Jack C de la Torre
- Alzheimer's disease is a vasocognopathy: a new term to describe its natureJack C de la Torre
Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
Neurol Res 26:517-24. 2004..Re-classification would allow a new strategy that could result in the tactical development and application of genuinely effective treatments, provide earlier diagnosis and reduce AD prevalence by focusing on the root of the problem...
- Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changesJack C de la Torre
1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Cereb Blood Flow Metab 25:663-72. 2005..These findings may identify therapeutic targets for preventing MCI and treating Alzheimer's disease...
- Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?Ali Aliyev
Microscopy Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
Neurol Res 26:547-53. 2004..We speculate that pharmacological intervention using NO donors and/or NO suppressors will be able to delay or minimize the development of brain pathology and further progression of mental retardation...
- The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's diseaseDilara Seyidova
Microscopy Research Center, Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
In Vivo 18:325-33. 2004..We theorize that pharmacological intervention using NO donors and/or NO suppressors should delay or minimize brain lesion development and further progression of brain pathology and dementia...
- Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesionsMark E Obrenovich
Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Neurotox Res 10:43-56. 2006....
- Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialecticsJack C de la Torre
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Lancet Neurol 3:184-90. 2004..The consensus of these studies indicates that chronic brain hypoperfusion is linked to AD risk factors, AD preclinical detection and pharmacotherapeutic action of AD symptoms...
- Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer diseaseGjumrakch Aliev
The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
Neurotox Res 5:491-504. 2003....
- Pathophysiology of neuronal energy crisis in Alzheimer's diseaseJack C de la Torre
Institute of Pathology, Case Western Reserve School of Medicine, Cleveland, Ohio, USA
Neurodegener Dis 5:126-32. 2008..This review offers inductive hypothetical darts relative to that critical question...
- How do heart disease and stroke become risk factors for Alzheimer's disease?Jack C de la Torre
Institute of Pathology, Case Western Reserve School of Medicine, Gig Harbor, WA, USA
Neurol Res 28:637-44. 2006..Heart disease and stroke are two of the major leading causes of death and disability in the world. Mainly affecting the elderly population, heart disease and stroke are important risk factors for Alzheimer's disease (AD)...
- Cerebrovascular gene linked to Alzheimer's disease pathologyJack C de la Torre
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Trends Mol Med 11:534-6. 2005..This, together with evidence linking a dysfunctional cerebrovasculature to the pathogenesis of AD, suggests that the homeobox gene MEOX2 downregulation provides a therapeutic target to AD and a better understanding of this disorder...
- Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trialMustafa Karaca
Department of Neurosurgery, Ihlas Medical Center, Bursa, Turkey
Neurol Res 24:73-80. 2002..This preliminary trial indicates that DMSO-FDP is well tolerated by this group of elderly patients and could be of benefit in reducing neurologic disability after stroke...
- Alzheimer's disease prevalence can be lowered with non-invasive testingJack C de la Torre
Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AR 85351, USA
J Alzheimers Dis 14:353-9. 2008..This clinical approach may have an important impact in reducing the number of new AD and VaD cases and lessen the catastrophic socio-economic burden these dementias are expected to have on the US healthcare system in the near future...