Research Topics
| W BurmanSummaryAffiliation: Denver Health Medical Center Country: USA Publications
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Publications
The effects of local review on informed consent documents from a multicenter clinical trials consortiumWilliam Burman
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
Control Clin Trials 24:245-55. 2003..Local approval of two multicenter clinical trials was time-consuming and resulted in many changes in centrally approved consent forms. These changes frequently decreased readability and introduced errors...- Clinical and radiographic features of HIV-related tuberculosisWilliam J Burman
Denver Public Health and the Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, USA
Semin Respir Infect 18:263-71. 2003.... - The impact of episodic CD4 cell count-guided antiretroviral therapy on quality of lifeWilliam J Burman
Denver Public Health Department and the Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
J Acquir Immune Defic Syndr 47:185-93. 2008..To evaluate the effect of episodic antiretroviral therapy on quality of life (QOL)... 
Episodic antiretroviral therapy increases HIV transmission risk compared with continuous therapy: results of a randomized controlled trialWilliam Burman
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
J Acquir Immune Defic Syndr 49:142-50. 2008..To compare the HIV transmission risk among patients randomized to episodic versus continuous antiretroviral therapy...- Issues in the management of HIV-related tuberculosisWilliam J Burman
Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Clin Chest Med 26:283-94, vi-vii. 2005..The author reviews these controversies and makes recommendations for the management of HIV-related tuberculosis... - Acquired rifamycin resistance with twice-weekly treatment of HIV-related tuberculosisWilliam Burman
Denver Public Health, Denver, CO 80204, USA
Am J Respir Crit Care Med 173:350-6. 2006..Rifabutin was recommended in place of rifampin during treatment of HIV-related tuberculosis (TB) to facilitate concomitant potent antiretroviral therapy, but this approach has not been evaluated in a prospective study... - Ensuring the involvement of children in the evaluation of new tuberculosis treatment regimensWilliam J Burman
PLoS Med 5:e176. 2008 - Moxifloxacin versus ethambutol in the first 2 months of treatment for pulmonary tuberculosisWilliam J Burman
Denver Public Health and the Department of Medicine, University of Colorado Health Sciences National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Respir Crit Care Med 174:331-8. 2006..Moxifloxacin has promising preclinical activity against Mycobacterium tuberculosis, but has not been evaluated in multidrug treatment of tuberculosis in humans... - Frequency, severity and duration of immune reconstitution events in HIV-related tuberculosisW Burman
Denver Public Health and the University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
Int J Tuberc Lung Dis 11:1282-9. 2007..Patients were enrolled in a prospective trial of rifabutin-based tuberculosis (TB) treatment for human immunodeficiency virus related TB. Antiretroviral therapy (ART) was encouraged, but not required... - Conventional and molecular epidemiology of trimethoprim-sulfamethoxazole resistance among urinary Escherichia coli isolatesWilliam J Burman
Department of Public Health, Denver Health and Hospital Authority, Colorado 80204, USA
Am J Med 115:358-64. 2003..We evaluated the epidemiology of trimethoprim-sulfamethoxazole-resistant E. coli in a large, public health care system in Denver, Colorado... - Relapse associated with active disease caused by Beijing strain of Mycobacterium tuberculosisWilliam J Burman
Infectious Disease Clinic, Denver Public Health, Denver, Colorado 80204, USA
Emerg Infect Dis 15:1061-7. 2009..1-108, p = 0.04). Active disease caused by a Beijing strain was associated with increased risk for relapse, particularly among Asian-Pacific Islanders... - Lack of toxicity from concomitant directly observed disulfiram and isoniazid-containing therapy for active tuberculosisW J Burman
Denver Public Health Department, Colorado 80204, USA
Int J Tuberc Lung Dis 6:839-42. 2002..However, the small number of patients on disulfiram limits the strength of this negative finding... - Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterialsW J Burman
Department of Public Health, Denver Health and Hospital Authority, University of Colorado Health Sciences Center, USA
Clin Pharmacokinet 40:327-41. 2001..Rifabutin toxicity is related to dose and concomitant use of CYP3A inhibitors. The rifamycins illustrate the complexity of predicting the pharmacodynamics of treatment of an intracellular pathogen with the capacity for dormancy... 
Rip Van Winkle wakes up: development of tuberculosis treatment in the 21st centuryWilliam J Burman
Infectious Diseases Clinic of Denver Public Health and Division of Infectious Diseases, University of Colorado, Denver, USA
Clin Infect Dis 50:S165-72. 2010..Novel drugs, such as TMC207, OPC-67683, PA824, SQ109, and PNU-100480, may improve the treatment of drug-resistant and drug-susceptible tuberculosis...- Review of false-positive cultures for Mycobacterium tuberculosis and recommendations for avoiding unnecessary treatmentW J Burman
Department of Public Health, Denver Health and Hospital Authority, CO, USA
Clin Infect Dis 31:1390-5. 2000..Laboratories and tuberculosis control programs should develop procedures to identify patients having only 1 positive culture. Such patients should be further evaluated for the possibility of a false-positive culture... - Breaking the camel's back: multicenter clinical trials and local institutional review boardsW J Burman
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
Ann Intern Med 134:152-7. 2001..Instead of rigid enforcement of outmoded regulations that do not contribute to patient safety, the responsibilities of the local IRB in the oversight of multicenter clinical trials must be systematically evaluated... - Clinical evaluation of the nelfinavir-rifabutin interaction in patients with tuberculosis and human immunodeficiency virus infectionDebra A Benator
Division of Infectious Diseases, Veterans Affairs Medical Center, Washington, D C 20422, USA
Pharmacotherapy 27:793-800. 2007..To characterize the bidirectional interaction between twice-daily nelfinavir and twice-weekly rifabutin and isoniazid in patients with tuberculosis and human immunodeficiency virus (HIV) infection... - CD4+ count-guided interruption of antiretroviral treatmentW M El-Sadr
Division of Infectious Diseases, Harlem Hospital Center and Columbia University, New York, NY 10037, USA
N Engl J Med 355:2283-96. 2006..Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV)... - Durability of adherence to antiretroviral therapy on initial and subsequent regimensEdward M Gardner
Denver Public Health, 605 Bannock Street, MC 2600, Denver, Colorado 80204, USA
AIDS Patient Care STDS 20:628-36. 2006..Adherence decreases during an initial regimen and on sequential antiretroviral regimens. Effective and durable interventions to prevent declining adherence are needed... - Emergence of fluoroquinolone resistance in outpatient urinary Escherichia coli isolatesLuke Johnson
University of Denver and Department of Patient Safety and Quality, Denver Health and Hospital Authority, Denver, Colo, USA
Am J Med 121:876-84. 2008..We evaluated the effects of that switch 6 years later... - Differential adherence to combination antiretroviral therapy is associated with virological failure with resistanceEdward M Gardner
Denver Public Health, Denver, Colorado 80204, USA
AIDS 22:75-82. 2008..To investigate the occurrence of differential adherence to components of combination antiretroviral therapy and assess its predictors and association with virological failure and antiretroviral medication resistance... - Impact of routine infectious diseases service consultation on the evaluation, management, and outcomes of Staphylococcus aureus bacteremiaTimothy C Jenkins
Division of Infectious Diseases, Denver Health and Hospital Authority, Colorado, USA
Clin Infect Dis 46:1000-8. 2008..Staphylococcus aureus bacteremia causes considerable morbidity and mortality, and strategies to improve management and outcomes of this disease are needed... - The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infectionEdward M Gardner
Denver Public Health, Denver, Colorado, USA
Clin Infect Dis 52:793-800. 2011.... - Selective drug taking during combination antiretroviral therapy in an unselected clinic populationEdward M Gardner
University of Colorado Health Sciences Center, Denver, CO 80204, USA
J Acquir Immune Defic Syndr 40:294-300. 2005..Multidrug therapy is necessary to achieve sustained viral suppression. Discordant adherence to individual components of a multidrug regimen may lead to adverse outcomes... - Skin and soft-tissue infections requiring hospitalization at an academic medical center: opportunities for antimicrobial stewardshipTimothy C Jenkins
Department of Medicine and Division of Infectious Diseases, Denver Health Medical Center, University of Colorado Denver, Denver, CO, USA
Clin Infect Dis 51:895-903. 2010..Although complicated skin and soft-tissue infections (SSTIs) are among the most common infections requiring hospitalization, their clinical spectrum, management, and outcomes have not been well described... - The association of adherence to antiretroviral therapy with healthcare utilization and costs for medical careEdward M Gardner
Denver Public Health, Denver, Colorado, USA
Appl Health Econ Health Policy 6:145-55. 2008..The association between antiretroviral adherence, healthcare utilization and medical costs has not been well studied... - Skin-test screening and tuberculosis transmission among the homelessPo Marn Kong
Denver Public Health, Denver, Colorado, USA
Emerg Infect Dis 8:1280-4. 2002..03). Our results suggest that the shelter-based screening program decreased the incidence of TB by decreasing its transmission among the homeless... - Epidemiology of healthcare-associated bloodstream infection caused by USA300 strains of methicillin-resistant Staphylococcus aureus in 3 affiliated hospitalsTimothy C Jenkins
Division of Infectious Diseases, Denver Health, CO 80204, USA
Infect Control Hosp Epidemiol 30:233-41. 2009..To describe the epidemiology of bloodstream infection caused by USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA), which are traditionally associated with cases of community-acquired infection, in the healthcare setting... - Antiretroviral medication adherence and class- specific resistance in a large prospective clinical trialEdward M Gardner
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
AIDS 24:395-403. 2010..To assess the association between adherence to antiretroviral therapy and the presence of class-specific antiretroviral medication resistance... - Widespread emergence of methicillin resistance in community-acquired Staphylococcus aureus infections in DenverMegan J Clancy
Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, CO. USA
South Med J 98:1069-75. 2005..In areas with high rates of methicillin-resistant S aureus outpatient infections, we recommend non-beta-lactam antibiotics for initial treatment of skin and soft tissue infections... - HIV transmission risk behavior and its relation to antiretroviral treatment adherenceRachel C Flaks
Department of Public Health, Denver Health and Hospital Authority, University of Colorado Health Sciences Center, Denver, Colorado, USA
Sex Transm Dis 30:399-404. 2003..Persons reporting high-risk behavior were less adherent to antiretroviral therapy, providing a behavioral basis for transmission of drug-resistant HIV... - Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosisMin Zhu
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Pharmacotherapy 22:686-95. 2002..Apparent half-life was somewhat shorter than that in previous reports. Compared with adults, absorption of pyrazinamide in children appeared more likely to be incomplete or delayed... - Conventional and molecular epidemiology of macrolide resistance among new Mycobacterium avium complex isolates recovered from HIV-infected patientsEdward M Gardner
Denver Public Health, Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80204, USA
Clin Infect Dis 41:1041-4. 2005..Initial MAC isolates in HIV-infected persons should routinely be tested for macrolide resistance... - Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patientsP Kazanjian
Division of Infectious Diseases, Dept of Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0378, USA
J Infect Dis 182:551-7. 2000..1; P=0.01). Thus, an increased duration of sulfa or sulfone prophylaxis increases the chance of developing a P. carinii mutation. The majority of patients with mutations respond to sulfa or sulfone therapy... - Risk-based human immunodeficiency virus (HIV) testing fails to detect the majority of HIV-infected persons in medical care SettingsTimothy C Jenkins
Denver Public Health, Denver, Colorado 80204, USA
Sex Transm Dis 33:329-33. 2006..Targeted testing based on clinical presentations is not likely to result in substantially earlier HIV diagnosis. Routine screening in high prevalence settings could be more effective... - Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndromeHelen McIlleron
Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
J Infect Dis 196:S63-75. 2007..These complexities of coadministration of antitubercular and antiretroviral agents are reviewed, and research priorities are highlighted... - American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosisHenry M Blumberg
Am J Respir Crit Care Med 167:603-62. 2003 - The hunt for the elusive surrogate marker of sterilizing activity in tuberculosis treatmentWilliam J Burman
Am J Respir Crit Care Med 167:1299-301. 2003 - Recurrent tuberculosis in the United States and Canada: relapse or reinfection?Robert M Jasmer
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 170:1360-6. 2004..We conclude that recurrent tuberculosis in the United States and Canada, countries with low rates of tuberculosis, is rarely due to reinfection with a new strain of M. tuberculosis... - Grade 4 events are as important as AIDS events in the era of HAARTRonald B Reisler
Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
J Acquir Immune Defic Syndr 34:379-86. 2003.... - Pharmacokinetics of rifapentine at 600, 900, and 1,200 mg during once-weekly tuberculosis therapyMarc Weiner
Department of Medicine, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
Am J Respir Crit Care Med 169:1191-7. 2004..The present pharmacokinetic study supports further trials to determine the optimal rifapentine dose for treatment of tuberculosis... - How much directly observed therapy is enough?William J Burman
Am J Respir Crit Care Med 170:474-5. 2004 - Short-course regimens for latent tuberculosis: what is ready for prime time?William J Burman
Enferm Infecc Microbiol Clin 25:297-9. 2007 - Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trialAndrew N Phillips
Department of Primary Care and Population Sciences, Royal Free University College Medical School, London, UK
Antivir Ther 13:177-87. 2008..Exploratory analyses were performed to better understand the reasons for this observation... - Tuberculosis in patients with HIV infectionPeter F Barnes
Center for Pulmonary and Infectious Disease Control, Departments of Medicine, Microbiology and Immunology, University of Texas Health Center, Tyler, Texas, USA
Infect Dis Clin North Am 16:107-26. 2002..New guidelines are available for the treatment of active and latent TB infection in patients with HIV...