Harold Swartz

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injection
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:177-84. 2002
  2. ncbi request reprint Tumor pO2 assessments in human xenograft tumors measured by EPR oximetry: location of paramagnetic materials
    JULIA A O'HARA
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
    Adv Exp Med Biol 530:205-14. 2003
  3. ncbi request reprint Axial oxygen diffusion in the Krogh model: modifications to account for myocardial oxygen tension in isolated perfused rat hearts measured by EPR oximetry
    Oleg Grinberg
    Adv Exp Med Biol 566:127-34. 2005
  4. ncbi request reprint In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation
    Harold M Swartz
    EPR Center for Viable Systems, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Radiat Prot Dosimetry 120:163-70. 2006
  5. pmc Clinical electron paramagnetic resonance (EPR) oximetry using India ink
    Benjamin B Williams
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:149-56. 2010
  6. ncbi request reprint Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ
    Harold M Swartz
    Dartmouth Medical School, EPR Center for Viable Systems, Hanover, NH 03755, USA
    Appl Radiat Isot 62:293-9. 2005
  7. ncbi request reprint Using EPR to measure a critical but often unmeasured component of oxidative damage: oxygen
    Harold M Swartz
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Antioxid Redox Signal 6:677-86. 2004
  8. ncbi request reprint Measuring real levels of oxygen in vivo: opportunities and challenges
    Harold M Swartz
    Department of Radiology, Dartmouth Medical School, 7785 Vail, Room 702, Hanover, NH 03755, U S A
    Biochem Soc Trans 30:248-52. 2002
  9. pmc Use of electron paramagnetic resonance spectroscopy to evaluate the redox state in vivo
    Harold M Swartz
    Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1757-71. 2007
  10. ncbi request reprint Clinical applications of EPR: overview and perspectives
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    NMR Biomed 17:335-51. 2004

Research Grants

  1. CENTER FOR THE STUDY OF VIABLE SYSTEMS
    Harold Swartz; Fiscal Year: 2000
  2. Determination of Clinical Feasibility of EPR Oximetry of Tumors
    Harold Swartz; Fiscal Year: 2007
  3. Measurement of pO2 in tissues in vivo and in vitro
    Harold Swartz; Fiscal Year: 2006
  4. Near infrared/MR system for imaging brain oxygenation
    Harold Swartz; Fiscal Year: 2004
  5. CORE--SCIENTIFIC
    Harold Swartz; Fiscal Year: 2002

Detail Information

Publications73

  1. ncbi request reprint Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injection
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:177-84. 2002
    ....
  2. ncbi request reprint Tumor pO2 assessments in human xenograft tumors measured by EPR oximetry: location of paramagnetic materials
    JULIA A O'HARA
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
    Adv Exp Med Biol 530:205-14. 2003
    ..We monitored tumor pO2 during growth and also examined the tumor histological structure overall and in the region of the paramagnetic material in the tumor at the time of necropsy...
  3. ncbi request reprint Axial oxygen diffusion in the Krogh model: modifications to account for myocardial oxygen tension in isolated perfused rat hearts measured by EPR oximetry
    Oleg Grinberg
    Adv Exp Med Biol 566:127-34. 2005
    ..These results are consistent with recent results of others, which stress the importance of taking into account the details of what is measured by various methods...
  4. ncbi request reprint In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation
    Harold M Swartz
    EPR Center for Viable Systems, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Radiat Prot Dosimetry 120:163-70. 2006
    ....
  5. pmc Clinical electron paramagnetic resonance (EPR) oximetry using India ink
    Benjamin B Williams
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:149-56. 2010
    ..These studies demonstrate the feasibility of EPR oximetry in a clinical setting and the potential for more widespread use in the treatment of these and other oxygen-dependent diseases...
  6. ncbi request reprint Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ
    Harold M Swartz
    Dartmouth Medical School, EPR Center for Viable Systems, Hanover, NH 03755, USA
    Appl Radiat Isot 62:293-9. 2005
    ..In its current state of development, it probably is sufficient for most applications related to terrorism or nuclear warfare, for decision-making for action for individuals in regard to acute effects from exposure to ionizing radiation...
  7. ncbi request reprint Using EPR to measure a critical but often unmeasured component of oxidative damage: oxygen
    Harold M Swartz
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Antioxid Redox Signal 6:677-86. 2004
    ..The principles and applications of EPR oximetry to viable systems, including cell suspensions and intact animals, are described in this paper...
  8. ncbi request reprint Measuring real levels of oxygen in vivo: opportunities and challenges
    Harold M Swartz
    Department of Radiology, Dartmouth Medical School, 7785 Vail, Room 702, Hanover, NH 03755, U S A
    Biochem Soc Trans 30:248-52. 2002
    ..The key to their successful use requires an understanding of the capabilities of the techniques and of the nature of the process that is being investigated. This paper provides a framework for obtaining such an understanding...
  9. pmc Use of electron paramagnetic resonance spectroscopy to evaluate the redox state in vivo
    Harold M Swartz
    Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1757-71. 2007
    ..It seems likely that the use of in vivo EPR to measure redox processes will become an increasingly utilized and valuable tool...
  10. ncbi request reprint Clinical applications of EPR: overview and perspectives
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    NMR Biomed 17:335-51. 2004
    ....
  11. pmc Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutants
    Jiangang Shen
    EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biophys J 84:1291-8. 2003
    ..The results are consistent with our earlier findings suggesting that such oxygen gradients may be a general phenomenon found in most or all cell systems under appropriate conditions...
  12. pmc Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonators
    Huagang Hou
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, United States
    J Magn Reson 214:22-8. 2012
    ..We report a recently developed electron paramagnetic resonance (EPR) oximetry approach with multiple probe implantable resonators (IRs) that allow repeated measurements of oxygen in tissue at depths of greater than 10mm...
  13. doi request reprint Surface loop resonator design for in vivo EPR tooth dosimetry using finite element analysis
    Jennifer D Pollock
    Dartmouth College, Hanover, NH, USA
    Health Phys 98:339-44. 2010
    ..The effects of loop positioning in the mouth are examined, and it is shown that the sensitivity to loop position along a row of molars is decreased as the loop is moved away from the teeth...
  14. pmc Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen
    Nadeem Khan
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    J Neurosci Methods 204:111-7. 2012
    ..Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2)...
  15. pmc Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 173:651-8. 2010
    ..5% BN formulation led to a significant growth inhibition. EPR oximetry provided dynamic information on the changes in tumor pO(2), which could be used to identify responders and non-responders and schedule therapy during the experiments...
  16. pmc Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomas
    Sriram Mupparaju
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Oncol Rep 26:281-6. 2011
    ..This vital information could also be used to schedule radiotherapy to enhance therapeutic outcome...
  17. ncbi request reprint Spin traps: in vitro toxicity and stability of radical adducts
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Free Radic Biol Med 34:1473-81. 2003
    ..It then should be feasible to select the spin trap(s) best suited for the proposed study...
  18. pmc Repeated tumor pO(2) measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapy
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
    Radiother Oncol 91:126-31. 2009
    ..To investigate the temporal effects of single or fractionated radiotherapy on subcutaneous RIF-1 tumor pO(2) and to determine the therapeutic outcomes when the timing of fractionations is guided by tumor pO(2)...
  19. ncbi request reprint Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 42:23-9. 2003
    ..The results indicate that the concentration of cholesterol in the plasma membrane can be an important factor for the magnitude of the oxygen gradient observed across the cell membrane...
  20. ncbi request reprint In vivo measurements of EPR signals in whole human teeth
    Akinori Iwasaki
    Department of Radiology, Dartmouth Medical School, 702 Vail, Hanover, NH 03755, USA
    Appl Radiat Isot 62:187-90. 2005
    ..These initial results make us optimistic that intra-oral measurements of the teeth will be feasible for accurate determination of exposures over the whole range in which acute clinical effects are possible...
  21. ncbi request reprint Differentiation of the observed low frequency (1200MHz) EPR signals in whole human teeth
    Akinori Iwasaki
    Department of Radiology, Dartmouth Medical School, 702 Vail, Hanover, NH 03755, USA
    Appl Radiat Isot 62:133-9. 2005
    ..It can be suppressed by improvements in hardware and software, or subtracted...
  22. doi request reprint Cerebral oxygenation of the cortex and striatum following normobaric hyperoxia and mild hypoxia in rats by EPR oximetry using multi-probe implantable resonators
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Adv Exp Med Biol 701:61-7. 2011
    ..In addition, the ability to simultaneously measure the pO(2) in several areas of the brain provides important information that could potentially help differentiate the pO(2) changes that can occur due to global or local mechanisms...
  23. pmc Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1169-82. 2007
    ..We are confident that in vivo EPR oximetry will play a crucial role in the understanding and clinical management of various pathologies in the years to come...
  24. ncbi request reprint Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 59:834-43. 2004
    ....
  25. pmc Development of in vivo tooth EPR for individual radiation dose estimation and screening
    Benjamin B Williams
    Dartmouth Medical School, 704 Vail HP7785, Hanover, NH 03755, USA
    Health Phys 98:327-38. 2010
    ..In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals...
  26. ncbi request reprint Seeing is believing--visualizing drug delivery in vitro and in vivo
    Harold Swartz
    Hinman Box 7785, 702 Vail Building, Dartmouth Medical School, Hanover, NH 03755 3863, USA
    Adv Drug Deliv Rev 57:1085-6. 2005
    ..This issue of ADDR features novel, non-radioactive methods potentially useful for drug delivery scientists in selecting the most appropriate imaging techniques for solving the drug delivery problem at hand...
  27. ncbi request reprint Impact of mouse strain differences in innate hindlimb collateral vasculature
    Armin Helisch
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Arterioscler Thromb Vasc Biol 26:520-6. 2006
    ..To assess the importance of genetic background for collateral artery development...
  28. ncbi request reprint Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005
    ..Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors...
  29. doi request reprint Proposed triage categories for large-scale radiation incidents using high-accuracy biodosimetry methods
    Michael E Rea
    New England Center for Emergency Preparedness, Dartmouth Medical School, Hanover, NH 03756, USA
    Health Phys 98:136-44. 2010
    ....
  30. doi request reprint The view from the trenches: part 1-emergency medical response plans and the need for EPR screening
    Robert M Gougelet
    Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Health Phys 98:118-27. 2010
    ..The effective screening of potentially-exposed victims directly following a nuclear attack could decrease the number of patients seeking immediate medical care by greater than 90%...
  31. doi request reprint A critical assessment of biodosimetry methods for large-scale incidents
    Harold M Swartz
    The EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 98:95-108. 2010
    ..In conclusion, biodosimetry techniques have different properties, and knowledge of their properties for meeting the different needs for different stages will result in their most effective use in a nuclear disaster mass-casualty event...
  32. pmc Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 172:592-7. 2009
    ..This multimodal approach could be used to enhance the outcome of radiotherapy. Furthermore, tumor pO2 could be a potential marker of therapeutic response...
  33. pmc Radiation dose prediction using data on time to emesis in the case of nuclear terrorism
    Eugene Demidenko
    Section of Biostatistics and Epidemiology, Hanover, New Hampshire, USA
    Radiat Res 171:310-9. 2009
    ..More reliable methods for after-the-fact assessment of radiation dose are needed to complement the use of time to emesis...
  34. ncbi request reprint The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiat Res 168:218-25. 2007
    ..This is the first study to demonstrate the ability of efaproxiral to increase tumor oxygenation and to increase the tumor growth inhibition of radiotherapy over 5 days of treatment...
  35. ncbi request reprint High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat
    Benjamin B Williams
    Dartmouth EPR Center, Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1691-8. 2007
    ..These measurements demonstrate the capabilities of the HSRMS oximetry technique and set the stage for more extensive physiologic studies...
  36. ncbi request reprint Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 26:203-13. 2005
    ..26 to 0.95 (carbogen) were similar by the two methods and (4) in some rats breathing carbogen, absolute values of PtO(2) were above the sensitive range of the OxyLite method...
  37. pmc Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 73:878-85. 2009
    ..3 Gy of radiation and carbogen inhalation on orthotopic 9L and C6 gliomas and on the contralateral brain pO(2) in rats using a new and potentially widely useful method, multisite in vivo electron paramagnetic resonance oximetry...
  38. ncbi request reprint Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry study
    Jeff F Dunn
    NMR and EPR Research Centers, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, USA
    J Magn Reson Imaging 16:511-21. 2002
    ..To examine, using blood oxygen level dependent (BOLD) MRI and EPR oximetry, the changes in oxygenation of intracranial tumors induced by carbogen breathing...
  39. ncbi request reprint Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cancer Res 63:1025-33. 2003
    ..4 +/- 1.4 days, and when PDT was given at the same time as radiation, the delay was 8.1 +/- 1.5 days. This observation indicates that the combined effect in the latter case was greater than additive (P = 0.049)...
  40. pmc Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy
    Zrinka Abramovic
    Laboratory of Biophysics, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Adv Exp Med Biol 701:75-82. 2011
    ..This approach can be potentially used to enhance radiotherapeutic outcome by scheduling radiation doses when an increase in tumor pO(2) is observed after topical applications of BN formulations...
  41. ncbi request reprint In vivo electron paramagnetic resonance oximetry with particulate materials
    Jeff F Dunn
    NMR and EPR Research Centers, Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Methods 30:159-66. 2003
    ..Examples of biological studies are included that show how EPR oximetry may be used on both awake and anesthetized animals...
  42. ncbi request reprint An improved external loop resonator for in vivo L-band EPR spectroscopy
    Ildar Salikhov
    EPR Center for the Study of Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Magn Reson 164:54-9. 2003
    ..The sensitivity was 1.2-1.6 times greater in the rat and 4.2 times without tissue...
  43. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
    ..We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy...
  44. ncbi request reprint Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 25:1413-23. 2004
    ....
  45. pmc Dosimetry based on EPR spectral analysis of fingernail clippings
    Dean E Wilcox
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Health Phys 98:309-17. 2010
    ..Second, decomposition of the EPR spectra from irradiated fingernails into MIS and RIS components can be used to isolate and thus quantify the RIS for determining individual exposure dose...
  46. doi request reprint The view from the trenches: part 2-technical considerations for EPR screening
    Roberto J Nicolalde
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 98:128-35. 2010
    ....
  47. ncbi request reprint pO2 and regional blood flow in a rabbit model of limb ischemia
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 25:659-70. 2004
    ..Within two weeks of occlusion the pO2 is recovered to 45% of baseline. This study demonstrates, for the first time, the applicability of EPR oximetry in animals larger than rodents...
  48. ncbi request reprint Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopy
    Nadeem Khan
    EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Cell Biochem 234:341-57. 2002
    ..The current state of the art for these and other measurements is discussed, especially in relationship to experiments that are likely to be useful for studies of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS)...
  49. pmc Implantable resonators--a technique for repeated measurement of oxygen at multiple deep sites with in vivo EPR
    Hongbin Li
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703, Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:265-72. 2010
    ..The technique also is quite useful for following changes in tumor pO(2), including applications with simultaneous measurements in tumors and adjacent normal tissues...
  50. ncbi request reprint Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurements
    Huagang Hou
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 26:131-41. 2005
    ..In addition, the ability simultaneously to measure the pO2 in several sites provides important additional information that should help to differentiate between changes in the PO2 due toglobal or local mechanisms...
  51. ncbi request reprint Oxygen effects on the EPR signals from wood charcoals: experimental results and the development of a model
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Phys Chem B 111:13316-24. 2007
    ..An attenuated, but similar, EPR response to oxygen by chars when they are immersed in aqueous solution is attributed to water competition with oxygen for adsorption on the char surface...
  52. ncbi request reprint "Distant spin trapping": a method for expanding the availability of spin trapping measurements
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, 7785 Vail, Room 702, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biochem Biophys Methods 62:125-30. 2005
    ..This should significantly expand the ability to use spin trapping in biology and medicine...
  53. ncbi request reprint The effect of oxygen therapy on brain damage and cerebral pO(2) in transient focal cerebral ischemia in the rat
    Huagang Hou
    Department of Radiology, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 28:963-76. 2007
    ..The ability to measure the pO(2) in several sites provides important information that should help to optimize the design of hyperoxic therapies for stroke...
  54. ncbi request reprint The effect of RSR13, a synthetic allosteric modifier of hemoglobin, on brain tissue pO2 (measured by EPR oximetry) following severe hemorrhagic shock in rats
    Minoru Miyake
    EPR Center for the Study of Viable Systems, Department of Radiology, 7785 Vail Dartmouth Medical School, Hanover, NH, USA
    Adv Exp Med Biol 530:319-29. 2003
    ..There was no difference in the blood pressure or heart rate between groups. RSR13 may have useful applications to decrease the effects of acute hemorrhagic hypoxemia by increasing brain oxygenation...
  55. ncbi request reprint Electron paramagnetic resonance assessment of brain tissue oxygen tension in anesthetized rats
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Anesth Analg 96:1467-72, table of contents. 2003
    ....
  56. ncbi request reprint The dose-dependent effect of RSR13, a synthetic allosteric modifier of hemoglobin, on physiological parameters and brain tissue oxygenation in rats
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dept of Radiology, Dartmouth Medical School, 7785 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 530:287-96. 2003
    ..This capability is likely to be very useful in circumstances where the pO2 of the brain is compromised...
  57. ncbi request reprint Measurements of oxygen in tissues: overview and perspectives on methods
    Harold M Swartz
    EPR Center for Study of Viable Systems, Biomedical NMR Laboratory, Department of Diagnostic Radiology, Dartmouth Medical School, 7785 Vail Building, Hanover, NH 03755, USA
    Adv Exp Med Biol 530:1-12. 2003
    ..Citations are given for each method to point the reader in the direction of relevant literature...
  58. ncbi request reprint Simultaneous detection of pO2 and NO by electron paramagnetic resonance
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    Methods Enzymol 359:52-66. 2002
  59. ncbi request reprint Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, United Kingdom
    Nitric Oxide 6:18-28. 2002
    ..These site-specific measurements of pO2 provide in vivo evidence that the principal cause of liver hypoxia during hypodynamic sepsis is reduced oxygen supply to the sinusoid and can be alleviated by maintaining sinusoidal perfusion...
  60. ncbi request reprint The effects of anesthesia on cerebral tissue oxygen tension: use of EPR oximetry to make repeated measurements
    Harold M Swartz
    Department of Diagnostic Radiology, Dartmouth Medical School, 7785 Vail Building Hanover, NH 03755 USA
    Adv Exp Med Biol 530:569-75. 2003
    ..The results indicate that the tissue O2 can be measured directly using EPR oximetry, and data can be obtained non-invasively during the course of anesthesia...
  61. ncbi request reprint Measurements of oxygen in vivo: overview and perspectives on methods to measure oxygen within cells and tissues
    Roger Springett
    Antioxid Redox Signal 9:1295-301. 2007
  62. ncbi request reprint Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock
    Melanie Madhani
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Biochim Biophys Acta 1588:232-40. 2002
    ..We propose that the beneficial effects of PR-39 on liver in this septic model were mediated by increased levels of local NO and preservation of oxygen supply to the liver sinusoids...
  63. ncbi request reprint In vivo EPR: when, how and why?
    Bernard Gallez
    NMR Biomed 17:223-5. 2004
    ....
  64. ncbi request reprint Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 104:264-70. 2008
    ..These results demonstrate seizure-induced increase in IsoF formation and its correlation with changes in hippocampal pO2 and mitochondrial dysfunction...
  65. pmc Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy
    Hirotada Fujii
    School of Health Sciences, Sapporo Medical University, Sapporo, Japan
    Radiother Oncol 86:354-60. 2008
    ..The goal of this study was to clarify the dynamics of oxygenation (partial pressure of oxygen, pO(2)) in SCC VII murine tumors in mice after X-ray irradiation...
  66. ncbi request reprint Simultaneous NIR-EPR spectroscopy of rat brain oxygenation
    Yasuko S Sakata
    Adv Exp Med Biol 566:357-62. 2005
    ..Further studies will be required to determine the exact mechanisms for the delay between the recovery of SmcO2 and t-pO2...
  67. ncbi request reprint In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry)
    Rheal A Towner
    Department of Physiology and Pharmacology, North Queensland Magnetic Resonance Centre, School of Biomedical and Molecular Sciences, James Cook University, Molecular Sciences Building, Townsville, QLD, Australia
    Chem Biol Interact 139:231-50. 2002
    ....
  68. ncbi request reprint Cerebral PtO2, acute hypoxia, and volatile anesthetics in the rat brain
    Huagang Hou
    Adv Exp Med Biol 566:179-85. 2005
    ....
  69. ncbi request reprint Black magic and EPR oximetry: from lab to initial clinical trials
    Nadeem Khan
    Adv Exp Med Biol 566:119-25. 2005
    ..We are very encouraged with these results and are confident that EPR oximetry using India ink will be a non-invasive, fast, and reliable technique for pO2 measurements in clinical studies...
  70. ncbi request reprint Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, U K
    Adv Exp Med Biol 530:645-52. 2003
    ..The exact mechanism is unclear, but increased NO as a result of decreased superoxide production seems to play an important role in alleviating tissue hypoxia...
  71. ncbi request reprint Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    James L Tatum
    National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
    Int J Radiat Biol 82:699-757. 2006
    ....
  72. ncbi request reprint Modeling of the response of ptO2 in rat brain to changes in physiological parameters
    Oleg Y Grinberg
    Adv Exp Med Biol 566:111-8. 2005
    ..An acceptable agreement of the computed and the experimental changes of the cerebral PtO2 was obtained for these experimental conditions...
  73. ncbi request reprint The difficulties in comparing in vivo oxygen measurements: turning the problems into virtues
    Harold M Swartz
    Adv Exp Med Biol 566:295-301. 2005
    ....

Research Grants13

  1. CENTER FOR THE STUDY OF VIABLE SYSTEMS
    Harold Swartz; Fiscal Year: 2000
    ..V. DISSEMINATION- To make available to the user community all of the instrumental and conceptual developments of the Center through descriptions, schematics, and on site examination of our developments. ..
  2. Determination of Clinical Feasibility of EPR Oximetry of Tumors
    Harold Swartz; Fiscal Year: 2007
    ..Determining the feasibility of following changes in pO2 over the full time course of clinical fractionated radiation therapy; c. Determining the feasibility of continuous measurements for up to 120 minutes. ..
  3. Measurement of pO2 in tissues in vivo and in vitro
    Harold Swartz; Fiscal Year: 2006
    ....
  4. Near infrared/MR system for imaging brain oxygenation
    Harold Swartz; Fiscal Year: 2004
    ..This grant will produce a novel imaging modality which can non-invasively monitor cerebral oxygenation, structure, and blood flow. ..
  5. CORE--SCIENTIFIC
    Harold Swartz; Fiscal Year: 2002
    ..The activities of the core will be directed by the PI of the PPG, who will coordinate the support functions and the services provided by the expert collaborators of the core. ..