Elizabeth F Smith

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity
    Erin E Dymek
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 179:515-26. 2007
  2. pmc Pcdp1 is a central apparatus protein that binds Ca(2+)-calmodulin and regulates ciliary motility
    Christen G DiPetrillo
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 189:601-12. 2010
  3. ncbi request reprint Regulation of flagellar dynein by the axonemal central apparatus
    Elizabeth F Smith
    Dartmouth College, Department of Biological Sciences, Hanover, New Hampshire 03755, USA
    Cell Motil Cytoskeleton 52:33-42. 2002
  4. doi request reprint Cilia 2010: the surprise organelle of the decade
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Sci Signal 4:mr1. 2011
  5. pmc Hydin seek: finding a function in ciliary motility
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 176:403-4. 2007
  6. pmc The radial spokes and central apparatus: mechano-chemical transducers that regulate flagellar motility
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell Motil Cytoskeleton 57:8-17. 2004
  7. pmc Regulation of flagellar dynein by calcium and a role for an axonemal calmodulin and calmodulin-dependent kinase
    Elizabeth F Smith
    Dartmouth College, Department of Biological Sciences, Hanover, New Hampshire 03755, USA
    Mol Biol Cell 13:3303-13. 2002
  8. ncbi request reprint Calmodulin and PF6 are components of a complex that localizes to the C1 microtubule of the flagellar central apparatus
    Matthew J Wargo
    Dartmouth College, Department of Biological Sciences, 301 Gilman Hall, Hanover, NH 03755, USA
    J Cell Sci 118:4655-65. 2005
  9. pmc The CSC is required for complete radial spoke assembly and wild-type ciliary motility
    Erin E Dymek
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Biol Cell 22:2520-31. 2011
  10. ncbi request reprint A kinesin-like calmodulin-binding protein in Chlamydomonas: evidence for a role in cell division and flagellar functions
    Erin E Dymek
    Dartmouth College, Department of Biological Sciences, 301 Gilman, Hanover, NH 03755, USA
    J Cell Sci 119:3107-16. 2006

Research Grants

  1. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2007
  2. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
  3. Calcium regulation of flagellar motility
    Elizabeth F Smith; Fiscal Year: 2010
  4. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009

Collaborators

Detail Information

Publications18

  1. pmc A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity
    Erin E Dymek
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 179:515-26. 2007
    ..These combined results indicate that the CaM- and spoke-associated complex mediates regulatory signals between the radial spokes and dynein arms...
  2. pmc Pcdp1 is a central apparatus protein that binds Ca(2+)-calmodulin and regulates ciliary motility
    Christen G DiPetrillo
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 189:601-12. 2010
    ..These combined results reveal that the central pair Pcdp1 (FAP221) complex is essential for control of ciliary motility...
  3. ncbi request reprint Regulation of flagellar dynein by the axonemal central apparatus
    Elizabeth F Smith
    Dartmouth College, Department of Biological Sciences, Hanover, New Hampshire 03755, USA
    Cell Motil Cytoskeleton 52:33-42. 2002
    ..These data are also consistent with localization of axonemal CK1 and PP2A near the dynein arms...
  4. doi request reprint Cilia 2010: the surprise organelle of the decade
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Sci Signal 4:mr1. 2011
    ..Presentations at the 2010 Conference on the Biology of Cilia and Flagella revealed new insights into the functions and assembly of cilia and highlighted their ever-expanding roles in development and disease...
  5. pmc Hydin seek: finding a function in ciliary motility
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 176:403-4. 2007
    ..reinhardtii offers, Lechtreck and Witman determined the precise axonemal location of hydin, a protein that, when mutated, causes hydrocephalus, and defined a unique role for hydin in ciliary motility...
  6. pmc The radial spokes and central apparatus: mechano-chemical transducers that regulate flagellar motility
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell Motil Cytoskeleton 57:8-17. 2004
  7. pmc Regulation of flagellar dynein by calcium and a role for an axonemal calmodulin and calmodulin-dependent kinase
    Elizabeth F Smith
    Dartmouth College, Department of Biological Sciences, Hanover, New Hampshire 03755, USA
    Mol Biol Cell 13:3303-13. 2002
    ....
  8. ncbi request reprint Calmodulin and PF6 are components of a complex that localizes to the C1 microtubule of the flagellar central apparatus
    Matthew J Wargo
    Dartmouth College, Department of Biological Sciences, 301 Gilman Hall, Hanover, NH 03755, USA
    J Cell Sci 118:4655-65. 2005
    ..The finding of a calmodulin-containing complex as an asymmetrically assembled component of the central apparatus implicates the central apparatus in calcium modulation of flagellar waveform...
  9. pmc The CSC is required for complete radial spoke assembly and wild-type ciliary motility
    Erin E Dymek
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Biol Cell 22:2520-31. 2011
    ..Our results not only indicate that the CSC is required for spoke assembly and wild-type motility, but also provide evidence for heterogeneity among the radial spokes...
  10. ncbi request reprint A kinesin-like calmodulin-binding protein in Chlamydomonas: evidence for a role in cell division and flagellar functions
    Erin E Dymek
    Dartmouth College, Department of Biological Sciences, 301 Gilman, Hanover, NH 03755, USA
    J Cell Sci 119:3107-16. 2006
    ..However, during telophase and cytokinesis CrKCBP co-localizes with the microtubules associated with the phycoplast. These studies implicate CrKCBP in flagellar functions as well as cell division...
  11. pmc PF15p is the chlamydomonas homologue of the Katanin p80 subunit and is required for assembly of flagellar central microtubules
    Erin E Dymek
    Department of Biological Sciences, 301 Gilman, Dartmouth College, Hanover, NH 03755, USA
    Eukaryot Cell 3:870-9. 2004
    ..These results reveal a novel role for the katanin p80 subunit in the assembly and/or stability of the central pair of flagellar microtubules...
  12. ncbi request reprint Analysis of microtubule sliding patterns in Chlamydomonas flagellar axonemes reveals dynein activity on specific doublet microtubules
    Matthew J Wargo
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Sci 117:2533-44. 2004
    ..In addition, analysis of microtubule sliding in mutant axonemes reveals that the control mechanism is disrupted in some mutants...
  13. pmc Analyses of functional domains within the PF6 protein of the central apparatus reveal a role for PF6 sub-complex members in regulating flagellar beat frequency
    Daniel J Goduti
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cytoskeleton (Hoboken) 69:179-94. 2012
    ..Analysis of double mutants lacking the amino terminus of PF6 and outer dynein arms reveal that C1a may play a role in modulating both inner and outer dynein arm activity...
  14. pmc PF19 encodes the p60 catalytic subunit of katanin and is required for assembly of the flagellar central apparatus in Chlamydomonas
    Erin E Dymek
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Sci 125:3357-66. 2012
    ..In addition, we show that in Chlamydomonas the microtubule severing activity of p60 katanin is not required for stress-induced deflagellation or cell cycle progression as has been previously reported...
  15. pmc The CSC connects three major axonemal complexes involved in dynein regulation
    Thomas Heuser
    Biology Department, Rosenstiel Center, Brandeis University, Waltham, MA 02454, USA
    Mol Biol Cell 23:3143-55. 2012
    ..Our results also indicate that although structurally very similar, RS1 and RS2 likely serve different functions in regulating flagellar motility...
  16. pmc The Pcdp1 complex coordinates the activity of dynein isoforms to produce wild-type ciliary motility
    Christen G DiPetrillo
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Biol Cell 22:4527-38. 2011
    ..These results define a unique role for C1d in coordinating the activity of specific dynein isoforms to control ciliary motility...
  17. pmc Asymmetry of the central apparatus defines the location of active microtubule sliding in Chlamydomonas flagella
    Matthew J Wargo
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 100:137-42. 2003
    ..In addition, our results indicate that in high calcium conditions required to generate symmetric waveforms, the outer dynein arms are potential targets of the central pair-radial spoke control system...
  18. ncbi request reprint A novel Tctex2-related light chain is required for stability of inner dynein arm I1 and motor function in the Chlamydomonas flagellum
    Linda M DiBella
    Department of Biochemistry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3305, USA
    J Biol Chem 279:21666-76. 2004
    ..Furthermore, using a microtubule sliding assay we observed that dynein motor function is reduced in vitro. These data indicate that Tctex2b is required for the stability of inner dynein arm I1 and wild-type axonemal dynein function...

Research Grants9

  1. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2007
    ..This observation further illustrates the importance of controlling ciliary and flagellar waveforms appropriate for particular cell types. ..
  2. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis (reviewed in Badano et al, 2006). ..
  3. Calcium regulation of flagellar motility
    Elizabeth F Smith; Fiscal Year: 2010
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis (reviewed in Badano et al, 2006). ..
  4. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis (reviewed in Badano et al, 2006). ..