Frederick J de Serres

Summary

Country: USA

Publications

  1. ncbi request reprint Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys
    Frederick J de Serres
    Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514 6716, USA
    Chest 122:1818-29. 2002
  2. doi request reprint Ethnic differences in alpha-1 antitrypsin deficiency in the United States of America
    Frederick J de Serres
    Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Ther Adv Respir Dis 4:63-70. 2010
  3. ncbi request reprint Estimating the risk for alpha-1 antitrypsin deficiency among COPD patients: evidence supporting targeted screening
    Frederick J de Serres
    Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
    COPD 3:133-9. 2006
  4. ncbi request reprint Prevalence of α1-antitrypsin deficiency alleles PI*S and PI*Z worldwide and effective screening for each of the five phenotypic classes PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ: a comprehensive review
    Frederick J de Serres
    Center for Evaluation of Risks to Human Reproduction, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Ther Adv Respir Dis 6:277-95. 2012
  5. ncbi request reprint Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World
    Frederick J de Serres
    National Institute of Environmental Health Sciences, Laboratory of Molecular Toxicology, Environmental Toxicology Program, Research Triangle Park, NC 27709 2233, USA
    Genet Med 7:175-84. 2005
  6. pmc Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed
    Frederick J de Serres
    Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1851-4. 2003
  7. ncbi request reprint [PI*S and PI*Z alpha 1-antitrypsin deficiency: estimated prevalence and number of deficient subjects in Spain]
    Ignacio Blanco
    Seccion de Neumologia, Servicio de Medicina Interna, Hospital Valle del Nalon, Langreo, Principado de Asturias, Spain
    Med Clin (Barc) 123:761-5. 2004
  8. ncbi request reprint Alpha-1-antitrypsin phenotypes and HLA-B27 typing in uveitis patients in southeast Iran
    Saeid Ghavami
    Department of Clinical Biochemistry, School of Medicine, Zahedan Medical University, Zahedan, Iran
    Clin Biochem 38:425-32. 2005

Detail Information

Publications8

  1. ncbi request reprint Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys
    Frederick J de Serres
    Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514 6716, USA
    Chest 122:1818-29. 2002
    ..There is a limited database of individuals affected by this disease worldwide. It has been estimated, for example, that there are 70,000 to 100,00 individuals affected in the United States, with comparable numbers in Europe...
  2. doi request reprint Ethnic differences in alpha-1 antitrypsin deficiency in the United States of America
    Frederick J de Serres
    Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Ther Adv Respir Dis 4:63-70. 2010
    ..Our earlier publications have demonstrated that alpha-1 antitrypsin (AAT) deficiency is not a rare disorder in the United States with at least 33,728 PI*ZZ homozygote individuals at risk...
  3. ncbi request reprint Estimating the risk for alpha-1 antitrypsin deficiency among COPD patients: evidence supporting targeted screening
    Frederick J de Serres
    Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
    COPD 3:133-9. 2006
    ..The result of the present study supports the concept of targeted screening for alpha-1 antitrypsin deficiency in countries with large populations of white (Caucasian) COPD patients...
  4. ncbi request reprint Prevalence of α1-antitrypsin deficiency alleles PI*S and PI*Z worldwide and effective screening for each of the five phenotypic classes PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ: a comprehensive review
    Frederick J de Serres
    Center for Evaluation of Risks to Human Reproduction, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Ther Adv Respir Dis 6:277-95. 2012
    ..The database also provides useful information for the identification of countries with high numbers of PI*ZZ individuals for augmentation therapy within a given geographic region...
  5. ncbi request reprint Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World
    Frederick J de Serres
    National Institute of Environmental Health Sciences, Laboratory of Molecular Toxicology, Environmental Toxicology Program, Research Triangle Park, NC 27709 2233, USA
    Genet Med 7:175-84. 2005
    ..In addition, to discuss the unique susceptibility of these populations and emigrants to Europe and the New World to the adverse health effects associated with exposure to environmental microbes, chemicals, and particulates...
  6. pmc Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed
    Frederick J de Serres
    Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1851-4. 2003
    ..Such exposures are known to result in both lung and liver disease as well as other adverse health effects...
  7. ncbi request reprint [PI*S and PI*Z alpha 1-antitrypsin deficiency: estimated prevalence and number of deficient subjects in Spain]
    Ignacio Blanco
    Seccion de Neumologia, Servicio de Medicina Interna, Hospital Valle del Nalon, Langreo, Principado de Asturias, Spain
    Med Clin (Barc) 123:761-5. 2004
    ....
  8. ncbi request reprint Alpha-1-antitrypsin phenotypes and HLA-B27 typing in uveitis patients in southeast Iran
    Saeid Ghavami
    Department of Clinical Biochemistry, School of Medicine, Zahedan Medical University, Zahedan, Iran
    Clin Biochem 38:425-32. 2005
    ..In this study, the role of AAT in uveitis is analyzed...