Todd M Schaefer

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:6509-16. 2005
  2. pmc Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 112:428-36. 2004
  3. ncbi request reprint Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 174:992-1002. 2005
  4. ncbi request reprint Migration inhibitory factor secretion by polarized uterine epithelial cells is enhanced in response to the TLR3 agonist poly (I:C)
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, 710W Borwell, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 54:193-202. 2005
  5. pmc Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Fertil Steril 89:1497-506. 2008
  6. doi request reprint CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Am J Reprod Immunol 62:60-71. 2009
  7. ncbi request reprint Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 176:6647-55. 2006
  8. ncbi request reprint Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse
    Gisela Soboll
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 55:434-46. 2006
  9. pmc Effect of oestradiol and pathogen-associated molecular patterns on class II-mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract
    Daniel O Ochiel
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Immunology 135:51-62. 2012
  10. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004

Collaborators

Detail Information

Publications17

  1. ncbi request reprint IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:6509-16. 2005
    ....
  2. pmc Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 112:428-36. 2004
    ....
  3. ncbi request reprint Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 174:992-1002. 2005
    ....
  4. ncbi request reprint Migration inhibitory factor secretion by polarized uterine epithelial cells is enhanced in response to the TLR3 agonist poly (I:C)
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, 710W Borwell, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 54:193-202. 2005
    ..The goals of this study were to determine if uterine epithelial cells produce the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF), and to see if toll-like receptor (TLR) agonists stimulate MIF secretion...
  5. pmc Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Fertil Steril 89:1497-506. 2008
    ..To examine the expression of toll-like receptors (TLR) by primary human Fallopian tube epithelial cells (FTEC) and to determine whether exposure to the TLR3 agonist poly(I:C) induces an antiviral response...
  6. doi request reprint CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Am J Reprod Immunol 62:60-71. 2009
    ..The role of CCL20/MIP3alpha as an antiviral is unknown. In this study, we have examined the production of CCL20/MIP3alpha by epithelial cells from the upper female reproductive tract as well as its activity as an antiviral molecule...
  7. ncbi request reprint Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 176:6647-55. 2006
    ..These data indicate dynamic immunologic interaction between uterine macrophages and epithelial cells and implicate a role for estradiol in the modulation of the immune response...
  8. ncbi request reprint Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse
    Gisela Soboll
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 55:434-46. 2006
    ....
  9. pmc Effect of oestradiol and pathogen-associated molecular patterns on class II-mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract
    Daniel O Ochiel
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Immunology 135:51-62. 2012
    ..Further, these findings suggest that antigen-presenting cells in the uterus and vagina respond to selected Toll-like receptor agonists with altered antigen presentation...
  10. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004
    ..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
  11. ncbi request reprint Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Hum Reprod 21:2432-9. 2006
    ..Recent insight into the immunological capabilities of the trophoblast suggests that the placenta may function as an active barrier by recognizing and responding to pathogens through Toll-like receptors (TLRs)...
  12. ncbi request reprint Increased expression of interferon-inducible genes in macaque lung tissues during simian immunodeficiency virus infection
    Todd M Schaefer
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Microbes Infect 8:1839-50. 2006
    ....
  13. ncbi request reprint Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines
    Shrabani Basu
    Department of Infectious Diseases and Microbiology, University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cytokine 18:140-8. 2002
    ..These studies of rhesus macaque chemokine sequences demonstrate that chemokine genes are highly conserved across species, and provide a large foundation for the study of chemokine biology and genetics in nonhuman primates...
  14. ncbi request reprint Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-gamma in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome
    Todd A Reinhart
    Department of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Blood 99:3119-28. 2002
    ....
  15. pmc Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE)
    Lana E Hanford
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:50019-24. 2004
    ..Finally, our data indicated that sRAGE in the mouse is likely produced by carboxyl-terminal truncation, in contrast to the alternative splicing mechanism reported in humans...
  16. ncbi request reprint The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs
    Todd M Schaefer
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Virology 302:106-22. 2002
    ....
  17. ncbi request reprint Virologic and immunologic events in hilar lymph nodes during simian immunodeficiency virus infection: development of polarized inflammation
    Beth A Fallert
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 47:16-26. 2008
    ....