Jack C de la Torre

Summary

Country: USA

Publications

  1. ncbi Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes
    Jack C de la Torre
    1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cereb Blood Flow Metab 25:663-72. 2005
  2. ncbi Alzheimer's disease is a vasocognopathy: a new term to describe its nature
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Neurol Res 26:517-24. 2004
  3. ncbi Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
    Ali Aliyev
    Microscopy Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurol Res 26:547-53. 2004
  4. ncbi The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease
    Dilara Seyidova
    Microscopy Research Center, Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    In Vivo 18:325-33. 2004
  5. ncbi Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions
    Mark E Obrenovich
    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurotox Res 10:43-56. 2006
  6. ncbi Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Lancet Neurol 3:184-90. 2004
  7. ncbi Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease
    Gjumrakch Aliev
    The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
    Neurotox Res 5:491-504. 2003
  8. ncbi Pathophysiology of neuronal energy crisis in Alzheimer's disease
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    Neurodegener Dis 5:126-32. 2008
  9. ncbi How do heart disease and stroke become risk factors for Alzheimer's disease?
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Gig Harbor, WA, USA
    Neurol Res 28:637-44. 2006
  10. ncbi Cerebrovascular gene linked to Alzheimer's disease pathology
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Trends Mol Med 11:534-6. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes
    Jack C de la Torre
    1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cereb Blood Flow Metab 25:663-72. 2005
    ..These findings may identify therapeutic targets for preventing MCI and treating Alzheimer's disease...
  2. ncbi Alzheimer's disease is a vasocognopathy: a new term to describe its nature
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Neurol Res 26:517-24. 2004
    ..Re-classification would allow a new strategy that could result in the tactical development and application of genuinely effective treatments, provide earlier diagnosis and reduce AD prevalence by focusing on the root of the problem...
  3. ncbi Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
    Ali Aliyev
    Microscopy Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurol Res 26:547-53. 2004
    ..We speculate that pharmacological intervention using NO donors and/or NO suppressors will be able to delay or minimize the development of brain pathology and further progression of mental retardation...
  4. ncbi The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease
    Dilara Seyidova
    Microscopy Research Center, Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    In Vivo 18:325-33. 2004
    ..We theorize that pharmacological intervention using NO donors and/or NO suppressors should delay or minimize brain lesion development and further progression of brain pathology and dementia...
  5. ncbi Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions
    Mark E Obrenovich
    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurotox Res 10:43-56. 2006
    ....
  6. ncbi Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Lancet Neurol 3:184-90. 2004
    ..The consensus of these studies indicates that chronic brain hypoperfusion is linked to AD risk factors, AD preclinical detection and pharmacotherapeutic action of AD symptoms...
  7. ncbi Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease
    Gjumrakch Aliev
    The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
    Neurotox Res 5:491-504. 2003
    ....
  8. ncbi Pathophysiology of neuronal energy crisis in Alzheimer's disease
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    Neurodegener Dis 5:126-32. 2008
    ..This review offers inductive hypothetical darts relative to that critical question...
  9. ncbi How do heart disease and stroke become risk factors for Alzheimer's disease?
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Gig Harbor, WA, USA
    Neurol Res 28:637-44. 2006
    ..Heart disease and stroke are two of the major leading causes of death and disability in the world. Mainly affecting the elderly population, heart disease and stroke are important risk factors for Alzheimer's disease (AD)...
  10. ncbi Cerebrovascular gene linked to Alzheimer's disease pathology
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Trends Mol Med 11:534-6. 2005
    ..This, together with evidence linking a dysfunctional cerebrovasculature to the pathogenesis of AD, suggests that the homeobox gene MEOX2 downregulation provides a therapeutic target to AD and a better understanding of this disorder...
  11. ncbi Alzheimer's disease prevalence can be lowered with non-invasive testing
    Jack C de la Torre
    Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AR 85351, USA
    J Alzheimers Dis 14:353-9. 2008
    ..This clinical approach may have an important impact in reducing the number of new AD and VaD cases and lessen the catastrophic socio-economic burden these dementias are expected to have on the US healthcare system in the near future...