. doi request reprint Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
    Biomech Model Mechanobiol 8:85-98. 2009
    ..Predicted strains within ONH tissues are potentially biologically significant and support the hypothesis that biomechanical factors contribute to the initial insult that leads to RGC loss in glaucoma...
  6. doi request reprint Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
    Biomech Model Mechanobiol 8:99-109. 2009
    ..We need to better understand inter-individual differences in scleral biomechanical properties and whether they are clinically important...
  7. pmc Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:345-63. 2011
    ....
  8. pmc Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
    Invest Ophthalmol Vis Sci 50:5785-99. 2009
    ..To characterize optic nerve head (ONH) connective tissue deformation after acute (15 or 30 minutes) intraocular pressure (IOP) elevation in six adult normal monkeys using three-dimensional (3-D) histomorphometry...
  9. pmc Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 52:7109-21. 2011
    ..To quantify the lamina cribrosa insertion into the peripapillary sclera and optic nerve pia in normal (N) and early experimental glaucoma (EEG) monkey eyes...
  10. doi request reprint Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma
    Richard E Norman
    Mechanical and Industrial Engineering, University of Toronto, 5 King s College Rd, Toronto, Ontario M5S 3G8, Canada
    Exp Eye Res 93:4-12. 2011
    ..The relationship between scleral thickness and material properties needs to be studied in human eyes...
  11. pmc Changes in the biomechanical response of the optic nerve head in early experimental glaucoma
    Michael D Roberts
    Ocular Biomechanics Laboratories, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 51:5675-84. 2010
    ..To investigate the biomechanical response of the optic nerve head (ONH) connective tissues to IOP elevation in three pairs of monkey eyes in which one eye had early experimental glaucoma (EG)...
  12. ncbi request reprint Predicted extension, compression and shearing of optic nerve head tissues
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada
    Exp Eye Res 85:312-22. 2007
    ..The largest deformations are compressive, followed by shearing and stretching. Models of IOP-induced RGC damage need to be further refined by characterizing the cellular response to these different modes of strain...
  13. pmc IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related?
    Ian A Sigal
    Ocular Biomechanics Laboratory, Devers Eye Institute, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 52:9023-32. 2011
    ..To study the association between the intraocular pressure (IOP)-induced anterior-posterior lamina cribrosa deformation (LCD) and scleral canal expansion (SCE)...
  14. pmc Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes
    Michael D Roberts
    Ocular Biomechanics, Legacy Health System, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:295-307. 2010
    ..To investigate the biomechanical response to IOP elevation of normal monkey eyes using eye-specific, three-dimensional (3-D) finite element (FE) models of the ONH that incorporate lamina cribrosa (LC) microarchitectural information...
  15. pmc Effect of acute intraocular pressure elevation on the monkey optic nerve head as detected by spectral domain optical coherence tomography
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health, Portland, Oregon 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:9431-7. 2011
    ..To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SD-OCT)...
  16. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
    ....
  17. ncbi request reprint Reconstruction of human optic nerve heads for finite element modeling
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
    Technol Health Care 13:313-29. 2005
    ..We validate the method using a virtual eye, and demonstrate its use in computing optic nerve head biomechanics...
  18. doi request reprint Dimensions of the human sclera: Thickness measurement and regional changes with axial length
    Richard E Norman
    Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada
    Exp Eye Res 90:277-84. 2010
    ..Significant intra-individual and inter-individual variation in scleral thickness was evident. This may be indicative of inter-individual differences in ocular biomechanics...
  19. pmc Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism
    J Crawford Downs
    Ocular Biomechanics Laboratory of the Devers Eye Institute, Legacy Health, 1225 NE 2nd Ave, Portland, OR 97232, USA
    Exp Eye Res 93:133-40. 2011
    ..It is plausible that biomechanics-driven connective tissue remodeling is a mechanism in the progression of laminar morphology from a normal state to that of a cupped, excavated glaucomatous state...
  20. pmc An applet to estimate the IOP-induced stress and strain within the optic nerve head
    Ian A Sigal
    Ocular Biomechanics Laboratory, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 52:5497-506. 2011
    ..The objective of this work was to introduce an approach to model ONH biomechanics that combines the ease of use and speed of analytical models with the flexibility and power of numerical models...
  21. doi request reprint 3D morphometry of the human optic nerve head
    Ian A Sigal
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada
    Exp Eye Res 90:70-80. 2010
    ..Emerging clinical imaging techniques such as deep-scanning OCT will be limited to investigation of the central and mid-peripheral regions of the LC due to optical "occluding" by the peripapillary sclera...
  22. doi request reprint Mesh morphing and response surface analysis: quantifying sensitivity of vertebral mechanical behavior
    Ian A Sigal
    Orthopaedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, UB19, Toronto, ON, M4N 3M5, Canada
    Ann Biomed Eng 38:41-56. 2010
    ....