Research Topics
| Michael A FlierlSummaryAffiliation: Denver Health Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Management strategies for acute spinal cord injury: current options and future perspectivesPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, Denver, CO 80204, USA
Curr Opin Crit Care 18:651-60. 2012..Spinal cord injury is a devastating acute neurological condition with loss of function and poor long-term prognosis. This review summarizes current management strategies and innovative concepts on the horizon...
Heterotopic ossification in the reaming tract of a percutaneous antegrade femoral nail: a case reportSergiu Botolin
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, 777 Bannock Street, Denver, CO, 80204, USA
J Med Case Rep 7:90. 2013..The occurrence of excessive, symptomatic heterotopic ossification around the entry site of an antegrade femoral nail is rarely described in the literature...- Incidence and pattern of technical complications in balloon-guided osteoplasty for depressed tibial plateau fractures: a pilot study in 20 consecutive patientsCyril Mauffrey
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Patient Saf Surg 7:8. 2013..However, no study has yet been published to describe the technical limitations, intraoperative complications, and surgical bailout strategies for this new technology... - The impact of a standardized "spine damage-control" protocol for unstable thoracic and lumbar spine fractures in severely injured patients: a prospective cohort studyPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, Denver, Colorado 80204, USA
J Trauma Acute Care Surg 74:590-6. 2013.... - Thoracic hyperextension injury with complete "bony disruption" of the thoracic cage: Case report of a potentially life-threatening injuryJames Bailey
Department of Orthopaedics, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO, 80204, USA
World J Emerg Surg 7:14. 2012..abstract:.. - Introducing standardized "readbacks" to improve patient safety in surgery: a prospective survey in 92 providers at a public safety-net hospitalHari Prabhakar
Harvard Medical School, 107 Ave Louis Pasteur, Boston, MA 02115, USA
BMC Surg 12:8. 2012.... - Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine traumaHiroyuki Yoshihara
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Patient Saf Surg 5:18. 2011..abstract:.. - Complications and safety aspects of kyphoplasty for osteoporotic vertebral fractures: a prospective follow-up study in 102 consecutive patientsYohan Robinson
Charite Campus Benjamin Franklin, Centre for Trauma and Reconstructive Surgery, Berlin, Germany
Patient Saf Surg 2:2. 2008..The present study was designed to evaluate the incidence and patterns of perioperative complications in order to determine the safety of this procedure for patients undergoing kyphoplasty... - Pitfalls and complications in the treatment of cervical spine fractures in patients with ankylosing spondylitisChristoph E Heyde
Department of Trauma, Orthopedics, and Reconstructive Surgery, Charite, University Medical Center, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Patient Saf Surg 2:15. 2008..An emphasis is placed on the risks and complication patterns in the treatment of these rare, but challenging injuries... - Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in miceDenise Harhausen
Experimentelle Neurologie, Charite Universitatsmedizin Berlin, CCM, Berlin, Germany
J Neuroinflammation 7:15. 2010..The complement system is a crucial mediator of inflammation and cell lysis after cerebral ischemia. However, there is little information about the exact contribution of the membrane attack complex (MAC) and its inhibitor-protein CD59... - Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in miceIris Leinhase
Department of Trauma and Reconstructive Surgery, Charite University Medical School, Campus Benjamin Franklin, Berlin, Germany
J Neuroinflammation 4:13. 2007..This neutralizing antibody represents a specific and potent inhibitor of the alternative complement pathway in mice... - Management of bleeding following major trauma: an updated European guidelineRolf Rossaint
Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
Crit Care 14:R52. 2010..Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes... - Outcome of diaphyseal forearm fracture-nonunions treated by autologous bone grafting and compression platingFernando Baldy dos Reis
Department of Orthopaedics and Traumatology, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
Ann Surg Innov Res 3:5. 2009..CONCLUSION: Revision osteosynthesis of forearm nonunions by autologous iliac crest bone grafting and compression plating represents a safe and efficacious modality for the treatment of these challenging conditions... - Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsisMichael A Flierl
Department of Orthopaedics, School of Medicine, University of Colorado, Denver Health Medical Center, Denver, CO, 80204, USA
Ann Intensive Care 1:53. 2011..abstract:.. - Femur shaft fracture fixation in head-injured patients: when is the right time?Michael A Flierl
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO 80204, USA
J Orthop Trauma 24:107-14. 2010.... - [Current concepts of patient safety: rapid response system]P F Stahel
Department of Orthopaedic Surgery and Department of Neurosurgery, Denver Health Medical Center, University of Colorado, School of Medicine, 777 Bannock Street, 80204, Denver, CO, USA
Unfallchirurg 113:239-46. 2010..The implementation of a standardized RRS should also be considered in German hospitals with the aim of improving patient safety and reducing preventable in-hospital mortality... - Management of a trochanteric fracture complicated by a bent solid intramedullary femoral nail in situ: description of techniquePhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO 80204, USA
J Orthop Trauma 24:e25-30. 2010.... - Prevalence of sacral dysmorphia in a prospective trauma population: Implications for a "safe" surgical corridor for sacro-iliac screw placementErik A Hasenboehler
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado Denver, School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Patient Saf Surg 5:8. 2011..abstract:.. - Targeted modulation of the neuroinflammatory response after spinal cord injury: the ongoing quest for the "holy grail"Philip F Stahel
Department of Orthopaedic Surgery, University of Colorado Denver, School of Medicine Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
Am J Pathol 177:2685-7. 2010..This Commentary discusses the role of inflammation after spinal cord injury... - Wrong-site and wrong-patient procedures in the universal protocol era: analysis of a prospective database of physician self-reported occurrencesPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 80204, USA
Arch Surg 145:978-84. 2010..To determine the frequency, root cause, and outcome of wrong-site and wrong-patient procedures in the era of the Universal Protocol... - Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease?Michael A Flierl
Department of Internal Medicine, Denver Health Medical Center, Denver, CO, USA
Ann Gen Psychiatry 10:16. 2011..The present study was designed to evaluate the role of complement C3 levels, the extent of complement activation and of complement hemolytic activity in serum, as potential new biomarkers for the severity of anorexia nervosa... - Current trends in resuscitation strategy for the multiply injured patientPhilip F Stahel
Department of Orthopaedic Surgery, University of Colorado, Denver, Colorado 80204, USA
Injury 40:S27-35. 2009..This review article provides a brief overview of the existing resuscitation protocols for multiply injured patients, including ATLS and "damage control", and will address developing controversies in the field... - Fatal outcome after insufficient spine fixation for pyogenic thoracic spondylodiscitis: an imperative for 360 degrees fusion of the infected spineMichael A Flierl
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Patient Saf Surg 3:4. 2009..Pyogenic spondylodiscitis represents a potentially life-threatening condition. Due to the low incidence, evidence-based surgical recommendations in the literature are equivocal, and the treatment modalities remain controversial... - "Metabolic staging" after major trauma - a guide for clinical decision making?Philip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 80204, USA
Scand J Trauma Resusc Emerg Med 18:34. 2010..The potential clinical impact of metabolic staging, and of an appropriately adapted "metabolic control" and nutritional support, remains to be determined... - Bias towards publishing positive results in orthopedic and general surgery: a patient safety issue?Erik A Hasenboehler
Department of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Patient Saf Surg 1:4. 2007..This "publication bias" may alter the balance of the available evidence-based literature and may affect patient safety in surgery by depriving important information from unpublished negative studies... - Advocating "spine damage control" as a safe and effective treatment modality for unstable thoracolumbar fractures in polytrauma patients: a hypothesisPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, Colorado 80204, USA
J Trauma Manag Outcomes 3:6. 2009..IMPLICATIONS OF HYPOTHESIS: A "spine damage control" protocol may save lives and improve outcomes in severely injured patients with associated spine injuries... - Transfusion strategies in postinjury coagulopathyPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204, USA
Curr Opin Anaesthesiol 22:289-98. 2009..The present review will attempt to define the current 'optimal' transfusion strategies for the coagulopathic trauma patient and to assess potential weaknesses in the pertinent literature... - Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in micePhilip F Stahel
Department of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO 80204, USA
J Neuroinflammation 6:2. 2009..CD59 is the major regulator of MAC formation and represents an essential protector from homologous cell injury after complement activation in the injured brain... - Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsisMichael A Flierl
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO 80204, USA
Crit Care 13:R12. 2009..However, its pathophysiology remains unclear. The present study investigated the effect of complement C5a blockade in preventing BBB damage and pituitary dysfunction during experimental sepsis... - Influence of preoperative 7.5% hypertonic saline on neutrophil activation after reamed intramedullary nailing of femur shaft fractures: a prospective randomized pilot studyJuan F Agudelo
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado Denver, School of Medicine, Denver, CO 80204, USA
J Orthop Trauma 26:86-91. 2012..We hypothesized that preoperative administration of 7.5% HTS attenuates PMNL priming after IMN of unilateral femur shaft fractures compared with 0.9% normal saline... - Mouse closed head injury model induced by a weight-drop deviceMichael A Flierl
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado, USA
Nat Protoc 4:1328-37. 2009..In experienced hands, this CHI model can be carried out in as little as 30 s per animal, with additional time required for subsequent posttraumatic analysis and data collection... - Survival following a vertical free fall from 300 feet: the crucial role of body position to impact surfaceSebastian Weckbach
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado Denver, School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Scand J Trauma Resusc Emerg Med 19:63. 2011..The role of early patient transfer to a level 1 trauma center, and "damage control" management protocols for avoiding delayed morbidity and mortality in this critically injured patient are discussed... - Bench-to-bedside review: Burn-induced cerebral inflammation--a neglected entity?Michael A Flierl
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO 80204, USA
Crit Care 13:215. 2009..In this paper, we illustrate the molecular events leading to blood-brain barrier breakdown, with a focus on the subsequent neuroinflammatory changes leading to cerebral edema in patients with severe burns... 
Traction table-related complications in orthopaedic surgeryMichael A Flierl
Department of Orthopaedic Surgery, Denver Health Medical Center, CO, USA
J Am Acad Orthop Surg 18:668-75. 2010....- Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"?Miriam D Neher
Department of Orthopaedic Surgery, University of Colorado Denver, School of Medicine, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
J Biomed Sci 18:90. 2011.... - Pathophysiology of septic encephalopathy--an unsolved puzzleMichael A Flierl
Department of Orthopaedic Surgery, University of Colorado School of Medicine, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA
Crit Care 14:165. 2010..A better understanding of the pathophysiological events leading to septic encephalopathy appears crucial to advance the clinical care for this vulnerable patient population... - Stress radiograph to detect true extent of symphyseal disruption in presumed anteroposterior compression type I pelvic injuriesTakashi Suzuki
Department of Orthopaedic Surgery, Denver Health Medical Center, Denver, Colorado, USA
J Trauma 69:880-5. 2010..We instituted a protocol in which a stress examination was performed for patients presenting with an APC-I injury diagnosed with static radiographs to reveal the true extent of the injury... - Locking plates: tips and tricksWade R Smith
Department of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, CO 80204, USA
J Bone Joint Surg Am 89:2298-307. 2007 - Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injurySebastian Weckbach
Department of Orthopaedics, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204, USA
J Neurotrauma 29:1233-42. 2012..The attenuated extent of post-traumatic complement activation seen in Rag1(-/-) mice implies a cross-talk between innate and adaptive immune responses, which requires further investigation in future studies... - Treatment of complex proximal femoral fractures with the proximal femur locking compression plateErik A Hasenboehler
Dept of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock St, Denver, CO 80204, USA
Orthopedics 30:618-23. 2007..The PF-LCP represents a feasible alternative for the treatment of unstable inter- and subtrochanteric fractures... - Technical problems and complications in the removal of the less invasive stabilization systemTakashi Suzuki
Department of Orthopaedic Surgery, Denver Health Medical Centre, University of Colorado at Denver, School of Medicine, Denver, CO, USA
J Orthop Trauma 24:369-73. 2010..This study was designed to evaluate the frequency of intraoperative problems and complications involved with Less Invasive Stabilization System (LISS) plate removal... - Improving accuracy of total knee component cementation: description of a simple techniqueWilliam B Lutes
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
J Orthop Surg Res 4:38. 2009..abstract:.. - A retrospective analysis of comminuted intra-articular fractures of the tibial plafond: Open reduction and internal fixation versus external Ilizarov fixationStacy Bacon
Department of Orthopaedic Surgery, Denver Health Medical Centre, University of Colorado School of Medicine, Denver, CO 80204, USA
Injury 39:196-202. 2008..Future prospective randomised trials are required to determine with more scientific accuracy the optimal treatment strategy for these challenging injuries... - Direct retroperitoneal pelvic packing versus pelvic angiography: A comparison of two management protocols for haemodynamically unstable pelvic fracturesPatrick M Osborn
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Injury 40:54-60. 2009..To evaluate the outcomes of haemodynamically unstable cases of pelvic ring injury treated with a protocol focused on either direct retroperitoneal pelvic packing or early pelvic angiography and embolisation... - Outcome and complications of posterior transiliac plating for vertically unstable sacral fracturesTakashi Suzuki
Department of Orthopaedic Surgery, Denver Health Medical Centre, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Injury 40:405-9. 2009..We caution its use in the presence of a known Morel-Lavallee lesion, as this may increase the wound complication and infection risk... - Locking plates: tips and tricksWade R Smith
Denver Health Medical Center, University of Colorado, Denver, Colorado, USA
Instr Course Lect 57:25-36. 2008..Nonclinical factors likely include a push by industry for new technology and new markets as well as the general interest of the public in "minimally invasive" surgery... - Safety and efficacy of conversion from external fixation to plate fixation in humeral shaft fracturesTakashi Suzuki
Department of Orthopaedic Surgery, Denver Health Medical Centre, University of Colorado at Denver School of Medicine, Denver, CO, USA
J Orthop Trauma 24:414-9. 2010..The purpose of this study was to evaluate the outcome and complications of patients who sustained humeral shaft fractures and were treated with initial unilateral external fixation followed by plate fixation... - Postoperative surgical site infection following acetabular fracture fixationTakashi Suzuki
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Injury 41:396-9. 2010..To reduce the incidence of SSI following acetabular fracture surgery, special attention should be directed at the care of obese patients, patients requiring ICU care, and patients with associated Morel-Lavallée lesions... - Role of biological modifiers regulating the immune response after traumaPhilip F Stahel
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock Street, Denver, CO 80204, USA
Injury 38:1409-22. 2007.... - Combined injuries of the pelvis and acetabulum: nature of a devastating dyadTakashi Suzuki
Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, Denver, CO 80204, USA
J Orthop Trauma 24:303-8. 2010..We hypothesize that this combination of injuries affects not only the postinjury hemodynamics of the patient, but the outcome of subsequent acetabular fracture treatment... - Nocardia osteomyelitis: a rare complication after intramedullary nailing of a closed tibial shaft fractureTodd Vander Heiden
Department of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO 80204, USA
J Orthop Trauma 23:232-6. 2009..In addition, we provide a review of the literature in the field and discuss optimized treatment strategies... - Pharmacology of traumatic brain injury: where is the "golden bullet"?Kathryn Beauchamp
Division of Neurosurgery, Department of Surgery, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204, USA
Mol Med 14:731-40. 2008..We review the published prospective clinical trials on pharmacological treatment modalities for TBI patients and outline future promising therapeutic avenues in the field...