Research Topics
| Roy Davis AltmanSummaryAffiliation: David Geffen School of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Heritability patterns in hand osteoarthritis: the role of osteophytesMariko L Ishimori
Division of Rheumatology, Cedars Sinai Medical Center, 8700 Beverly Blvd, B 131, Los Angeles, CA 90048, USA
Arthritis Res Ther 12:R180. 2010..The objective of the present study was to assess heritability of clinical and radiographic features of hand osteoarthritis (OA) in affected patients and their siblings...- Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysisH Richard Barthel
Private Practice Rheumatology, P, O, Box 30813, Santa Barbara, CA 93130, USA
Arthritis Res Ther 12:R7. 2010..The current analysis examined the relationship of pain relief with measures of function and global rating of disease in patients with hand OA... 
Measurement of structural progression in osteoarthritis of the hip: the Barcelona consensus groupR D Altman
Division of Rheumatology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, USA
Osteoarthritis Cartilage 12:515-24. 2004..To outline the best available method of measurement for detecting progression of osteoarthritis (OA) of the hip especially in therapeutic trials...- Practical considerations for the pharmacologic management of osteoarthritisRoy Davis Altman
Am J Manag Care 15:S236-43. 2009.... 
Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trialRoy D Altman
Department of Rheumatology and Immunology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
J Rheumatol 36:1991-9. 2009..To measure the efficacy and safety of diclofenac sodium gel in patients with primary hand osteoarthritis (OA)...- A double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX trial)Roy D Altman
Division of Rheumatology and Immunology, University of California Los Angeles, Los Angeles, CA 90095, USA
Semin Arthritis Rheum 39:1-9. 2009..To report the FLEXX trial, the first well-controlled study assessing the safety and efficacy of Euflexxa (1% sodium hyaluronate; IA-BioHA) therapy for knee osteoarthritis (OA) at 26 weeks... - Structure-/disease-modifying agents for osteoarthritisRoy D Altman
Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Semin Arthritis Rheum 34:3-5. 2005..This has led to increasing interest in structure/disease modification as the goal in OA therapy. However, there are no universally proven structure-/ disease-modifying interventions... - Topical therapy for osteoarthritis: clinical and pharmacologic perspectivesRoy Altman
David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, CA 90024, USA
Postgrad Med 121:139-47. 2009..This review discusses the pharmacology, clinical efficacy, and safety profiles of diclofenac sodium 1% gel, salicylates, and capsaicin for the management of hand and knee OA... - Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled studyR D Altman
David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
Osteoarthritis Cartilage 15:454-61. 2007..To examine the efficacy and safety of two doses of long-acting acetaminophen in patients with osteoarthritis (OA) of the hip or knee... - Glucosamine therapy for knee osteoarthritis: pharmacokinetic considerationsRoy D Altman
Professor of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Expert Rev Clin Pharmacol 2:359-71. 2009..This review describes the current knowledge regarding the pharmacokinetics of glucosamine to provide a means for the interpretation of the pharmacodynamic and clinical efficacy results obtained in the different clinical trials... - Early management of osteoarthritisRoy Davis Altman
Am J Manag Care 16:S41-7. 2010..Several societies have developed therapeutic guidelines, with general overall agreement between publications. Therapy of OA is multimodal and requires a combination of pharmacologic and nonpharmacologic treatments... - Pharmacologic treatment of knee osteoarthritis in athletic womenRoy D Altman
Department of Rheumatology and Immunology, University of California, Los Angeles, CA, USA
Phys Sportsmed 39:39-44. 2011..These findings, along with additional future studies, may have particular relevance to the choice of the most effective treatment options for athletic women with OA of the knee... - Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX TrialR D Altman
Division of Rheumatology and Immunology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90024, United States
Osteoarthritis Cartilage 19:1169-75. 2011..To evaluate the safety of repeated intra-articular (IA) injections of Euflexxa® (1% sodium hyaluronate; IA--BioHA) for painful knee osteoarthritis (OA)... - Topical therapies for osteoarthritisRoy D Altman
David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, 90024, USA
Drugs 71:1259-79. 2011.... - Opioid therapy for osteoarthritis and chronic low back painRoy D Altman
Department of Rheumatology and Immunology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
Postgrad Med 122:87-97. 2010..Opioids are prescribed more frequently for CLBP and OA than for any other noncancer pain, and the judicious use of opioids is recommended by treatment guidelines for the management of CLBP and OA pain... - New guidelines for topical NSAIDs in the osteoarthritis treatment paradigmRoy D Altman
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Curr Med Res Opin 26:2871-6. 2010..For example, nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular, gastrointestinal, and renal adverse events. Topical NSAIDs offer efficacy with reduced systemic drug exposure... - Measurement of structure (disease) modification in osteoarthritisR D Altman
Professor of Medicine, University of Miami, Miami, Florida 33125, USA
Osteoarthritis Cartilage 12:S69-76. 2004..It may be that the radiograph will not achieve the needed degree of validation and will be supplanted by magnetic resonance imaging as the surrogate marker of joint status... - Non-avian-derived hyaluronan for the treatment of osteoarthritis of the kneeRoy D Altman
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Expert Rev Clin Immunol 6:21-7. 2010.... - Atlas of individual radiographic features in osteoarthritis, revisedR D Altman
The David Geffen School of Medicine, The University of California at Los Angeles, Los Angeles, CA 91390, USA
Osteoarthritis Cartilage 15:A1-56. 2007..Develop a radiographic atlas of osteoarthritis (OA) to be used as a template and guide for grading radiographs of osteoarthritic lesions of the hand, hip and knee... - Total joint replacement of hip or knee as an outcome measure for structure modifying trials in osteoarthritisR D Altman
Rheumatology and Immunology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Osteoarthritis Cartilage 13:13-9. 2005..g., >0.3-0.7 mm) combined with a lack of clinically relevant improvement in symptoms (e.g., >/=20-25%) for 'failure' of a secondary outcome in structure modifying trials of the hip and knee... - Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study GroupR D Altman
Department of Rheumatology and Immunology, University of Miami, Florida, USA
J Rheumatol 25:2203-12. 1998..To determine efficacy and safety of intraarticular (IA) hyaluronic acid (HA; Hyalgan) versus placebo and a nonsteroidal antiinflammatory drug for osteoarthritis (OA) of the knee... - A rationale for combining acetaminophen and NSAIDs for mild-to-moderate painR D Altman
David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Rehabilitation Building, Box 951361, Los Angeles, CA 90024, USA
Clin Exp Rheumatol 22:110-7. 2004..Further studies are warranted to determine the clinical utility and safety of acetaminophen/NSAID combinations as analgesic therapy for common conditions associated with mild-to-moderate pain... - Paget's disease of bone: rheumatologic complicationsR D Altman
Miami VA Medical Center, Department of Medicine, University of Miami, Florida 33125, USA
Bone 24:47S-48S. 1999..Back pain is particularly common and one must be careful before attributing back pain to Paget's disease; otherwise, both the physician and patient may be disappointed in the results of therapy... - Intra-articular sodium hyaluronate in osteoarthritis of the kneeR D Altman
Department of Rheumatology and Immunology, University of Miami School of Medicine, and the Geriatric Research, Education, and Clinical Center, VA Hospital, FL, USA
Semin Arthritis Rheum 30:11-8. 2000..To better understand the therapeutic role of HA, this review focuses on comparative clinical trial data... - Safety and efficacy of intra-articular sodium hyaluronate (Hyalgan) in a randomized, double-blind study for osteoarthritis of the ankleMichael M Cohen
Miami Veterans Affairs Medical Center, Surgical Service, 1201 NW 16th St, Miami, FL 33125, USA
Foot Ankle Int 29:657-63. 2008..This double-blind, randomized, controlled study examined the safety and efficacy of intraarticular sodium hyaluronate (Hyalgan) in the treatment of pain associated with ankle OA... - Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the kneeRoy D Altman
GRECC, Miami VAMC, Miami, FL, USA
Osteoarthritis Cartilage 12:642-9. 2004..Future trials of OA that examine a local therapy might need to consider restricting the study population to those patients having OA of only the signal joint... - Status of hyaluronan supplementation therapy in osteoarthritisRoy D Altman
Department of Rheumatology, University of Miami School of Medicine, PO Box 106960, FL 33101, USA
Curr Rheumatol Rep 5:7-14. 2003..Thus, compared with currently approved nonoperative therapies for osteoarthritis, hyaluronans may also have beneficial effects on the disease process in osteoarthritis... - Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritisDavid R Clemmons
Division of Endocrinology, University of North Carolina, Chapel Hill, 27599 7170, USA
Arthritis Rheum 46:694-703. 2002.... - Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteriaThao Pham
, AP-HP, Rheumatology B Department, Cochin Hospital, Paris, France
J Rheumatol 30:1648-54. 2003..The conclusions of the task force were presented and discussed during the OMERACT 6 conference, where a simplified set of responder criteria (OMERACT-OARSI set of criteria) was proposed... - Pain relief in osteoarthritis: the rationale for combination therapyRoy D Altman
J Rheumatol 31:5-7. 2004 - Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changesJean Pierre Raynauld
Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, and Université de Montréal, Montreal, Quebec, Canada
Arthritis Rheum 50:476-87. 2004..To evaluate the change in osteoarthritic (OA) knee cartilage volume over a two-year period with the use of magnetic resonance imaging (MRI) and to correlate the MRI changes with radiologic changes... - Use of a permanent magnetic field to inhibit the development of canine osteoarthritisRichard A Rogachefsky
Department of Orthopedics, University of Miami School of Medicine, Miami, Florida, USA
Bioelectromagnetics 25:260-70. 2004..Further studies are needed to delineate more precisely the effect of the magnetic field in reducing the severity of OA... - Increased radiographic damage scores at the onset of seropositive rheumatoid arthritis in older patients are associated with osteoarthritis of the hands, but not with more rapid progression of damageDinesh Khanna
University of California at Los Angeles, USA
Arthritis Rheum 52:2284-92. 2005..To investigate the impact of patient age at symptom onset on radiographic joint damage at study entry, and on subsequent progression of damage in a cohort of patients with early seropositive rheumatoid arthritis (RA)... - Recommendations for the registration of agents to be used in the prevention and treatment of glucocorticoid-induced osteoporosis: updated recommendations from the Group for the Respect of Ethics and Excellence in ScienceEric C Abadie
Department of Public Health, Epidemiology, and Health Economics, , , Belgium
Semin Arthritis Rheum 35:1-4. 2005..Demonstration of antifracture efficacy should have been previously demonstrated in PMO... - Reversible posterior leukoencephalopathy in patients with systemic lupus erythematosusMolly D Magnano
Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA
Semin Arthritis Rheum 35:396-402. 2006..Fortunately, this cause of "secondary" CNS symptoms in patients with SLE is readily reversible when diagnosed early and treated with blood pressure control and supportive care...