Stephen I Deutsch

Summary

Country: USA

Publications

  1. ncbi Williams syndrome: a genetic deletion disorder presenting clues to the biology of sociability and clinical challenges of hypersociability
    Stephen I Deutsch
    Department of Veterans Affairs Medical Center, Mental Health Service Line, Washington, DC, USA
    CNS Spectr 12:903-7. 2007
  2. doi Sodium butyrate, an epigenetic interventional strategy, attenuates a stress-induced alteration of MK-801's pharmacologic action
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, NW, Washington, DC 20422, United States
    Eur Neuropsychopharmacol 18:565-8. 2008
  3. ncbi Topiramate antagonizes MK-801 in an animal model of schizophrenia
    Stephen I Deutsch
    Mental Health Service Line, Veterans Integrated Service Network 5, 849 International Drive, Suite 275, Linthicum, MD 21090, USA
    Eur J Pharmacol 449:121-5. 2002
  4. ncbi Guanosine possesses specific modulatory effects on NMDA receptor-mediated neurotransmission in intact mice
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Eur Neuropsychopharmacol 18:299-302. 2008
  5. ncbi Hypothesized deficiency of guanine-based purines may contribute to abnormalities of neurodevelopment, neuromodulation, and neurotransmission in Lesch-Nyhan syndrome
    Stephen I Deutsch
    Mental Health Service Line, VISN5, Department of Veterans Affairs Medical Center, NW, Washington, DC 20422, USA
    Clin Neuropharmacol 28:28-37. 2005
  6. ncbi Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States
    Eur Neuropsychopharmacol 18:147-51. 2008
  7. ncbi Mitochondrial myopathy complicated by eating disorder: a case report highlighting the potential interaction of genetic, metabolic, and psychodynamic factors
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    CNS Spectr 12:289-92. 2007
  8. ncbi Therapeutic implications of a selective alpha7 nicotinic receptor abnormality in schizophrenia
    Stephen I Deutsch
    Department of Veterans Affairs Medical Center, Washington, DC, USA
    Isr J Psychiatry Relat Sci 42:33-44. 2005
  9. ncbi Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States
    Eur Neuropsychopharmacol 16:547-51. 2006
  10. ncbi Rare neurodevelopmental abnormalities of sarcosinemia may involve glycinergic stimulation of a primed N-methyl-d-aspartate receptor
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving St, NW, Washington, DC 20422, USA
    Clin Neuropharmacol 29:361-3. 2006

Collaborators

Detail Information

Publications40

  1. ncbi Williams syndrome: a genetic deletion disorder presenting clues to the biology of sociability and clinical challenges of hypersociability
    Stephen I Deutsch
    Department of Veterans Affairs Medical Center, Mental Health Service Line, Washington, DC, USA
    CNS Spectr 12:903-7. 2007
    ..An illustrative example of an effective strategically planned psychosocial intervention for a patient with Williams syndrome is briefly presented...
  2. doi Sodium butyrate, an epigenetic interventional strategy, attenuates a stress-induced alteration of MK-801's pharmacologic action
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, NW, Washington, DC 20422, United States
    Eur Neuropsychopharmacol 18:565-8. 2008
    ..These data encourage development of epigenetic strategies to prevent some of the deleterious consequences of stress...
  3. ncbi Topiramate antagonizes MK-801 in an animal model of schizophrenia
    Stephen I Deutsch
    Mental Health Service Line, Veterans Integrated Service Network 5, 849 International Drive, Suite 275, Linthicum, MD 21090, USA
    Eur J Pharmacol 449:121-5. 2002
    ..Topiramate was shown to inhibit MK-801-elicited "popping" behavior in a complex dose-dependent manner...
  4. ncbi Guanosine possesses specific modulatory effects on NMDA receptor-mediated neurotransmission in intact mice
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Eur Neuropsychopharmacol 18:299-302. 2008
    ....
  5. ncbi Hypothesized deficiency of guanine-based purines may contribute to abnormalities of neurodevelopment, neuromodulation, and neurotransmission in Lesch-Nyhan syndrome
    Stephen I Deutsch
    Mental Health Service Line, VISN5, Department of Veterans Affairs Medical Center, NW, Washington, DC 20422, USA
    Clin Neuropharmacol 28:28-37. 2005
    ..Conceivably, guanosine or its analogues and excitatory amino acid receptor antagonists could participate in the pharmacotherapy of this devastating disorder...
  6. ncbi Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States
    Eur Neuropsychopharmacol 18:147-51. 2008
    ....
  7. ncbi Mitochondrial myopathy complicated by eating disorder: a case report highlighting the potential interaction of genetic, metabolic, and psychodynamic factors
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    CNS Spectr 12:289-92. 2007
    ..This case report highlights the phenotypic variability of mitochondrial myopathies. An increased risk of eating disorder may be associated with drugs that interfere with mitochondrial oxidative respiration...
  8. ncbi Therapeutic implications of a selective alpha7 nicotinic receptor abnormality in schizophrenia
    Stephen I Deutsch
    Department of Veterans Affairs Medical Center, Washington, DC, USA
    Isr J Psychiatry Relat Sci 42:33-44. 2005
    ..g., galantamine)...
  9. ncbi Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States
    Eur Neuropsychopharmacol 16:547-51. 2006
    ..Ultimately, inhibition of tau phosphorylation may be an important therapeutic target in Alzheimer's disease and other neuropsychiatric disorders...
  10. ncbi Rare neurodevelopmental abnormalities of sarcosinemia may involve glycinergic stimulation of a primed N-methyl-d-aspartate receptor
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving St, NW, Washington, DC 20422, USA
    Clin Neuropharmacol 29:361-3. 2006
    ..Thus, neurodevelopmental and neurological abnormalities may manifest rarely in sarcosinemia in the context of relatively unique genetic factors and fetal insult or stress...
  11. doi First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington DC 20422, USA
    Clin Neuropharmacol 31:34-9. 2008
    ..Three patients requested continuation of the adjunctive combination at the end of the trial. These results suggest further investigation of the combination of CDP-choline and galantamine as an alpha7 nAChR agonist intervention...
  12. doi Epigenetic therapeutic strategies for the treatment of neuropsychiatric disorders: ready for prime time?
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Clin Neuropharmacol 31:104-19. 2008
    ..The epigenetic therapeutic strategy has much promise, and its development will foster collaboration and cross fertilization between molecular and cell biologists, oncologists, psychiatrists, and neurologists...
  13. doi Valproate-induced hyperammonemic encephalopathy and normal liver functions: possible synergism with topiramate
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Clin Neuropharmacol 32:350-2. 2009
    ..Topiramate's inhibition of carbonic anhydrase activity may be the basis of its possible synergy with valproate by affecting levels of HCO3...
  14. doi Temporal lobe epilepsy confused with panic disorder: implications for treatment
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Clin Neuropharmacol 32:160-2. 2009
    ..Although uncertain, the contribution of sustained exposure to carbon monoxide as an adult may have contributed to the emergence of panic symptoms, which would be an unusual clinical presentation...
  15. ncbi Methyllycaconitine fails to inhibit electrically precipitated tonic hindlimb extension in mice
    Stephen I Deutsch
    Mental Health Service Line, Veterans Integrated Service Network, Linthicum, Maryland, USA
    Clin Neuropharmacol 26:62-4. 2003
    ....
  16. doi An epigenetic intervention interacts with genetic strain differences to modulate the stress-induced reduction of flurazepam's antiseizure efficacy in the mouse
    Stephen I Deutsch
    Mental Health Service Line 116A, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Eur Neuropsychopharmacol 19:398-401. 2009
    ..Epigenetic mechanisms, genetic strain differences and a standard stress interacted to alter flurazepam's antiseizure efficacy. These data support examination and development of epigenetic treatment strategies...
  17. ncbi Adjuvant topiramate administration: a pharmacologic strategy for addressing NMDA receptor hypofunction in schizophrenia
    Stephen I Deutsch
    Mental Health Service Line, Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Clin Neuropharmacol 26:199-206. 2003
    ..These results encourage further testing of topiramate and kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists in schizophrenia patients and support the heuristic model of NRH...
  18. ncbi Modulation of MK-801-elicited mouse popping behavior by galantamine is complex and dose-dependent
    Stephen I Deutsch
    Mental Health Service Line, Veterans Integrated Service Network VISN 5, 849 International Drive, Suite 275, Linthicum, MD 21090, USA
    Life Sci 73:2355-61. 2003
    ..05). This MK-801-elicited popping was significantly attenuated by 100 mg/kg of galantamine (T(22) = 2.24, P < 0.05). The data show that nicotinic interventions can influence NMDA receptor-mediated neurotransmission in the intact mouse...
  19. ncbi Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington, DC, USA
    CNS Spectr 13:393-403. 2008
    ....
  20. ncbi Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications
    Stephen I Deutsch
    Mental Health Service Line and Research Service, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States
    Prog Neuropsychopharmacol Biol Psychiatry 30:1369-80. 2006
    ..In summary, hyperphosphorylation of tau may be an underlying point of pathological convergence for several neuropsychiatric disorders, and prevention of tau hyperphosphorylation may be an important therapeutic target...
  21. ncbi Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophrenia
    Eddie N Billingslea
    Mental Health Service Line, Veterans Integrated Service Network VISN 5, Department of Veterans Affairs, 849 International Drive, Suite 275, Linthicum, MD 21090, USA
    Pharmacol Biochem Behav 74:351-6. 2003
    ....
  22. ncbi Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain
    Katrice D Long
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Brain Res Bull 69:626-30. 2006
    ..The results could be relevant to the development of glycinergic interventions for the treatment of neuropsychiatric disorders...
  23. ncbi Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia
    John Mastropaolo
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Behav Brain Res 153:419-22. 2004
    ..The development of alpha7-nicotinic acetylcholine receptor agonist interventions for schizophrenia must consider their potential liability to elicit seizure activity...
  24. doi Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist
    Pin Yu Perera
    Pathology and Laboratory Service, Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Eur Neuropsychopharmacol 18:814-9. 2008
    ....
  25. pmc Neural basis of implicit memory for socio-emotional information in schizophrenia
    Barbara L Schwartz
    Mental Health Service 116A, Washington DC Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Psychiatry Res 206:173-80. 2013
    ..The findings suggest that schizophrenia patients have altered neural sensitivity in regions of the ventral visual processing stream that underlie early perceptual learning of objects and faces...
  26. ncbi Exogenously administered D-serine failed to potentiate the ability of MK-801 to antagonize electrically precipitated seizures in nonhandled control and stressed mice
    Katrice D Long
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Eur Neuropsychopharmacol 17:53-7. 2007
    ..These data do not support the development of d-serine as a viable therapeutic intervention for schizophrenia and, possibly, other disorders...
  27. doi Attention to gaze and emotion in schizophrenia
    Barbara L Schwartz
    Mental Health Service Line, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Neuropsychology 24:711-20. 2010
    ..Nonverbal cues are powerful social signals but are often processed implicitly, outside the focus of attention. The aim of this research was to assess implicit processing of social cues in individuals with schizophrenia...
  28. ncbi Behavioral consequences of methyllycaconitine in mice: a model of alpha7 nicotinic acetylcholine receptor deficiency
    Melissa Chilton
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Life Sci 74:3133-9. 2004
    ....
  29. doi Recognition memory probes affect what is remembered in schizophrenia
    Barbara L Schwartz
    Mental Health Service, 116A, Washington DC Veterans Affairs Medical Center, 50 Irving Street, N W, Washington, DC 20422, USA
    Psychiatry Res 167:21-7. 2009
    ..The data point to the importance of retrieval processes in schizophrenia, and highlight the need for further research on ways to help patients with schizophrenia access what they have learned...
  30. ncbi Adjuvant galantamine administration improves negative symptoms in a patient with treatment-refractory schizophrenia
    Richard B Rosse
    Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Clin Neuropharmacol 25:272-5. 2002
    ..This latter property may have contributed to the observed improvement in negative symptoms observed in this patient. Importantly, positive symptoms were unchanged during this 2-month trial.(7)..
  31. ncbi Imitation of facial expressions in schizophrenia
    Barbara L Schwartz
    Psychiatry Service, Washington Veterans Affairs Medical Center, Washington, DC, USA
    Psychiatry Res 145:87-94. 2006
    ..Preliminary findings suggest that exposure to model expressions and practice in generating these expressions can improve the accuracy of certain posed expressions in schizophrenia...
  32. ncbi Progressive worsening of adaptive functions in Down syndrome may be mediated by the complexing of soluble Abeta peptides with the alpha 7 nicotinic acetylcholine receptor: therapeutic implications
    Stephen I Deutsch
    Mental Health Service Line, VISN5, Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Clin Neuropharmacol 26:277-83. 2003
    ..Ideally, selective cholinergic interventions would slow the progression of the worsening of adaptive function and emergence of dementia in persons with Down syndrome...
  33. ncbi Implicit learning of visuospatial sequences in schizophrenia
    Barbara L Schwartz
    Mental Health Service Line, Washington, DC, Veterans Affairs Medical Center, 20422, USA
    Neuropsychology 17:517-33. 2003
    ..Pathology in motor sequencing systems and poor working memory may lead to deficits in learning sequence structure in schizophrenia...
  34. ncbi Fluoxetine's effects on cognitive performance in patients with traumatic brain injury
    Stefanie A Horsfield
    Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Int J Psychiatry Med 32:337-44. 2002
    ..Theoretically, fluoxetine-induced "neuronal remodeling" might improve cognition, independently of a primary effect on mood...
  35. ncbi Source monitoring in alcoholism
    Barbara L Schwartz
    Psychiatry Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
    J Clin Exp Neuropsychol 24:806-17. 2002
    ..Tasks of source memory may offer the neuropsychologist a valuable new tool for evaluating cognitive functions in neurobehavioral disorders...
  36. ncbi The "Yoking" of glutamatergic brain mechanisms involved in controlling brain neuronal excitability and psychosis to brain mechanisms involved in appetite regulation: a new hypothesis on the origin of psychosis
    Richard B Rosse
    Department of Veterans Affairs Medical Center, Mental Health Service Line 116A, VISN 5, 50 Irving Street, NW, Washington, DC 20422, USA
    Med Hypotheses 62:406-12. 2004
    ..g. [Acta Psychiatr. Scand. 100 (1999) 3] reported by others and body mass index and cocaine-induced psychosis by our group (i.e. [Israel J. Psychiatr. (2004), in submission])...
  37. ncbi Adjuvant therapeutic effects of galantamine on apathy in a schizophrenia patient
    David S Arnold
    J Clin Psychiatry 65:1723-4. 2004
  38. pmc Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors
    Rafal T Olszewski
    Department of Biology, Georgetown University, Washington D C 20057, USA
    Biol Psychiatry 63:86-91. 2008
    ..We previously reported that ZJ43, a potent inhibitor of the enzymes that inactivate synaptically released NAAG, reduced motor and stereotypic effects of PCP in the rat...
  39. ncbi A "work in-progress": novel approaches to the treatment of schizophrenia
    Stephen I Deutsch
    Isr J Psychiatry Relat Sci 42:2-4. 2005
  40. ncbi Comorbid presentation of Kartagener's syndrome and schizophrenia: support of an etiologic hypothesis of anomalous development of cerebral asymmetry?
    Timothy M Quast
    Schizophr Res 74:283-5. 2005