Charles L Sentman

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Unique characteristics of NK cells throughout the human female reproductive tract
    Teddy F Mselle
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Clin Immunol 124:69-76. 2007
  2. ncbi request reprint Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone
    Charles L Sentman
    Department of, Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 173:6760-6. 2004
  3. pmc Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs
    Satarupa Basu
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 61:52-61. 2009
  4. pmc Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 183:2365-72. 2009
  5. pmc Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
    Juan R Cubillos-Ruiz
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Clin Invest 119:2231-44. 2009
  6. pmc Chimeric NKG2D receptor-expressing T cells as an immunotherapy for multiple myeloma
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Hematol 36:1318-28. 2008
  7. ncbi request reprint Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Res 67:5003-8. 2007
  8. pmc Chimeric NKG2D expressing T cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 183:6939-47. 2009
  9. ncbi request reprint Immunotherapy with chimeric NKG2D receptors leads to long-term tumor-free survival and development of host antitumor immunity in murine ovarian cancer
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 180:72-8. 2008
  10. ncbi request reprint Human NK cell IFN-gamma production is regulated by endogenous TGF-beta
    Sarah K Meadows
    Department of Microbiology and Immunology, Dartmouth Medical School, 6W Borwell Bldg, One Medical Center Drive, Lebanon, NH 03756, USA
    Int Immunopharmacol 6:1020-8. 2006

Collaborators

  • A L Howell
  • Tong Zhang
  • CHARLES ROBERT WIRA
  • Kenneth R Meehan
  • Patricia A Pioli
  • Mimi Ghosh
  • Diana Martinez
  • Fabian Benencia
  • Li Wang
  • Li Shen
  • Tibor Keler
  • Edward Usherwood
  • Martin Grundy
  • Amorette Barber
  • Mikael Eriksson
  • Paul Spear
  • Teddy F Mselle
  • Sarah K Meadows
  • Satarupa Basu
  • Melissa A Barber
  • Juan R Cubillos-Ruiz
  • Bethany A Gagne
  • Jose Conejo-Garcia
  • Agnieszka Rynda-Apple
  • Mitsuhiro Iyori
  • Laleh Talebian
  • Uciane K Scarlett
  • Jose R Conejo-Garcia
  • Satyan Kalkunte
  • Eduardo Huarte
  • Joseph A Wahle
  • Marie Louise Sentman
  • Ming Ru Wu
  • Jia Yan Wu
  • Zbigniew M Szczepiorkowski
  • John M Hill
  • Haddon Pantel
  • Dawn A Fischer
  • Marc S Ernstoff
  • Yolanda Nesbeth
  • Yvon Durant
  • Agnieszka Rynda
  • Satoshi Yamamoto
  • Andrew T Gewirtz
  • Ross Kedl
  • Raul Elgueta
  • Xavier Engle
  • Christina J Megli
  • Patrick De Baetselier
  • Jillian Wu
  • Ronald J Buckanovich
  • Pablo Sarobe
  • Jo A Van Ginderachter
  • Radu V Stan
  • Clinton O Chichester
  • Francesca Gotsch
  • Yolanda C Nesbeth
  • Roberto Romero
  • Surendra Sharma
  • Katherine F Roby
  • Leslie R Demars
  • Jennifer M Smith
  • Emily L Goll
  • William G Kerr
  • Amy L Costello
  • Kim H T Paraiso

Detail Information

Publications41

  1. ncbi request reprint Unique characteristics of NK cells throughout the human female reproductive tract
    Teddy F Mselle
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Clin Immunol 124:69-76. 2007
    ..These data suggest that unique characteristics of the tissues may account of specific localization of different NK cell subsets...
  2. ncbi request reprint Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone
    Charles L Sentman
    Department of, Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 173:6760-6. 2004
    ....
  3. pmc Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs
    Satarupa Basu
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 61:52-61. 2009
    ..In the human endometrium, uterine natural killer (uNK) cells and uterine macrophages are present in significant numbers and in close proximity, yet how they cooperatively respond to infectious challenge is poorly understood...
  4. pmc Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 183:2365-72. 2009
    ..In summary, chNKG2D T cells required both cytotoxicity and cytokine secretion as well as the participation of host immune cells for development of a host antitumor immune response and complete efficacy...
  5. pmc Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
    Juan R Cubillos-Ruiz
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Clin Invest 119:2231-44. 2009
    ....
  6. pmc Chimeric NKG2D receptor-expressing T cells as an immunotherapy for multiple myeloma
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Hematol 36:1318-28. 2008
    ..T cells expressing this receptor kill and produce cytokines in response to NKG2D-ligand+ tumor cells. Therefore, we investigated whether human chNKG2D T cells respond against human myeloma cells...
  7. ncbi request reprint Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Res 67:5003-8. 2007
    ..In addition, we show that chNKG2D T cells can be used therapeutically in a murine model of ovarian cancer. These data indicate that treatment with chNKG2D-expressing T cells is a potential immunotherapy for ovarian cancer...
  8. pmc Chimeric NKG2D expressing T cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 183:6939-47. 2009
    ..This induction of an immune response likely contributes to chNKG2D T cells' ability to eliminate established tumors...
  9. ncbi request reprint Immunotherapy with chimeric NKG2D receptors leads to long-term tumor-free survival and development of host antitumor immunity in murine ovarian cancer
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 180:72-8. 2008
    ..The chNKG2D T cells reduced the ovarian tumor burden using both cytotoxic and cytokine-dependent pathways. Specifically, chNKG2D T cell expression of perforin, GM-CSF, and IFN-gamma were essential for complete antitumor efficacy...
  10. ncbi request reprint Human NK cell IFN-gamma production is regulated by endogenous TGF-beta
    Sarah K Meadows
    Department of Microbiology and Immunology, Dartmouth Medical School, 6W Borwell Bldg, One Medical Center Drive, Lebanon, NH 03756, USA
    Int Immunopharmacol 6:1020-8. 2006
    ..Our findings also suggest that TGF-beta associated with other blood cells may be involved in limiting NK cell activation. Thus, inhibiting endogenous TGF-beta provides a means to shift NK cell activation and promote cellular immunity...
  11. ncbi request reprint Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways
    Tong Zhang
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Cancer Res 67:11029-36. 2007
    ..Taken together, these results indicate that chNKG2D T-cell-mediated therapeutic effects are mediated by both cytokine-dependent and cytotoxic mechanisms in vivo...
  12. ncbi request reprint NK cells negatively regulate antigen presentation and tumor-specific CTLs in a syngeneic lymphoma model
    Melissa A Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 178:6140-7. 2007
    ..These data suggest that NK cells can inhibit the development of effective adaptive immunity in the absence of signals that trigger NK cell activation...
  13. pmc Estradiol regulates MICA expression in human endometrial cells
    Satarupa Basu
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Clin Immunol 129:325-32. 2008
    ..Thus, estrogens regulate expression of MICA. These data suggest hormonal regulation of innate immunity and NKG2D-mediated recognition in other tissues and diseases where estrogen may be involved...
  14. ncbi request reprint NK cells rapidly remove B16F10 tumor cells in a perforin and interferon-gamma independent manner in vivo
    Martin A Grundy
    Department of Microbiology and Immunology, Dartmouth Medical School, 6W Borwell Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Immunol Immunother 56:1153-61. 2007
    ..Our data indicate that during early responses against B16F10 cells, NK cells use another mechanism(s) besides perforin and IFN-gamma to prevent tumor metastasis...
  15. ncbi request reprint NK cell receptors as tools in cancer immunotherapy
    Charles L Sentman
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Adv Cancer Res 95:249-92. 2006
    ..NK cells have various receptor systems designed to recognize infected and abnormal cells. Understanding NK cell receptors and their recognition mechanisms provides new tools for the development of immunotherapies against cancer...
  16. ncbi request reprint Ly49G2 receptor blockade reduces tumor burden in a leukemia model but not in a solid tumor model
    Melissa A Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, 6W Borwell Bldg, Lebanon, NH 03756, USA
    Cancer Immunol Immunother 57:655-62. 2008
    ..It is possible to enhance NK cell cytotoxicity against tumor cells by preventing the interaction of these inhibitory receptors with their MHC class I ligands...
  17. pmc Novel mobilization strategies to enhance autologous immune effector cells in multiple myeloma
    Laleh Talebian
    Blood and Marrow Transplant Program, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Front Biosci (Elite Ed) 3:1500-8. 2011
    ..004), cells that are extremely potent at killing myeloma cells using non-MHC-I restricted and TCR-independent mechanisms. Novel mobilization techniques can improve the mobilized graft and may improve clinical outcomes in myeloma patients...
  18. ncbi request reprint Endogenous transforming growth factor-beta inhibits toll-like receptor mediated activation of human uterine natural killer cells
    Mikael Eriksson
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 56:321-8. 2006
    ..Our aim was to determine whether uterine natural killer (uNK) cell cytokine production induced by stimulation through TLRs could be regulated by endogenous transforming growth factor (TGF)-beta in human endometrium...
  19. pmc Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells
    Tong Zhang
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
    J Immunol 190:2455-63. 2013
    ..The in vivo antiangiogenesis effects mediated by chNKG2D-bearing T cells at the tumor site were dependent on IFN-γ and perforin. These results provide a novel mechanism for NKG2D-based targeting of solid tumors...
  20. pmc Adoptive cellular therapy using cells enriched for NKG2D+CD3+CD8+T cells after autologous transplantation for myeloma
    Kenneth R Meehan
    Blood and Marrow Transplant Program, Dartmouth Hitchcock Medical Center, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Biol Blood Marrow Transplant 19:129-37. 2013
    ..02). We postulate that this regimen that increased the number and function of the NKG2D(+)CD3(+)CD8(+) T cells after transplantation may improve clinical outcomes by eliminating residual malignant cells in vivo...
  21. pmc Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF
    Paul Spear
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
    J Immunol 188:6389-98. 2012
    ..This study demonstrates that the activation of host macrophages by CAR T cell-derived cytokines transformed the tumor microenvironment from immunosuppressive to immunostimulatory and contributed to inhibition of ovarian tumor growth...
  22. pmc TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells
    Mitsuhiro Iyori
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 187:3087-95. 2011
    ..In summary, these data indicate a novel alternative pathway for DC/NK cell interactions in antitumor immunity and may reflect homeostasis of both DCs and NK cells for regulation of CD8(+) T cell function in physiological conditions...
  23. ncbi request reprint TLRs mediate IFN-gamma production by human uterine NK cells in endometrium
    Mikael Eriksson
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Immunol 176:6219-24. 2006
    ..These data also indicate that the uNK cells do not respond directly to TLR stimulation, but rather their production of IFN-gamma is dependent upon interactions with other cells within EM...
  24. pmc Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells
    Tong Zhang
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Cancer Res 71:2066-76. 2011
    ..Together, these results establish scFv-NKG2D as a promising biological fusion protein to induce effective antitumor immunity...
  25. pmc NKG2D receptor regulates human effector T-cell cytokine production
    Amorette Barber
    Department of Microbiology and Immunology, Dartmouth Medical School, 6W Borwell Bldg, One Medical Center Drive, Lebanon, NH 03756, USA
    Blood 117:6571-81. 2011
    ..Thus, human effector T cells alter their function depending on which innate receptors are engaged in conjunction with the TCR complex...
  26. ncbi request reprint NK cell function in the human female reproductive tract
    Charles L Sentman
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 57:108-15. 2007
    ..Uterine NK cells have a unique phenotype compared with blood NK cell subsets, yet little is known about how NK cells function as a part of the innate immune cell network in the female reproductive tract...
  27. pmc An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo
    Tong Zhang
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
    J Immunol 189:2290-9. 2012
    ..Overall, this study demonstrates the specificity and therapeutic potential of adoptive immunotherapy with NKp30 CAR-expressing T cells against B7-H6+ tumor cells in vivo...
  28. ncbi request reprint Immunodeficient mice have elevated numbers of NK cells in non-lymphoid tissues
    Martin A Grundy
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Exp Cell Res 312:3920-6. 2006
    ..This study describes a means to identify NK cells within complex tissue environments, and the increase in NK cells in non-lymphoid tissues may explain much of the increased NK cell activity observed in T-cell-deficient mice...
  29. pmc Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12
    Teddy F Mselle
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Virol 83:11188-95. 2009
    ....
  30. ncbi request reprint Generation of antitumor responses by genetic modification of primary human T cells with a chimeric NKG2D receptor
    Tong Zhang
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Cancer Res 66:5927-33. 2006
    ..5 mug/mL. These data indicate the feasibility of using chNKG2D receptors in primary human T cells and suggest that this approach may be a promising means for cancer immunotherapy...
  31. ncbi request reprint Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta
    Mikael Eriksson
    Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 76:667-75. 2004
    ..Further, data demonstrate that uNK cells can produce immunoregulatory cytokines and that inhibition of uNK cells by locally produced TGF-beta1 is a likely mechanism to regulate NK cell function in the human EM...
  32. pmc NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors
    Paul Spear
    Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
    Immunol Cell Biol 91:435-40. 2013
    ..These data indicate that NKG2D CAR T-cell treatment can be an effective therapy against heterogeneous tumors and induce tumor-specific immunity against ligand-deficient tumor cells. ..
  33. pmc Immune mobilization of autologous blood progenitor cells: direct influence on the cellular subsets collected
    Kenneth R Meehan
    Blood and Marrow Transplant Program, Section of Hematology and Oncology, 1 Medical Center Drive, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Cytotherapy 12:1013-21. 2010
    ..A phase I trial examined the ability of immunotherapy to mobilize progenitor and activated T cells...
  34. pmc NKG2D ligands as therapeutic targets
    Paul Spear
    Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Cancer Immun 13:8. 2013
    ..In this review, the NKG2D receptor and its ligands are discussed in the context of cancer, infection, and autoimmunity. In addition, therapies targeting NKG2D ligands in cancer are also reviewed. ..
  35. ncbi request reprint Control of murine gammaherpesvirus infection is independent of NK cells
    Edward J Usherwood
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eur J Immunol 35:2956-61. 2005
    ..We conclude that NK cells contribute little to the control of MHV-68 infection, and therefore, NK cells are not essential for controlling all herpesvirus infections...
  36. ncbi request reprint Innate and adaptive immunity in female genital tract: cellular responses and interactions
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunol Rev 206:306-35. 2005
    ..By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health...
  37. pmc Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity
    Eduardo Huarte
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03766, USA
    Cancer Res 68:7684-91. 2008
    ....
  38. ncbi request reprint GFP transgenic mice show dynamics of lung macrophages
    Martin Grundy
    Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Exp Cell Res 310:409-16. 2005
    ..These EGFP+ cells are phagocytic and can be activated to migrate within the lung in response to LPS stimulation. In this study, we describe a new model system that allows the specific study of macrophages in the lung...
  39. pmc Chimeric NK-receptor-bearing T cells mediate antitumor immunotherapy
    Tong Zhang
    Department of Microbiology and Immunology, Dartmouth Medical School, 6W Borwell Bldg, One Medical Center Dr, Lebanon, NH 03756, USA
    Blood 106:1544-51. 2005
    ..Taken together, our findings indicate that modification of T cells with chimeric NKG2D receptors represents a promising approach for immunotherapy against cancer...
  40. ncbi request reprint Cutting edge: dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets
    Joseph A Wahle
    Department of Interdisciplinary Oncology, H Lee Moffitt Comprehensive Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 176:7165-9. 2006
    ....
  41. pmc Evolution of non-cytotoxic uterine natural killer cells
    Satyan Kalkunte
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Am J Reprod Immunol 59:425-32. 2008
    ..This article discusses the factors and pathways that bridge the angiogenic and non-cytotoxic response machineries at the maternal-fetal interface...