Pablo A Valdes

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. doi request reprint System and methods for wide-field quantitative fluorescence imaging during neurosurgery
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Opt Lett 38:2786-8. 2013
  2. pmc Quantitative, spectrally-resolved intraoperative fluorescence imaging
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Sci Rep 2:798. 2012
  3. pmc A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery
    P A Valdes
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 37:1817-9. 2012
  4. pmc Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Photochem Photobiol 86:471-5. 2010
  5. pmc Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery
    Pablo A Valdes
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 16:116007. 2011
  6. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
  7. pmc Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Neurosurg 115:11-7. 2011
  8. pmc δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    Neuro Oncol 13:846-56. 2011
  9. pmc Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article
    David W Roberts
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Neurosurg 114:595-603. 2011
  10. pmc Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    J Neuropathol Exp Neurol 71:806-13. 2012

Detail Information

Publications19

  1. doi request reprint System and methods for wide-field quantitative fluorescence imaging during neurosurgery
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Opt Lett 38:2786-8. 2013
    ....
  2. pmc Quantitative, spectrally-resolved intraoperative fluorescence imaging
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Sci Rep 2:798. 2012
    ..The wide-field qFI technique has broad implications for intraoperative surgical guidance because it provides near real-time quantitative assessment of multiple fluorescent biomarkers across the operative field...
  3. pmc A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery
    P A Valdes
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 37:1817-9. 2012
    ..The simplicity of the method lends itself to the enticing prospect that the method could be applicable to wide-field applications in quantitative fluorescence imaging and dosimetry in photodynamic therapy...
  4. pmc Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Photochem Photobiol 86:471-5. 2010
    ..These results indicate that iron chelation therapy could significantly increase delta-ALA-induced PpIX fluorescence in malignant gliomas, pointing to a potential role of iron chelation therapy for more effective FGR of brain tumors...
  5. pmc Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery
    Pablo A Valdes
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 16:116007. 2011
    ..Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients...
  6. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
    ..These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development...
  7. pmc Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Neurosurg 115:11-7. 2011
    ..The authors show that diagnostically significant but visually imperceptible concentrations of PpIX can be quantitatively measured in vivo and used to discriminate normal from neoplastic brain tissue across a range of tumor histologies...
  8. pmc δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    Neuro Oncol 13:846-56. 2011
    ..This work suggests a need for improved PpIX fluorescence detection technologies to achieve better sensitivity and quantification of PpIX in tissue during surgery...
  9. pmc Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article
    David W Roberts
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Neurosurg 114:595-603. 2011
    ....
  10. pmc Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    J Neuropathol Exp Neurol 71:806-13. 2012
    ..To our knowledge, this is the first time that Gd measurements by inductively coupled plasma mass spectrometry have been used in human gliomas...
  11. pmc Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Neurosurg Focus 30:E8. 2011
    ....
  12. doi request reprint 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence in Meningioma: Qualitative and Quantitative Measurements In Vivo
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire Thayer School of Engineering, Hanover, New Hampshire Geisel School of Medicine at Dartmouth, Hanover, New Hampshire Departments of Pathology and Neurology, Georgetown University Medical Center, Washington, DC Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada Engineering Physics Department, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Neurosurgery 10:74-83. 2014
    ..To date, the clinical utility of 5-ALA in meningiomas is not fully understood, with most descriptive studies using qualitative approaches to 5-ALA-PpIX...
  13. doi request reprint Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report
    Wesley J Whitson
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neurosurgery 68:E1768-72; discussion E1772-3. 2011
    ..We present the case of a recurrent atypical meningioma operated on with 5-ALA fluorescence-guided resection for delineation of tumor tissue from surrounding uninvolved dura...
  14. pmc Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, N H, USA
    Stereotact Funct Neurosurg 88:1-10. 2010
    ..We present the implementation of deformation modeling for brain shift compensation in protoporphyrin IX FGR, integrating these two sources of information for maximum surgical benefit...
  15. doi request reprint Pulsed-light imaging for fluorescence guided surgery under normal room lighting
    Kristian Sexton
    Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 38:3249-52. 2013
    ..Resection of orthotopic brain tumors in mice also suggests that the pulsed-light system provides superior sensitivity in vivo...
  16. doi request reprint Genetics of glioblastoma: a window into its imaging and histopathologic variability
    Clifford J Belden
    Department of Radiology, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    Radiographics 31:1717-40. 2011
    ..It is equally critical that radiologists understand which genetic pathway is targeted by each specific therapeutic agent or class of agents in order to accurately interpret changes in the imaging appearances of treated tumors...
  17. pmc Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model
    Valerie L Jacobs
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, U S A
    ASN Neuro 3:e00063. 2011
    ..We end with a comprehensive review of the CNS-1 rodent model...
  18. doi request reprint Cause-specific mortality among neurosurgeons
    S Scott Lollis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 113:474-8. 2010
    ..The authors sought to determine a cause-specific mortality profile for US neurosurgeons during the period 1979-2005...
  19. pmc Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Photochem Photobiol B 98:77-94. 2010
    ....