Mark A Smith

Summary

Affiliation: Davidson College
Country: USA

Publications

  1. pmc The effects of social learning on the acquisition of cocaine self-administration
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA Program in Neuroscience, Davidson College, Davidson, NC 28035, USA Electronic address
    Drug Alcohol Depend 141:1-8. 2014
  2. pmc Social preference and drug self-administration: a preclinical model of social choice within peer groups
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035, USA Electronic address
    Drug Alcohol Depend 135:140-5. 2014
  3. pmc The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine
    M A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Pharmacol Biochem Behav 104:40-6. 2013
  4. pmc The effects of exercise on cocaine self-administration, food-maintained responding, and locomotor activity in female rats: importance of the temporal relationship between physical activity and initial drug exposure
    Mark A Smith
    Department of Psychology, Box 7037, Davidson College, Davidson, NC 28035 7037, USA
    Exp Clin Psychopharmacol 20:437-46. 2012
  5. pmc Wheel running decreases the positive reinforcing effects of heroin
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Pharmacol Rep 64:960-4. 2012
  6. pmc Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male rats
    Mark A Smith
    Department of Psychology, Program in Neuroscience, Davidson College, Box 7037, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 224:81-90. 2012
  7. pmc Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female rats
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Drug Alcohol Depend 121:54-61. 2012
  8. pmc Effects of environmental enrichment on sensitivity to mu, kappa, and mixed-action opioids in female rats
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
    Physiol Behav 94:563-8. 2008
  9. ncbi request reprint Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine
    Mark A Smith
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pharmacol Biochem Behav 88:238-46. 2008
  10. ncbi request reprint Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats
    Mark A Smith
    Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 162:255-64. 2002

Research Grants

  1. Social and Enviromental Influences on Opioid Sensitivity
    Mark Smith; Fiscal Year: 2006
  2. Physical Activity and Substance Abuse
    Mark Smith; Fiscal Year: 2009
  3. Physical Activity and Substance Abuse
    Mark A Smith; Fiscal Year: 2010

Collaborators

Detail Information

Publications44

  1. pmc The effects of social learning on the acquisition of cocaine self-administration
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA Program in Neuroscience, Davidson College, Davidson, NC 28035, USA Electronic address
    Drug Alcohol Depend 141:1-8. 2014
    ....
  2. pmc Social preference and drug self-administration: a preclinical model of social choice within peer groups
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035, USA Electronic address
    Drug Alcohol Depend 135:140-5. 2014
    ..Few experimental studies have examined the role of selection in substance use, possibly because few preclinical models allow subjects to choose or select individuals based on a shared self-administration history...
  3. pmc The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine
    M A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Pharmacol Biochem Behav 104:40-6. 2013
    ..These data suggest that nalbuphine attenuates the development of sensitization to the behavioral effects of cocaine...
  4. pmc The effects of exercise on cocaine self-administration, food-maintained responding, and locomotor activity in female rats: importance of the temporal relationship between physical activity and initial drug exposure
    Mark A Smith
    Department of Psychology, Box 7037, Davidson College, Davidson, NC 28035 7037, USA
    Exp Clin Psychopharmacol 20:437-46. 2012
    ..These data suggest that exercise may reduce cocaine use in drug-experienced individuals with no prior history of aerobic activity without decreasing other types of positively reinforced behaviors...
  5. pmc Wheel running decreases the positive reinforcing effects of heroin
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Pharmacol Rep 64:960-4. 2012
    ..The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration...
  6. pmc Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male rats
    Mark A Smith
    Department of Psychology, Program in Neuroscience, Davidson College, Box 7037, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 224:81-90. 2012
    ..This represents a limitation of animal models because it fails to capture the complex social environments in which drug use often occur...
  7. pmc Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female rats
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Drug Alcohol Depend 121:54-61. 2012
    ..Next, a second period of abstinence occurred in which both cocaine and the cocaine-associated cues were withheld. After 5 days of abstinence, cue-induced reinstatement was examined in both groups...
  8. pmc Effects of environmental enrichment on sensitivity to mu, kappa, and mixed-action opioids in female rats
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
    Physiol Behav 94:563-8. 2008
    ..These data indicate that environmental enrichment does not alter sensitivity to the effects of opioid receptor agonists in female rats, and suggest that females may respond differently to environmental enrichment than males...
  9. ncbi request reprint Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine
    Mark A Smith
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pharmacol Biochem Behav 88:238-46. 2008
    ..These data suggest that lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine in rats with a history of binge-abstinence self-administration...
  10. ncbi request reprint Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats
    Mark A Smith
    Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 162:255-64. 2002
    ..Although the relationship between aging and sensitivity to the antinociceptive effects of mu opioids has been examined extensively, relatively few studies have examined this relationship in kappa opioids...
  11. ncbi request reprint The motor-impairing effects of GABA(A) and GABA(B) agonists in gamma-hydroxybutyrate (GHB)-treated rats: cross-tolerance to baclofen but not flunitrazepam
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
    Eur J Pharmacol 552:83-9. 2006
    ..These findings are consistent with the in vivo behavioral profile of GHB, which reveals a greater role for GABA(B) receptors than for GABA(A) receptors in its behavioral effects...
  12. pmc Aerobic exercise decreases the positive-reinforcing effects of cocaine
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035, USA
    Drug Alcohol Depend 98:129-35. 2008
    ..These data indicate that chronic exercise decreases the positive-reinforcing effects of cocaine and support the possibility that exercise may be an effective intervention in drug abuse prevention and treatment programs...
  13. pmc Chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
    Pharmacol Rep 60:561-5. 2008
    ..These data suggest that chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine...
  14. pmc The effects of repeated opioid administration on locomotor activity: II. Unidirectional cross-sensitization to cocaine
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, North Carolina 28035 7037, USA
    J Pharmacol Exp Ther 330:476-86. 2009
    ..These data indicate that agonist activity at mu receptors positively modulates cross-sensitization between opioids and cocaine, whereas agonist activity at kappa receptors negatively modulates this effect...
  15. pmc Effects of environmental enrichment on sensitivity to cocaine in female rats: importance of control rates of behavior
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, North Carolina 28035 7037, USA
    Behav Pharmacol 20:312-21. 2009
    ....
  16. pmc The effects of aerobic exercise on cocaine self-administration in male and female rats
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Psychopharmacology (Berl) 218:357-69. 2011
    ..In drug self-administration procedures, extended-access test sessions allow researchers to model maladaptive patterns of excessive and escalating drug intake that are characteristic of human substance-abusing populations...
  17. pmc Access to a running wheel inhibits the acquisition of cocaine self-administration
    Mark A Smith
    Department of Psychology, Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
    Pharmacol Biochem Behav 100:237-43. 2011
    ..These data indicate that access to a running wheel inhibits the acquisition of cocaine self-administration, and that physical activity may be an effective intervention in substance abuse prevention programs...
  18. ncbi request reprint Chronic exercise decreases sensitivity to mu opioids in female rats: correlation with exercise output
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
    Pharmacol Biochem Behav 85:12-22. 2006
    ..These data suggest that chronic exercise decreases sensitivity to mu opioids in female rats, and that these changes in sensitivity are positively correlated with exercise output...
  19. ncbi request reprint Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: dose- and time-dependent effects
    M A Smith
    Department of Psychology, Program in Neuroscience, and Center for Interdisciplinary Studies, Davidson College, Davidson, NC 28035 7037, USA
    Behav Pharmacol 14:641-7. 2003
    ..These data indicate that chronic naltrexone treatment enhances sensitivity to the antinociceptive effects of kappa opioids, and that this effect is both dose and time dependent...
  20. ncbi request reprint Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: differential effects across behavioral measures
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035, USA
    Pharmacol Biochem Behav 77:49-57. 2004
    ..Collectively, these data suggest that exercise alters sensitivity to the behavioral effects of kappa opioids, but that the direction and magnitude of this effect depends on the behavioral measure examined...
  21. ncbi request reprint Agonist and antagonist effects of benzodiazepines on motor performance: influence of intrinsic efficacy and task difficulty
    M A Smith
    Department of Psychology Program in Neuroscience, Davidson College, Davidson, North Carolina 28035 7037, USA
    Behav Pharmacol 15:215-23. 2004
    ....
  22. ncbi request reprint Social and environmental enrichment enhances sensitivity to the effects of kappa opioids: studies on antinociception, diuresis and conditioned place preference
    Mark A Smith
    Department of Psychology, Davidson College, Davidson NC 28035, USA
    Pharmacol Biochem Behav 76:93-101. 2003
    ..Collectively, these data suggest that enriched rats are more sensitive than isolated rats to the effects of kappa opioids, and that the kappa opioid receptor system is sensitive to social and environmental manipulations after weaning...
  23. ncbi request reprint Sensitivity to the effects of opioids in rats with free access to exercise wheels: mu-opioid tolerance and physical dependence
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 168:426-34. 2003
    ....
  24. ncbi request reprint Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor
    Mark A Smith
    Department of Psychology, Davidson College, NC 28035 7037, USA
    Psychopharmacology (Berl) 167:265-73. 2003
    ..Although the interactions between cocaine and high-efficacy mu opioids have been well characterized, the interactions between cocaine and lower efficacy opioids have not been as extensively examined...
  25. ncbi request reprint Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats. Influence of nociceptive intensity and intrinsic efficacy at the mu receptor
    M A Smith
    Department of Psychology, Davidson College, Davidson, NC 28036 1719, USA
    Psychopharmacology (Berl) 156:445-53. 2001
    ..Despite the widespread popularity of opioid analgesics, significant differences in the potency and effectiveness of these drugs are often observed across age groups...
  26. ncbi request reprint Sensitivity to the effects of sedative-hypnotics on motor performance: influence of task difficulty and chronic phenobarbital administration
    M A Smith
    Department of Psychology, Davidson College, NC 28036 1719, USA
    Behav Pharmacol 12:125-34. 2001
    ....
  27. ncbi request reprint Social and environmental influences on opioid sensitivity in rats: importance of an opioid's relative efficacy at the mu-receptor
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 181:27-37. 2005
    ..Evidence indicates that social and environmental enrichment can influence the functional maturation of the central nervous system and may affect an organism's sensitivity to centrally acting drugs...
  28. pmc The effects of repeated opioid administration on locomotor activity: I. Opposing actions of mu and kappa receptors
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, North Carolina, USA
    J Pharmacol Exp Ther 330:468-75. 2009
    ..These findings suggest that mu and kappa receptors have functionally opposing effects on opioid-mediated locomotor activity and sensitization-related processes...
  29. ncbi request reprint Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 178:309-16. 2005
    ..Behavioral procedures that incorporate dynamic changes in drug-maintained behavior are needed to model the development of cocaine addiction in humans...
  30. ncbi request reprint Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats
    Mark A Smith
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 173:105-11. 2004
    ..Previous studies have strongly implicated a role for GABA(B) receptors in modulating the reinforcing effects of cocaine...
  31. pmc Peer influences on drug self-administration: an econometric analysis in socially housed rats
    Geoffrey W Peitz
    Center for Interdisciplinary Studies, Davidson College, Davidson, North Carolina 28035, USA
    Behav Pharmacol 24:114-23. 2013
    ..These data suggest that the presence of an abstaining peer decreases the reinforcing strength of cocaine, thus supporting the development of social interventions in drug abuse prevention and treatment programs...
  32. ncbi request reprint An examination of the interactions between the antinociceptive effects of morphine and various mu-opioids: the role of intrinsic efficacy and stimulus intensity
    D Morgan
    Department of Psychology, University of North Carolina at Chapel Hill, 27599 3270, USA
    Anesth Analg 88:407-13. 1999
    ..Furthermore, the level of antinociception produced by the opioid, not necessarily the opioids' intrinsic efficacy, determines the type of interaction among opioids...
  33. ncbi request reprint Steady-state pharmacokinetic, safety, and tolerability profiles of quetiapine, norquetiapine, and other quetiapine metabolites in pediatric and adult patients with psychotic disorders
    Helen R Winter
    Clinical Pharmacokinetics, Clinical Pharmacology, Astra Zeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, DE 19850, USA
    J Child Adolesc Psychopharmacol 18:81-98. 2008
    ....
  34. ncbi request reprint Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004
    ..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...
  35. ncbi request reprint Temporal difference modeling of the blood-oxygen level dependent response during aversive conditioning in humans: effects of dopaminergic modulation
    Mahesh Menon
    Schizophrenia Program and PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Biol Psychiatry 62:765-72. 2007
    ....
  36. ncbi request reprint Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking
    Georgian T Mustata
    Case Western Reserve University, Department of Pathology, School of Medicine, 2085 Adelbert Rd, Cleveland, OH 44106, USA
    Diabetes 54:517-26. 2005
    ....
  37. ncbi request reprint Maternal deprivation increases cell death in the infant rat brain
    Li Xin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Brain Res Dev Brain Res 133:1-11. 2002
    ....
  38. ncbi request reprint Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Neurosci Res 85:3079-88. 2007
    ....
  39. ncbi request reprint Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation
    Carla M Maciag
    CNS Diseases Research, DuPont Pharmaceuticals Company, Wilmington, DE 19850, USA
    Neuropsychopharmacology 26:574-82. 2002
    ..These observations suggest that CRF antagonists are particularly effective in animals that are hyper-responsive to stress and may therefore have utility in the treatment of anxiety and affective disorders where CRF has been implicated...
  40. ncbi request reprint Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Mech Ageing Dev 128:522-8. 2007
    ..We have found significantly higher levels of IgG extravasation in the hippocampus of 12-month-old SAMP8 mice compared to SAMR1 mice, indicating an increased permeability of BBB in aged senescence-accelerated mice...
  41. ncbi request reprint Open-label steady-state pharmacokinetic drug interaction study on co-administered quetiapine fumarate and divalproex sodium in patients with schizophrenia, schizoaffective disorder, or bipolar disorder
    Helen R Winter
    AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA
    Hum Psychopharmacol 22:469-76. 2007
    ..To determine whether there is a pharmacokinetic drug interaction between quetiapine fumarate and divalproex sodium...
  42. ncbi request reprint Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential
    John N Bain
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Psychopharmacology (Berl) 169:150-60. 2003
    ..Dopaminergic pathways in the frontal and limbic cortex also may be targets for these agents, where pharmacological effects could result in heightened attention and/or support self-administration behavior...
  43. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  44. ncbi request reprint Rapid dose escalation with quetiapine: a pilot study
    Mark A Smith
    AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, PO Box 15437, Wilmington, DE 19850, USA
    J Clin Psychopharmacol 25:331-5. 2005
    ....

Research Grants3

  1. Social and Enviromental Influences on Opioid Sensitivity
    Mark Smith; Fiscal Year: 2006
    ..These studies should identify the critical biological, pharmacological and environmental factors contributing to differences in drug-seeking behavior across subject populations. ..
  2. Physical Activity and Substance Abuse
    Mark Smith; Fiscal Year: 2009
    ..This project will be the first systematic examination of the effects of exercise on a range of behavioral processes that are believed to be involved in the development of substance use disorders. ..
  3. Physical Activity and Substance Abuse
    Mark A Smith; Fiscal Year: 2010
    ..This project will be the first systematic examination of the effects of exercise on a range of behavioral processes that are believed to be involved in the development of substance use disorders. ..