Peter R Sinclair
Affiliation: Dartmouth Medical School
Sinclair P, Gorman N, Walton H, Sinclair J, Lee C, Rifkind A. Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney. Drug Metab Dispos. 1997;25:779-83 pubmed
Sinclair P, Walton H, Gorman N, Jacobs J, Sinclair J. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes. Toxicol Appl Pharmacol. 1997;147:171-9 pubmed
..We conclude that URO accumulation in chick hepatocyte cultures is limited not only by the induction of CYP1A, but also by the stimulation of intracellular UROGEN oxidation. ..
Sinclair P, Gorman N, Walton H, Bement W, Szakacs J, Gonzalez F, et al
. Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone. Arch Biochem Biophys. 2000;384:383-90 pubmed
..Acetone was not an inducer of hepatic CYP1A2 in the wild-type mice. Although acetone is an inducer of CYP2E1, CYP1A2 appears to have the essential role in acetone-enhancement of uroporphyria. ..
Sinclair P, Gorman N, Trask H, Bement W, Szakacs J, Elder G, et al
. Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda. Hepatology. 2003;37:351-8 pubmed
..Ethanol-treated Hfe(-/-) mice seem to be an excellent model for studies of alcohol-mediated PCT. ..