Jack C de la Torre

Summary

Country: USA

Publications

  1. ncbi request reprint Alzheimer's disease is incurable but preventable
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 20:861-70. 2010
  2. pmc Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia
    Jack C de la Torre
    Department of Psychology, University of TX at Austin, Austin, TX 78712, USA
    Cardiovasc Psychiatry Neurol 2012:367516. 2012
  3. doi request reprint Vascular risk factors: a ticking time bomb to Alzheimer's disease
    Jack C de la Torre
    Department of Psychology, University of Texas, Austin, TX 78712, USA
    Am J Alzheimers Dis Other Demen 28:551-9. 2013
  4. doi request reprint Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease
    Jack C de la Torre
    Department of Psychology, University of Texas, Austin, TX, USA
    J Alzheimers Dis 32:553-67. 2012
  5. doi request reprint A turning point for Alzheimer's disease?
    Jack C de la Torre
    Department of Psychology, University of Texas at Austin, Austin, TX, USA
    Biofactors 38:78-83. 2012
  6. ncbi request reprint Carotid artery ultrasound and echocardiography testing to lower the prevalence of Alzheimer's disease
    Jack C de la Torre
    Center for Alzheimer s Research, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Stroke Cerebrovasc Dis 18:319-28. 2009
  7. doi request reprint The vascular hypothesis of Alzheimer's disease: bench to bedside and beyond
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Neurodegener Dis 7:116-21. 2010
  8. ncbi request reprint Vascular risk factor detection and control may prevent Alzheimer's disease
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Ageing Res Rev 9:218-25. 2010
  9. ncbi request reprint Three postulates to help identify the cause of Alzheimer’s disease
    Jack C de la Torre
    Centerfor Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 24:657-68. 2011
  10. ncbi request reprint Alzheimer's disease prevalence can be lowered with non-invasive testing
    Jack C de la Torre
    Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AR 85351, USA
    J Alzheimers Dis 14:353-9. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Alzheimer's disease is incurable but preventable
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 20:861-70. 2010
    ..Evidence-based medicine is recommended for optimizing clinical decision-making in evaluating AD risk factors and their treatment...
  2. pmc Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia
    Jack C de la Torre
    Department of Psychology, University of TX at Austin, Austin, TX 78712, USA
    Cardiovasc Psychiatry Neurol 2012:367516. 2012
    ....
  3. doi request reprint Vascular risk factors: a ticking time bomb to Alzheimer's disease
    Jack C de la Torre
    Department of Psychology, University of Texas, Austin, TX 78712, USA
    Am J Alzheimers Dis Other Demen 28:551-9. 2013
    ..Preventive intervention of modifiable VRF may delay or block progression of AD. Intervention could target cerebral blood flow (CBF), since most VRFs act to lower CBF in aging individuals by promoting cerebrovascular dysfunction. ..
  4. doi request reprint Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease
    Jack C de la Torre
    Department of Psychology, University of Texas, Austin, TX, USA
    J Alzheimers Dis 32:553-67. 2012
    ..Keeping cerebral hemodynamic homeostasis by careful management of vascular risk factors could be a decisive therapeutic target in the prevention of AD...
  5. doi request reprint A turning point for Alzheimer's disease?
    Jack C de la Torre
    Department of Psychology, University of Texas at Austin, Austin, TX, USA
    Biofactors 38:78-83. 2012
    ..Modulation of these biofactors may help prevent or control incipient AD. © 2012 International Union of Biochemistry and Molecular Biology, Inc...
  6. ncbi request reprint Carotid artery ultrasound and echocardiography testing to lower the prevalence of Alzheimer's disease
    Jack C de la Torre
    Center for Alzheimer s Research, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Stroke Cerebrovasc Dis 18:319-28. 2009
    ..A 5- year delay in the onset of AD could reduce the prevalence of AD by 50%. We are making preparations to test the merit of CAUSE in a clinical study of a cognitively healthy elderly population...
  7. doi request reprint The vascular hypothesis of Alzheimer's disease: bench to bedside and beyond
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Neurodegener Dis 7:116-21. 2010
    ....
  8. ncbi request reprint Vascular risk factor detection and control may prevent Alzheimer's disease
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Ageing Res Rev 9:218-25. 2010
    ..Prevention-by-detection of VRF and target treatment, if found effective, could significantly promote healthier mental and physical aging and lessen the socio-economic calamity anticipated from the growing prevalence of dementia...
  9. ncbi request reprint Three postulates to help identify the cause of Alzheimer’s disease
    Jack C de la Torre
    Centerfor Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 24:657-68. 2011
    ..The three postulates may challenge or help validate a proposed cause-effect relationship to AD and serve as a useful model for designing more intelligent therapeutic interventions aimed at preventing AD...
  10. ncbi request reprint Alzheimer's disease prevalence can be lowered with non-invasive testing
    Jack C de la Torre
    Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AR 85351, USA
    J Alzheimers Dis 14:353-9. 2008
    ..This clinical approach may have an important impact in reducing the number of new AD and VaD cases and lessen the catastrophic socio-economic burden these dementias are expected to have on the US healthcare system in the near future...
  11. doi request reprint Pathophysiology of neuronal energy crisis in Alzheimer's disease
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    Neurodegener Dis 5:126-32. 2008
    ..This review offers inductive hypothetical darts relative to that critical question...
  12. ncbi request reprint How do heart disease and stroke become risk factors for Alzheimer's disease?
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Gig Harbor, WA, USA
    Neurol Res 28:637-44. 2006
    ..Heart disease and stroke are two of the major leading causes of death and disability in the world. Mainly affecting the elderly population, heart disease and stroke are important risk factors for Alzheimer's disease (AD)...
  13. ncbi request reprint Cerebrovascular gene linked to Alzheimer's disease pathology
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Trends Mol Med 11:534-6. 2005
    ..This, together with evidence linking a dysfunctional cerebrovasculature to the pathogenesis of AD, suggests that the homeobox gene MEOX2 downregulation provides a therapeutic target to AD and a better understanding of this disorder...
  14. ncbi request reprint The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease
    Dilara Seyidova
    Microscopy Research Center, Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    In Vivo 18:325-33. 2004
    ..We theorize that pharmacological intervention using NO donors and/or NO suppressors should delay or minimize brain lesion development and further progression of brain pathology and dementia...
  15. ncbi request reprint Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
    Ali Aliyev
    Microscopy Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurol Res 26:547-53. 2004
    ..We speculate that pharmacological intervention using NO donors and/or NO suppressors will be able to delay or minimize the development of brain pathology and further progression of mental retardation...
  16. ncbi request reprint Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions
    Mark E Obrenovich
    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurotox Res 10:43-56. 2006
    ....
  17. ncbi request reprint Alzheimer's disease is a vasocognopathy: a new term to describe its nature
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Neurol Res 26:517-24. 2004
    ..Re-classification would allow a new strategy that could result in the tactical development and application of genuinely effective treatments, provide earlier diagnosis and reduce AD prevalence by focusing on the root of the problem...
  18. ncbi request reprint Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes
    Jack C de la Torre
    1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cereb Blood Flow Metab 25:663-72. 2005
    ..These findings may identify therapeutic targets for preventing MCI and treating Alzheimer's disease...
  19. doi request reprint Three postulates to help identify the cause of Alzheimer's disease
    Jack C de la Torre
    Center for Alzheimer s Research, Banner Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 24:657-68. 2011
    ..The three postulates may challenge or help validate a proposed cause-effect relationship to AD and serve as a useful model for designing more intelligent therapeutic interventions aimed at preventing AD...
  20. doi request reprint Cerebrovascular and cardiovascular pathology in Alzheimer's disease
    Jack C de la Torre
    Sun Health Research Institute, Center for Alzheimer s Research, Sun City, Arizona 85351, USA
    Int Rev Neurobiol 84:35-48. 2009
    ..Considerable human data now point in a new direction for guiding future research into AD. This new research direction should open a window of opportunity for decisive management and treatment of this devastating disorder...
  21. ncbi request reprint Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease
    Gjumrakch Aliev
    The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
    Neurotox Res 5:491-504. 2003
    ....
  22. ncbi request reprint Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Lancet Neurol 3:184-90. 2004
    ..The consensus of these studies indicates that chronic brain hypoperfusion is linked to AD risk factors, AD preclinical detection and pharmacotherapeutic action of AD symptoms...
  23. ncbi request reprint Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial
    Mustafa Karaca
    Department of Neurosurgery, Ihlas Medical Center, Bursa, Turkey
    Neurol Res 24:73-80. 2002
    ..This preliminary trial indicates that DMSO-FDP is well tolerated by this group of elderly patients and could be of benefit in reducing neurologic disability after stroke...