Research Topics
Genomes and Genes | CHARLES ROBERT WIRASummaryAffiliation: Dartmouth Medical School Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The innate immune system: gatekeeper to the female reproductive tractCharles R Wira
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
Immunology 111:13-5. 2004- Epithelial cells in the female reproductive tract: a central role as sentinels of immune protectionCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
Am J Reprod Immunol 53:65-76. 2005..In this article, we will outline how polarized epithelial cells function as the first line of defense against potential pathogens in the female reproductive tract... - Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infectionsCharles R Wira
Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 65:196-211. 2011..The goal of this review is to examine the spectrum of antimicrobials in the FRT and the ways in which they are regulated to provide protection against pathogens that compromise reproductive health and threaten the lives of women... - Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogensCharles R Wira
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Am J Reprod Immunol 63:544-65. 2010..In doing so, a window of STI vulnerability is created during which potential pathogens including HIV enter the reproductive tract to infect host targets... - Oestradiol regulation of antigen presentation by uterine stromal cells: role of transforming growth factor-beta production by epithelial cells in mediating antigen-presenting cell functionCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
Immunology 109:398-406. 2003..Taken together, these results suggest that oestradiol inhibition of stromal cell antigen presentation is mediated through the stimulatory effect of oestradiol on TGF-beta production by epithelial cells... - Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not LactobacillusC R Wira
Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
Mucosal Immunol 4:335-42. 2011..crispatus, which is part of the normal vaginal microflora of humans... - Polarized uterine epithelial cells preferentially present antigen at the basolateral surface: role of stromal cells in regulating class II-mediated epithelial cell antigen presentationCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
J Immunol 175:1795-804. 2005..Overall, these results demonstrate that polarized epithelial cells are able to present Ags and suggest that uterine stromal cells communicate with epithelial cells via a soluble factor(s) to regulate Ag presentation in the uterus... - Innate and adaptive immunity in female genital tract: cellular responses and interactionsCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Immunol Rev 206:306-35. 2005..By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health... - Influence of stage of the reproductive cycle and estradiol on thymus cell antigen presentationCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Steroid Biochem Mol Biol 84:79-87. 2003..1 and B7.2. These studies demonstrate that sex hormones play a central role in regulating antigen presentation in the thymus... - Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentationCharles R Wira
Department of Physiology, Dartmouth Medical School, Borwell Building, 1 Medical Center Drive, Lebanon, NH 03756, USA
Endocrinology 143:2872-9. 2002..These studies suggest that estradiol regulation of antigen presentation by vaginal cells is mediated through the local production of TGFbeta by vaginal cells... - Sex hormone regulation of anti-bacterial activity in rat uterine secretions and apical release of anti-bacterial factor(s) by uterine epithelial cells in cultureJohn V Fahey
Department of Physiology, Borwell Building, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
J Steroid Biochem Mol Biol 93:59-66. 2005..Further these studies suggest that epithelial cells which line the uterine lumen are a primary source of anti-bacterial activity... - Hepatocyte growth factor regulation of uterine epithelial cell transepithelial resistance and tumor necrosis factor alpha release in cultureKatherine S Grant-Tschudy
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Biol Reprod 72:814-21. 2005..Furthermore, because neutralization of stromal media failed to affect TNFalpha secretion, these findings suggest that other growth factors, in addition to HGF, affect EC cytokine production... - Effect of oestradiol on mouse uterine epithelial cell tumour necrosis factor-alpha release is mediated through uterine stromal cellsKatherine S Grant-Tschudy
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756-0001, USA
Immunology 115:99-107. 2005.... - Unique characteristics of NK cells throughout the human female reproductive tractTeddy F Mselle
Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Clin Immunol 124:69-76. 2007..These data suggest that unique characteristics of the tissues may account of specific localization of different NK cell subsets... - Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus-type IGrant R Yeaman
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA
Immunology 113:524-33. 2004..These findings are important to define potential targets of HIV-1 infection within the FRT, and for the future design of approaches to reduce the susceptibility of women to infection by HIV-1... - CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tractMimi Ghosh
Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
Am J Reprod Immunol 62:60-71. 2009..The role of CCL20/MIP3alpha as an antiviral is unknown. In this study, we have examined the production of CCL20/MIP3alpha by epithelial cells from the upper female reproductive tract as well as its activity as an antiviral molecule... - Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production by human peripheral blood monocytesPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 179:6284-90. 2007..These results implicate a role for estradiol in the modulation of the immune response, and may lead to an enhanced understanding of gender-based differences in inflammatory control mechanisms... - Effect of oestradiol on PAMP-mediated CCL20/MIP-3 alpha production by mouse uterine epithelial cells in cultureGisela Soboll
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03765, USA
Immunology 118:185-94. 2006.... - Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligandsDaniel O Ochiel
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
J Leukoc Biol 88:435-44. 2010..These findings indicate collectively that epithelial cells confer a tolerogenic phenotype to DC in the endometrium. Our results suggest novel cellular and molecular mechanisms for the regulation of adaptive immunity within the FRT... - Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPsSatarupa Basu
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 61:52-61. 2009..In the human endometrium, uterine natural killer (uNK) cells and uterine macrophages are present in significant numbers and in close proximity, yet how they cooperatively respond to infectious challenge is poorly understood... - Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophagesAmy J Murphy
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
PLoS ONE 4:e5539. 2009..However, relatively little is known about the ability of E2 to regulate isoform expression of estrogen receptors (ERs) in these cells... - Functional expression of pattern recognition receptors in tissues of the human female reproductive tractKevin M Hart
Department of Immunology and Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Reprod Immunol 80:33-40. 2009..Results of these studies indicate that PRRs are functionally expressed in FRT tissues, and suggest that these receptors mediate microbial recognition and immune defense in the reproductive tract... - Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouseGisela Soboll
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 55:434-46. 2006..Not only do epithelial cells respond to TLR agonists by releasing MCP-1, which mediates inflammatory responses, but they also influence the expression of selected TLR genes to further enhance innate immune protection... - Expression of Toll-like receptors (TLR) and responsiveness to TLR agonists by polarized mouse uterine epithelial cells in cultureGisela Soboll
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Biol Reprod 75:131-9. 2006.... - Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-betaMikael Eriksson
Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
J Leukoc Biol 76:667-75. 2004..Further, data demonstrate that uNK cells can produce immunoregulatory cytokines and that inhibition of uNK cells by locally produced TGF-beta1 is a likely mechanism to regulate NK cell function in the human EM... - Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tractMimi Ghosh
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Immunology 129:207-19. 2010..Our data suggest that Trappin-2/Elafin might be an important endogenous microbicide of the female reproductive tract that is protective against HIV-1... - Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cellsDaniel O Ochiel
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
PLoS ONE 5:e14306. 2010..We hypothesized in this study that specific immune modulators secreted by uterine epithelial cells modulate susceptibility of dendritic cells (DC) to infection with HIV-1... - New approaches to making the microenvironment of the female reproductive tract hostile to HIVJohn V Fahey
Department of Physiology and Neurobiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Am J Reprod Immunol 65:334-43. 2011..all of which are under hormonal control, will open new avenues to therapeutic manipulation of the FRT mucosal microenvironment. By seeking new alternatives to preventing HIV infection in women, we may finally disrupt the HIV pandemic... - NK cell function in the human female reproductive tractCharles L Sentman
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 57:108-15. 2007..Uterine NK cells have a unique phenotype compared with blood NK cell subsets, yet little is known about how NK cells function as a part of the innate immune cell network in the female reproductive tract... - Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12Teddy F Mselle
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Virol 83:11188-95. 2009.... - Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2Patricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 176:6647-55. 2006..These data indicate dynamic immunologic interaction between uterine macrophages and epithelial cells and implicate a role for estradiol in the modulation of the immune response... - Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tractKimberly D Coleman
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Fertil Steril 92:1107-9. 2009..Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis... - Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)Mimi Ghosh
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Fertil Steril 89:1497-506. 2008..To examine the expression of toll-like receptors (TLR) by primary human Fallopian tube epithelial cells (FTEC) and to determine whether exposure to the TLR3 agonist poly(I:C) induces an antiviral response... - CCL20/macrophage inflammatory protein 3alpha and tumor necrosis factor alpha production by primary uterine epithelial cells in response to treatment with lipopolysaccharide or Pam3CysMardi A Crane-Godreau
Department of Physiology, Dartmouth Medical School, Borwell Building, 1 Medical Center Dr, Lebanon, NH 03756, USA
Infect Immun 73:476-84. 2005..Since CCL20 is known to be both chemotactic and antimicrobial, the increase in apical and basolateral release by UEC in response to PAMPs suggests a new mechanism of innate immune protection in the female reproductive tract... - Effect of Escherichia coli and Lactobacillus rhamnosus on macrophage inflammatory protein 3 alpha, tumor necrosis factor alpha, and transforming growth factor beta release by polarized rat uterine epithelial cells in cultureMardi A Crane-Godreau
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, 03756 0001, USA
Infect Immun 72:1866-73. 2004..These findings suggest that UEC responses to bacteria are selective and important in initiating and regulating immune protection in the female reproductive tract... - Effects of estradiol on lipopolysaccharide and Pam3Cys stimulation of CCL20/macrophage inflammatory protein 3 alpha and tumor necrosis factor alpha production by uterine epithelial cells in cultureMardi A Crane-Godreau
Department of Physiology, Dartmouth Medical School, Borwell Building, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA
Infect Immun 73:4231-7. 2005.... - Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)Todd M Schaefer
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 174:992-1002. 2005.... - Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cellsTodd M Schaefer
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Immunology 112:428-36. 2004.... - Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesteroneCharles L Sentman
Department of, Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 173:6760-6. 2004.... - Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxisLi Shen
Department of Immunology and Microbiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
Cell Immunol 230:23-32. 2004..These findings demonstrate that the majority of neutrophil chemoattractant activity produced by FRT EC results from the synergistic effects of IL-8 and GM-CSF... - Effect of estradiol on mouse uterine epithelial cell transepithelial resistance (TER)Katherine S Grant-Tschudy
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
Am J Reprod Immunol 52:252-62. 2004..The aim of this study was to test whether estradiol-17beta (E(2)) acts directly to regulate uterine epithelial cell monolayer integrity... - Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tractPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 72:5799-806. 2004..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract... - Secretion of monocyte chemotactic protein-1 by human uterine epithelium directs monocyte migration in cultureRichard A Meter
Department of Obstetrics and Gynecology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Fertil Steril 84:191-201. 2005..To determine whether primary human uterine epithelial cells in culture are able to influence monocyte chemotaxis and to establish whether the causal agent of chemotaxis is monocyte chemotactic protein (MCP)-1... - Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblastsSusana N Asin
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Infect Dis 190:236-45. 2004..These data suggest that uterine cells are targets for productive infection with X4-tropic strains and release unmodified R5-tropic viruses that would then be able to infect submucosal target cells, including T cells and macrophages... - HIV-1 infection of the female reproductive tractAlexandra L Howell
VA Medical Center, 215 North Main Street, White River Junction, VT 05009, USA
Curr HIV/AIDS Rep 2:35-8. 2005..This indicates that several mechanisms for viral infection and transmission are present throughout the FRT... - Antigen presentation by human uterine epithelial cells to autologous T cellsJohn V Fahey
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 55:1-11. 2006..Uterine epithelial cells express CD40 and CD1d. CONCLUSION: Antigen presentation is an additional aspect of uterine epithelial cell function in maintaining women's health... - Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivitySusana N Asin
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Infect Dis 187:1522-33. 2003..These data demonstrated that HIV-1 infects human epithelial cells of upper reproductive tract origin and that productive viral infection of epithelial cells may be an important mechanism of transmission of HIV-1 infection in women... - IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cellsTodd M Schaefer
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 175:6509-16. 2005.... - Paracrine mediators of mouse uterine epithelial cell transepithelial resistance in cultureKatherine S Grant-Tschudy
Department of Physiology, Dartmouth Medical School, Borwell Building, 1 Medical Center Drive, Lebanon, NH 03756-0001 USA
J Reprod Immunol 67:1-12. 2005..These studies suggest that factors, such as hormone balance, pathogen exposure as well as pregnancy, which affect cytokine and growth factor secretion, influence epithelial cell barrier protection within the female reproductive tract... - Effect of mouse uterine stromal cells on epithelial cell transepithelial resistance (TER) and TNFalpha and TGFbeta release in cultureKatherine S Grant
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Biol Reprod 69:1091-8. 2003..These results suggest that uterine stromal cells communicate with epithelial cells via a soluble factor(s) to maintain uterine integrity and epithelial secretory function... - Migration inhibitory factor secretion by polarized uterine epithelial cells is enhanced in response to the TLR3 agonist poly (I:C)Todd M Schaefer
Department of Physiology, Dartmouth Medical School, 710W Borwell, 1 Medical Center Drive, Lebanon, NH 03756, USA
Am J Reprod Immunol 54:193-202. 2005..The goals of this study were to determine if uterine epithelial cells produce the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF), and to see if toll-like receptor (TLR) agonists stimulate MIF secretion... - Effect of menstrual status on antibacterial activity and secretory leukocyte protease inhibitor production by human uterine epithelial cells in cultureJohn V Fahey
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
J Infect Dis 185:1606-13. 2002..These results indicate that menstrual status (pre- vs. postmenopausal) influences the production of SLPI and bactericidal activity by uterine epithelial cells... - Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodiesMimi Ghosh
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
PLoS ONE 5:e11366. 2010..Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CVL from healthy HIV(+) and (-) women inhibit HIV infection... - Inhibition of human polymorphonuclear cell oxidative burst by 17-beta-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxinVikki M Abrahams
Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Am J Reprod Immunol 50:463-72. 2003..This may have significant consequences on PMN function within the female reproductive tract. This study evaluated the effects of 17-beta-estradiol and TCDD on PMN oxidative burst... - Differential regulation of neutrophil chemotaxis to IL-8 and fMLP by GM-CSF: lack of direct effect of oestradiolLi Shen
Department of Immunology and Microbiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
Immunology 117:205-12. 2006..These data suggest that neutrophil function may be altered by cytokines such as GM-CSF through modulation of signalling and independently of surface receptor expression... - Endogenous transforming growth factor-beta inhibits toll-like receptor mediated activation of human uterine natural killer cellsMikael Eriksson
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 56:321-8. 2006..Our aim was to determine whether uterine natural killer (uNK) cell cytokine production induced by stimulation through TLRs could be regulated by endogenous transforming growth factor (TGF)-beta in human endometrium... - Estradiol regulates MICA expression in human endometrial cellsSatarupa Basu
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Clin Immunol 129:325-32. 2008..Thus, estrogens regulate expression of MICA. These data suggest hormonal regulation of innate immunity and NKG2D-mediated recognition in other tissues and diseases where estrogen may be involved... - Human fallopian tube neutrophils--a distinct phenotype from blood neutrophilsJennifer M Smith
Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Am J Reprod Immunol 56:218-29. 2006.... - Effects of menstrual cycle status and gender on human neutrophil phenotypeJennifer M Smith
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 58:111-9. 2007..The effects of gender and fluctuating ovarian hormones on neutrophil phenotype have yet to be characterized... - TLRs mediate IFN-gamma production by human uterine NK cells in endometriumMikael Eriksson
Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
J Immunol 176:6219-24. 2006..These data also indicate that the uNK cells do not respond directly to TLR stimulation, but rather their production of IFN-gamma is dependent upon interactions with other cells within EM... - PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activityMarla J Keller
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
AIDS 21:467-76. 2007..The objective of this study was to examine the effect of 14 daily applications of 0.5% PRO 2000 or placebo gel on mediators of mucosal immunity and intrinsic antimicrobial activity... - Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)Vikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Hum Reprod 21:2432-9. 2006.... - Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infectionGrant R Yeaman
Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA
Immunology 109:137-46. 2003..In addition, these studies provide evidence that the uterus, and potentially the entire upper reproductive tract, are important sites for the initial events involved in HIV infection...
Research Grants
- SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEMCharles Wira; Fiscal Year: 2007....
- Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsCharles Wira; Fiscal Year: 2007..These studies should provide the basis of knowledge essential for the development of more effective microbicides and therapeutic interventions. ..
- Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsCharles Wira; Fiscal Year: 2007..These studies should provide the basis of knowledge essential for the development of more effective microbicides, therapeutic interventions, ..
- SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEMCHARLES ROBERT WIRA; Fiscal Year: 2010....
- SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEMCharles Wira; Fiscal Year: 1993..If SC and/or IgA mRNA is hormonally regulated, then synthesis of message will be analyzed. In situ hybridization studies will be carried out to identify cells in the reproductive tract that synthesize SC and IgA...
- Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsCHARLES ROBERT WIRA; Fiscal Year: 2010..These studies should provide the basis of knowledge essential for the development of more effective microbicides and therapeutic interventions. ..