Ernest E Moore

Summary

Affiliation: Denver Health Medical Center
Country: USA

Publications

  1. ncbi Intubation alone does not mandate trauma surgeon presence on patient arrival to the emergency department
    David J Ciesla
    Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 56:937-41; discussion 941-2. 2004
  2. ncbi Blunt trauma induced splenic blushes are not created equal
    Clay Cothren Burlew
    From the Department of Surgery, Denver Health Medical Center, Denver CO, USA
    World J Emerg Surg 7:8. 2012
  3. ncbi Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery
    Fausto Catena
    Emergency Surgery Unit, Department of General and Multivisceral Transplant Surgery, S, Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 6:5. 2011
  4. ncbi WSES consensus conference: Guidelines for first-line management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Italy
    World J Emerg Surg 6:2. 2011
  5. ncbi Emergency department thoracotomy for the critically injured patient: Objectives, indications, and outcomes
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO, USA
    World J Emerg Surg 1:4. 2006
  6. ncbi Reconstruction of an emergency thoracotomy wound with free rectus abdominis flap: Anatomic and radiologic basis for the surgical technique
    Kaitlyn Gilman
    Department of Plastic and Reconstructive Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, Denver, 80204 Colorado USA
    World J Emerg Surg 5:12. 2010
  7. ncbi WSES SM (World Society of Emergency Surgery Summer Meeting) highlights: emergency surgery around the world (Brazil, Finland, USA)
    Renato Poggetti
    General, Emergency and Transplant Surgery DPT St Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 4:11. 2009
  8. ncbi Guidelenines in the management of obstructing cancer of the left colon: consensus conference of the world society of emergency surgery (WSES) and peritoneum and surgery (PnS) society
    Luca Ansaloni
    1st Unit of General Surgery, Ospedali Riuniti di Bergamo, Italy
    World J Emerg Surg 5:29. 2010
  9. ncbi Survival following a vertical free fall from 300 feet: the crucial role of body position to impact surface
    Sebastian Weckbach
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado Denver, School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Scand J Trauma Resusc Emerg Med 19:63. 2011
  10. ncbi "Metabolic staging" after major trauma - a guide for clinical decision making?
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 80204, USA
    Scand J Trauma Resusc Emerg Med 18:34. 2010

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. ncbi Intubation alone does not mandate trauma surgeon presence on patient arrival to the emergency department
    David J Ciesla
    Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 56:937-41; discussion 941-2. 2004
    ..Excluding stab wounds, field or ED intubation alone rarely requires emergent surgical decision-making. Therefore, field or ED intubation alone should not mandate trauma surgeon presence on patient arrival...
  2. ncbi Blunt trauma induced splenic blushes are not created equal
    Clay Cothren Burlew
    From the Department of Surgery, Denver Health Medical Center, Denver CO, USA
    World J Emerg Surg 7:8. 2012
    ..abstract:..
  3. ncbi Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery
    Fausto Catena
    Emergency Surgery Unit, Department of General and Multivisceral Transplant Surgery, S, Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 6:5. 2011
    ..abstract:..
  4. ncbi WSES consensus conference: Guidelines for first-line management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Italy
    World J Emerg Surg 6:2. 2011
    ..This document represents the executive summary of the final guidelines approved by the consensus conference...
  5. ncbi Emergency department thoracotomy for the critically injured patient: Objectives, indications, and outcomes
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO, USA
    World J Emerg Surg 1:4. 2006
    ..The optimal application of EDT requires a thorough understanding of its physiologic objectives, technical maneuvers, and the cardiovascular and metabolic consequences...
  6. ncbi Reconstruction of an emergency thoracotomy wound with free rectus abdominis flap: Anatomic and radiologic basis for the surgical technique
    Kaitlyn Gilman
    Department of Plastic and Reconstructive Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, Denver, 80204 Colorado USA
    World J Emerg Surg 5:12. 2010
    ..The deep inferior epigastric vessels of the flap were anastomosed to the right internal mammary vessels proximal to their transection level in the third-forth intercostal space. The flap healed with no further wound complications...
  7. ncbi WSES SM (World Society of Emergency Surgery Summer Meeting) highlights: emergency surgery around the world (Brazil, Finland, USA)
    Renato Poggetti
    General, Emergency and Transplant Surgery DPT St Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 4:11. 2009
    ..Brazil, Finland and US emergency surgery models are presented discussing all criticisms showed during the WSES Summer Meeting 2008...
  8. ncbi Guidelenines in the management of obstructing cancer of the left colon: consensus conference of the world society of emergency surgery (WSES) and peritoneum and surgery (PnS) society
    Luca Ansaloni
    1st Unit of General Surgery, Ospedali Riuniti di Bergamo, Italy
    World J Emerg Surg 5:29. 2010
    ..abstract:..
  9. ncbi Survival following a vertical free fall from 300 feet: the crucial role of body position to impact surface
    Sebastian Weckbach
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado Denver, School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Scand J Trauma Resusc Emerg Med 19:63. 2011
    ..The role of early patient transfer to a level 1 trauma center, and "damage control" management protocols for avoiding delayed morbidity and mortality in this critically injured patient are discussed...
  10. ncbi "Metabolic staging" after major trauma - a guide for clinical decision making?
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 80204, USA
    Scand J Trauma Resusc Emerg Med 18:34. 2010
    ..The potential clinical impact of metabolic staging, and of an appropriately adapted "metabolic control" and nutritional support, remains to be determined...
  11. ncbi Lower extremity compartment syndrome in the acute care surgery paradigm: safety lessons learned
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center and University of Colorado, Denver Health Sciences Center 777 Bannock St MC0206 Denver, Colorado 80204, USA
    Patient Saf Surg 3:11. 2009
    ..Periodic system review of our trauma and orthopedic data for complications of LECS led us to hypothesize that delayed diagnosis and limb loss were potentially preventable events in our trauma center...
  12. ncbi Fatal outcome after insufficient spine fixation for pyogenic thoracic spondylodiscitis: an imperative for 360 degrees fusion of the infected spine
    Michael A Flierl
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Patient Saf Surg 3:4. 2009
    ..Pyogenic spondylodiscitis represents a potentially life-threatening condition. Due to the low incidence, evidence-based surgical recommendations in the literature are equivocal, and the treatment modalities remain controversial...
  13. ncbi Advocating "spine damage control" as a safe and effective treatment modality for unstable thoracolumbar fractures in polytrauma patients: a hypothesis
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, Colorado 80204, USA
    J Trauma Manag Outcomes 3:6. 2009
    ..IMPLICATIONS OF HYPOTHESIS: A "spine damage control" protocol may save lives and improve outcomes in severely injured patients with associated spine injuries...
  14. ncbi Alcohol and trauma: the perfect storm
    Ernest E Moore
    Department of Surgery Denver Health Medical Center, Denver, CO 80204, USA
    J Trauma 59:S53-6; discussion S67-75. 2005
    ..A trauma center visit provides an opportune time and place to incorporate alcohol screening and brief interventions as a part of standard trauma care...
  15. ncbi The two-event construct of postinjury multiple organ failure
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO 80204, USA
    Shock 24:71-4. 2005
  16. ncbi Claude H. Organ, Jr. memorial lecture: splanchnic hypoperfusion provokes acute lung injury via a 5-lipoxygenase-dependent mechanism
    Ernest E Moore
    Department of Surgery, University of Colorado Denver, Denver, CO 80204, USA
    Am J Surg 200:681-9. 2010
    ..Elucidating these mediators and the timing of their participation in pulmonary inflammation is critical in translating our current knowledge to new therapeutic strategies at the bedside...
  17. ncbi Repair of the torn descending thoracic aorta using the centrifugal pump for partial left heart bypass
    Ernest E Moore
    Denver Health Medical Center University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Surg 240:38-43. 2004
    ..To describe the relevant anatomy and sequential technical maneuvers to repair blunt injuries to the descending thoracic aorta with partial left heart bypass...
  18. ncbi American Association for the Surgery of Trauma Organ Injury Scaling: 50th anniversary review article of the Journal of Trauma
    Ernest E Moore
    Department of Surgery, Denver Health, University of Colorado, Denver, Colorado 80204, USA
    J Trauma 69:1600-1. 2010
    ..A good example of this concept is the tumor, node, metastasis classification for solid organ malignancies: a system used worldwide to guide patient care and clinical investigation...
  19. ncbi Acute care surgery: the safety net hospital model
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO 80204-4507, USA
    Surgery 141:297-8. 2007
  20. ncbi Hemoglobin-based oxygen carriers in trauma care: scientific rationale for the US multicenter prehosptial trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, and Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80204, USA
    World J Surg 30:1247-57. 2006
    ..The hemoglobin-based oxygen carriers (HBOCs) tested currently in advanced clinical trials are polymerized hemoglobin solutions...
  21. ncbi Ruminations at sunset
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, Colorado 80204, USA
    J Trauma 63:1206-9. 2007
  22. ncbi Defining the limits of resuscitative emergency department thoracotomy: a contemporary Western Trauma Association perspective
    Ernest E Moore
    Department of Surgery, Denver Health, Denver, Colorado 80204, USA
    J Trauma 70:334-9. 2011
    ..The purpose of this prospective multicenter study was to identify injury patterns and physiologic profiles at ED arrival that are compatible with survival...
  23. ncbi Proteomic profiling of the mesenteric lymph after hemorrhagic shock: Differential gel electrophoresis and mass spectrometry analysis
    Ashley Zurawel
    Proteomics Facility, University of Colorado School of Medicine, Aurora, USA
    Clin Proteomics 8:1. 2011
    ..Mass spectrometry based proteomic analysis of proteins in mesenteric lymph can effectively be used to identify candidate mediators and loss of protective agents in shock models...
  24. ncbi Insights from studies of blood substitutes in trauma
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    Shock 24:197-205. 2005
    ..The current generation of HBOCs can be lifesaving for acute blood loss today, but the next generation might be biochemically tailored for specific clinical indications...
  25. ncbi Postinjury abdominal compartment syndrome does not preclude early enteral feeding after definitive closure
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, and the University of Colorado Health Sciences Center, 777 Bannock St, MC 0206, Denver, CO 80204, USA
    Am J Surg 188:653-8. 2004
    ..The purpose of this study was to determine if enteral nutrition was precluded by the intra-abdominal hypertension and bowel edema of the ACS...
  26. ncbi Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012
    ..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred...
  27. ncbi Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:358-64; discussion 364. 2012
    ..We sought to characterize mortality during the first 24 hours while controlling for time varying effects of transfusion to minimize survival bias...
  28. ncbi Validating the Western Trauma Association algorithm for managing patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial
    Walter L Biffl
    Department of Surgery, Denver Health Medical Center University of Colorado, Denver, Colorado 80204 4507, USA
    J Trauma 71:1494-502. 2011
    ..The purpose of this study was to evaluate the safety and efficacy of the algorithm in providing timely interventions for significant injuries...
  29. ncbi Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
    Nathan J D McLaughlin
    Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
    J Immunol 180:8192-203. 2008
    ..In conclusion, PAF transduces signals through CME, and such GPCR signaling may allow for pharmacological manipulation of these cells to decrease PMN-mediated acute organ injury...
  30. ncbi Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome
    Frederick A Moore
    Department of Surgery, The Methodist Hospital, Houston Texas, USA
    J Trauma 64:1010-23. 2008
    ....
  31. ncbi Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    Jeffry L Kashuk
    Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA 17033, USA
    Ann Surg 252:434-42; discussion 443-4. 2010
    ..We hypothesized that postinjury PF occurs early in severe shock, leading to postinjury coagulopathy, and ultimately hemorrhage-related death...
  32. ncbi Elderly patients may benefit from tight glucose control
    Theresa L Chin
    University of Colorado, Denver, CO, USA
    Surgery 152:315-21. 2012
    ..We queried our 17-year prospective database of patients at risk for postinjury multiple organ failure to examine the association between glucose levels and adverse outcomes...
  33. ncbi Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...
  34. ncbi Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
    Crit Care Med 41:399-404. 2013
    ..To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients...
  35. ncbi Early death and late morbidity after blood transfusion of injured children: a pilot study
    Fredric M Pieracci
    Department of Surgery, Denver Health Medical Center, Denver, CO 80206, USA
    J Pediatr Surg 47:1587-91. 2012
    ..The adverse immunomodulatory effects of blood transfusion are implicated in subsequent morbidity. We hypothesized that injured children requiring pRBC transfusion demonstrate patterns in outcome similar to those observed in adults...
  36. ncbi Blunt cerebrovascular injuries in the child
    Teresa S Jones
    Department of Surgery, Denver Health Medical Center, Denver, CO, USA
    Am J Surg 204:7-10. 2012
    ..The purpose of this study was to describe the incidence, injury patterns, and stroke rates of pediatric patients sustaining BCVIs...
  37. ncbi Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:892-8. 2012
    ..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT...
  38. ncbi Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 65:944-50. 2008
  39. ncbi Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury
    Rebecca D Edmonds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:292-8. 2011
    ..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients...
  40. ncbi Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute
    Jeffrey L Johnson
    Department of Surgery, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
    J Trauma 54:133-9; discussion 139-40. 2003
    ..Through the use of a polymerized human hemoglobin (PolyHeme), we have been able to measure the inflammatory response in patients resuscitated with minimal exposure to banked components in the early postinjury period...
  41. ncbi Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils
    Phillip C Eckels
    Department of Surgery, Denver Health Medical Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 297:C886-97. 2009
    ..Thus, amantadine and rimantadine have the potential to ameliorate PMN-mediated tissue damage in humans...
  42. ncbi Cervical spine fracture patterns mandating screening to rule out blunt cerebrovascular injury
    C Clay Cothren
    University of Colorado Health Sciences Center and the Department of Surgery, Denver Health Medical Center, CO 80204, USA
    Surgery 141:76-82. 2007
    ..We hypothesized that specific cervical spine fracture patterns that warrant screening evaluation exist, hence limiting unwarranted diagnostic imaging...
  43. ncbi Preperitonal pelvic packing for hemodynamically unstable pelvic fractures: a paradigm shift
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, Dencer, CO 80204, USA
    J Trauma 62:834-9; discussion 839-42. 2007
    ..We hypothesized that a modified technique of direct preperitoneal pelvic packing (PPP) would reduce the need for angiography, decrease blood transfusion requirements, and lower mortality...
  44. ncbi Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
    ....
  45. ncbi Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?
    Frederick A Moore
    Department of Surgery, The Methodist Hospital, Houston, TX, USA
    Am J Surg 196:948-58; discussion 958-60. 2008
    ..Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding...
  46. ncbi Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, CO, USA
    Ann Surg 251:604-14. 2010
    ....
  47. ncbi Outcomes in surgical versus medical patients with the secondary abdominal compartment syndrome
    C Clay Cothren
    The Department of Surgery, Denver Health Medical Center, 777 Bannock Street, MC 0206, Denver, CO 80204, USA
    Am J Surg 194:804-7; discussion 807-8. 2007
    ..The purpose of this study was to compare the clinical scenarios, physiologic indices, and outcomes of patients with SACS due to medical versus trauma etiologies...
  48. ncbi Effect of blood products transfusion on the development of postinjury multiple organ failure
    Jeffrey L Johnson
    Department of Surgery, University of Colorado Denver, USA
    Arch Surg 145:973-7. 2010
    ..Transfusion of fresh frozen plasma (FFP) and platelets is independently associated with the development of multiple organ failure (MOF) in critically injured patients...
  49. ncbi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  50. ncbi Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO 80204, USA
    Arch Surg 140:480-5; discussion 485-6. 2005
    ....
  51. ncbi Current trends in resuscitation strategy for the multiply injured patient
    Philip F Stahel
    Department of Orthopaedic Surgery, University of Colorado, Denver, Colorado 80204, USA
    Injury 40:S27-35. 2009
    ..This review article provides a brief overview of the existing resuscitation protocols for multiply injured patients, including ATLS and "damage control", and will address developing controversies in the field...
  52. ncbi Management of patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial
    Walter L Biffl
    Department of Surgery, Denver Health Medical Center University of Colorado Denver, Denver, Colorado 80204 4507, USA
    J Trauma 66:1294-301. 2009
    ....
  53. ncbi The impact of a standardized "spine damage-control" protocol for unstable thoracic and lumbar spine fractures in severely injured patients: a prospective cohort study
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, Denver, Colorado 80204, USA
    J Trauma Acute Care Surg 74:590-6. 2013
    ....
  54. ncbi V. Guidelines for sedation and analgesia during mechanical ventilation general overview
    Michael B Shapiro
    Department of Surgery, Northwestern University, Chicago, Illinois, USA
    J Trauma 63:945-50. 2007
  55. ncbi Rapid thrombelastography (r-TEG) identifies hypercoagulability and predicts thromboembolic events in surgical patients
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA
    Surgery 146:764-72; discussion 772-4. 2009
    ..We hypothesized that r-TEG can be used as a screening tool to identify hypercoagulable states in surgical patients and would predict subsequent thromboembolic events...
  56. ncbi Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4
    Janeen R Jordan
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Appl Physiol 104:1161-6. 2008
    ..Collectively, these data indicate that splanchnic ischemia/reperfusion activates gut PLA(2)-mediated release of AA into the lymph where it is delivered to the lungs, provoking LTB(4) production and subsequent PMN-mediated lung injury...
  57. ncbi Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, USA
    J Am Coll Surg 208:1-13. 2009
    ..This multicenter phase III trial was the first US study to assess survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injury...
  58. ncbi Diagnostic peritoneal lavage remains a valuable adjunct to modern imaging techniques
    John Y Cha
    Department of Surgery, University of South Florida College, Tampa, Florida, USA
    J Trauma 67:330-4; discussion 334-6. 2009
    ..We hypothesized that, while its indications may have changed, DPL remains essential in the rapid, effective triage of the trauma patient...
  59. ncbi HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans
    Erik D Peltz
    Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Shock 32:17-22. 2009
    ..Thus, HMGB1 may be integral to the early inflammatory response to trauma and is a potential target for future therapeutics...
  60. ncbi Hypertonic saline attenuates TNF-alpha-induced NF-kappaB activation in pulmonary epithelial cells
    Trevor L Nydam
    Center for Trauma Research and Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80045, USA
    Shock 31:466-72. 2009
    ..These results show that HTS inhibits TNF-alpha-induced NF-kappaB activation in the pulmonary epithelium and, further, our understanding of its beneficial effects in hemorrhage-induced ALI...
  61. ncbi Direct retroperitoneal pelvic packing versus pelvic angiography: A comparison of two management protocols for haemodynamically unstable pelvic fractures
    Patrick M Osborn
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Injury 40:54-60. 2009
    ..To evaluate the outcomes of haemodynamically unstable cases of pelvic ring injury treated with a protocol focused on either direct retroperitoneal pelvic packing or early pelvic angiography and embolisation...
  62. ncbi Local wound exploration remains a valuable triage tool for the evaluation of anterior abdominal stab wounds
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock St, MC 0206, Denver, CO 80204, USA
    Am J Surg 198:223-6. 2009
    ..In patients without immediate indications for laparotomy, we hypothesized that LWE/DPL would identify patients requiring surgery while limiting unnecessary hospital admissions...
  63. ncbi Refractory postinjury thrombocytopenia is associated with multiple organ failure and adverse outcomes
    Trevor L Nydam
    Department of Surgery, University of Colorado Health Science Center and School of Medicine, Aurora, Colorado 80045, USA
    J Trauma 70:401-6; discussion 406-7. 2011
    ..In addition, recent studies suggest that platelets play a critical role in postinjury hyperinflammation. Therefore, we hypothesized that postinjury thrombocytopenia is a marker for progression to MOF...
  64. ncbi Cervical spine fracture patterns predictive of blunt vertebral artery injury
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, 777 Bannock Street, Denver, CO 80204, USA
    J Trauma 55:811-3. 2003
    ..Because of the proximity of the cervical spine and vertebral arteries, we queried whether all patients with cervical spine fractures required arteriography to rule out VAI...
  65. ncbi A 12-year prospective study of postinjury multiple organ failure: has anything changed?
    David J Ciesla
    Department of Surgery, Denver Health Medical Center, CO 80204, USA
    Arch Surg 140:432-8; discussion 438-40. 2005
    ..The incidence and severity of postinjury multiple organ failure (MOF) has decreased over the last decade...
  66. ncbi Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury
    Tomohiko Masuno
    Department of Surgery, Denver Health Medical Center, CO 80204, USA
    Surgery 138:335-41. 2005
    ..CONCLUSIONS: The findings in this controlled in vivo study suggest prehospital HBOC resuscitation improves the recovery from postshock oxygen debt and reduces postinjury organ dysfunction...
  67. ncbi Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes
    Guillermo A Escobar
    Department of Surgery, University of Colorado Health Science Center Denver Health Medical Center, Denver, CO 80204, USA
    Ann Surg 246:129-34. 2007
    ..This suggests that stored blood contains bioactive factors that may modify the immunoinflammatory response...
  68. ncbi Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO, USA
    Surgery 152:270-6. 2012
    ..The potential benefit of halogenated ethers has not been investigated in models of trauma/hemorrhagic shock (T/HS). Therefore, we hypothesized that isoflurane decreases T/HS-mediated ALI through platelet inhibition...
  69. ncbi Initial experiences with point-of-care rapid thrombelastography for management of life-threatening postinjury coagulopathy
    Jeffry L Kashuk
    Department of Surgery and Anesthesia, Denver Health Medical Center, Denver, Colorado, USA
    Transfusion 52:23-33. 2012
    ..We designed a prospective study to test the hypothesis that integrating TEG into our MTP would facilitate goal-directed therapy and provide equivalent outcomes compared to conventional coagulation testing...
  70. ncbi Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation
    Walter L Biffl
    Department of Surgery, Rhode Island Hospital/Brown Medical School, Providence, RI, USA
    Surgery 134:86-91. 2003
    ..HTS may activate caspase-3, but alternative signaling pathways appear to be involved in modulating the effects of lipids on PMN apoptosis...
  71. ncbi Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model
    Marguerite R Kelher
    Bonfils Blood Center, Denver, CO 80230, USA
    Blood 113:2079-87. 2009
    ..We conclude that TRALI is the result of 2 events with the second events consisting of the plasma from stored blood and antibodies that prime PMNs...
  72. ncbi Transfusion strategies in postinjury coagulopathy
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204, USA
    Curr Opin Anaesthesiol 22:289-98. 2009
    ..The present review will attempt to define the current 'optimal' transfusion strategies for the coagulopathic trauma patient and to assess potential weaknesses in the pertinent literature...
  73. ncbi Proteome and system ontology of hemorrhagic shock: exploring early constitutive changes in postshock mesenteric lymph
    Erik D Peltz
    Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO 80204, USA
    Surgery 146:347-57. 2009
    ..We hypothesize that an unbiased inspection of the proteome of PSML will reveal previously unrecognized aberrations in systems biology provoked by hemorrhage-induced mesenteric IR injury in vivo...
  74. ncbi Decreased progression of postinjury lung dysfunction to the acute respiratory distress syndrome and multiple organ failure
    David J Ciesla
    Denver Health Medical Center, and the University of Colorado Health Sciences Center, Denver, Colo, USA
    Surgery 140:640-7; discussion 647-8. 2006
    ..We hypothesized that the collective effects of recently implemented therapeutic strategies have resulted in decreased activation of the systemic inflammatory response relative to priming in recent years...
  75. ncbi Anticoagulation is the gold standard therapy for blunt carotid injuries to reduce stroke rate
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, 80204, USA
    Arch Surg 139:540-5; discussion 545-6. 2004
    ..Aggressive screening, early angiographic diagnosis, and prompt anticoagulation for blunt carotid artery injuries (CAIs) improves neurologic outcome...
  76. ncbi Heme oxygenase-1 induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion
    Jonathan P Roach
    Department of Surgery, The University of Colorado Denver, Aurora, USA
    Shock 31:251-7. 2009
    ..These data encourage continued investigation into the role of HO-1 in protecting against posttraumatic organ dysfunction and the clinical potential of HBOC for HO-1 induction...
  77. ncbi Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:476-82; discussion 482-4. 2009
    ..We sought to determine whether preinjury statin (PIS) use was associated with improved outcome in severely injured blunt trauma patients...
  78. ncbi Gelsolin is depleted in post-shock mesenteric lymph
    Janeen R Jordan
    Department of Surgery, University of Colorado Health Science, Denver, Colorado 80204, USA
    J Surg Res 143:130-5. 2007
    ..We hypothesized that lipid binding proteins such as gelsolin may be depleted after trauma/hemorrhagic shock leading to increased lipid bioactivity...
  79. ncbi Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma
    Max V Wohlauer
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Am Coll Surg 214:739-46. 2012
    ..Although the current debate on acute traumatic coagulopathy has focused on the consumption or inhibition of coagulation factors, the question of early platelet dysfunction in this setting remains unclear...
  80. ncbi The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: scientific rationale, study design, and results
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, Denver, CO 80204, USA
    Crit Care Clin 25:325-56, Table of Contents. 2009
    ..The benefit-to-risk ratio of PolyHeme is favorable when blood is needed but is not available or an option...
  81. ncbi Progressive postinjury thrombocytosis is associated with thromboembolic complications
    Jeffry L Kashuk
    Department of Surgery, Division of Trauma, Acute Care, and Acute Care Surgery, Penn State Hershey Medical Center and College of Medicine, Hershey, PA 17033 0850, USA
    Surgery 148:667-74; discussion 674-5. 2010
    ..We hypothesized that progressive postinjury thrombocytosis contributes to a hypercoagulable state that is associated with thrombelastography...
  82. ncbi Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation
    Frederick A Moore
    Department of Surgery, University of Texas at Houston, 77030, USA
    J Trauma 61:82-9. 2006
  83. ncbi Bioactivity of postshock mesenteric lymph depends on the depth and duration of hemorrhagic shock
    Tomohiko Masuno
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO 80204, USA
    Shock 26:285-9. 2006
    ..Hemorrhagic shock provokes the release of bioactive agents in PSML that is dependent on both depth and duration of shock...
  84. ncbi Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
    ..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission...
  85. ncbi Emergency department resuscitative thoracotomy for nontorso injuries
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA
    Surgery 139:574-6. 2006
    ..CONCLUSIONS: Resuscitative EDT with aortic cross-clamping is a potential adjunct in the acute resuscitation of NTI involving penetrating neck or extremity vascular injuries...
  86. ncbi Preperitoneal pelvic packing/external fixation with secondary angioembolization: optimal care for life-threatening hemorrhage from unstable pelvic fractures
    Clay Cothren Burlew
    Department of Surgery, Denver Health Medical Center and the University of Colorado Denver, Denver, CO 80204, USA
    J Am Coll Surg 212:628-35; discussion 635-7. 2011
    ..We hypothesized that PPP/EF arrests hemorrhage rapidly, facilitates emergent operative procedures, and ensures efficient use of angioembolization (AE)...
  87. ncbi The academic trauma center is a model for the future trauma and acute care surgeon
    David J Ciesla
    Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 58:657-61; discussion 661-2. 2005
    ..Recent discussions on the future of trauma surgery stimulated us to review our experience as a possible model for the future trauma and acute care surgeon...
  88. ncbi Normal mesenteric lymph blunts the pulmonary inflammatory response to endotoxin
    Aaron M Cheng
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Surg Res 136:166-71. 2006
    ..Decreased protective lipoproteins after HS and resuscitation may contribute to the toxicity associated with PSML from the ischemic gut...
  89. ncbi Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?
    Jeffry L Kashuk
    Department of Surgery and Surgical Research, Denver Health Medical Center, Denver, Colorado 80204 4507, USA
    J Trauma 65:261-70; discussion 270-1. 2008
    ..Consequently, we reviewed our massive transfusion practices during a 5-year period to test the hypothesis that 1:1 FFP:RBC within the first 6 hours reduces life threatening coagulopathy...
  90. ncbi The next generation in shock resuscitation
    Frederick A Moore
    Department of Surgery, University of Texas Houston Medical School, Houston, TX 77030, USA
    Lancet 363:1988-96. 2004
    ....
  91. ncbi Treatment-related outcomes from blunt cerebrovascular injuries: importance of routine follow-up arteriography
    Walter L Biffl
    Department of Surgery, Denver Health Medical Center, The University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Surg 235:699-706; discussion 706-7. 2002
    ..To assess the impact of routine follow-up arteriography on the management and outcome of patients with acute blunt cerebrovascular injuries (BCVI)...
  92. ncbi Blood substitutes: the future is now
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO 80204, USA
    J Am Coll Surg 196:1-17. 2003
  93. ncbi The injured child is resistant to multiple organ failure: a different inflammatory response?
    Casey M Calkins
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    J Trauma 53:1058-63. 2002
    ..The purpose of this study was to describe the incidence, course, and severity of pediatric postinjury MOF. We hypothesized that the incidence and severity of postinjury MOF in children would be less when compared with adults...
  94. ncbi Noninvasive diagnosis of blunt cerebrovascular injuries: a preliminary report
    Walter L Biffl
    Department of Surgery, Rhode Island Hospital Brown University, Providence, USA
    J Trauma 53:850-6. 2002
    ..We hypothesized that CTA or MRA could reliably identify BCVI, obviating the need for arteriography. The purpose of this study was to determine the accuracy of CTA and MRA in identifying BCVI in asymptomatic patients...
  95. ncbi Pediatric blunt vertebral artery injury: case report and treatment plan
    Louis Seitz Brunworth
    Department of Surgery, Denver Health Medical Center and the University of Colorado Denver School of Medicine, Denver, CO, USA
    J Pediatr Surg 44:e5-9. 2009
    ..With few reports in the literature of blunt cerebrovascular injuries in the pediatric population, a review of the appropriate screening parameters, treatment plans, and follow-up is helpful for the practicing physician...
  96. ncbi Lung-sparing techniques are associated with improved outcome compared with anatomic resection for severe lung injuries
    Clay Cothren
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 80204, USA
    J Trauma 53:483-7. 2002
    ..The purpose of this study was to compare the morbidity and mortality associated with nonanatomic and anatomic lung resection in the management of severe pulmonary injuries...
  97. ncbi Risk factors for delirium after major trauma
    Erik M Angles
    Department of Surgery, University of Colorado at Denver, Health Sciences Center, 12631 East 17th Ave, Mail Stop C313, PO Box 6511, Aurora, CO, USA
    Am J Surg 196:864-9; discussion 869-70. 2008
    ..This study aimed to describe the natural history of delirium after major injury, to identify risk factors that predict the development of postinjury delirium, and to compare outcome measures in subjects with and without delirium...
  98. ncbi Derivation of a clinical decision rule to exclude thoracic aortic imaging in patients with blunt chest trauma after motor vehicle collisions
    Todd C Ungar
    Department of Emergency Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA
    J Trauma 61:1150-5. 2006
    ..CONCLUSION: We report a clinical decision rule with a high NPV for exclusion of TAI. This may standardize the approach to such patients and may reduce the need for CT...
  99. ncbi Has the trauma surgeon become house staff for the surgical subspecialist?
    David J Ciesla
    Department of Surgery, Washington Hospital Center, 110 Irving St NW, Suite 4B 39, Washington, DC 20005, USA
    Am J Surg 192:732-7. 2006
    ..The role of the trauma surgeon is perceived to be mostly supportive of other procedure-oriented specialties. We designed this study to characterize the surgical and nonsurgical responsibilities of the contemporary trauma surgeon...
  100. ncbi Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin
    Forest R Sheppard
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Trauma 57:720-4; discussion 724-5. 2004
    ..These experimental results corroborate our previous clinical studies and further encourage the study of PolyHb as a resuscitation strategy to decrease postinjury MOF...
  101. ncbi The Outreach Trauma Program: a model for survival of the academic trauma center
    Walter L Biffl
    Department of Surgery, Denver Health Medical Center, and University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 52:840-6. 2002
    ....