David W Roberts

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
  2. pmc Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article
    David W Roberts
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Neurosurg 114:595-603. 2011
  3. pmc Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Neurosurg 115:11-7. 2011
  4. ncbi request reprint Stereopsis-guided brain shift compensation
    Hai Sun
    Dartmouth Medical School, 172 Kellogg Building, Hanover, NH 03755 USA
    IEEE Trans Med Imaging 24:1039-52. 2005
  5. pmc δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    Neuro Oncol 13:846-56. 2011
  6. doi request reprint Subdural interhemispheric grid electrodes for intracranial epilepsy monitoring: feasibility, safety, and utility: clinical article
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 117:1182-8. 2012
  7. pmc Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    J Neuropathol Exp Neurol 71:806-13. 2012
  8. doi request reprint Postoperative stereotactic radiosurgery without whole-brain radiation therapy for brain metastases: potential role of preoperative tumor size
    Alan C Hartford
    Section of Radiation Oncology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Int J Radiat Oncol Biol Phys 85:650-5. 2013
  9. doi request reprint Interictal PET and ictal subtraction SPECT: sensitivity in the detection of seizure foci in patients with medically intractable epilepsy
    Atman Desai
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 54:341-50. 2013
  10. pmc Mutual-information-based image to patient re-registration using intraoperative ultrasound in image-guided neurosurgery
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:4612-24. 2008

Collaborators

Detail Information

Publications75

  1. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
    ..These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development...
  2. pmc Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article
    David W Roberts
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Neurosurg 114:595-603. 2011
    ....
  3. pmc Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Neurosurg 115:11-7. 2011
    ..The authors show that diagnostically significant but visually imperceptible concentrations of PpIX can be quantitatively measured in vivo and used to discriminate normal from neoplastic brain tissue across a range of tumor histologies...
  4. ncbi request reprint Stereopsis-guided brain shift compensation
    Hai Sun
    Dartmouth Medical School, 172 Kellogg Building, Hanover, NH 03755 USA
    IEEE Trans Med Imaging 24:1039-52. 2005
    ..Based on data from two representative clinical cases, we show that stereopsis guidance improves the accuracy of brain shift compensation both at and below the cortical surface...
  5. pmc δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    Neuro Oncol 13:846-56. 2011
    ..This work suggests a need for improved PpIX fluorescence detection technologies to achieve better sensitivity and quantification of PpIX in tissue during surgery...
  6. doi request reprint Subdural interhemispheric grid electrodes for intracranial epilepsy monitoring: feasibility, safety, and utility: clinical article
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 117:1182-8. 2012
    ..The authors investigated their experience with interhemispheric grid electrodes (IHGEs) to assess the hypothesis that they are feasible, safe, and useful...
  7. pmc Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    J Neuropathol Exp Neurol 71:806-13. 2012
    ..To our knowledge, this is the first time that Gd measurements by inductively coupled plasma mass spectrometry have been used in human gliomas...
  8. doi request reprint Postoperative stereotactic radiosurgery without whole-brain radiation therapy for brain metastases: potential role of preoperative tumor size
    Alan C Hartford
    Section of Radiation Oncology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Int J Radiat Oncol Biol Phys 85:650-5. 2013
    ....
  9. doi request reprint Interictal PET and ictal subtraction SPECT: sensitivity in the detection of seizure foci in patients with medically intractable epilepsy
    Atman Desai
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 54:341-50. 2013
    ..To determine the relative utility of these methods in the localization of seizure foci, we compared interictal PET and ictal subtraction SPECT to subdural and depth electrode recordings in patients with medically intractable epilepsy...
  10. pmc Mutual-information-based image to patient re-registration using intraoperative ultrasound in image-guided neurosurgery
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:4612-24. 2008
    ..2 deg, respectively). The proposed scheme is automatic, sufficiently robust, and computationally efficient (<2 min), and holds promise for routine clinical use in the operating room during image-guided neurosurgical procedures...
  11. pmc Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, N H, USA
    Stereotact Funct Neurosurg 88:1-10. 2010
    ..We present the implementation of deformation modeling for brain shift compensation in protoporphyrin IX FGR, integrating these two sources of information for maximum surgical benefit...
  12. doi request reprint Outcome of frontal lobe epilepsy surgery
    Stefanie P Lazow
    Department of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 53:1746-55. 2012
    ..The aim of this study is to define multiple outcome measures and determine whether there are certain subpopulations of preferred surgical candidates that have a more favorable seizure prognosis...
  13. doi request reprint Long-term seizure, cognitive, and psychiatric outcome following trans-middle temporal gyrus amygdalohippocampectomy and standard temporal lobectomy
    Krzysztof A Bujarski
    Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    J Neurosurg 119:16-23. 2013
    ....
  14. doi request reprint Occipitotemporal hippocampal depth electrodes in intracranial epilepsy monitoring: safety and utility
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 118:345-52. 2013
    ..The authors investigated the usefulness of hippocampal depth electrodes in the era of more advanced imaging techniques...
  15. pmc Quantitative, spectrally-resolved intraoperative fluorescence imaging
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Sci Rep 2:798. 2012
    ..The wide-field qFI technique has broad implications for intraoperative surgical guidance because it provides near real-time quantitative assessment of multiple fluorescent biomarkers across the operative field...
  16. pmc Combining multiple true 3D ultrasound image volumes through re-registration and rasterization
    Songbai Ji
    Dartmouth College, Thayer School of Engineering, HB8000, Hanover, NH 03755, USA
    Med Image Comput Comput Assist Interv 12:795-802. 2009
    ..2 mm) and rotational (38.5 degrees) capture ranges for the MI re-registration of two volumetric 3DUS images. The technique is applicable in any clinical application in which volumetric true 3DUS is acquired...
  17. pmc Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery
    Pablo A Valdes
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 16:116007. 2011
    ..Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients...
  18. doi request reprint 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence in Meningioma: Qualitative and Quantitative Measurements In Vivo
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire Thayer School of Engineering, Hanover, New Hampshire Geisel School of Medicine at Dartmouth, Hanover, New Hampshire Departments of Pathology and Neurology, Georgetown University Medical Center, Washington, DC Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada Engineering Physics Department, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Neurosurgery 10:74-83. 2014
    ..To date, the clinical utility of 5-ALA in meningiomas is not fully understood, with most descriptive studies using qualitative approaches to 5-ALA-PpIX...
  19. pmc Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Neurosurg Focus 30:E8. 2011
    ....
  20. doi request reprint Frameless robotically targeted stereotactic brain biopsy: feasibility, diagnostic yield, and safety
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 116:1002-6. 2012
    ..The authors hypothesized that robotic brain biopsy is a safe, accurate procedure, with a high diagnostic yield and a safety profile comparable to other stereotactic biopsy methods...
  21. pmc Model-based estimation of ventricular deformation in the cat brain
    Fenghong Liu
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Comput Comput Assist Interv 12:308-15. 2009
    ....
  22. pmc Intraoperative patient registration using volumetric true 3D ultrasound without fiducials
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Med Phys 39:7540-52. 2012
    ....
  23. doi request reprint Robotic image-guided depth electrode implantation in the evaluation of medically intractable epilepsy
    William J Spire
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, One MedicalCenter Drive, Lebanon, New Hampshire 03756, USA
    Neurosurg Focus 25:E19. 2008
    ..The authors describe their experience with a technique for robotic implantation of depth electrodes in patients concurrently undergoing craniotomy and placement of subdural monitoring electrodes for the evaluation of intractable epilepsy...
  24. doi request reprint Seizure prognosis of patients with low-grade tumors
    Cynthia A Kahlenberg
    Dartmouth College, Hanover, NH, United States
    Seizure 21:540-5. 2012
    ..Seizures frequently impact the quality of life of patients with low grade tumors. Management is often based on best clinical judgment. We examined factors that correlate with seizure outcome to optimize seizure management...
  25. doi request reprint Stereotactic depth electrode investigation of the insula in the evaluation of medically intractable epilepsy
    Atman Desai
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 114:1176-86. 2011
    ..The authors describe their experience with stereotactic implantation of insular depth electrodes in patients with medically intractable epilepsy...
  26. pmc Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Photochem Photobiol 86:471-5. 2010
    ..These results indicate that iron chelation therapy could significantly increase delta-ALA-induced PpIX fluorescence in malignant gliomas, pointing to a potential role of iron chelation therapy for more effective FGR of brain tumors...
  27. doi request reprint Surgical techniques for investigating the role of the insula in epilepsy: a review
    Atman Desai
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neurosurg Focus 32:E6. 2012
    ..The authors review each of these techniques with respect to current concepts in insular epilepsy...
  28. doi request reprint Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report
    Wesley J Whitson
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neurosurgery 68:E1768-72; discussion E1772-3. 2011
    ..We present the case of a recurrent atypical meningioma operated on with 5-ALA fluorescence-guided resection for delineation of tumor tissue from surrounding uninvolved dura...
  29. pmc Hippocampal interictal epileptiform activity disrupts cognition in humans
    Jonathan K Kleen
    Department of Neurology, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Neurology 81:18-24. 2013
    ..We investigated whether interictal epileptiform discharges (IED) in the human hippocampus are related to impairment of specific memory processes, and which characteristics of hippocampal IED are most associated with memory dysfunction...
  30. doi request reprint Genetics of glioblastoma: a window into its imaging and histopathologic variability
    Clifford J Belden
    Department of Radiology, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    Radiographics 31:1717-40. 2011
    ..It is equally critical that radiologists understand which genetic pathway is targeted by each specific therapeutic agent or class of agents in order to accurately interpret changes in the imaging appearances of treated tumors...
  31. doi request reprint A comparative analysis of coregistered ultrasound and magnetic resonance imaging in neurosurgery
    Alex Hartov
    Thayer School of Engineering, Dartmouth College, HB 8000, Hanover, NH 03755, USA
    Neurosurgery 62:91-9; discussion 99-101. 2008
    ..This work presents qualitative and quantitative side-by-side comparisons of oblique coregistered magnetic resonance imaging (MRI) scans and ultrasound images obtained during 35 neurosurgical procedures...
  32. pmc Cortical surface strain estimation using stereovision
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Comput Comput Assist Interv 14:412-9. 2011
    ..The technique offers a new approach for soft tissue strain estimation for the purpose of biomechanical characterization...
  33. ncbi request reprint Assimilating intraoperative data with brain shift modeling using the adjoint equations
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755 800, USA
    Med Image Anal 9:281-93. 2005
    ..The scheme is illustrated in a 2D simulation and in a 2D approximation based on a patient case using actual OR data...
  34. ncbi request reprint Data-guided brain deformation modeling: evaluation of a 3-D adjoint inversion method in porcine studies
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 53:1893-900. 2006
    ..The guidelines established for selection of model parameters are starting points for further optimization of the method under clinical conditions...
  35. doi request reprint Outcome prediction in intracranial tumor surgery: the National Surgical Quality Improvement Program 2005-2010
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    J Neurooncol 113:57-64. 2013
    ....
  36. ncbi request reprint Coregistered intraoperative ultrasonography in resection of malignant glioma
    Dimitrios C Nikas
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neurosurg Focus 14:e6. 2003
    ..The authors present their experience with coregistration of preoperative imaging data to intraoperative ultrasonography in the resection of high-grade gliomas, focusing on methodology and clinical observation...
  37. pmc Brain-skull contact boundary conditions in an inverse computational deformation model
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Anal 13:659-72. 2009
    ..9 min on average, but may be further reduced by applying an iterative solver to the linear systems of equations involved and/or by local refinement of the mesh in regions of interest...
  38. doi request reprint Brain stimulation for the treatment of epilepsy
    Barbara C Jobst
    Dartmouth Medical School, Hanover, New Hampshire, USA
    Epilepsia 51:88-92. 2010
    ..A large randomized multicenter trial has been conducted testing this system for focal epilepsy...
  39. doi request reprint System and methods for wide-field quantitative fluorescence imaging during neurosurgery
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Opt Lett 38:2786-8. 2013
    ....
  40. doi request reprint Robotic placement of a CNS ventricular reservoir for administration of chemotherapy
    S Scott Lollis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Br J Neurosurg 23:516-20. 2009
    ..It also permits careful pre-operative study and optimization of the catheter trajectory, which may be beneficial in minimizing risk to bridging veins and sulcal vessels...
  41. doi request reprint Technique for the localization of intracranially implanted electrodes
    Terrance M Darcey
    Section of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neurosurg 113:1182-5. 2010
    ..In this paper, the authors describe a straightforward method for implanted electrode localization, and detail their experience to date with the technique...
  42. pmc Real-time interpolation for true 3-dimensional ultrasound image volumes
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Ultrasound Med 30:243-52. 2011
    ....
  43. ncbi request reprint Cortical surface tracking using a stereoscopic operating microscope
    Hai Sun
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    Neurosurgery 56:86-97; discussion 86-97. 2005
    ..To measure and compensate for soft tissue deformation during image-guided neurosurgery, we have developed a novel approach to estimate the three-dimensional (3-D) topology of the cortical surface and track its motion over time...
  44. doi request reprint Intractable occipital lobe epilepsy: clinical characteristics and surgical treatment
    Barbara C Jobst
    Department of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 51:2334-7. 2010
    ..Occipital seizure onset can be easily missed in nonlesional epilepsy. Comprehensive intracranial EEG coverage of all three occipital surfaces leads to better outcomes...
  45. doi request reprint Orbitofrontal and insular epilepsy
    Matthias F Kriegel
    Department of Neurology, Dartmouth Medical School, Hanover, NH, USA
    J Clin Neurophysiol 29:385-91. 2012
    ..Orbitofrontal and insular epilepsy are difficult to recognize because clinical presentations are variable and surgical approaches remain difficult...
  46. doi request reprint Robotic catheter ventriculostomy: feasibility, efficacy, and implications
    S Scott Lollis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 108:269-74. 2008
    ..The authors hypothesized that image-guided robotic placement of a ventriculostomy catheter is safe, highly accurate, and highly reproducible...
  47. doi request reprint Tumor bed dynamics after surgical resection of brain metastases: implications for postoperative radiosurgery
    Lesley A Jarvis
    Section of Radiation Oncology, Department of Radiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    Int J Radiat Oncol Biol Phys 84:943-8. 2012
    ..To analyze 2 factors that influence timing of radiosurgery after surgical resection of brain metastases: target volume dynamics and intracranial tumor progression in the interval between surgery and cavity stereotactic radiosurgery (SRS)...
  48. doi request reprint Deep brain stimulation of the nucleus accumbens reduces alcohol intake in alcohol-preferring rats
    Michael B Henderson
    Department of Neurosurgery, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Neurosurg Focus 29:E12. 2010
    ....
  49. pmc Deep brain stimulation results in local glutamate and adenosine release: investigation into the role of astrocytes
    Vivianne L Tawfik
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Neurosurgery 67:367-75. 2010
    ....
  50. doi request reprint Toward feedback controlled deep brain stimulation: dynamics of glutamate release in the subthalamic nucleus in rats
    Christina E Behrend
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States
    J Neurosci Methods 180:278-89. 2009
    ..We conclude that the transfer function between HFS and neurotransmitter levels in the brain can be used to design DBS protocols that generate specific temporal patterns of glutamate release in the STN...
  51. ncbi request reprint Displacement estimation with co-registered ultrasound for image guided neurosurgery: a quantitative in vivo porcine study
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA
    IEEE Trans Med Imaging 22:1358-68. 2003
    ....
  52. doi request reprint Pulsed-light imaging for fluorescence guided surgery under normal room lighting
    Kristian Sexton
    Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 38:3249-52. 2013
    ..Resection of orthotopic brain tumors in mice also suggests that the pulsed-light system provides superior sensitivity in vivo...
  53. doi request reprint Cause-specific mortality among neurosurgeons
    S Scott Lollis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 113:474-8. 2010
    ..The authors sought to determine a cause-specific mortality profile for US neurosurgeons during the period 1979-2005...
  54. doi request reprint Epilepsy surgery in tuberous sclerosis: a review
    Linton T Evans
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA linton evans hitchcock org
    Neurosurg Focus 32:E5. 2012
    ..This patient ultimately underwent resection of an epileptogenic region within the occipital lobe...
  55. pmc A phase II study of thalidomide and irinotecan for treatment of glioblastoma multiforme
    Camilo E Fadul
    Department of Medicine, Section of Hematology Oncology, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center Drive, One Medical Center Drive, Lebanon, NH 03756, USA
    J Neurooncol 90:229-35. 2008
    ..To evaluate the combination of thalidomide and irinotecan, we conducted a phase II trial in adults with newly-diagnosed or recurrent GBM...
  56. ncbi request reprint A noncontacting 3-D digitizer for use in image-guided neurosurgery
    Hai Sun
    Thayer School of Engineering, Hanover, NH, USA
    Stereotact Funct Neurosurg 80:120-4. 2003
    ..We show that this approach improves the accuracy of registration in a phantom study, and demonstrate the ability to capture cortical motion in six clinical cases...
  57. ncbi request reprint Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease
    Kendall H Lee
    Section of Neurosurgery, Dartmouth Hitchcock Medical School, Lebanon, New Hampshire, 03756, USA
    Eur J Neurosci 23:1005-14. 2006
    ..Taken together, these results suggest that enhanced dopamine release within the basal ganglia may be an important mechanism whereby high-frequency stimulation of the subthalamic nucleus improves motor symptoms of Parkinson's disease...
  58. doi request reprint New-onset obsessive-compulsive disorder following neurosurgery for medication-refractory seizure disorder
    Robert M Roth
    Department of Psychiatry, Neuropsychology Service, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Epilepsy Behav 14:677-80. 2009
    ..To our knowledge, the present case is only the fourth reported of de novo onset OCD following neurosurgery for seizure disorder, and the first in a patient without either preexisting obsessive traits or an OCD spectrum disorder...
  59. ncbi request reprint Ventriculoperitoneal shunt insertion for the treatment of refractory perilymphatic fistula
    S Scott Lollis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 105:1-5. 2006
    ..The goal of this study was to provide preliminary data regarding clinical and functional outcome, including postoperative morbidity, related to ventriculoperitoneal (VP) shunt insertion for refractory perilymphatic fistula...
  60. ncbi request reprint Statistical mapping of scalp-recorded ictal EEG records using wavelet analysis
    John J Battiston
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    Epilepsia 44:664-72. 2003
    ..The wavelet transform (WT) is well suited for the analysis of signals whose characteristics vary rapidly over time. We devised a computerized method for objective scoring of scalp-recorded seizures that takes advantage of the WT...
  61. ncbi request reprint Abolition of spindle oscillations and 3-Hz absence seizurelike activity in the thalamus by using high-frequency stimulation: potential mechanism of action
    Kendall H Lee
    Section of Neurosurgery and Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosurg 103:538-45. 2005
    ..The authors studied the effects of HFS on thalamocortical relay neurons in a ferret in vitro slice preparation to test the hypothesis that HFS abolishes synchronized oscillations by neurotransmitter release...
  62. ncbi request reprint Validation of ictal single photon emission computed tomography with depth encephalography and epilepsy surgery
    Vijay M Thadani
    Section of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neurosurg Rev 27:27-33. 2004
    ..Surgical outcome tends to be better when the two modalities give concordant results...
  63. ncbi request reprint Neurotransmitter release from high-frequency stimulation of the subthalamic nucleus
    Kendall H Lee
    Section of Neurosurgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosurg 101:511-7. 2004
    ..In the present study, the authors tested the hypothesis that HFS within the STN changes neuronal action potential firing rates during the stimulation period by modifying neurotransmitter release...
  64. ncbi request reprint Does asymmetric basal ganglia or thalamic activation aid in seizure foci lateralization on ictal SPECT studies?
    Jitka Sojkova
    Dartmouth Medical School, Hanover, New Hampshire, USA
    J Nucl Med 44:1379-86. 2003
    ..We hypothesized that lateralization of activation of these subcortical structures may aid in the lateralization of seizure foci in patients in whom the cortical focus is subtle or equivocal...
  65. ncbi request reprint Effect of high-frequency stimulation of the subthalamic nucleus on subthalamic neurons: an intracellular study
    Kendall H Lee
    Section of Neurosurgery, Dartmouth Medical School, Lebanon, NH, USA
    Stereotact Funct Neurosurg 80:32-6. 2003
    ....
  66. ncbi request reprint In vivo quantification of retraction deformation modeling for updated image-guidance during neurosurgery
    Leah A Platenik
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 49:823-35. 2002
    ....
  67. ncbi request reprint TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity
    Grace Patlewicz
    European Chemicals Bureau, TP 582, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, 21020 Ispra, VA, Italy
    Regul Toxicol Pharmacol 48:225-39. 2007
    ..Improvements for TIMES-SS were proposed where appropriate. TIMES-SS is a promising tool to aid in the evaluation of skin sensitization hazard under legislative programs such as REACH...
  68. ncbi request reprint Determination of the platinum drug cis-amminedichloro(2-methylpyridine)platinum(II) in human urine by liquid chromatography-tandem mass spectrometry
    Tomoyuki Oe
    Center for Cancer Pharmacology, Department of Pharmacology, University of Pennsylvania, 1254 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 792:217-27. 2003
    ..Formation of the adduct was prevented by the addition of 50% (w/v) sodium chloride to the urine. The assay can be used to quantify intact ZD0473 in the urine of subjects dosed with this new platinum drug...
  69. ncbi request reprint Statistical analysis of multidimensional fuzzy set ordinations
    David W Roberts
    Department of Ecology, Montana State University, Bozeman, Montana 59717 3460, USA
    Ecology 89:1246-60. 2008
    ..Environmental variable effect sizes are easily estimated, and probabilities of observing the results obtained are easily calculated by parametric distributions or permutation statistics...
  70. ncbi request reprint Radiosurgery and radiotherapy
    David W Roberts
    J Neurosurg 101:573; discussion 573. 2004
  71. ncbi request reprint A review of the status of alternative approaches to animal testing and the development of integrated testing strategies for assessing the toxicity of chemicals under REACH--a summary of a DEFRA-funded project conducted by Liverpool John Moores University
    Christina Grindon
    Fund for the Replacement of Animals in Medical Experiments, Russell and Burch House, 96 98 North Sherwood Street, Nottingham NG1 4EE, UK
    Altern Lab Anim 34:149-58. 2006
    ..This paper is a prelude to a series of individual papers on detailed suggestions for applying non-animal methods to each of the major toxicity endpoints in REACH...
  72. doi request reprint A comparison of reactivity schemes for the prediction skin sensitization potential
    Grace Patlewicz
    European Commission, DG Joint Research Centre, Institute for Health and Consumer Protection, European Chemicals Bureau TP582, 21027 Ispra VA, Italy
    Chem Res Toxicol 21:521-41. 2008
    ..The similarities and differences of the schemes are highlighted, together with modifications that could be made to TIMES-SS to harmonize the two approaches...
  73. ncbi request reprint DESPOT, a process-based tree growth model that allocates carbon to maximize carbon gain
    Thomas N Buckley
    Environmental Biology Group and CRC for Greenhouse Accounting, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
    Tree Physiol 26:129-44. 2006
    ..Of those that do lead to sustainable growth, the ratios at maturity of net to gross primary productivity and of leaf area to sapwood area are highly conserved...
  74. ncbi request reprint How should leaf area, sapwood area and stomatal conductance vary with tree height to maximize growth?
    Thomas N Buckley
    Environmental Biology Group and CRC for Greenhouse Accounting, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
    Tree Physiol 26:145-57. 2006
    ..Although many data are consistent with the prediction that L/S should decline with H, many others are not, and we discuss possible reasons for these discrepancies...
  75. ncbi request reprint Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization
    David W Roberts
    School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, UK
    Chem Res Toxicol 20:1019-30. 2007
    ..This understanding is necessary if reliable non-animal approaches, including (quantitative) structure-activity relationships (Q)SARs, read-across, and experimental chemistry based models, are to be developed...