Brad Fortune

..To compare peripapillary retinal nerve fiber layer thickness (RNFLT), RNFL retardance, and retinal function at the onset of optic nerve head (ONH) surface topography change in experimental glaucoma (EG)...

..To compare the diagnostic performance of multifocal visual evoked potential (mfVEP) and standard automated perimetry (SAP), in eyes with high-risk ocular hypertension or early glaucoma...

..The mfVEP response depends on the polarity of a contrast step, irrespective of the state of contrast adaptation...

..To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT), or retardance...

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..No permanent changes in peripapillary retinal or RNFL thickness (for up to 1 month of follow-up) were caused by 60 minutes of IOP elevation to 50 mm Hg...

..To evaluate the effect on diagnostic performance of reducing multifocal visual-evoked potential (mfVEP) recording duration from 16 to 8 minutes per eye...

..To evaluate and compare three commonly used multifocal electroretinogram (mfERG) stimuli, as well as the standard transient pattern-reversal ERG (pERG) and the photopic full-field ERG, for detection of local GC damage...

..To characterize optic nerve head (ONH) blood flow (BF) changes in nonhuman primate experimental glaucoma (EG) using laser speckle flowgraphy (LSFG) and the microsphere method and to evaluate the correlation between the two methods...

..We determined the relationship between total optic nerve axon counts and peripapillary retinal nerve fiber layer thickness (RNFLT) measured in vivo by spectral domain optical coherence tomography (SDOCT)...

..CONCLUSIONS: The existence of BOA in nonhuman primates warrants caution on the part of investigators who use these animals in experimental models of ophthalmic disease...

..To test the hypothesis that specific locations and patterns of threshold findings within the visual field have predictive value for progressive glaucomatous optic neuropathy (pGON)...

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..Clinical Relevance The study supports the clinical observation of endothelin involvement in glaucoma and provides direct evidence that the endothelin system is associated with glaucomatous pathologic abnormalities...

..Maximum IOP provided the best predictability of structural change, either causally or because it captures the contributions of both mean and variability...

..Repeated IOP spikes above this level may cause permanent, nonspecific damage, perhaps via ischemic mechanisms. Thus, IOP should be monitored frequently in these models...

..Quantitative analysis of dAR may provide a direct view of vasomotorial activity in the resistant vessels and thus a new approach to assess the autoregulatory capacity in the ONH...

..Our second aim was to assess the repeatability of false alarm rates determined previously for the mfVEP using various cluster criteria...

..To characterize the hemodynamic features and the association with structural damage in the optic nerve head (ONH) of idiopathic bilateral optic atrophy (BOA) in rhesus macaque monkeys...

..To test whether the enhanced depth imaging (EDI) modality improves anterior and posterior lamina cribrosa surface (ALCS and PLCS) visibility compared with conventional spectral-domain optical coherence tomography (SD-OCT)...

..To evaluate the effects of chronic optic nerve ischemia in a nonhuman primate model and to evaluate the regional variability of axonal loss...

..To characterize retinal functional consequences of elevated intraocular pressure (IOP) in a rat model of experimental glaucoma...

..To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SD-OCT)...

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..This study tested a hypothesis that the magnitude of blood flow change in the ONH induced between two same intraocular pressure (IOP) alterations depends on the level of mean systemic blood pressure (BP)...

..To evaluate electrophysiologic function in glaucoma by using a new stimulus designed to enhance ganglion cell and optic nerve head component (ONHC) contributions to multifocal electroretinogram (mfERG) responses...

..One of the most important parameters seems to be use of a monopolar signal derivation, with the contralateral cornea serving as the reference position...

..To investigate spectral domain optical coherence tomography (SD-OCT)-detected optic disc margin anatomy in the monkey eye by colocalizing disc photographs to SD-OCT scans acquired from the same eyes...

..To assess the inter-ocular and inter-session reliability for a range of parameters derived from the photopic electroretinogram (ERG) in a group of normal non-human primates...

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..The vasoreactivity to altered systemic PaCO2 in the retina in rats is similar to that of most other species studied. However, the choroidal vascular system exhibited complicated features that remain to be further clarified...

..The optimal dose for the retina was approximately 2.5x10(6), 0.5x10(6) for the choroid, and 5x10(6) approximately 10(7) for the optic nerve. The 15 microm MS are inappropriate for ocular blood flow measurements in rats...

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..The mitochondria-rich varicosities and the presence of intercellular junctions suggest that the varicosities may be functional sites that serve local high-energy demands of unmyelinated fibers and signal transmission...

..To describe a normative database for the multifocal VEP (mfVEP) and to evaluate specificity for a range of cluster criteria...

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..The relationships between glial cells, neuronal cells, and the vasculature, as well as the potential role of glial cells in pathologic mechanisms during different stages of neuronal damage in glaucoma, are discussed...

..To observe temporal changes in retinal physiology and histology in a rat model of laser-induced retinal vein occlusion (RVO)...

..Hence, the increase of the cone response during light adaptation is sufficient to explain b-wave amplitude growth...

..Vernier acuity, or other similar hyperacuity tasks that assess spatial sampling, may be useful in the detection of early glaucomatous damage, before it is detected with traditional perimetric tests...

..Results demonstrate that axonal transport of CTB can be monitored in vivo in the rodent anterior visual pathway, is dependent on intact microtubules, and occurs by active transport mechanisms...

..To compare conventional pattern-reversal visual evoked potentials (cVEPs) with multifocal VEPs (mfVEPs)...

..Simulation studies support an optical basis for the observed age-related changes. It is concluded that mfERG changes between the ages of 20 and 70 are due predominantly to preretinal optical factors...

..To describe methods for measuring interocular latency differences of multifocal visual evoked potentials (mfVEP) and for determining regions with abnormal interocular latencies in patients...

..To describe a methodology for measuring abnormal timing of monocular multifocal visual evoked potentials (mfVEP)...

..This project evaluates and advances clinical tools for detecting early damage and progression of glaucoma. ..

..This project evaluates and advances clinical tools for detecting early damage and progression of glaucoma. ..