Ernest E Moore

Summary

Affiliation: Denver Health Medical Center
Country: USA

Publications

  1. ncbi request reprint Intubation alone does not mandate trauma surgeon presence on patient arrival to the emergency department
    David J Ciesla
    Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 56:937-41; discussion 941-2. 2004
  2. pmc World society of emergency surgery study group initiative on Timing of Acute Care Surgery classification (TACS)
    Yoram Kluger
    Department of Surgery, Rambam Health Care Center, Haifa, Israel
    World J Emerg Surg 8:17. 2013
  3. pmc 2013 WSES guidelines for management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:3. 2013
  4. pmc Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:1. 2013
  5. pmc Thoracic hyperextension injury with complete "bony disruption" of the thoracic cage: Case report of a potentially life-threatening injury
    James Bailey
    Department of Orthopaedics, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO, 80204, USA
    World J Emerg Surg 7:14. 2012
  6. pmc Blunt trauma induced splenic blushes are not created equal
    Clay Cothren Burlew
    From the Department of Surgery, Denver Health Medical Center, Denver CO, USA
    World J Emerg Surg 7:8. 2012
  7. pmc Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery
    Fausto Catena
    Emergency Surgery Unit, Department of General and Multivisceral Transplant Surgery, S, Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 6:5. 2011
  8. pmc WSES consensus conference: Guidelines for first-line management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Italy
    World J Emerg Surg 6:2. 2011
  9. pmc Emergency department thoracotomy for the critically injured patient: Objectives, indications, and outcomes
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO, USA
    World J Emerg Surg 1:4. 2006
  10. pmc Reconstruction of an emergency thoracotomy wound with free rectus abdominis flap: Anatomic and radiologic basis for the surgical technique
    Kaitlyn Gilman
    Department of Plastic and Reconstructive Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, Denver, 80204 Colorado USA
    World J Emerg Surg 5:12. 2010

Collaborators

Detail Information

Publications149 found, 100 shown here

  1. ncbi request reprint Intubation alone does not mandate trauma surgeon presence on patient arrival to the emergency department
    David J Ciesla
    Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 56:937-41; discussion 941-2. 2004
    ..We hypothesized that field or ED intubation in the absence of other major criteria does not require trauma surgeon presence on patient arrival...
  2. pmc World society of emergency surgery study group initiative on Timing of Acute Care Surgery classification (TACS)
    Yoram Kluger
    Department of Surgery, Rambam Health Care Center, Haifa, Israel
    World J Emerg Surg 8:17. 2013
    ..Standardizing timing of interventions in surgical emergencies will promote clinical investigation as well as a commitment by administrative authorities to proper operating theater provision for acute care surgery...
  3. pmc 2013 WSES guidelines for management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:3. 2013
    ..The 2013 update of the World Society of Emergency Surgery (WSES) guidelines for the management of intra-abdominal infections contains evidence-based recommendations for management of patients with intra-abdominal infections...
  4. pmc Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:1. 2013
    ..7%) patients.The overall mortality rate was 10.1% (71/702). The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013...
  5. pmc Thoracic hyperextension injury with complete "bony disruption" of the thoracic cage: Case report of a potentially life-threatening injury
    James Bailey
    Department of Orthopaedics, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO, 80204, USA
    World J Emerg Surg 7:14. 2012
    ..abstract:..
  6. pmc Blunt trauma induced splenic blushes are not created equal
    Clay Cothren Burlew
    From the Department of Surgery, Denver Health Medical Center, Denver CO, USA
    World J Emerg Surg 7:8. 2012
    ..abstract:..
  7. pmc Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery
    Fausto Catena
    Emergency Surgery Unit, Department of General and Multivisceral Transplant Surgery, S, Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 6:5. 2011
    ..abstract:..
  8. pmc WSES consensus conference: Guidelines for first-line management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Italy
    World J Emerg Surg 6:2. 2011
    ..This document represents the executive summary of the final guidelines approved by the consensus conference...
  9. pmc Emergency department thoracotomy for the critically injured patient: Objectives, indications, and outcomes
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO, USA
    World J Emerg Surg 1:4. 2006
    ..The optimal application of EDT requires a thorough understanding of its physiologic objectives, technical maneuvers, and the cardiovascular and metabolic consequences...
  10. pmc Reconstruction of an emergency thoracotomy wound with free rectus abdominis flap: Anatomic and radiologic basis for the surgical technique
    Kaitlyn Gilman
    Department of Plastic and Reconstructive Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, Denver, 80204 Colorado USA
    World J Emerg Surg 5:12. 2010
    ..The deep inferior epigastric vessels of the flap were anastomosed to the right internal mammary vessels proximal to their transection level in the third-forth intercostal space. The flap healed with no further wound complications...
  11. pmc WSES SM (World Society of Emergency Surgery Summer Meeting) highlights: emergency surgery around the world (Brazil, Finland, USA)
    Renato Poggetti
    General, Emergency and Transplant Surgery DPT St Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 4:11. 2009
    ..Brazil, Finland and US emergency surgery models are presented discussing all criticisms showed during the WSES Summer Meeting 2008...
  12. pmc Guidelenines in the management of obstructing cancer of the left colon: consensus conference of the world society of emergency surgery (WSES) and peritoneum and surgery (PnS) society
    Luca Ansaloni
    1st Unit of General Surgery, Ospedali Riuniti di Bergamo, Italy
    World J Emerg Surg 5:29. 2010
    ..abstract:..
  13. pmc Survival following a vertical free fall from 300 feet: the crucial role of body position to impact surface
    Sebastian Weckbach
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado Denver, School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Scand J Trauma Resusc Emerg Med 19:63. 2011
    ..The role of early patient transfer to a level 1 trauma center, and "damage control" management protocols for avoiding delayed morbidity and mortality in this critically injured patient are discussed...
  14. pmc "Metabolic staging" after major trauma - a guide for clinical decision making?
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 80204, USA
    Scand J Trauma Resusc Emerg Med 18:34. 2010
    ..The potential clinical impact of metabolic staging, and of an appropriately adapted "metabolic control" and nutritional support, remains to be determined...
  15. pmc Lower extremity compartment syndrome in the acute care surgery paradigm: safety lessons learned
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center and University of Colorado, Denver Health Sciences Center 777 Bannock St MC0206 Denver, Colorado 80204, USA
    Patient Saf Surg 3:11. 2009
    ..Periodic system review of our trauma and orthopedic data for complications of LECS led us to hypothesize that delayed diagnosis and limb loss were potentially preventable events in our trauma center...
  16. pmc Fatal outcome after insufficient spine fixation for pyogenic thoracic spondylodiscitis: an imperative for 360 degrees fusion of the infected spine
    Michael A Flierl
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Patient Saf Surg 3:4. 2009
    ..Pyogenic spondylodiscitis represents a potentially life-threatening condition. Due to the low incidence, evidence-based surgical recommendations in the literature are equivocal, and the treatment modalities remain controversial...
  17. pmc Advocating "spine damage control" as a safe and effective treatment modality for unstable thoracolumbar fractures in polytrauma patients: a hypothesis
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, Colorado 80204, USA
    J Trauma Manag Outcomes 3:6. 2009
    ..IMPLICATIONS OF HYPOTHESIS: A "spine damage control" protocol may save lives and improve outcomes in severely injured patients with associated spine injuries...
  18. pmc Claude H. Organ, Jr. memorial lecture: splanchnic hypoperfusion provokes acute lung injury via a 5-lipoxygenase-dependent mechanism
    Ernest E Moore
    Department of Surgery, University of Colorado Denver, Denver, CO 80204, USA
    Am J Surg 200:681-9. 2010
    ..Elucidating these mediators and the timing of their participation in pulmonary inflammation is critical in translating our current knowledge to new therapeutic strategies at the bedside...
  19. ncbi request reprint Alcohol and trauma: the perfect storm
    Ernest E Moore
    Department of Surgery Denver Health Medical Center, Denver, CO 80204, USA
    J Trauma 59:S53-6; discussion S67-75. 2005
    ..A trauma center visit provides an opportune time and place to incorporate alcohol screening and brief interventions as a part of standard trauma care...
  20. ncbi request reprint The two-event construct of postinjury multiple organ failure
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO 80204, USA
    Shock 24:71-4. 2005
  21. pmc Proteomic profiling of the mesenteric lymph after hemorrhagic shock: Differential gel electrophoresis and mass spectrometry analysis
    Ashley Zurawel
    Proteomics Facility, University of Colorado School of Medicine, Aurora, USA
    Clin Proteomics 8:1. 2011
    ..Mass spectrometry based proteomic analysis of proteins in mesenteric lymph can effectively be used to identify candidate mediators and loss of protective agents in shock models...
  22. ncbi request reprint Hemoglobin-based oxygen carriers in trauma care: scientific rationale for the US multicenter prehosptial trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, and Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80204, USA
    World J Surg 30:1247-57. 2006
    ..The hemoglobin-based oxygen carriers (HBOCs) tested currently in advanced clinical trials are polymerized hemoglobin solutions...
  23. doi request reprint Defining the limits of resuscitative emergency department thoracotomy: a contemporary Western Trauma Association perspective
    Ernest E Moore
    Department of Surgery, Denver Health, Denver, Colorado 80204, USA
    J Trauma 70:334-9. 2011
    ..The purpose of this prospective multicenter study was to identify injury patterns and physiologic profiles at ED arrival that are compatible with survival...
  24. ncbi request reprint Acute care surgery: the safety net hospital model
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO 80204 4507, USA
    Surgery 141:297-8. 2007
  25. doi request reprint Ruminations at sunset
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, Colorado 80204, USA
    J Trauma 63:1206-9. 2007
  26. ncbi request reprint Insights from studies of blood substitutes in trauma
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    Shock 24:197-205. 2005
    ..The current generation of HBOCs can be lifesaving for acute blood loss today, but the next generation might be biochemically tailored for specific clinical indications...
  27. doi request reprint American Association for the Surgery of Trauma Organ Injury Scaling: 50th anniversary review article of the Journal of Trauma
    Ernest E Moore
    Department of Surgery, Denver Health, University of Colorado, Denver, Colorado 80204, USA
    J Trauma 69:1600-1. 2010
    ..A good example of this concept is the tumor, node, metastasis classification for solid organ malignancies: a system used worldwide to guide patient care and clinical investigation...
  28. pmc Repair of the torn descending thoracic aorta using the centrifugal pump for partial left heart bypass
    Ernest E Moore
    Denver Health Medical Center University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Surg 240:38-43. 2004
    ..To describe the relevant anatomy and sequential technical maneuvers to repair blunt injuries to the descending thoracic aorta with partial left heart bypass...
  29. ncbi request reprint Postinjury abdominal compartment syndrome does not preclude early enteral feeding after definitive closure
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, and the University of Colorado Health Sciences Center, 777 Bannock St, MC 0206, Denver, CO 80204, USA
    Am J Surg 188:653-8. 2004
    ..The purpose of this study was to determine if enteral nutrition was precluded by the intra-abdominal hypertension and bowel edema of the ACS...
  30. ncbi request reprint Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012
    ..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred...
  31. ncbi request reprint Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:358-64; discussion 364. 2012
    ..We sought to characterize mortality during the first 24 hours while controlling for time varying effects of transfusion to minimize survival bias...
  32. doi request reprint Validating the Western Trauma Association algorithm for managing patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial
    Walter L Biffl
    Department of Surgery, Denver Health Medical Center University of Colorado, Denver, Colorado 80204 4507, USA
    J Trauma 71:1494-502. 2011
    ..The purpose of this study was to evaluate the safety and efficacy of the algorithm in providing timely interventions for significant injuries...
  33. doi request reprint Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    Jeffry L Kashuk
    Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA 17033, USA
    Ann Surg 252:434-42; discussion 443-4. 2010
    ..We hypothesized that postinjury PF occurs early in severe shock, leading to postinjury coagulopathy, and ultimately hemorrhage-related death...
  34. pmc Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
    Nathan J D McLaughlin
    Bonfils Blood Center, University of Colorado Denver School of Medicine, Children s Hospital, Denver, CO 80230, USA
    J Immunol 180:8192-203. 2008
    ..In conclusion, PAF transduces signals through CME, and such GPCR signaling may allow for pharmacological manipulation of these cells to decrease PMN-mediated acute organ injury...
  35. doi request reprint Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome
    Frederick A Moore
    Department of Surgery, The Methodist Hospital, Houston Texas, USA
    J Trauma 64:1010-23. 2008
    ....
  36. pmc Platelets are dominant contributors to hypercoagulability after injury
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, Colorado, USA
    J Trauma Acute Care Surg 74:756-62; discussion 762-5. 2013
    ..Thus, we designed a phase II randomized controlled trial to test the hypothesis that TEG-guided prophylaxis with escalating low-molecular weight heparin (LMWH), followed by antiplatelet therapy would reduce VTE incidence...
  37. pmc Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis
    Joshua B Brown
    Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 74:1207-12; discussion 1212-4. 2013
    ..Optimal PH crystalloid resuscitation strategies remain unclear in blunt trauma as does the influence of PH hypotension. The objective was to characterize outcomes for PH crystalloid volume in patients with and without PH hypotension...
  38. pmc Elderly patients may benefit from tight glucose control
    Theresa L Chin
    University of Colorado, Denver, CO, USA
    Surgery 152:315-21. 2012
    ..We queried our 17-year prospective database of patients at risk for postinjury multiple organ failure to examine the association between glucose levels and adverse outcomes...
  39. doi request reprint Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...
  40. pmc Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
    Crit Care Med 41:399-404. 2013
    ..To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients...
  41. doi request reprint Early death and late morbidity after blood transfusion of injured children: a pilot study
    Fredric M Pieracci
    Department of Surgery, Denver Health Medical Center, Denver, CO 80206, USA
    J Pediatr Surg 47:1587-91. 2012
    ..The adverse immunomodulatory effects of blood transfusion are implicated in subsequent morbidity. We hypothesized that injured children requiring pRBC transfusion demonstrate patterns in outcome similar to those observed in adults...
  42. doi request reprint Blunt cerebrovascular injuries in the child
    Teresa S Jones
    Department of Surgery, Denver Health Medical Center, Denver, CO, USA
    Am J Surg 204:7-10. 2012
    ..The purpose of this study was to describe the incidence, injury patterns, and stroke rates of pediatric patients sustaining BCVIs...
  43. pmc Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:892-8. 2012
    ..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT...
  44. ncbi request reprint Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute
    Jeffrey L Johnson
    Department of Surgery, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
    J Trauma 54:133-9; discussion 139-40. 2003
    ..Through the use of a polymerized human hemoglobin (PolyHeme), we have been able to measure the inflammatory response in patients resuscitated with minimal exposure to banked components in the early postinjury period...
  45. pmc Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils
    Phillip C Eckels
    Department of Surgery, Denver Health Medical Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 297:C886-97. 2009
    ..Thus, amantadine and rimantadine have the potential to ameliorate PMN-mediated tissue damage in humans...
  46. doi request reprint Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury
    Rebecca D Edmonds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:292-8. 2011
    ..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients...
  47. doi request reprint Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 65:944-50. 2008
  48. pmc Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma Acute Care Surg 73:1395-400. 2012
    ..It remains unclear whether presence of ATC alters sex-based outcomes after injury. This study's objective was to characterize the sex dimorphism after severe injury in the presence and absence of ATC...
  49. doi request reprint Current trends in resuscitation strategy for the multiply injured patient
    Philip F Stahel
    Department of Orthopaedic Surgery, University of Colorado, Denver, Colorado 80204, USA
    Injury 40:S27-35. 2009
    ..This review article provides a brief overview of the existing resuscitation protocols for multiply injured patients, including ATLS and "damage control", and will address developing controversies in the field...
  50. ncbi request reprint Outcomes in surgical versus medical patients with the secondary abdominal compartment syndrome
    C Clay Cothren
    The Department of Surgery, Denver Health Medical Center, 777 Bannock Street, MC 0206, Denver, CO 80204, USA
    Am J Surg 194:804-7; discussion 807-8. 2007
    ..The purpose of this study was to compare the clinical scenarios, physiologic indices, and outcomes of patients with SACS due to medical versus trauma etiologies...
  51. doi request reprint Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  52. doi request reprint Management of patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial
    Walter L Biffl
    Department of Surgery, Denver Health Medical Center University of Colorado Denver, Denver, Colorado 80204 4507, USA
    J Trauma 66:1294-301. 2009
    ....
  53. doi request reprint Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?
    Frederick A Moore
    Department of Surgery, The Methodist Hospital, Houston, TX, USA
    Am J Surg 196:948-58; discussion 958-60. 2008
    ..Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding...
  54. doi request reprint Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
    ....
  55. ncbi request reprint Preperitonal pelvic packing for hemodynamically unstable pelvic fractures: a paradigm shift
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, Dencer, CO 80204, USA
    J Trauma 62:834-9; discussion 839-42. 2007
    ..We hypothesized that a modified technique of direct preperitoneal pelvic packing (PPP) would reduce the need for angiography, decrease blood transfusion requirements, and lower mortality...
  56. doi request reprint Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, CO, USA
    Ann Surg 251:604-14. 2010
    ....
  57. ncbi request reprint Cervical spine fracture patterns mandating screening to rule out blunt cerebrovascular injury
    C Clay Cothren
    University of Colorado Health Sciences Center and the Department of Surgery, Denver Health Medical Center, CO 80204, USA
    Surgery 141:76-82. 2007
    ..We hypothesized that specific cervical spine fracture patterns that warrant screening evaluation exist, hence limiting unwarranted diagnostic imaging...
  58. ncbi request reprint Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, CO 80204, USA
    Arch Surg 140:480-5; discussion 485-6. 2005
    ..Carotid stenting has been advocated in patients with grade III blunt carotid artery injuries (hereafter referred to as "blunt CAIs") because of the persistence of the pseudoaneurysm and concern for subsequent embolization or rupture...
  59. doi request reprint Effect of blood products transfusion on the development of postinjury multiple organ failure
    Jeffrey L Johnson
    Department of Surgery, University of Colorado Denver, USA
    Arch Surg 145:973-7. 2010
    ..Transfusion of fresh frozen plasma (FFP) and platelets is independently associated with the development of multiple organ failure (MOF) in critically injured patients...
  60. doi request reprint Hypercoagulability following blunt solid abdominal organ injury: when to initiate anticoagulation
    Brandon C Chapman
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street MC0206, Denver, CO 80206, USA
    Am J Surg 206:917-22; discussion 922-3. 2013
    ..The optimal time to initiate venous thromboembolism pharmacoprophylaxis after blunt abdominal solid organ injury is unknown...
  61. doi request reprint The impact of a standardized "spine damage-control" protocol for unstable thoracic and lumbar spine fractures in severely injured patients: a prospective cohort study
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, Denver, Colorado 80204, USA
    J Trauma Acute Care Surg 74:590-6. 2013
    ....
  62. ncbi request reprint A 12-year prospective study of postinjury multiple organ failure: has anything changed?
    David J Ciesla
    Department of Surgery, Denver Health Medical Center, CO 80204, USA
    Arch Surg 140:432-8; discussion 438-40. 2005
    ..The incidence and severity of postinjury multiple organ failure (MOF) has decreased over the last decade...
  63. doi request reprint Direct retroperitoneal pelvic packing versus pelvic angiography: A comparison of two management protocols for haemodynamically unstable pelvic fractures
    Patrick M Osborn
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
    Injury 40:54-60. 2009
    ..To evaluate the outcomes of haemodynamically unstable cases of pelvic ring injury treated with a protocol focused on either direct retroperitoneal pelvic packing or early pelvic angiography and embolisation...
  64. ncbi request reprint Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury
    Tomohiko Masuno
    Department of Surgery, Denver Health Medical Center, CO 80204, USA
    Surgery 138:335-41. 2005
    ..The purpose of this in vivo study is to simulate an existing multicenter prehospital trial of HBOC versus crystalloid to determine the effects in a controlled 2-event construct of postinjury multiple organ failure...
  65. doi request reprint Refractory postinjury thrombocytopenia is associated with multiple organ failure and adverse outcomes
    Trevor L Nydam
    Department of Surgery, University of Colorado Health Science Center and School of Medicine, Aurora, Colorado 80045, USA
    J Trauma 70:401-6; discussion 406-7. 2011
    ..In addition, recent studies suggest that platelets play a critical role in postinjury hyperinflammation. Therefore, we hypothesized that postinjury thrombocytopenia is a marker for progression to MOF...
  66. doi request reprint Local wound exploration remains a valuable triage tool for the evaluation of anterior abdominal stab wounds
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock St, MC 0206, Denver, CO 80204, USA
    Am J Surg 198:223-6. 2009
    ..In patients without immediate indications for laparotomy, we hypothesized that LWE/DPL would identify patients requiring surgery while limiting unnecessary hospital admissions...
  67. doi request reprint Hypertonic saline attenuates TNF-alpha-induced NF-kappaB activation in pulmonary epithelial cells
    Trevor L Nydam
    Center for Trauma Research and Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80045, USA
    Shock 31:466-72. 2009
    ..These results show that HTS inhibits TNF-alpha-induced NF-kappaB activation in the pulmonary epithelium and, further, our understanding of its beneficial effects in hemorrhage-induced ALI...
  68. ncbi request reprint HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans
    Erik D Peltz
    Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Shock 32:17-22. 2009
    ..Thus, HMGB1 may be integral to the early inflammatory response to trauma and is a potential target for future therapeutics...
  69. pmc Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes
    Guillermo A Escobar
    Department of Surgery, University of Colorado Health Science Center Denver Health Medical Center, Denver, CO 80204, USA
    Ann Surg 246:129-34. 2007
    ..This suggests that stored blood contains bioactive factors that may modify the immunoinflammatory response...
  70. doi request reprint Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4
    Janeen R Jordan
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Appl Physiol (1985) 104:1161-6. 2008
    ..Collectively, these data indicate that splanchnic ischemia/reperfusion activates gut PLA(2)-mediated release of AA into the lymph where it is delivered to the lungs, provoking LTB(4) production and subsequent PMN-mediated lung injury...
  71. ncbi request reprint Cervical spine fracture patterns predictive of blunt vertebral artery injury
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, 777 Bannock Street, Denver, CO 80204, USA
    J Trauma 55:811-3. 2003
    ..Because of the proximity of the cervical spine and vertebral arteries, we queried whether all patients with cervical spine fractures required arteriography to rule out VAI...
  72. doi request reprint Rapid thrombelastography (r-TEG) identifies hypercoagulability and predicts thromboembolic events in surgical patients
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA
    Surgery 146:764-72; discussion 772-4. 2009
    ..We hypothesized that r-TEG can be used as a screening tool to identify hypercoagulable states in surgical patients and would predict subsequent thromboembolic events...
  73. ncbi request reprint V. Guidelines for sedation and analgesia during mechanical ventilation general overview
    Michael B Shapiro
    Department of Surgery, Northwestern University, Chicago, Illinois, USA
    J Trauma 63:945-50. 2007
  74. doi request reprint Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, USA
    J Am Coll Surg 208:1-13. 2009
    ..This multicenter phase III trial was the first US study to assess survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injury...
  75. doi request reprint Diagnostic peritoneal lavage remains a valuable adjunct to modern imaging techniques
    John Y Cha
    Department of Surgery, University of South Florida College, Tampa, Florida, USA
    J Trauma 67:330-4; discussion 334-6. 2009
    ..We hypothesized that, while its indications may have changed, DPL remains essential in the rapid, effective triage of the trauma patient...
  76. doi request reprint Prediction of postinjury multiple-organ failure in the emergency department: development of the Denver Emergency Department Trauma Organ Failure score
    Jody A Vogel
    From the Departments of Emergency Medicine J A V, M M L, E H, N S, R L B, J S H and Surgery E E M C G, Denver Health Medical Center, Denver and University of Colorado School of Medicine J A V, R L B, E E M, J S H and Department of Epidemiology J S H, Colorado School of Public Health, Aurora, Colorado
    J Trauma Acute Care Surg 76:140-5. 2014
    ..The aim of this study was to derive and internally validate an instrument to predict the development of MOF in adult trauma patients using clinical and laboratory data available in the emergency department...
  77. doi request reprint Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy
    Michael P Chapman
    From the Department of Surgery M P C, C R R, J N H, T L C, J R S, A s, A B, University of Colorado Denver Denver Health Medical Center M P C, E E M, C R R, A G, J N H, T L C, J R S, A S Medical College of Georgia M P C and Bonfils Blood Center C C S, Denver, Colorado
    J Trauma Acute Care Surg 75:961-7; discussion 967. 2013
    ..We wished to determine the validity of this hypothesis and establish a threshold value to treat fibrinolysis, based on prediction of massive transfusion requirement and risk of mortality...
  78. doi request reprint Who should we feed? Western Trauma Association multi-institutional study of enteral nutrition in the open abdomen after injury
    Clay Cothren Burlew
    Department of Surgery, Denver Health Medical Center, Denver, CO
    J Trauma Acute Care Surg 73:1380-7; discussion 1387-8. 2012
    ..The purpose of this study was to analyze the use of EN for patients with an open abdomen after trauma and the effect of EN on fascial closure rates and nosocomial infections...
  79. pmc Hyperosmolarity attenuates TNF-α-mediated proinflammatory activation of human pulmonary microvascular endothelial cells
    Anirban Banerjee
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Shock 39:366-72. 2013
    ..01). In conclusion, HTS reduces PMN-HMVEC adhesion and TNF-α-induced proinflammatory activation of primary HMVECs via attenuation of nuclear factor-κB signaling...
  80. pmc Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO, USA
    Surgery 152:270-6. 2012
    ..The potential benefit of halogenated ethers has not been investigated in models of trauma/hemorrhagic shock (T/HS). Therefore, we hypothesized that isoflurane decreases T/HS-mediated ALI through platelet inhibition...
  81. doi request reprint Initial experiences with point-of-care rapid thrombelastography for management of life-threatening postinjury coagulopathy
    Jeffry L Kashuk
    Department of Surgery and Anesthesia, Denver Health Medical Center, Denver, Colorado, USA
    Transfusion 52:23-33. 2012
    ..We designed a prospective study to test the hypothesis that integrating TEG into our MTP would facilitate goal-directed therapy and provide equivalent outcomes compared to conventional coagulation testing...
  82. doi request reprint Transfusion strategies in postinjury coagulopathy
    Philip F Stahel
    Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204, USA
    Curr Opin Anaesthesiol 22:289-98. 2009
    ..The present review will attempt to define the current 'optimal' transfusion strategies for the coagulopathic trauma patient and to assess potential weaknesses in the pertinent literature...
  83. doi request reprint Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:476-82; discussion 482-4. 2009
    ..We sought to determine whether preinjury statin (PIS) use was associated with improved outcome in severely injured blunt trauma patients...
  84. doi request reprint Proteome and system ontology of hemorrhagic shock: exploring early constitutive changes in postshock mesenteric lymph
    Erik D Peltz
    Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO 80204, USA
    Surgery 146:347-57. 2009
    ..We hypothesize that an unbiased inspection of the proteome of PSML will reveal previously unrecognized aberrations in systems biology provoked by hemorrhage-induced mesenteric IR injury in vivo...
  85. pmc Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model
    Marguerite R Kelher
    Bonfils Blood Center, Denver, CO 80230, USA
    Blood 113:2079-87. 2009
    ..We conclude that TRALI is the result of 2 events with the second events consisting of the plasma from stored blood and antibodies that prime PMNs...
  86. ncbi request reprint Anticoagulation is the gold standard therapy for blunt carotid injuries to reduce stroke rate
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado Health Sciences Center, 80204, USA
    Arch Surg 139:540-5; discussion 545-6. 2004
    ..Aggressive screening, early angiographic diagnosis, and prompt anticoagulation for blunt carotid artery injuries (CAIs) improves neurologic outcome...
  87. pmc Gelsolin is depleted in post-shock mesenteric lymph
    Janeen R Jordan
    Department of Surgery, University of Colorado Health Science, Denver, Colorado 80204, USA
    J Surg Res 143:130-5. 2007
    ..We hypothesized that lipid binding proteins such as gelsolin may be depleted after trauma/hemorrhagic shock leading to increased lipid bioactivity...
  88. doi request reprint Heme oxygenase-1 induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion
    Jonathan P Roach
    Department of Surgery, The University of Colorado Denver, Aurora, USA
    Shock 31:251-7. 2009
    ..These data encourage continued investigation into the role of HO-1 in protecting against posttraumatic organ dysfunction and the clinical potential of HBOC for HO-1 induction...
  89. ncbi request reprint Decreased progression of postinjury lung dysfunction to the acute respiratory distress syndrome and multiple organ failure
    David J Ciesla
    Denver Health Medical Center, and the University of Colorado Health Sciences Center, Denver, Colo, USA
    Surgery 140:640-7; discussion 647-8. 2006
    ..We hypothesized that the collective effects of recently implemented therapeutic strategies have resulted in decreased activation of the systemic inflammatory response relative to priming in recent years...
  90. ncbi request reprint Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation
    Walter L Biffl
    Department of Surgery, Rhode Island Hospital Brown Medical School, Providence, RI, USA
    Surgery 134:86-91. 2003
    ..We hypothesized that clinically relevant HTS would provoke PMN apoptosis, as well as prevent stored blood- and lipid-mediated delayed PMN apoptosis through activation of p38 mitogen-activated protein kinase (MAPK) and caspase-3...
  91. pmc Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma
    Max V Wohlauer
    Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Am Coll Surg 214:739-46. 2012
    ..Although the current debate on acute traumatic coagulopathy has focused on the consumption or inhibition of coagulation factors, the question of early platelet dysfunction in this setting remains unclear...
  92. ncbi request reprint Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation
    Frederick A Moore
    Department of Surgery, University of Texas at Houston, 77030, USA
    J Trauma 61:82-9. 2006
  93. ncbi request reprint Bioactivity of postshock mesenteric lymph depends on the depth and duration of hemorrhagic shock
    Tomohiko Masuno
    Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO 80204, USA
    Shock 26:285-9. 2006
    ..Hemorrhagic shock provokes the release of bioactive agents in PSML that is dependent on both depth and duration of shock...
  94. doi request reprint Progressive postinjury thrombocytosis is associated with thromboembolic complications
    Jeffry L Kashuk
    Department of Surgery, Division of Trauma, Acute Care, and Acute Care Surgery, Penn State Hershey Medical Center and College of Medicine, Hershey, PA 17033 0850, USA
    Surgery 148:667-74; discussion 674-5. 2010
    ..We hypothesized that progressive postinjury thrombocytosis contributes to a hypercoagulable state that is associated with thrombelastography...
  95. ncbi request reprint Emergency department resuscitative thoracotomy for nontorso injuries
    Forest R Sheppard
    Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA
    Surgery 139:574-6. 2006
    ..However, adjunctive use of aortic cross-clamping during EDT for hemorrhagic shock also may be useful in the acute resuscitation of patient with nontorso injuries (NTI). We questioned the utility of EDT in patients with nontorso trauma...
  96. pmc The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: scientific rationale, study design, and results
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, Denver, CO 80204, USA
    Crit Care Clin 25:325-56, Table of Contents. 2009
    ..The benefit-to-risk ratio of PolyHeme is favorable when blood is needed but is not available or an option...
  97. doi request reprint Preperitoneal pelvic packing/external fixation with secondary angioembolization: optimal care for life-threatening hemorrhage from unstable pelvic fractures
    Clay Cothren Burlew
    Department of Surgery, Denver Health Medical Center and the University of Colorado Denver, Denver, CO 80204, USA
    J Am Coll Surg 212:628-35; discussion 635-7. 2011
    ..We hypothesized that PPP/EF arrests hemorrhage rapidly, facilitates emergent operative procedures, and ensures efficient use of angioembolization (AE)...
  98. ncbi request reprint Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation
    Nathan J D McLaughlin
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Immunol 176:7039-50. 2006
    ..We conclude that PAF signaling requires CME, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the PAFR for transduction before endosomal scission...
  99. ncbi request reprint The academic trauma center is a model for the future trauma and acute care surgeon
    David J Ciesla
    Denver Health Medical Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 58:657-61; discussion 661-2. 2005
    ..Recent discussions on the future of trauma surgery stimulated us to review our experience as a possible model for the future trauma and acute care surgeon...
  100. ncbi request reprint Normal mesenteric lymph blunts the pulmonary inflammatory response to endotoxin
    Aaron M Cheng
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    J Surg Res 136:166-71. 2006
    ..We hypothesize that NML protects against inflammatory insults to the pulmonary endothelium and that this effect is lost in PSML...
  101. doi request reprint Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?
    Jeffry L Kashuk
    Department of Surgery and Surgical Research, Denver Health Medical Center, Denver, Colorado 80204 4507, USA
    J Trauma 65:261-70; discussion 270-1. 2008
    ..Consequently, we reviewed our massive transfusion practices during a 5-year period to test the hypothesis that 1:1 FFP:RBC within the first 6 hours reduces life threatening coagulopathy...