Walter M St-John

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Characterizations of eupnea, apneusis and gasping in a perfused rat preparation
    W M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Building, Lebanon, NH 03755, USA
    Respir Physiol 123:201-13. 2000
  2. ncbi request reprint Respiratory-modulated neuronal activities of the rostral medulla which may generate gasping
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 135:97-101. 2003
  3. doi request reprint Electromyography of intrinsic laryngeal muscles by Fritz Buchthal
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 93:210-2. 2008
  4. pmc Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 160:353-6. 2008
  5. ncbi request reprint Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors
    Walter M St-John
    Dept of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Appl Physiol 104:665-73. 2008
  6. ncbi request reprint Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 155:97-100. 2007
  7. ncbi request reprint Uncoupling of rhythmic hypoglossal from phrenic activity in the rat
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 89:727-37. 2004
  8. ncbi request reprint Changes in respiratory-modulated neural activities, consistent with obstructive and central apnea, during fictive seizures in an in situ anaesthetized rat preparation
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Building, Lebanon, NH 03756, USA
    Epilepsy Res 70:218-28. 2006
  9. ncbi request reprint High-frequency oscillations in phrenic activity during pontile and medullary respiratory rhythms in rats
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 92:457-66. 2007
  10. ncbi request reprint High-frequency oscillations of phrenic activity in eupnea and gasping of in situ rat: influence of temperature
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Physiol Regul Integr Comp Physiol 285:R404-12. 2003

Research Grants

  1. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1993
  2. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1999
  3. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2003
  4. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2007
  5. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1990

Detail Information

Publications59

  1. ncbi request reprint Characterizations of eupnea, apneusis and gasping in a perfused rat preparation
    W M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Building, Lebanon, NH 03755, USA
    Respir Physiol 123:201-13. 2000
    ..We conclude that the perfused juvenile rat preparation exhibits patterns of eupnea, apneusis and gasping which are similar to in vivo mammalian preparations...
  2. ncbi request reprint Respiratory-modulated neuronal activities of the rostral medulla which may generate gasping
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 135:97-101. 2003
    ..This discharge peaked at the onset of the gasp and then decremented during neural inspiration. We hypothesize that these 'pre-inspiratory' neuronal activities generate the gasp by intrinsic pacemaker mechanisms...
  3. doi request reprint Electromyography of intrinsic laryngeal muscles by Fritz Buchthal
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 93:210-2. 2008
  4. pmc Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 160:353-6. 2008
    ..However, gasping does depend upon a conductance through persistent sodium channels...
  5. ncbi request reprint Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors
    Walter M St-John
    Dept of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Appl Physiol 104:665-73. 2008
    ..125 microM) and methysergide (above 2.5 microM). We conclude that activation of adrenergic and 5-HT2 receptors is important to sustain gasping and to restore rhythmic respiratory activity after hypoxia-induced depression...
  6. ncbi request reprint Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 155:97-100. 2007
    ..These administrations did cause sedation. We conclude that conductance through persistent sodium channels plays little role in the neurogenesis of eupnea...
  7. ncbi request reprint Uncoupling of rhythmic hypoglossal from phrenic activity in the rat
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 89:727-37. 2004
    ..Indeed, our results establish that hypoglossal discharge alone is an equivocal index of the pattern of overall ventilatory activity and that this is accentuated by hypercapnia and hypothermia...
  8. ncbi request reprint Changes in respiratory-modulated neural activities, consistent with obstructive and central apnea, during fictive seizures in an in situ anaesthetized rat preparation
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Building, Lebanon, NH 03756, USA
    Epilepsy Res 70:218-28. 2006
    ..These changes characterize central apnea. The major conclusion is that seizures may result in recurrent periods of obstructive and central apnea. Thus, seizures can adversely alter respiratory function in a profound manner...
  9. ncbi request reprint High-frequency oscillations in phrenic activity during pontile and medullary respiratory rhythms in rats
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 92:457-66. 2007
    ..Indeed, both pons and medulla appear essential for all aspects of eupnoea to be expressed...
  10. ncbi request reprint High-frequency oscillations of phrenic activity in eupnea and gasping of in situ rat: influence of temperature
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Physiol Regul Integr Comp Physiol 285:R404-12. 2003
    ..Results provide additional support for the conclusion that the in situ preparation demonstrates distinctly different patterns of automatic ventilatory activity, comparable to eupnea and gasping in vivo...
  11. pmc Maternal drinking of alcohol: the newborn has the worst hangover
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Physiol 586:1201. 2008
  12. pmc Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Appl Physiol 107:679-85. 2009
    ..The accuracy of this method of classification has not been established...
  13. ncbi request reprint Influence of levels of carbon dioxide and oxygen upon gasping in perfused rat preparation
    Walter M St -John
    Dartmouth Hitchcock Medical Center, Department of Physiology, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
    Respir Physiol 129:279-87. 2002
    ..This release is caused by cellular mechanisms that change the balance between membrane ionic currents. Moreover, these cellular mechanisms may be explicitly induced by alterations in the ionic and metabolic homeostasis...
  14. pmc Mylohyoid discharge of the in situ rat: a probe of pontile respiratory activities in eupnea and gasping
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03765, USA
    J Appl Physiol 108:614-20. 2010
    ..Results also provide additional support for our conclusion that activity of any single cranial nerve does not provide an accurate index of the type of respiratory rhythm, be it eupnea or gasping...
  15. ncbi request reprint Neurogenesis of gasping does not require inhibitory transmission using GABA(A) or glycine receptors
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 132:265-77. 2002
    ..We conclude that the neurogenesis of gasping is not dependent upon fast, chloride-mediated inhibitory synaptic transmission...
  16. ncbi request reprint Maintenance of eupnea and gasping following alterations in potassium ion concentration of perfusates of in situ rat preparation
    W M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neurosci Methods 142:125-9. 2005
    ..These results add further support to the conclusion that the in situ preparation represents a model that accurately reproduces mechanisms of rhythm generation of both eupnea and gasping in vivo...
  17. pmc Discharge of the hypoglossal nerve cannot distinguish eupnea from gasping, as defined by phrenic discharge, in the in situ mouse
    WALTER M ST JOHN
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Appl Physiol 107:686-95. 2009
    ..These findings have significant negative implications for conclusions drawn from the in vitro medullary slice of mouse...
  18. pmc Location and properties of respiratory neurones with putative intrinsic bursting properties in the rat in situ
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    J Physiol 587:3175-88. 2009
    ..Based upon the present and previous findings, we hypothesize that this burster discharge may be released when the brain is subject to severe hypoxia or ischaemia, and that this burster discharge could underlie gasping...
  19. ncbi request reprint Gasping is elicited by briefer hypoxia or ischemia following blockade of glycinergic transmission
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 133:167-71. 2002
    ..These results support the concept that a loss of inhibitory glycinergic transmission is a critical factor in release of pacemaker mechanisms for gasping from the pontomedullary neuronal circuit for eupnea...
  20. ncbi request reprint Inhibition of medullary raphe serotonergic neurons has age-dependent effects on the CO2 response in newborn piglets
    Michelle L Messier
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Appl Physiol 96:1909-19. 2004
    ..Inhibition of serotonergic medullary raphé and extra-raphé neurons decreases ventilatory CO2 sensitivity and alters cardiovascular variables and sleep cycling, which may contribute to the sudden infant death syndrome...
  21. pmc The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 170:96-102. 2010
    ..We conclude that OX(1)R in the rostral medullary raphe contribute to the hypercapnic chemoreflex in wakefulness, during the dark period in rats...
  22. ncbi request reprint Role of pontile mechanisms in the neurogenesis of eupnea
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 143:321-32. 2004
    ..Evidence from previous studies that support the validity of these criteria is presented herein. We conclude that pontile mechanisms play a critical role in the neurogenesis of eupnea...
  23. pmc Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons
    Kevin J Cummings
    Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1783-96. 2009
    ..007). Within the first two postnatal weeks, the medullary 5-HT system plays an important role in cardiorespiratory control, mitigating spontaneous bradycardia, stabilizing the breathing pattern, and dampening the hypercapnic Ve response...
  24. ncbi request reprint Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats
    Natalie C Taylor
    Department of Physiology, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 153:203-16. 2006
    ..In the Cool condition the ventilatory response to hypoxia is inhibited but appropriately so for the lower VO2 ...
  25. pmc Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 570:385-96. 2006
    ..We conclude that CA neurones (1) promote wakefulness, (2) participate in central respiratory chemoreception, (3) stimulate breathing frequency, and (4) minimize breathing variability in REM sleep...
  26. ncbi request reprint Characterization of hypoxia-induced ventilatory depression in newborn piglets
    Rene St-Jacques
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 88:509-15. 2003
    ..We conclude that a region of the caudal mesencephalon or pons is necessary for the manifestation of depressions of ventilatory activity in the newborn pig...
  27. ncbi request reprint Gap junction blockade does not alter eupnea or gasping in the juvenile rat
    Joshua R Rodman
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 152:51-60. 2006
    ..These findings do not rule out a role for gap junctions in the expression of eupnea or gasping, but they do demonstrate that these intermembrane channels are not obligatory for either rhythm to occur...
  28. pmc Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats
    Aihua Li
    Department of Physiology, Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 577:307-18. 2006
    ..These effects of caudal MR serotonergic neurons could be at a chemoreceptor site, e.g. the RTN, or at 'downstream' sites involved in rhythm and pattern generation...
  29. pmc Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks
    Kevin J Cummings
    Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03766, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1333-42. 2010
    ....
  30. ncbi request reprint Tonic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation
    Michael B Harris
    Dept of Physiology, Dartmouth College, Borwell Bldg, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    Am J Physiol Regul Integr Comp Physiol 285:R215-21. 2003
    ....
  31. pmc Noeud vital for breathing in the brainstem: gasping--yes, eupnoea--doubtful
    WALTER M ST JOHN
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Philos Trans R Soc Lond B Biol Sci 364:2625-33. 2009
    ..to normal breathing? Are these rhythms similar to those of gasping, which is recruited when normal, eupnoeic breathing fails, or are these rhythms unique to the in vitro preparation and not related to any breathing pattern in vivo?..
  32. ncbi request reprint Phrenic, vagal and hypoglossal activities in rat: pre-inspiratory, inspiratory, expiratory components
    J C Leiter
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Respir Physiol Neurobiol 142:115-26. 2004
    ..During eupnea, the activity patterns in the phrenic, hypoglossal and vagal nerves seem to originate from different sets of pre-motor neurons...
  33. pmc Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Appl Physiol 108:1417-24. 2010
    ..We comment on the organization of this distributed central chemoreceptor system and suggest that interactions among sites are synergistic and not additive, which is an important aspect of its normal function...
  34. pmc Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 586:2321-9. 2008
    ..This genetic model allows examination of the role of excess 5-HT in ECF in the development of the control of breathing and central chemoreception, which may be pertinent to SIDS...
  35. doi request reprint Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 164:394-400. 2008
    ....
  36. ncbi request reprint Muscimol inhibition of medullary raphé neurons decreases the CO2 response and alters sleep in newborn piglets
    Michelle L Messier
    Department of Physiology, Dartmouth Medical School, Borwell Building, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 133:197-214. 2002
    ..Disturbances of medullary raphé function can alter central chemoreception and normal sleep architecture, which may contribute to the pathogenesis of SIDS...
  37. pmc Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756 0001, USA
    J Physiol 544:603-16. 2002
    ..We conclude that neurons with NK1R-ir somata or processes in the RTN/Ppy region are either chemosensitive or they modulate chemosensitivity. They also provide a tonic drive to breathe and may affect arousal...
  38. ncbi request reprint CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat
    Aihua Li
    Department of Physiology, Dartmouth Medical School, 706E Borwell Building, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 133:11-22. 2002
    ..9 (0.7) Torr (N=5), which may inhibit other chemoreceptor sites. Multiple chemoreceptor sites may interact to provide high sensitivity in systemic hypercapnia and stability during heterogeneous stimulation and inhibition...
  39. ncbi request reprint Ventral medulla pHi measured in vivo by 31P NMR is not regulated during hypercapnia in anesthetized rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, 706E Borwell Building, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 130:139-49. 2002
    ..Regional differences in pHi regulation between cortex and ventral medulla may be due to both chemosensitive and non-chemosensitive neurons...
  40. ncbi request reprint The retrotrapezoid nucleus (RTN): local cytoarchitecture and afferent connections
    Carlos Cream
    Department of Physiology, 706E Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 130:121-37. 2002
    ..Other sources of input include the Kölliker-fuse nucleus, subceruleus, A5 region, and the paralemniscal zone...
  41. ncbi request reprint CO2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Appl Physiol 92:2119-30. 2002
    ..Central chemoreceptors in the NTS affect breathing in both sleep and wakefulness. The threshold for arousal in caudal NTS is greater than that for the stimulation of breathing...
  42. pmc Antagonism of rat orexin receptors by almorexant attenuates central chemoreception in wakefulness in the active period of the diurnal cycle
    Aihua Li
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Physiol 588:2935-44. 2010
    ..The results support our hypothesis that the orexin system participates importantly in central chemoreception in a vigilance-state- and diurnal-cycle-dependent manner and indicate a role for orexin in the important process of sighing...
  43. pmc Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Physiol 556:235-53. 2004
    ..001; two-way ANOVA; P < 0.05, Tukey's post hoc test). We conclude that separate populations of serotonergic and adjacent NK1R-expressing neurones in the medulla are both involved in central chemoreception in vivo...
  44. ncbi request reprint Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Appl Physiol 101:1596-606. 2006
    ..NK1R-ir neurons in the ventral medulla are essential for normal central chemoreception, provide a drive to breathe, and modulate the peripheral chemoreceptor responses. These effects are not state dependent...
  45. ncbi request reprint Central chemoreception 2005: a brief review
    Eugene Nattie
    Department of Physiology, Borwell Bldg, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Auton Neurosci 126:332-8. 2006
    ....
  46. ncbi request reprint Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2
    Natalie C Taylor
    Department of Physiology, Dartmouth Medical Center, Borwell Bldg, Lebanon, NH 03756 000, USA
    J Appl Physiol 97:1763-73. 2004
    ..Chronic fluoxetine treatment in the medullary raphe increases the ventilatory response to hypercapnia in an unanesthetized rat model, an effect that may be due to facilitation of chemosensitive serotonergic neurons...
  47. pmc Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats
    Natalie C Taylor
    Department of Physiology, Dartmouth Medical Sshool, Lebanon, NH 03756, USA
    J Physiol 566:543-57. 2005
    ..We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT1A receptors are also involved in thermoregulation and arousal...
  48. ncbi request reprint Acoustic plethysmography measures breathing in unrestrained neonatal mice
    J Andrew Daubenspeck
    Physiology Department, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Appl Physiol 104:262-8. 2008
    ..In addition, this approach should be useful to study unrestrained neonatal mice under conditions where body temperature approaches environmental temperature and barometric plethysmography cannot be used...
  49. ncbi request reprint Multiple central chemoreceptor sites: cell types and function in vivo
    Gene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:343-7. 2008
    ..They affect physiological control systems in many ways, perhaps not all measurable, via the study of the steady-state CO2 response...
  50. ncbi request reprint Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:371-6. 2008
    ..Conclusions: Central CA neurons have a net excitatory effect on breathing and chemoreception but a net inhibitory effect on blood pressure...
  51. pmc Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 587:2059-67. 2009
    ..We conclude that projections of orexin-containing neurons to the RTN contribute, via OX(1)Rs in the region, to the hypercapnic chemoreflex control during wakefulness and to a lesser extent, non-rapid eye movement sleep...
  52. ncbi request reprint Respiratory rhythm generation during gasping depends on persistent sodium current
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK
    Nat Neurosci 9:311-3. 2006
    ..We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism...
  53. ncbi request reprint Long-term intracellular recordings of respiratory neuronal activities in situ during eupnea, gasping and blockade of synaptic transmission
    Julian F R Paton
    Department of Physiology, School of Medical Science, University of Bristol, Bristol, England BS8 1TD, UK
    J Neurosci Methods 147:138-45. 2005
    ....
  54. ncbi request reprint Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Eur J Neurosci 18:239-57. 2003
    ..These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping...
  55. ncbi request reprint Modelling respiratory rhythmogenesis: focus on phase switching mechanisms
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 551:189-94. 2004
  56. ncbi request reprint Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation
    Veronica A L Toppin
    Institute of Arctic Biology, University of Alaska Fairbanks, Alaska, USA
    J Appl Physiol 103:220-7. 2007
    ..In greatly reduced in vitro preparations, the importance of any individual neuromodulator, such as serotonin, may be exaggerated compared with its role in more intact preparations...
  57. ncbi request reprint Counterpoint: Medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Julian F R Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Appl Physiol 103:718-20; discussion 721-2. 2007
  58. ncbi request reprint Phasic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation
    Michael B Harris
    Institute of Arctic Biology, Irving I, University of Alaska Fairbanks, Fairbanks, AK 99775 7000, USA
    Am J Physiol Regul Integr Comp Physiol 289:R450-R455. 2005
    ....
  59. ncbi request reprint Ionic currents and endogenous rhythm generation in the pre-Bötzinger complex: modelling and in vitro studies
    Olivier Pierrefiche
    GRAP JE UFR de Pharmacie, 80036 Amiens, France
    Adv Exp Med Biol 551:121-6. 2004

Research Grants28

  1. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1993
    ....
  2. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1999
    ..Results will provide a basis for understanding the failure of mechanisms for ventilatory neurogenesis, in apneas of neonates and adults. ..
  3. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2003
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apneas" or the "sudden infant death syndrome." ..
  4. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2007
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." ..
  5. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1990
    ..We believe that results of studies proposed herein will provide significant insights into the mechanisms responsible for the neurogenesis of automatic ventilatory activity...