Research Topics
| J N WeinsteinSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT) observational cohortJames N Weinstein
Dartmouth Medical School, Hanover, NH, USA
JAMA 296:2451-9. 2006..However, the large numbers of patients who crossed over between assigned groups precluded any conclusions about the comparative effectiveness of operative therapy vs usual care...
Trends and geographic variations in major surgery for degenerative diseases of the hip, knee, and spineJames N Weinstein
Department of Orthopaedic Surgery, Dartmouth Medical School, Dartmouth Hitchcock Medical Center in Lebanon, New Hampshire, USA
Health Aff (Millwood) . 2004..Involving the patient in choice of treatments (shared decision making) and outcomes research are promising strategies for reducing unwarranted regional variation and local constancy in surgery risk...
Informed patient choice: patient-centered valuing of surgical risks and benefitsJames N Weinstein
Department of Orthopaedic Surgery, Dartmouth Medical School, Lebanon, New Hampshire, USA
Health Aff (Millwood) 26:726-30. 2007..We describe feasibility and efficacy within our organization and address ways to foster the further adoption of this approach...
Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trialJames N Weinstein
Dartmouth Medical School, Hanover, NH, USA
JAMA 296:2441-50. 2006..Lumbar diskectomy is the most common surgical procedure performed for back and leg symptoms in US patients, but the efficacy of the procedure relative to nonoperative care remains controversial...
Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeonsB A Winkelstein
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125 One Medical Center Dr, Lebanon, NH 03756, USA
J Neurosci Methods 111:49-57. 2001..Results indicate a direct correlation of local nerve root injury severity with the ensuing physiologic responses associated with nociception...
Is a condition-specific instrument for patients with low back pain/leg symptoms really necessary? The responsiveness of the Oswestry Disability Index, MODEMS, and the SF-36Thomas L Walsh
The Spine Center at Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Spine (Phila Pa 1976) 28:607-15. 2003..Analysis of longitudinal data collected prospectively from patients seen in 27 National Spine Network member centers across the United States...
Does multilevel lumbar stenosis lead to poorer outcomes?: a subanalysis of the Spine Patient Outcomes Research Trial (SPORT) lumbar stenosis studyDaniel K Park
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
Spine (Phila Pa 1976) 35:439-46. 2010..A subanalysis study...
Degenerative spondylolisthesis: does fusion method influence outcome? Four-year results of the spine patient outcomes research trialWilliam A Abdu
Departments of Orthopaedics, Dartmouth Medical School, Dartmouth College, Hanover, NH 03756, USA
Spine (Phila Pa 1976) 34:2351-60. 2009..Clinical trial subgroup analysis...
Association between obesity and functional status in patients with spine diseaseJason C Fanuele
Dartmouth Medical School, Hanover, New Hampshire, USA
Spine 27:306-12. 2002..05). CONCLUSIONS: General and disease-specific functional health status was significantly worse for patients with a higher body mass index. Obese patients also displayed more severe pain symptoms than nonobese spine patients...
The impact of comorbidities on the change in short-form 36 and oswestry scores following lumbar spine surgeryJames Slover
Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
Spine 31:1974-80. 2006....
Magnetic resonance imaging interpretation in patients with symptomatic lumbar spine disc herniations: comparison of clinician and radiologist readingsJon D Lurie
Department of Medicine, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Spine (Phila Pa 1976) 34:701-5. 2009..Retrospective review of imaging data from a clinical trial...
SPORT lumbar intervertebral disk herniation and back pain: does treatment, location, or morphology matter?Adam M Pearson
Dartmouth Medical School, Lebanon, NH 03756, USA
Spine (Phila Pa 1976) 33:428-35. 2008..Diskectomy candidates with at least 6 weeks of sciatica and confirmatory imaging were enrolled in a randomized or observational cohort...
United States' trends and regional variations in lumbar spine surgery: 1992-2003James N Weinstein
Department of Orthopaedics, Dartmouth Medical School, Hanover, NH 03756, USA
Spine (Phila Pa 1976) 31:2707-14. 2006..Repeated cross-sectional analysis using national Medicare data from the Dartmouth Atlas Project...
Surgical versus nonsurgical therapy for lumbar spinal stenosisJames N Weinstein
Dartmouth Institute for Health Policy and Clinical Practice, Department of Orthopedics, Dartmouth Medical School, Hanover, NH 03756, USA
N Engl J Med 358:794-810. 2008..Surgery for spinal stenosis is widely performed, but its effectiveness as compared with nonsurgical treatment has not been shown in controlled trials...
Reliability of magnetic resonance imaging readings for lumbar disc herniation in the Spine Patient Outcomes Research Trial (SPORT)Jon D Lurie
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Spine (Phila Pa 1976) 33:991-8. 2008..Assessment of the reliability of standardized magnetic resonance imaging (MRI) interpretations and measurements...
A longitudinal comparison of 5 preference-weighted health state classification systems in persons with intervertebral disk herniationChristine M McDonough
Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College, Lebanon, New Hampshire 03756, USA
Med Decis Making 31:270-80. 2011..To assess the longitudinal validity of widely used preference-weighted measurement systems for economic studies of intervertebral disk herniation (IDH)...
The cost effectiveness of surgical versus nonoperative treatment for lumbar disc herniation over two years: evidence from the Spine Patient Outcomes Research Trial (SPORT)Anna N A Tosteson
Dartmouth Medical School, Hanover, NH 03756, USA anna tosteson dartmouth edu
Spine (Phila Pa 1976) 33:2108-15. 2008....
Computerized questionnaires and the quality of survey dataBrett Hanscom
Dartmouth Medical School, Hanover, New Hampshire, USA
Spine (Phila Pa 1976) 27:1797-801. 2002..A retrospective data quality analysis was conducted...
Surgical versus nonoperative treatment for lumbar spinal stenosis four-year results of the Spine Patient Outcomes Research TrialJames N Weinstein
Department of Orthopaedics, Dartmouth Medical School, Hanover, NH 03756, USA
Spine (Phila Pa 1976) 35:1329-38. 2010..Randomized trial and concurrent observational cohort study...
Surgical versus nonoperative treatment for lumbar disc herniation: four-year results for the Spine Patient Outcomes Research Trial (SPORT)James N Weinstein
Department of Orthopaedics, Dartmouth Medical School, Hanover, NH 03756, USA
Spine (Phila Pa 1976) 33:2789-800. 2008..Concurrent, prospective, randomized, and observational cohort study...
The role of mechanical deformation in lumbar radiculopathy: an in vivo modelBeth A Winkelstein
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Spine (Phila Pa 1976) 27:27-33. 2002..In vivo strain techniques were used in an animal radiculopathy model...
Surgical compared with nonoperative treatment for lumbar degenerative spondylolisthesis. four-year results in the Spine Patient Outcomes Research Trial (SPORT) randomized and observational cohortsJames N Weinstein
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Bone Joint Surg Am 91:1295-304. 2009..Questions remain regarding the long-term effects of surgical treatment compared with those of nonoperative treatment...
Reliability of readings of magnetic resonance imaging features of lumbar spinal stenosisJon D Lurie
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
Spine (Phila Pa 1976) 33:1605-10. 2008..A reliability assessment of standardized magnetic resonance imaging (MRI) interpretations and measurements...
Spine patient outcomes research trial: radiographic predictors of clinical outcomes after operative or nonoperative treatment of degenerative spondylolisthesisAdam M Pearson
Dartmouth Medical School, Lebanon, NH, USA
Spine (Phila Pa 1976) 33:2759-66. 2008..Subgroup analyses according to treatment received...
Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesisJames N Weinstein
Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
N Engl J Med 356:2257-70. 2007..Management of degenerative spondylolisthesis with spinal stenosis is controversial. Surgery is widely used, but its effectiveness in comparison with that of nonsurgical treatment has not been demonstrated in controlled trials...
Extending the P4P agenda, part 1: how Medicare can improve patient decision making and reduce unnecessary careJohn E Wennberg
Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School in Hanover, New Hampshire, USA
Health Aff (Millwood) 26:1564-74. 2007..This paper outlines a strategy to achieve informed patient choice as the standard of practice for preference-sensitive care...
Patient preferences and expectations for care: determinants in patients with lumbar intervertebral disc herniationJon D Lurie
Dartmouth Medical School, Lebanon, NH 03756, USA
Spine (Phila Pa 1976) 33:2663-8. 2008..Prospective observational cohort...
Surgical treatment of spinal stenosis with and without degenerative spondylolisthesis: cost-effectiveness after 2 yearsAnna N A Tosteson
Multidisciplinary Clinical Research Center in Musculoskeletal Diseases, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
Ann Intern Med 149:845-53. 2008..The SPORT (Spine Patient Outcomes Research Trial) reported favorable surgery outcomes over 2 years among patients with stenosis with and without degenerative spondylolisthesis, but the economic value of these surgeries is uncertain...
Rates of advanced spinal imaging and spine surgeryJon D Lurie
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, New Hampshire, USA
Spine (Phila Pa 1976) 28:616-20. 2003..Small area analysis...
An observational study on the prevalence and pattern of opioid use in 25,479 patients with spine and radicular painGilbert J Fanciullo
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Spine (Phila Pa 1976) 27:201-5. 2002..A cross-sectional analysis of data obtained from patients with spinal and radicular pain and their spine center treating physicians was performed...
Medical versus surgical treatment for low back pain: evidence and clinical practiceN J Birkmeyer
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, NH, USA
Eff Clin Pract 2:218-27. 1999..Although low back pain is one of the most common health problems, it is still difficult to choose between surgical and medical treatment...
Cluster analysis classification of SF-36 profiles for patients with spinal painGilbert J Fanciullo
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Spine (Phila Pa 1976) 28:2276-82. 2003..A k-means cluster analysis of patients with spinal and radicular pain based on the SF-36 Health Survey scales...
Design of the Spine Patient outcomes Research Trial (SPORT)Nancy J O Birkmeyer
Department of Surgery, Community and Family Medicine, Clinical Trials Center, Dartmouth Medical School, Lebanon
Spine 27:1361-72. 2002..CONCLUSIONS: The results of this study will provide high-quality scientific evidence to aid clinical decision-making and improve treatment outcomes for these common, costly, and, in some instances, debilitating conditions...
The impact of spinal problems on the health status of patients: have we underestimated the effect?J C Fanuele
Department of Surgery, Section of Orthopaedics, and Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
Spine (Phila Pa 1976) 25:1509-14. 2000..A prospective study of 17,774 patients who consulted spine centers in which the impact of spinal disorders and comorbidities on physical functional status were evaluated...
Lumbar discectomy outcomes vary by herniation level in the Spine Patient Outcomes Research TrialJ D Lurie
Multidisciplinary Clinical Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
J Bone Joint Surg Am 90:1811-9. 2008....
The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sexMichael L LaCroix-Fralish
Department of Pharmacology and Toxicology, Dartmouth College, Hanover, NH, USA
Spine 30:1821-7. 2005..Our results correlate with data compiled in identical mouse and rat strains after L5-L6 nerve ligation, suggesting that the precise nature of the injury is not relevant to the inheritance of neuropathic symptom sensitivity...
Repeated injury to the lumbar nerve roots produces enhanced mechanical allodynia and persistent spinal neuroinflammationJ L Hunt
Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, USA
Spine (Phila Pa 1976) 26:2073-9. 2001..Neuroinflammatory activation in the spinal cord further supports the hypothesis that central neuroinflammation plays an important role in chronic radicular pain...
Prophylactic pinning of the contralateral hip in slipped capital femoral epiphysis : evaluation of long-term outcome for the contralateral hip with use of decision analysisW Randall Schultz
Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Bone Joint Surg Am 84:1305-14. 2002..Long-term follow-up studies are needed to establish the efficacy of prophylactic pinning, but the predictions in the present study, which are based on findings in the literature, support the safety of this procedure...
Spine fellowship education and its association with the part-II oral certification examinationHarry N Herkowitz
Department of Orthopaedic Surgery, William Beaumont Hospital, 3535 West Thirteen Mile Road, Suite 744, Royal Oak, MI 48073, USA
J Bone Joint Surg Am 88:668-70. 2006
Variation in hip fracture treatment: are black and white patients treated equally?Jason C Fanuele
Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
Am J Orthop (Belle Mead NJ) 38:E13-7. 2009..09) in adjusted mean rates for THA (0.47%), HA (8.24%), ORIF (94.8%), or NM (2.11%). There were no significant disparities by race across hospital referral regions with regard to type of fracture treatment...
Racial variation in treatment preferences and willingness to randomize in the Spine Patient Outcomes Research Trial (SPORT)Addisalem Arega
Dartmouth Medical School, Hanover, NH, USA
Spine 31:2263-9. 2006..Treatment preferences were strongly related to both race and willingness to be randomized...
Can condition-specific health surveys be specific to spine disease? An analysis of the effect of comorbidities on baseline condition-specific and general health survey scoresJames Slover
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Spine (Phila Pa 1976) 31:1265-71. 2006..This is an observational cross-sectional study of 26,290 patients seen and evaluated in the 25 centers of the National Spine Network...
Historical perspective. Ernest Amory Codman, 1869-1940. A pioneer of evidence-based medicine: the end result ideaS C Kaska
Dartmouth Medical School, Hanover, New Hampshire, USA
Spine (Phila Pa 1976) 23:629-33. 1998..This historical perspective is a tribute to Codman's contributions to medical science and highlights his remarkable career...
Racial, ethnic, and geographic disparities in rates of knee arthroplasty among Medicare patientsJonathan Skinner
Center for the Evaluative Clinical Sciences and Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
N Engl J Med 349:1350-9. 2003..There are large variations in the use of knee arthroplasty among Medicare enrollees according to race or ethnic group and sex. Are racial and ethnic disparities more pronounced in some regions than in others, and if so, why?..
The geographic incidence and treatment variation of common fractures of elderly patientsScott M Sporer
Department of Orthopaedic Surgery, Rush Medical College, Einfield, IL 60190, USA
J Am Acad Orthop Surg 14:246-55. 2006....
Fractures of the distal part of the radius. The evolution of practice over time. Where's the evidence?Kenneth J Koval
Department of Orthopaedics, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
J Bone Joint Surg Am 90:1855-61. 2008..The present study was designed to identify changes in practice patterns regarding operative fixation of distal radial fractures between 1999 and 2007 and to assess the results of those treatments over time...
Nail or plate fixation of intertrochanteric hip fractures: changing pattern of practice. A review of the American Board of Orthopaedic Surgery DatabaseJeffrey O Anglen
Department of Orthopaedic Surgery, Indiana University, 541 Clinical Drive, Suite 600, Indianapolis, IN 46202, USA
J Bone Joint Surg Am 90:700-7. 2008..A study of the Part II database was undertaken to detect changing patterns of care for intertrochanteric fractures...
Support and satellite cells within the rabbit dorsal root ganglion: ultrastructure of a perineuronal support cellKris Siemionow
Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Spine 31:1882-7. 2006..CONCLUSION: A new type of support cell representing a different cell line or a highly adapted cell with specific functional capacities was identified...
Dorsal root sensitivity to interleukin-1 beta, interleukin-6 and tumor necrosis factor in ratsA Cuneyt Ozaktay
Wayne State University, Bioengineering Center, 818W Hancock, Detroit, MI 48201, USA
Eur Spine J 11:467-75. 2002..IL-1beta, IL-6, and TNF may be neurotoxic to dorsal root axons. Furthermore IL-1beta and TNF may sensitize the peripheral receptive fields. This study suggests that dorsal roots may be impaired by these proinflammatory cytokines...
Emerging technology in spine: should we rethink the past or move forward in spite of the past?James N Weinstein
Spine (Phila Pa 1976) 28:S1. 2003
Chordoma of the mobile spine: fifty years of experienceStefano Boriani
Department of Orthopedics, Traumatology and Spine Surgery, Ospedale Maggiore, Bologna, Italy
Spine 31:493-503. 2006..All of these (6) had been previously treated and/or had en bloc resections with contaminated margins. CONCLUSIONS: The only treatment protocol associated with CDF at follow-up longer than 5 years is margin-free en bloc resection...
What is different about workers' compensation patients? Socioeconomic predictors of baseline disability status among patients with lumbar radiculopathySteven J Atlas
General Medicine Division, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Spine (Phila Pa 1976) 32:2019-26. 2007..Combined analysis of 2 prospective clinical studies...
Introduction: disc degeneration: summaryHoward S An
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA
Spine 29:2677-8. 2004
Partnership: doctor and patient: advocacy for informed choice vs. informed consentJames N Weinstein
Spine 30:269-72. 2005
Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in ratsA Cuneyt Ozaktay
Bioengineering Center, Wayne State University, 818 W Hancock, Detroit, MI 48201, USA
Eur Spine J 15:1529-37. 2006..This study provides added evidence to the role of cytokines in modulating afferent activity following inflammation...
Health professional's guide to rehabilitation of the patient with osteoporosisFrancis J Bonner
Medical Director, Rehabilitation Hospital of South Jersey, Vineland, NJ, USA
Osteoporos Int 14:S1-22. 2003
Editorial conflict of interest: art or science? The hippocratic solutionJames N Weinstein
Spine (Phila Pa 1976) 27:3-5. 2002
An AOA critical issue. The future of the orthopaedic surgeon-proceduralist or keeper of the musculoskeletal system?Scott D Boden
The Emory Spine Center, 59 Executive Park Drive, Suite 3000, Atlanta, GA 30329, USA
J Bone Joint Surg Am 87:2812-21. 2005
Slipped disk discussionsJames N Weinstein
Health News 8:4. 2002
Summary statement: treatment of the painful motion segmentGunnar B J Andersson
Spine 30:S1. 2005
Workforce analysis in orthopaedic surgery: how can we improve the accuracy of our predictions?Frances A Farley
University of Michigan Medical Center, Ann Arbor, MI 48109 0328, USA
J Am Acad Orthop Surg 15:268-73. 2007..Orthopaedic organizations should develop collaborative relationships with experts in the field and devise a true working model that allows for ongoing strategic planning...
Evidence-based medicine summary statementGunnar B J Andersson
Rush-Presbyterian-St. Luke's Medical Center, , , Sweden
Spine 32:S64-5. 2007
American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mixWilliam E Garrett
Duke University Medical Center, Box 3338, Durham, NC 27710, USA
J Bone Joint Surg Am 88:660-7. 2006
Research Grants
- Orthopaedic Resident Clinician/Researcher ProgramJames Weinstein; Fiscal Year: 2007..The purpose of the Dartmouth NRSA program is to help ensure that a diverse and highly trained workforce is available to assume leadership roles related to the nation's biomedical and behavioral research agenda. ..
- Low Back: A Multi-Center Clinical TrialJames Weinstein; Fiscal Year: 2007..abstract_text> ..
