Kenneth M Tichauer

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Advantages of a dual-tracer model over reference tissue models for binding potential measurement in tumors
    K M Tichauer
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 57:6647-59. 2012
  2. pmc In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging
    Kenneth M Tichauer
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Mol Imaging Biol 14:584-92. 2012
  3. pmc Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 17:066001. 2012
  4. doi Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
  5. doi Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
    Jonathan T Elliott
    University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
    J Biomed Opt 15:037014. 2010
  6. doi Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 106:1506-12. 2009
  7. pmc Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 110:9025-30. 2013
  8. pmc Dual-tracer background subtraction approach for fluorescent molecular tomography
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:16003. 2013
  9. doi A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Rev Sci Instrum 80:054302. 2009
  10. ncbi Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    J Appl Physiol 100:850-7. 2006

Collaborators

Detail Information

Publications22

  1. pmc Advantages of a dual-tracer model over reference tissue models for binding potential measurement in tumors
    K M Tichauer
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 57:6647-59. 2012
    ..23% ± 9.07%). These findings highlight the potential for using a dual-tracer approach to quantify receptor expression in tumors with abnormal hemodynamics, possibly to inform the choice or progress of molecular cancer therapies...
  2. pmc In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging
    Kenneth M Tichauer
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Mol Imaging Biol 14:584-92. 2012
    ..A dual-reporter methodology capable of quantifying available receptor binding potential of tumors in vivo within a clinically relevant time scale is presented...
  3. pmc Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 17:066001. 2012
    ....
  4. doi Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
    ....
  5. doi Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
    Jonathan T Elliott
    University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
    J Biomed Opt 15:037014. 2010
    ..The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neurointensive care...
  6. doi Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 106:1506-12. 2009
    ..This study highlights the potential for combining NIRS measures of CMRO(2) with EEG in the neonatal intensive care unit to improve early detection of perinatal hypoxia-ischemia...
  7. pmc Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 110:9025-30. 2013
    ..3 ± 0.5 nM (n = 5), consistent with values estimated in comparative invasive imaging and ex vivo studies...
  8. pmc Dual-tracer background subtraction approach for fluorescent molecular tomography
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:16003. 2013
    ..The approach is demonstrated in simulations, a phantom study, and in a mouse glioma imaging study, demonstrating substantial improvement over conventional and homogenous background subtraction image reconstruction approaches...
  9. doi A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Rev Sci Instrum 80:054302. 2009
    ..No significant changes in regional CMRO(2) were observed. The average regional differential pathlength prior to ET-1 injection was 8.4+/-0.2 cm (range of 7.1-9.6 cm) and did not significantly change after the injury...
  10. ncbi Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    J Appl Physiol 100:850-7. 2006
    ..This study demonstrates that NIRS can measure decreases in CMRO2 caused by HI. The results highlight the potential for NIRS to be used in the neonatal intensive care unit to detect delayed brain damage...
  11. doi Using near-infrared spectroscopy to measure cerebral metabolic rate of oxygen under multiple levels of arterial oxygenation in piglets
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor St, London, ON N6A 4V2, Canada
    J Appl Physiol (1985) 109:878-85. 2010
    ..In conclusion, the bolus-tracking technique of measuring CSvO2, and therefore CMRO2, is accurate and robust for an SaO2>50% but provides reduced accuracy under more severe hypoxic levels...
  12. doi Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study
    Jeff D Winter
    Imaging Division, Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada
    Pediatr Res 65:181-7. 2009
    ..Therefore, the CMRO(2) decrease is likely a combination of impaired mitochondrial function and reduced energy demands during the acute phase, which has been previously observed in the mature brain...
  13. doi Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Phys Med Biol 57:8285-95. 2012
    ..Considering that determining the AIF is required for performing quantitative tracer kinetics, this method provides a flexible tool for measuring the arterial dye concentration that could be used in a variety of applications...
  14. pmc High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas
    Kimberley S Samkoe
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Mol Imaging Biol 14:472-9. 2012
    ..Here, the in vivo delivery and binding kinetics of epidermal growth factor receptor (EGFR) was determined for normal pancreas and AsPC-1 orthotopic pancreatic tumors known to overexpress EGFR...
  15. doi Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets
    Mamadou Diop
    Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
    J Biomed Opt 15:057004. 2010
    ..The discrepancy between the two methods at higher CBF could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements...
  16. doi Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
    Pediatr Res 65:301-6. 2009
    ..This study demonstrated that near-infrared spectroscopy could detect early changes in CMRO2 after hypoxia-ischemia for a range of insult severities and CMRO2 could be used to distinguish insult severity by 8 h after the insult...
  17. pmc Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image quality
    Robert W Holt
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 37:2559-61. 2012
    ....
  18. pmc Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 36:3723-5. 2011
    ....
  19. doi Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusion
    Joel A Cooper
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, ON, Canada N6A 4V2
    J Appl Physiol (1985) 110:1691-8. 2011
    ..939 (R(2) = 0.907) following middle cerebral artery occlusion. These results suggest that calibrating the HbD signal by baseline hemodynamic measurements provides a clinically feasible method of monitoring CBF changes during neurosurgery...
  20. doi Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension
    Matthew J Murphy
    Imaging Research Laboratories, Robarts Research Institute, PO Box 5015, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Physiol Meas 32:395-405. 2011
    ..The results of this study suggest that the use of MTT, not requiring hemodynamic manipulation, is more sensitive to subtle changes in CPP, as would occur in the early stages of cerebrovascular disease...
  21. doi Angular domain fluorescence lifetime imaging: a tissue-like phantom study
    Mohamadreza Najiminaini
    Imaging Program, Lawson Health Research Institute, London, ON, Canada
    Opt Express 18:23247-57. 2010
    ..Results from a tissue-mimicking phantom demonstrated that ADFLI provides better spatial resolution and image contrast for fluorescent probes at greater depths compared to a lens and pinhole system...
  22. ncbi Measurement of cerebral oxidative metabolism with near-infrared spectroscopy: a validation study
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
    J Cereb Blood Flow Metab 26:722-30. 2006
    ..Since NIRS is safe and measurements can be obtained at the bedside, it is believed that this technique could assist in the early diagnosis of cerebral energy dysfunction after hypoxia-ischemia...