Affiliation: Dartmouth Medical School
- Overview of the principles and practice of biodosimetryHarold M Swartz
EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
Radiat Environ Biophys 53:221-32. 2014..Emerging biodosimetric methods can fill this critically important gap...
- Advances in probes and methods for clinical EPR oximetryHarold M Swartz
EPR Center for the Study of Viable Systems, The Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA
Adv Exp Med Biol 812:73-9. 2014..This paper presents an overview of recent developments in our ability to make meaningful measurements of oxygen partial pressures in human subjects under clinical settings. ..
- Clinical EPR: Unique Opportunities and Some ChallengesHarold M Swartz
Department of Radiology, Geisel School of Medicine at Dartmouth, Dartmouth College, 48 Lafayette Street, Lebanon, NH 03766 Electronic address
Acad Radiol 21:197-206. 2014..Further work is in progress to translate this unique technology to routine clinical practice. ..
- Electron paramagnetic resonance dosimetry for a large-scale radiation incidentHarold M Swartz
Dartmouth Medical School, Hanover, NH 03755, USA
Health Phys 103:255-67. 2012..The authors conclude that electron paramagnetic resonance dosimetry is likely to be a useful part of triage for a large-scale radiation incident...
- A critical assessment of biodosimetry methods for large-scale incidentsHarold M Swartz
The EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Health Phys 98:95-108. 2010..In conclusion, biodosimetry techniques have different properties, and knowledge of their properties for meeting the different needs for different stages will result in their most effective use in a nuclear disaster mass-casualty event...
- Seeing is believing--visualizing drug delivery in vitro and in vivoHarold Swartz
Hinman Box 7785, 702 Vail Building, Dartmouth Medical School, Hanover, NH 03755 3863, USA
Adv Drug Deliv Rev 57:1085-6. 2005..This issue of ADDR features novel, non-radioactive methods potentially useful for drug delivery scientists in selecting the most appropriate imaging techniques for solving the drug delivery problem at hand...
- Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutantsJiangang Shen
EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Biophys J 84:1291-8. 2003..The results are consistent with our earlier findings suggesting that such oxygen gradients may be a general phenomenon found in most or all cell systems under appropriate conditions...
- Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonatorsHuagang Hou
EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, United States
J Magn Reson 214:22-8. 2012..We report a recently developed electron paramagnetic resonance (EPR) oximetry approach with multiple probe implantable resonators (IRs) that allow repeated measurements of oxygen in tissue at depths of greater than 10mm...
- Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygenNadeem Khan
EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
J Neurosci Methods 204:111-7. 2012..Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2)...
- Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetryHuagang Hou
EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Radiat Res 173:651-8. 2010..5% BN formulation led to a significant growth inhibition. EPR oximetry provided dynamic information on the changes in tumor pO(2), which could be used to identify responders and non-responders and schedule therapy during the experiments...
- Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomasSriram Mupparaju
EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Oncol Rep 26:281-6. 2011..This vital information could also be used to schedule radiotherapy to enhance therapeutic outcome...
- Repeated tumor pO(2) measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapyHuagang Hou
Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
Radiother Oncol 91:126-31. 2009..To investigate the temporal effects of single or fractionated radiotherapy on subcutaneous RIF-1 tumor pO(2) and to determine the therapeutic outcomes when the timing of fractionations is guided by tumor pO(2)...
- Cerebral oxygenation of the cortex and striatum following normobaric hyperoxia and mild hypoxia in rats by EPR oximetry using multi-probe implantable resonatorsHuagang Hou
EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
Adv Exp Med Biol 701:61-7. 2011..In addition, the ability to simultaneously measure the pO(2) in several areas of the brain provides important information that could potentially help differentiate the pO(2) changes that can occur due to global or local mechanisms...
- Real-time monitoring of ischemic and contralateral brain pO2 during stroke by variable length multisite resonatorsHuagang Hou
EPR Center for Viable Systems, Department of Diagnostic Radiology, The Geisel School of Medicine, 48 Lafayette Street, Lebanon, NH 03766 Norris Cotton Cancer Center, One Medical Center Drive, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA Electronic address
Magn Reson Imaging 32:563-9. 2014..Electron paramagnetic resonance (EPR) oximetry using variable length multi-probe implantable resonator (IR), was used to investigate the temporal changes in the ischemic and contralateral brain pO2 during stroke in rats...
- Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolismNadeem Khan
Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Biochemistry 42:23-9. 2003..The results indicate that the concentration of cholesterol in the plasma membrane can be an important factor for the magnitude of the oxygen gradient observed across the cell membrane...
- Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injectionBrian W Pogue
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Comp Biochem Physiol A Mol Integr Physiol 132:177-84. 2002....
- Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopyNadeem Khan
EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
Mol Cell Biochem 234:341-57. 2002..The current state of the art for these and other measurements is discussed, especially in relationship to experiments that are likely to be useful for studies of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS)...