Wendy A Wells

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Pathologists' agreement with experts and reproducibility of breast ductal carcinoma-in-situ classification schemes
    W A Wells
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Am J Surg Pathol 24:651-9. 2000
  2. ncbi request reprint Analysis of the microvasculature and tissue type ratios in normal vs. benign and malignant breast tissue
    Wendy A Wells
    Departments of Pathology, Community and Family Medicine, and Radiology, Dartmouth Medical School, Hanover, USA
    Anal Quant Cytol Histol 26:166-74. 2004
  3. ncbi request reprint Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
  4. pmc Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment
    Ashley M Laughney
    Thayer School of Engineering, Dartmouth College Hanover, Lebanon, New Hampshire, USA
    Clin Cancer Res 18:6315-25. 2012
  5. pmc Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Radiology 252:551-60. 2009
  6. ncbi request reprint Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 32:933-5. 2007
  7. ncbi request reprint Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1143-56. 2007
  8. pmc Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?
    Marius G Pakalniskis
    Department of Pathology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiology 259:365-74. 2011
  9. pmc System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues
    Ashley M Laughney
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:036012. 2013
  10. pmc Scanning in situ spectroscopy platform for imaging surgical breast tissue specimens
    Venkataramanan Krishnaswamy
    Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, New Hampshire 03755, USA
    Opt Express 21:2185-94. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Pathologists' agreement with experts and reproducibility of breast ductal carcinoma-in-situ classification schemes
    W A Wells
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Am J Surg Pathol 24:651-9. 2000
    ....
  2. ncbi request reprint Analysis of the microvasculature and tissue type ratios in normal vs. benign and malignant breast tissue
    Wendy A Wells
    Departments of Pathology, Community and Family Medicine, and Radiology, Dartmouth Medical School, Hanover, USA
    Anal Quant Cytol Histol 26:166-74. 2004
    ..To analyze the microvasculature and tissue type ratios in normal vs. benign and malignant breast tissue to establish a baseline for expected values against which future imaging studies can be benchmarked...
  3. ncbi request reprint Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
    ....
  4. pmc Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment
    Ashley M Laughney
    Thayer School of Engineering, Dartmouth College Hanover, Lebanon, New Hampshire, USA
    Clin Cancer Res 18:6315-25. 2012
    ....
  5. pmc Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Radiology 252:551-60. 2009
    ....
  6. ncbi request reprint Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 32:933-5. 2007
    ..Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography...
  7. ncbi request reprint Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1143-56. 2007
    ..The MRI-guided NIR images of oxygen saturation provide higher resolution and superior SNR and will likely be used in the future to study and characterize specific tissue volumes...
  8. pmc Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?
    Marius G Pakalniskis
    Department of Pathology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiology 259:365-74. 2011
    ..To investigate if changes in tumor angiogenesis associated with complete pathologic response (pCR) or partial pathologic response (pPR) to treatment can be demonstrated by using diffuse optical spectroscopic (DOS) tomography...
  9. pmc System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues
    Ashley M Laughney
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:036012. 2013
    ..SFDI could potentially reduce the high secondary excision rate associated with breast conserving surgery; its clinical translation further requires reduced image reconstruction time and smart inking strategies...
  10. pmc Scanning in situ spectroscopy platform for imaging surgical breast tissue specimens
    Venkataramanan Krishnaswamy
    Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, New Hampshire 03755, USA
    Opt Express 21:2185-94. 2013
    ....
  11. pmc Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 15:061703. 2010
    ..The method provides potentially complementary information to DCE-MRI for tumor characterization...
  12. pmc Phase contrast microscopy analysis of breast tissue: differences in benign vs. malignant epithelium and stroma
    Wendy A Wells
    Department of Pathology, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    Anal Quant Cytol Histol 31:197-207. 2009
    ..To assess how optical scatter properties in breast tissue, as measured by phase contrast microscopy and interpreted pathophysiologically, might be exploited as a diagnostic tool to differentiate cancer from benign tissue...
  13. ncbi request reprint Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    Technol Cancer Res Treat 4:513-26. 2005
    ..These changes represent potential diagnostic indicators, which can be assessed to characterize breast tumors...
  14. ncbi request reprint Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051704. 2005
    ....
  15. ncbi request reprint Spot 14: A marker of aggressive breast cancer and a potential therapeutic target
    William B Kinlaw
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 147:4048-55. 2006
    ..Thus, S14 is a marker for aggressive breast cancer and a potential target as well. Future effort will center on validation of S14 as a therapeutic target and producing antagonists of its action...
  16. pmc Automated classification of breast pathology using local measures of broadband reflectance
    Ashley M Laughney
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 15:066019. 2010
    ..The increased sensitivity of this technique may render it useful to guide the surgeon or pathologist where to sample pathology for microscopic assessment...
  17. doi request reprint A validation study of a new molecular diagnostic assay: the Dartmouth-Hitchcock Medical Center experience with the GeneSearch BLN assay in breast sentinel lymph nodes
    Laura J Tafe
    Translational Research Program, Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 88:1-6. 2010
    ..2 mm, with our standard lymph node processing...
  18. ncbi request reprint Multispectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast
    Troy O McBride
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 7:72-9. 2002
    ....
  19. ncbi request reprint Validation of novel optical imaging technologies: the pathologists' view
    Wendy A Wells
    Dartmouth Medical School, Department of Pathology, 1 Rope Ferry Road, Hanover, New Hampshire 03755, USA
    J Biomed Opt 12:051801. 2007
    ....
  20. pmc The correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: initial clinical experience
    Ryan J Halter
    Thayer School of Engineering, Darmouth College, Hanover, NH 03755, USA
    Physiol Meas 30:S121-36. 2009
    ..We present these results in addition to a case study demonstrating how discrete point spectroscopy measurements of the tissue can be correlated and used to validate EM imaging studies...
  21. ncbi request reprint Measurement error and confidence intervals for ROC curves
    Tor D Tosteson
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Biom J 47:409-16. 2005
    ..An application from a study of emerging imaging modalities in breast cancer is used to demonstrate the new techniques...
  22. doi request reprint A comprehensive assay for CFTR mutational analysis using next-generation sequencing
    Ahmad N Abou Tayoun
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, and Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH
    Clin Chem 59:1481-8. 2013
    ..Fast sequencing of the entire coding sequence in a scalable manner could expand the detection of CFTR mutations and facilitate management of costs and turnaround times in the clinical laboratory...
  23. doi request reprint The emerging role of the molecular diagnostics laboratory in breast cancer personalized medicine
    Francine B de Abreu
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire Dartmouth Hitchcock Medical Center and the Norris Cotton Cancer Center, Lebanon, New Hampshire
    Am J Pathol 183:1075-83. 2013
    ..These advances in both imaging and genomics contribute to more personalized and predictive patient management. We review the progress made in breast cancer diagnosis and management using these new tools. ..
  24. ncbi request reprint Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker
    Wendy A Wells
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 98:231-40. 2006
    ....
  25. ncbi request reprint Leiomyosarcoma of the popliteal vein
    Timothy P Killoran
    Department of Radiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Skeletal Radiol 32:174-8. 2003
    ..Findings on ultrasound, MRI and CT angiography are reviewed, with particular emphasis on the value of CT angiography in fully evaluating the extent of the mass and in assisting percutaneous biopsy...
  26. ncbi request reprint Electromagnetic breast imaging: average tissue property values in women with negative clinical findings
    Steven P Poplack
    Department of Radiology, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    Radiology 231:571-80. 2004
    ..Each technique yielded information on breast tissue features (eg, conductivity, permittivity, light scattering, and absorption) that had not previously all been measured in the same individuals...
  27. ncbi request reprint Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms
    Steven P Poplack
    Department of Radiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Radiology 243:350-9. 2007
    ..To prospectively assess quantitatively the inherent contrast of electromagnetic (EM) properties that can be imaged by using available technology in women with abnormal findings at conventional breast imaging who underwent subsequent biopsy...
  28. ncbi request reprint Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation
    Kanokwan Kittiniyom
    David and Doreen Hermelin Laboratory of Molecular Oncogenetics, Hermelin Brain Tumor Center and Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Genes Chromosomes Cancer 40:190-203. 2004
    ..These studies indicate that mechanisms such as imprinting or monoallelic expression in combination with loss of heterozygosity may be responsible for loss of the DAL-1/4.1B protein in early breast disease...