Research Topics
| Jeffry L KashukSummaryAffiliation: Denver Health Medical Center Country: USA Publications
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Publications
Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?Jeffry L Kashuk
Department of Surgery and Surgical Research, Denver Health Medical Center, Denver, Colorado 80204 4507, USA
J Trauma 65:261-70; discussion 270-1. 2008..Consequently, we reviewed our massive transfusion practices during a 5-year period to test the hypothesis that 1:1 FFP:RBC within the first 6 hours reduces life threatening coagulopathy...- Rapid thrombelastography (r-TEG) identifies hypercoagulability and predicts thromboembolic events in surgical patientsJeffry L Kashuk
Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA
Surgery 146:764-72; discussion 772-4. 2009..We hypothesized that r-TEG can be used as a screening tool to identify hypercoagulable states in surgical patients and would predict subsequent thromboembolic events... 
Lower extremity compartment syndrome in the acute care surgery paradigm: safety lessons learnedJeffry L Kashuk
Department of Surgery, Denver Health Medical Center and University of Colorado, Denver Health Sciences Center 777 Bannock St MC0206 Denver, Colorado 80204, USA
Patient Saf Surg 3:11. 2009..Periodic system review of our trauma and orthopedic data for complications of LECS led us to hypothesize that delayed diagnosis and limb loss were potentially preventable events in our trauma center...- Noncitrated whole blood is optimal for evaluation of postinjury coagulopathy with point-of-care rapid thrombelastographyJeffry L Kashuk
Department of Surgery, Denver Health Medical Center, University of Colorado at Denver, Denver, CO 80204, USA
J Surg Res 156:133-8. 2009..Additionally, we sought to compare the use of r-TEG with conventional coagulation tests in analysis of postinjury coagulopathy... - Primary repair of civilian colon injuries is safe in the damage control scenarioJeffry L Kashuk
Department of Surgery, Denver Health Medical Center, University of Colorado Denver and Health Sciences Center, Denver, CO 80204, USA
Surgery 146:663-8; discussion 668-70. 2009..We hypothesized that, even in the high-risk DL group, primary repair could be safely used after patient stabilization and that the open abdomen would facilitate the safety of this procedure... - Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of traumaJeffry L Kashuk
Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA 17033, USA
Ann Surg 252:434-42; discussion 443-4. 2010..We hypothesized that postinjury PF occurs early in severe shock, leading to postinjury coagulopathy, and ultimately hemorrhage-related death... - Initial experiences with point-of-care rapid thrombelastography for management of life-threatening postinjury coagulopathyJeffry L Kashuk
Department of Surgery and Anesthesia, Denver Health Medical Center, Denver, Colorado, USA
Transfusion 52:23-33. 2012..We designed a prospective study to test the hypothesis that integrating TEG into our MTP would facilitate goal-directed therapy and provide equivalent outcomes compared to conventional coagulation testing... - Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastographyJeffry L Kashuk
Department of Surgery, Denver Health Medical Center, University of Colorado Denver, CO, USA
Ann Surg 251:604-14. 2010.... - Progressive postinjury thrombocytosis is associated with thromboembolic complicationsJeffry L Kashuk
Department of Surgery, Division of Trauma, Acute Care, and Acute Care Surgery, Penn State Hershey Medical Center and College of Medicine, Hershey, PA 17033 0850, USA
Surgery 148:667-74; discussion 674-5. 2010..We hypothesized that progressive postinjury thrombocytosis contributes to a hypercoagulable state that is associated with thrombelastography... - Effect of blood products transfusion on the development of postinjury multiple organ failureJeffrey L Johnson
Department of Surgery, University of Colorado Denver, USA
Arch Surg 145:973-7. 2010..Transfusion of fresh frozen plasma (FFP) and platelets is independently associated with the development of multiple organ failure (MOF) in critically injured patients... - Diagnostic peritoneal lavage remains a valuable adjunct to modern imaging techniquesJohn Y Cha
Department of Surgery, University of South Florida College, Tampa, Florida, USA
J Trauma 67:330-4; discussion 334-6. 2009..We hypothesized that, while its indications may have changed, DPL remains essential in the rapid, effective triage of the trauma patient... - Differentiation of enzymatic from platelet hypercoagulability using the novel thrombelastography parameter delta (delta)Eduardo Gonzalez
Department of Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, Colorado, USA
J Surg Res 163:96-101. 2010..Delta).. - One thousand bedside percutaneous tracheostomies in the surgical intensive care unit: time to change the gold standardLucy Z Kornblith
Department of Surgery, Denver Health Medical Center and theUniversity of Colorado, Denver, CO, USA
J Am Coll Surg 212:163-70. 2011..Because this has been our preferred technique in the surgical ICU for more than 20 years, we reviewed our experience to ascertain its safety. We hypothesize that BPT has acceptably minimal morbidity, even in high-risk patients... - Patterns of early and late ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus in a trauma populationJeffry L Kashuk
Department of Surgery, Division of Acute Care Surgery, Penn State Hershey Medical Center and College of Medicine, Hershey, PA 17033, USA
J Trauma 69:519-22. 2010..We sought to determine the prevalence of early (≤4 days) and late (>4 days) MRSA pneumonia in ventilated multisystem trauma patients and to correlate findings with admission nasal swabs... - Transfusion strategies in postinjury coagulopathyPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204, USA
Curr Opin Anaesthesiol 22:289-98. 2009..The present review will attempt to define the current 'optimal' transfusion strategies for the coagulopathic trauma patient and to assess potential weaknesses in the pertinent literature... - Hemolysis, elevated liver enzymes, and low platelets syndrome: when is surgical help needed?Ann M Kulungowski
Department of Surgery, Denver Health Medical Center and University of Colorado at Denver and Health Sciences Center, 777 Bannock St, MC 0206, Denver, CO 80204, USA
Am J Surg 198:916-20. 2009..Epidemiologic data are lacking to predict patients at risk for hemorrhage requiring surgical consultation. We sought to identify early clinical predictors of hemorrhagic complications in patients at risk for HELLP syndrome... - Treatment for blunt cerebrovascular injuries: equivalence of anticoagulation and antiplatelet agentsC Clay Cothren
Department of Surgery, Denver Health Medical Center, Denver, CO 80204, USA
Arch Surg 144:685-90. 2009..We hypothesize that the 2 antithrombotic treatment regimens, systemic heparin sodium vs antiplatelet agents, are equivalent for the treatment of blunt cerebrovascular injuries (BCVIs) to prevent devastating injury-related strokes... - Local wound exploration remains a valuable triage tool for the evaluation of anterior abdominal stab woundsC Clay Cothren
Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock St, MC 0206, Denver, CO 80204, USA
Am J Surg 198:223-6. 2009..In patients without immediate indications for laparotomy, we hypothesized that LWE/DPL would identify patients requiring surgery while limiting unnecessary hospital admissions... - Coagulation abnormalities in the trauma patient: the role of point-of-care thromboelastographyEduardo Gonzalez
Department of Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, Colorado, USA
Semin Thromb Hemost 36:723-37. 2010..This overview addresses coagulation status and thromboprophylaxis management in the trauma patient and the emerging role of POC TEG... - Posttraumatic contrast-induced acute kidney injury: minimal consequences or significant threat?Kazuhide Matsushima
Division of Trauma, Acute Care and Critical Care Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17036, USA
J Trauma 70:415-9; discussion 419-20. 2011..We hypothesized that CIAKI incidence would be higher than that previously reported... - Unanswered questions in the use of blood component therapy in traumaSteven R Allen
Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA, USA
Scand J Trauma Resusc Emerg Med 19:5. 2011..Accordingly, recent experience from both military and civilian centers have begun to address these controversies, with certain management trends emerging which appear to significantly impact the way we approach these patients... - Two-stage brachial-basilic transposition fistula provides superior patency rates for dialysis access in a safety-net populationEduardo Gonzalez
Department of Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO, USA
Surgery 148:687-93; discussion 693-4. 2010.... - The use of thrombelastography to determine coagulation status in severe anorexia nervosa: a case seriesJennifer L Gaudiani
Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA
Int J Eat Disord 43:382-5. 2010..Hospitalized medical patients have been shown to have appropriate prophylaxis for venous thromboembolic (VTE) disease in only 40% of cases...