KAREN A SKORUPSKI

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. Kovacikova G, Lin W, Taylor R, Skorupski K. The Fatty Acid Regulator FadR Influences the Expression of the Virulence Cascade in the El Tor Biotype of Vibrio cholerae by Modulating the Levels of ToxT via Two Different Mechanisms. J Bacteriol. 2017;199: pubmed publisher
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    Skorupski K, Taylor R. Positive selection vectors for allelic exchange. Gene. 1996;169:47-52 pubmed
    ..In this report, we show that these vectors can be used to efficiently introduce point mutations and deletions into the chromosome of Vibrio cholerae. ..
  3. Skorupski K, Taylor R. Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae. Proc Natl Acad Sci U S A. 1997;94:265-70 pubmed
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    Skorupski K, Taylor R. Sequence and functional analysis of the gene encoding Vibrio cholerae cAMP receptor protein. Gene. 1997;198:297-303 pubmed
    ..In the Vc crp mutant, the cloned crp gene also restored the normal repression of ToxR-regulated virulence genes which occurs under certain environmental conditions. ..
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    Skorupski K, Taylor R. A new level in the Vibrio cholerae ToxR virulence cascade: AphA is required for transcriptional activation of the tcpPH operon. Mol Microbiol. 1999;31:763-71 pubmed
    ..TcpP/TcpH, together with ToxR/ToxS, then activate the expression of toxT, resulting ultimately in the production of virulence factors such as cholera toxin and TCP...