M D Rutkowski

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Limited role of macrophages in generation of nerve injury-induced mechanical allodynia
    M D Rutkowski
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, 1 Medical Center Drive, 03756, Lebanon, NH, USA
    Physiol Behav 71:225-35. 2000
  2. ncbi Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain
    J L Arruda
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Brain Res 879:216-25. 2000
  3. ncbi Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
    B A Winkelstein
    Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Comp Neurol 439:127-39. 2001
  4. ncbi Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons
    B A Winkelstein
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125 One Medical Center Dr, Lebanon, NH 03756, USA
    J Neurosci Methods 111:49-57. 2001
  5. ncbi Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain
    J L Arruda
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, Lebanon, NH 03756, USA
    Brain Res Mol Brain Res 62:228-35. 1998
  6. ncbi Cyclooxygenase-2 inhibitor SC-236 attenuates mechanical allodynia following nerve root injury in rats
    T A Deleo
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    J Orthop Res 18:977-82. 2000
  7. ncbi Gender differences in rat neuropathic pain sensitivity is dependent on strain
    J A DeLeo
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, HB 7125, Lebanon, USA
    Neurosci Lett 282:197-9. 2000
  8. ncbi The role of the N-methyl-D-aspartate receptor NR1 subunit in peripheral nerve injury-induced mechanical allodynia, glial activation and chemokine expression in the mouse
    S Bursztajn
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neuroscience 125:269-75. 2004
  9. ncbi Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain
    M D Rutkowski
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 146:94-8. 2004

Collaborators

Detail Information

Publications9

  1. ncbi Limited role of macrophages in generation of nerve injury-induced mechanical allodynia
    M D Rutkowski
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, 1 Medical Center Drive, 03756, Lebanon, NH, USA
    Physiol Behav 71:225-35. 2000
    ..In summary, these data suggest a limited role of activated macrophages in the onset of mechanical allodynia in an animal model of neuropathy...
  2. ncbi Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain
    J L Arruda
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Brain Res 879:216-25. 2000
    ..Spinal glial activation was unaltered by any treatment. These data provide further evidence for the role of central IL-6 and neuroimmune modulation in the etiology of mechanical allodynia following peripheral nerve injury...
  3. ncbi Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
    B A Winkelstein
    Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Comp Neurol 439:127-39. 2001
    ..Overall, these data implicate alternate nociceptive mechanisms in these anatomically different injuries that are not distinguished by behavioral testing or the neuroimmune markers used in this study...
  4. ncbi Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons
    B A Winkelstein
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125 One Medical Center Dr, Lebanon, NH 03756, USA
    J Neurosci Methods 111:49-57. 2001
    ..Results indicate a direct correlation of local nerve root injury severity with the ensuing physiologic responses associated with nociception...
  5. ncbi Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain
    J L Arruda
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, Lebanon, NH 03756, USA
    Brain Res Mol Brain Res 62:228-35. 1998
    ....
  6. ncbi Cyclooxygenase-2 inhibitor SC-236 attenuates mechanical allodynia following nerve root injury in rats
    T A Deleo
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    J Orthop Res 18:977-82. 2000
    ..In addition, these data support continued basic science research to further elucidate central inflammatory processes that follow nerve root injury...
  7. ncbi Gender differences in rat neuropathic pain sensitivity is dependent on strain
    J A DeLeo
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, HB 7125, Lebanon, USA
    Neurosci Lett 282:197-9. 2000
    ..These data suggest that the choice of rat gender and strain should be considered in experimental neuropathic pain studies, especially in the assessment of potential analgesics...
  8. ncbi The role of the N-methyl-D-aspartate receptor NR1 subunit in peripheral nerve injury-induced mechanical allodynia, glial activation and chemokine expression in the mouse
    S Bursztajn
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neuroscience 125:269-75. 2004
    ..The results support the findings that chemokine signaling releases glutamate in the spinal cord...
  9. ncbi Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain
    M D Rutkowski
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 146:94-8. 2004
    ..We observed intense B7.2 microglial immunoreactivity in the lumbar spinal cord following the injury but no expression of B7.1. These data suggest a role of protective CNS autoimmunity following peripheral nerve injury...