Research Topics
| Mark A SmithSummaryAffiliation: Davidson College Country: USA Publications
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Publications
The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaineM A Smith
Department of Psychology, Davidson College, Davidson, NC 28035, USA
Pharmacol Biochem Behav 104:40-6. 2013..These data suggest that nalbuphine attenuates the development of sensitization to the behavioral effects of cocaine...
The effects of exercise on cocaine self-administration, food-maintained responding, and locomotor activity in female rats: importance of the temporal relationship between physical activity and initial drug exposureMark A Smith
Department of Psychology, Box 7037, Davidson College, Davidson, NC 28035 7037, USA
Exp Clin Psychopharmacol 20:437-46. 2012..These data suggest that exercise may reduce cocaine use in drug-experienced individuals with no prior history of aerobic activity without decreasing other types of positively reinforced behaviors...
Wheel running decreases the positive reinforcing effects of heroinMark A Smith
Department of Psychology, Program in Neuroscience, Davidson College, Davidson, NC 28035, USA
Pharmacol Rep 64:960-4. 2012..Conclusion: These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin...- Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male ratsMark A Smith
Department of Psychology, Program in Neuroscience, Davidson College, Box 7037, Davidson, NC 28035 7037, USA
Psychopharmacology (Berl) 224:81-90. 2012..This represents a limitation of animal models because it fails to capture the complex social environments in which drug use often occur... - Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female ratsMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035, USA
Drug Alcohol Depend 121:54-61. 2012..Next, a second period of abstinence occurred in which both cocaine and the cocaine-associated cues were withheld. After 5 days of abstinence, cue-induced reinstatement was examined in both groups... - Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaineMark A Smith
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Pharmacol Biochem Behav 88:238-46. 2008..These data suggest that lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine in rats with a history of binge-abstinence self-administration... - Access to a running wheel inhibits the acquisition of cocaine self-administrationMark A Smith
Department of Psychology, Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
Pharmacol Biochem Behav 100:237-43. 2011..These data indicate that access to a running wheel inhibits the acquisition of cocaine self-administration, and that physical activity may be an effective intervention in substance abuse prevention programs... - The motor-impairing effects of GABA(A) and GABA(B) agonists in gamma-hydroxybutyrate (GHB)-treated rats: cross-tolerance to baclofen but not flunitrazepamMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
Eur J Pharmacol 552:83-9. 2006..These findings are consistent with the in vivo behavioral profile of GHB, which reveals a greater role for GABA(B) receptors than for GABA(A) receptors in its behavioral effects... - Chronic exercise decreases sensitivity to mu opioids in female rats: correlation with exercise outputMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
Pharmacol Biochem Behav 85:12-22. 2006..These data suggest that chronic exercise decreases sensitivity to mu opioids in female rats, and that these changes in sensitivity are positively correlated with exercise output... - Effects of environmental enrichment on sensitivity to mu, kappa, and mixed-action opioids in female ratsMark A Smith
Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
Physiol Behav 94:563-8. 2008..These data indicate that environmental enrichment does not alter sensitivity to the effects of opioid receptor agonists in female rats, and suggest that females may respond differently to environmental enrichment than males... - Aerobic exercise decreases the positive-reinforcing effects of cocaineMark A Smith
Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035, USA
Drug Alcohol Depend 98:129-35. 2008..These data indicate that chronic exercise decreases the positive-reinforcing effects of cocaine and support the possibility that exercise may be an effective intervention in drug abuse prevention and treatment programs... - Chronic exercise increases sensitivity to the conditioned rewarding effects of cocaineMark A Smith
Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
Pharmacol Rep 60:561-5. 2008..These data suggest that chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine... - The effects of repeated opioid administration on locomotor activity: II. Unidirectional cross-sensitization to cocaineMark A Smith
Department of Psychology, Davidson College, Davidson, North Carolina 28035 7037, USA
J Pharmacol Exp Ther 330:476-86. 2009..These data indicate that agonist activity at mu receptors positively modulates cross-sensitization between opioids and cocaine, whereas agonist activity at kappa receptors negatively modulates this effect... - Effects of environmental enrichment on sensitivity to cocaine in female rats: importance of control rates of behaviorMark A Smith
Department of Psychology, Davidson College, Davidson, North Carolina 28035 7037, USA
Behav Pharmacol 20:312-21. 2009.... - The effects of aerobic exercise on cocaine self-administration in male and female ratsMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035, USA
Psychopharmacology (Berl) 218:357-69. 2011..In drug self-administration procedures, extended-access test sessions allow researchers to model maladaptive patterns of excessive and escalating drug intake that are characteristic of human substance-abusing populations... - Social and environmental influences on opioid sensitivity in rats: importance of an opioid's relative efficacy at the mu-receptorMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
Psychopharmacology (Berl) 181:27-37. 2005..Evidence indicates that social and environmental enrichment can influence the functional maturation of the central nervous system and may affect an organism's sensitivity to centrally acting drugs... - Social and environmental enrichment enhances sensitivity to the effects of kappa opioids: studies on antinociception, diuresis and conditioned place preferenceMark A Smith
Department of Psychology, Davidson College, Davidson NC 28035, USA
Pharmacol Biochem Behav 76:93-101. 2003..Collectively, these data suggest that enriched rats are more sensitive than isolated rats to the effects of kappa opioids, and that the kappa opioid receptor system is sensitive to social and environmental manipulations after weaning... - Sensitivity to the effects of opioids in rats with free access to exercise wheels: mu-opioid tolerance and physical dependenceMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
Psychopharmacology (Berl) 168:426-34. 2003.... - Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptorMark A Smith
Department of Psychology, Davidson College, NC 28035 7037, USA
Psychopharmacology (Berl) 167:265-73. 2003..Although the interactions between cocaine and high-efficacy mu opioids have been well characterized, the interactions between cocaine and lower efficacy opioids have not been as extensively examined... - Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male ratsMark A Smith
Program in Neuroscience, Davidson College, Davidson, NC 28035 7037, USA
Psychopharmacology (Berl) 162:255-64. 2002..Although the relationship between aging and sensitivity to the antinociceptive effects of mu opioids has been examined extensively, relatively few studies have examined this relationship in kappa opioids... - Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats. Influence of nociceptive intensity and intrinsic efficacy at the mu receptorM A Smith
Department of Psychology, Davidson College, Davidson, NC 28036 1719, USA
Psychopharmacology (Berl) 156:445-53. 2001..Despite the widespread popularity of opioid analgesics, significant differences in the potency and effectiveness of these drugs are often observed across age groups... - Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: differential effects across behavioral measuresMark A Smith
Department of Psychology, Davidson College, Davidson, NC 28035, USA
Pharmacol Biochem Behav 77:49-57. 2004..Collectively, these data suggest that exercise alters sensitivity to the behavioral effects of kappa opioids, but that the direction and magnitude of this effect depends on the behavioral measure examined... - Agonist and antagonist effects of benzodiazepines on motor performance: influence of intrinsic efficacy and task difficultyM A Smith
Department of Psychology Program in Neuroscience, Davidson College, Davidson, North Carolina 28035 7037, USA
Behav Pharmacol 15:215-23. 2004.... - Sensitivity to the effects of sedative-hypnotics on motor performance: influence of task difficulty and chronic phenobarbital administrationM A Smith
Department of Psychology, Davidson College, NC 28036 1719, USA
Behav Pharmacol 12:125-34. 2001.... - Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: dose- and time-dependent effectsM A Smith
Department of Psychology, Program in Neuroscience, and Center for Interdisciplinary Studies, Davidson College, Davidson, NC 28035 7037, USA
Behav Pharmacol 14:641-7. 2003..These data indicate that chronic naltrexone treatment enhances sensitivity to the antinociceptive effects of kappa opioids, and that this effect is both dose and time dependent... - The effects of repeated opioid administration on locomotor activity: I. Opposing actions of mu and kappa receptorsMark A Smith
Department of Psychology and Program in Neuroscience, Davidson College, Davidson, North Carolina, USA
J Pharmacol Exp Ther 330:468-75. 2009..These findings suggest that mu and kappa receptors have functionally opposing effects on opioid-mediated locomotor activity and sensitization-related processes... - Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in ratsDrake Morgan
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Psychopharmacology (Berl) 178:309-16. 2005..Behavioral procedures that incorporate dynamic changes in drug-maintained behavior are needed to model the development of cocaine addiction in humans... - Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in ratsMark A Smith
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Psychopharmacology (Berl) 173:105-11. 2004..CONCLUSIONS: These findings suggest that positive allosteric modulators of the GABA(B) receptor may hold promise as potential pharmacotherapies for cocaine abuse and dependence... - An examination of the interactions between the antinociceptive effects of morphine and various mu-opioids: the role of intrinsic efficacy and stimulus intensityD Morgan
Department of Psychology, University of North Carolina at Chapel Hill, 27599 3270, USA
Anesth Analg 88:407-13. 1999..When opioids are given in combination, the effects can only be predicted on the basis of the antinociception obtained when the drugs are administered alone... - Peer influences on drug self-administration: an econometric analysis in socially housed ratsGeoffrey W Peitz
Center for Interdisciplinary Studies, Davidson College, Davidson, North Carolina 28035, USA
Behav Pharmacol 24:114-23. 2013..These data suggest that the presence of an abstaining peer decreases the reinforcing strength of cocaine, thus supporting the development of social interventions in drug abuse prevention and treatment programs... - Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potentialJohn N Bain
Alzheimer's Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-2300, USA
Psychopharmacology (Berl) 169:150-60. 2003.... - Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linkingGeorgian T Mustata
Case Western Reserve University, Department of Pathology, School of Medicine, 2085 Adelbert Rd, Cleveland, OH 44106, USA
Diabetes 54:517-26. 2005.... - Rapid dose escalation with quetiapine: a pilot studyMark A Smith
AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, PO Box 15437, Wilmington, DE 19850, USA
J Clin Psychopharmacol 25:331-5. 2005.... - Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neuronsDaniel Alvira
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Neurosci Res 85:3079-88. 2007.... - Maternal deprivation increases cell death in the infant rat brainLi Xin Zhang
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Brain Res Dev Brain Res 133:1-11. 2002.... - Temporal difference modeling of the blood-oxygen level dependent response during aversive conditioning in humans: effects of dopaminergic modulationMahesh Menon
Schizophrenia Program and PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
Biol Psychiatry 62:765-72. 2007.... - Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separationCarla M Maciag
CNS Diseases Research, DuPont Pharmaceuticals Company, Wilmington, DE 19850, USA
Neuropsychopharmacology 26:574-82. 2002..These observations suggest that CRF antagonists are particularly effective in animals that are hyper-responsive to stress and may therefore have utility in the treatment of anxiety and affective disorders where CRF has been implicated... - Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescenceCarme Pelegri
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Mech Ageing Dev 128:522-8. 2007..We have found significantly higher levels of IgG extravasation in the hippocampus of 12-month-old SAMP8 mice compared to SAMR1 mice, indicating an increased permeability of BBB in aged senescence-accelerated mice... - Open-label steady-state pharmacokinetic drug interaction study on co-administered quetiapine fumarate and divalproex sodium in patients with schizophrenia, schizoaffective disorder, or bipolar disorderHelen R Winter
AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA
Hum Psychopharmacol 22:469-76. 2007..To determine whether there is a pharmacokinetic drug interaction between quetiapine fumarate and divalproex sodium... - Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesDaniel J Klionsky
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 4:151-75. 2008..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response... - Steady-state pharmacokinetic, safety, and tolerability profiles of quetiapine, norquetiapine, and other quetiapine metabolites in pediatric and adult patients with psychotic disordersHelen R Winter
Clinical Pharmacokinetics, Clinical Pharmacology, Astra Zeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, DE 19850, USA
J Child Adolesc Psychopharmacol 18:81-98. 2008.... - Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged ratsGemma Casadesus
USDA, HNRC on Aging at Tufts University, Boston, MA, USA
Nutr Neurosci 7:309-16. 2004..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...
Research Grants
- Social and Enviromental Influences on Opioid SensitivityMark Smith; Fiscal Year: 2006..These studies should identify the critical biological, pharmacological and environmental factors contributing to differences in drug-seeking behavior across subject populations. ..
- Physical Activity and Substance AbuseMark A Smith; Fiscal Year: 2010..This project will be the first systematic examination of the effects of exercise on a range of behavioral processes that are believed to be involved in the development of substance use disorders. ..