BRIAN WILLIAM POGUE

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Image analysis for discrimination of cervical neoplasia
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Biomed Opt 5:72-82. 2000
  2. ncbi request reprint Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 9:541-52. 2004
  3. pmc Protoporphyrin IX fluorescence photobleaching increases with the use of fractionated irradiation in the esophagus
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 13:034009. 2008
  4. ncbi request reprint Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cancer Res 63:1025-33. 2003
  5. ncbi request reprint Fluorescence imaging in vivo: raster scanned point-source imaging provides more accurate quantification than broad beam geometries
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover NH 03755, USA
    Technol Cancer Res Treat 3:15-21. 2004
  6. ncbi request reprint Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:755-63. 2002
  7. ncbi request reprint Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injection
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:177-84. 2002
  8. ncbi request reprint In vivo NADH fluorescence monitoring as an assay for cellular damage in photodynamic therapy
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 74:817-24. 2001
  9. ncbi request reprint Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Biomed Opt 6:397-403. 2001
  10. ncbi request reprint Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin
    B W Pogue
    Thayer School of Engineering, 8000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 74:700-6. 2001

Research Grants

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Image analysis for discrimination of cervical neoplasia
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Biomed Opt 5:72-82. 2000
    ..Further research in this field can lead to advances in computer-aided diagnosis as well as the potential for online image enhancement in digital colposcopy...
  2. ncbi request reprint Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 9:541-52. 2004
    ....
  3. pmc Protoporphyrin IX fluorescence photobleaching increases with the use of fractionated irradiation in the esophagus
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 13:034009. 2008
    ....
  4. ncbi request reprint Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cancer Res 63:1025-33. 2003
    ..4 +/- 1.4 days, and when PDT was given at the same time as radiation, the delay was 8.1 +/- 1.5 days. This observation indicates that the combined effect in the latter case was greater than additive (P = 0.049)...
  5. ncbi request reprint Fluorescence imaging in vivo: raster scanned point-source imaging provides more accurate quantification than broad beam geometries
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover NH 03755, USA
    Technol Cancer Res Treat 3:15-21. 2004
    ..Raster scanned imaging appears to provide a more uniform and accurate way to quantify fluorescence signals from distributed tissues in vivo...
  6. ncbi request reprint Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:755-63. 2002
    ..Increasing measurement noise causes a need to constrain the minimum regularization parameter to higher values in order to achieve a minimum in the overall image MSE...
  7. ncbi request reprint Tumor PO(2) changes during photodynamic therapy depend upon photosensitizer type and time after injection
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:177-84. 2002
    ....
  8. ncbi request reprint In vivo NADH fluorescence monitoring as an assay for cellular damage in photodynamic therapy
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 74:817-24. 2001
    ..This signal was monotonically correlated to the deposited dose used here and could provide a direct dosimetric measure of PDT-induced cellular death in the tissue being treated...
  9. ncbi request reprint Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Biomed Opt 6:397-403. 2001
    ..This imaging and data normalization procedure may be applied to cervical lesions of different grades, to determine if a quantitative estimate provides predictive value during the colposcopic diagnosis...
  10. ncbi request reprint Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin
    B W Pogue
    Thayer School of Engineering, 8000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 74:700-6. 2001
    ..The results suggest that hypoxic or poorly perfused vessels may be more susceptible to acute stasis than normoxic vessels in this treatment protocol...
  11. ncbi request reprint Calibration of near-infrared frequency-domain tissue spectroscopy for absolute absorption coefficient quantitation in neonatal head-simulating phantoms
    B W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Biomed Opt 5:185-93. 2000
    ....
  12. pmc Implementation of a computationally efficient least-squares algorithm for highly under-determined three-dimensional diffuse optical tomography problems
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:1682-97. 2008
    ..Use of these new alternative forms becomes effective when the ratio of the number of imaging property parameters exceeds the number of measurements by a factor greater than 2...
  13. ncbi request reprint Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
    ....
  14. pmc Noninvasive measurement of aminolevulinic acid-induced protoporphyrin IX fluorescence allowing detection of murine glioma in vivo
    Summer L Gibbs-Strauss
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 14:014007. 2009
    ..The red light bleaching is found to increase the ability to accurately quantify PpIX fluorescence in vivo, but decreases the specificity of detection between tumor-bearing and nontumor-bearing groups...
  15. ncbi request reprint Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part II--Experimental interpretation
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:764-72. 2002
    ..Precalibration of the algorithm through statistical evaluation of phantom studies may provide a better measure of the image accuracy than that implied by minimization of the standard objective function...
  16. ncbi request reprint Pretreatment photosensitizer dosimetry reduces variation in tumor response
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 64:1211-20. 2006
    ..Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency...
  17. ncbi request reprint Automated region detection based on the contrast-to-noise ratio in near-infrared tomography
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 43:1053-62. 2004
    ..4. A new linear convolution method of CNR calculation was developed for automated region of interest (ROI) detection...
  18. ncbi request reprint Spectral priors improve near-infrared diffuse tomography more than spatial priors
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 30:1968-70. 2005
    ..When both spatial and spectral priors were applied in a healthy volunteer, glandular tissue showed a higher [Hb(T)], water fraction, and scattering power compared to adipose tissue...
  19. pmc Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 100:12349-54. 2003
    ..These breast constituents vary significantly between individuals and can be altered because of changes in breast physiology or pathological state...
  20. ncbi request reprint The effects of internal refractive index variation in near-infrared optical tomography: a finite element modelling approach
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Phys Med Biol 48:2713-27. 2003
    ....
  21. ncbi request reprint Multispectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast
    Troy O McBride
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 7:72-9. 2002
    ....
  22. ncbi request reprint Estimation of subcellular particle size histograms with electron microscopy for prediction of optical scattering in breast tissue
    Matthew Bartek
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:064007. 2006
    ..The ability to image reduced scattering coefficient spectra of bulk breast tissues exists, and so this data provides insight into how bulk imaging may be mapped over to predict factors related to the tissue ultrastructure...
  23. ncbi request reprint Breast deformation modelling for image reconstruction in near infrared optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 49:1131-45. 2004
    ..Finally, assuming a non-deformed breast shape for image reconstruction is shown to lead to poor quality images since the geometry of the breast is greatly altered, whereas using the correct deformed geometry produces the best images...
  24. pmc Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data
    Jia Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 13:041305. 2008
    ..The system and algorithms developed here should provide an optimal way to quantify regions with the goal of image-guided breast tissue spectroscopy within the MRI...
  25. pmc Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine gliomas
    Summer L Gibbs-Strauss
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Acad Radiol 17:7-17. 2010
    ....
  26. pmc Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 35:82-4. 2010
    ..Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid...
  27. pmc Diagnostic detection of diffuse glioma tumors in vive with molecular fluorescent probe-based transmission spectroscopy
    Summer L Gibbs-Strauss
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755 8000, USA
    Med Phys 36:974-83. 2009
    ..Optical transmitted fluorescent signal may add significant benefit for clinical cases of diffuse infiltrative growth pattern glioma tumors given sufficient optimization of the signal acquisition for each patient...
  28. ncbi request reprint Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051704. 2005
    ....
  29. ncbi request reprint Receiver operating characteristic and location analysis of simulated near-infrared tomography images
    Xiaomei Song
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 12:054013. 2007
    ..Interobserver variance performance in detecting objects in these images was low, suggesting that because of the low spatial resolution, detection tasks with NIR tomography is likely consistent between human observers...
  30. ncbi request reprint Analysis of effective molecular diffusion rates for verteporfin in subcutaneous versus orthotopic Dunning prostate tumors
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 79:323-31. 2004
    ....
  31. ncbi request reprint Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy
    Bin Chen
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 61:1216-26. 2005
    ..The sequence of photosensitizer and light delivery can influence the effect of combined treatments...
  32. ncbi request reprint Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagus
    Chao Sheng
    Thayer School of Engineering, Dartmouth College, Harvard Medical School, Boston, MA, USA
    Photochem Photobiol 83:738-48. 2007
    ..This detection system and rodent model can be used for prospective dosimetry studies that focus on optimization of esophageal PDT...
  33. ncbi request reprint Image analysis methods for diffuse optical tomography
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:33001. 2006
    ..Each of these three major areas of image interpretation and analysis are reviewed in the context of medical imaging as well as how they are used to quantify the performance of diffuse optical imaging of tissue...
  34. pmc Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:8828-33. 2006
    ..Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images...
  35. ncbi request reprint Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the Dunning rat prostate tumor
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 82:1348-57. 2006
    ..This study presents a method to systematically analyze micro-heterogeneity as well as possible methods to increase delivery and homogeneity of photosensitizer within tumor tissue...
  36. ncbi request reprint Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications
    Bin Chen
    Department of Surgery, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Clin Cancer Res 12:917-23. 2006
    ..However, the mechanism involved in this event is still not clear, and the therapeutic implications associated with this pathophysiologic change have not been fully explored...
  37. ncbi request reprint Blood flow dynamics after photodynamic therapy with verteporfin in the RIF-1 tumor
    Bin Chen
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Radiat Res 160:452-9. 2003
    ..These results support the hypothesis that temporal pharmacokinetic changes in the distribution of the photosensitizer between the tumor parenchyma and blood vessels can significantly alter the tumor target of PDT...
  38. ncbi request reprint Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure
    Ben Brooksby
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051504. 2005
    ..This approach is expected to improve recovery of abnormalities within the breast, as the inclusion of structural information increases the accuracy of recovery of embedded heterogeneities, at least in phantom studies...
  39. ncbi request reprint Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors
    Chao Sheng
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Photochem Photobiol 79:520-5. 2004
    ..Finally, our research suggests that the tools or methods we are studying for quantifying PS levels and tissue damage are necessary for the understanding of PDT effect and therapeutic ratio in experimental in vivo tumor research...
  40. pmc Video-rate near infrared tomography to image pulsatile absorption properties in thick tissue
    Zhiqiu Li
    Thayer School of Engineering, Dartmouth College, Hanover NH 0375, USA
    Opt Express 17:12043-56. 2009
    ..The ability to image thick tissue and the capacity to image periodic changes in absorption makes this design well suited for tracking thick tissue hemodynamics in vivo during MR or CT imaging...
  41. pmc Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D262-72. 2009
    ..Specifically, fluorescence measurements are favorable if background drug concentrations are below 135-200 nM for LuTex and 25-50 nM for ICG, while absorption measurements are more sensitive above these ranges...
  42. pmc A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging
    Dax Kepshire
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Rev Sci Instrum 80:043701. 2009
    ..This multimodality imaging system will have a wide range of applications in preclinical cancer research ranging from studies of the tumor microenvironment and treatment efficacy for emerging cancer therapeutics...
  43. ncbi request reprint Comparisons of three alternative breast modalities in a common phantom imaging experiment
    Dun Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 30:2194-205. 2003
    ..Future work includes the minimization of bias (artifacts) on the periphery of electrical impedance spectroscopy images to improve cross modality correlation and implementation of the multimodality diagnosis for breast cancer detection...
  44. pmc Sensitivity of hemoglobin concentration on optical probe positioning in image-guided near infrared spectroscopy
    Subhadra Srinivasan
    Dartmouth College, Hanover, NH 03755 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:1994-6. 2009
    ..Image guidance is necessary for accurate positioning, and multi-plane acquisition can improve this accuracy...
  45. pmc Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Photochem Photobiol 86:471-5. 2010
    ..These results indicate that iron chelation therapy could significantly increase delta-ALA-induced PpIX fluorescence in malignant gliomas, pointing to a potential role of iron chelation therapy for more effective FGR of brain tumors...
  46. pmc Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Photochem Photobiol B 98:77-94. 2010
    ....
  47. pmc MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 17:271-6. 2010
    ..This report demonstrates the diagnostic potential of magnetic resonance imaging (MRI)-coupled fluorescence molecular tomography (FMT) to determine epidermal growth factor receptor (EGFR) status in brain cancer...
  48. pmc System development for high frequency ultrasound-guided fluorescence quantification of skin layers
    Josiah D Gruber
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:026028. 2010
    ..Pilot in-vivo data are also presented, showing recovery of subcutaneous tumor tissue values of protoporphyrin IX in a subcutaneous U251 tumor, which has less fluorescence than the skin...
  49. pmc Radiologic and near-infrared/optical spectroscopic imaging: where is the synergy?
    Brian W Pogue
    Dartmouth College, Hanover, New Hampshire 03755, USA
    AJR Am J Roentgenol 195:321-32. 2010
    ..Examples of clinical systems under research and development are shown...
  50. ncbi request reprint In vivo near-infrared spectral detection of pressure-induced changes in breast tissue
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 28:1212-4. 2003
    ..In addition, the technique provides a unique approach to measuring tissue elastic changes in vivo in the female breast and may offer a new method for dynamic contrast imaging based on elasto-optical measurements...
  51. pmc Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors
    Scott C Davis
    Dartmouth College, Thayer School of Engineering, HB 8000, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:051602. 2010
    ..Bulk fluorescence spectroscopy techniques performed as well as most imaging techniques, suggesting that complex imaging algorithms may be unnecessary to diagnose EGFR status in these tissue volumes...
  52. ncbi request reprint Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    Technol Cancer Res Treat 4:513-26. 2005
    ..These changes represent potential diagnostic indicators, which can be assessed to characterize breast tumors...
  53. pmc Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D130-6. 2009
    ..No statistically valid correlations were found between the applied pressure and the changes in tissue oxygen saturation (S(t)O(2)) or water percentage (H(2)O) across the range of BMI values studied...
  54. pmc Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy
    Venkataramanan Krishnaswamy
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 14:014004. 2009
    ....
  55. ncbi request reprint Video-rate near-infrared optical tomography using spectrally encoded parallel light delivery
    Daqing Piao
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 30:2593-5. 2005
    ..35 mm diameter inclusion with an absorption coefficient of 0.01 mm(-1) and a reduced scattering coefficient of 1.5 mm(-1) that is moving along a circular path inside a 1% Intralipid solution...
  56. ncbi request reprint Spectral derivative based image reconstruction provides inherent insensitivity to coupling and geometric errors
    Heng Xu
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 30:2912-4. 2005
    ....
  57. ncbi request reprint Multiepitope HER2 targeting enhances photoimmunotherapy of HER2-overexpressing cancer cells with pyropheophorbide-a immunoconjugates
    Mark D Savellano
    Surgical Research Laboratory, Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Res 65:6371-9. 2005
    ..Consequently, it seems that multitargeted photoimmunotherapy should also be useful against cancers that overexpress other receptors...
  58. ncbi request reprint Magnetic-resonance-imaging-coupled broadband near-infrared tomography system for small animal brain studies
    Heng Xu
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 44:2177-88. 2005
    ....
  59. ncbi request reprint Protoporphyrin IX level correlates with number of mitochondria, but increase in production correlates with tumor cell size
    Summer L Gibbs
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 82:1334-41. 2006
    ..The study indicates that use of L1 in tumors with a lower innate production of PpIX with ALA alone may be the most productive approach to this combined delivery...
  60. ncbi request reprint Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041102. 2006
    ..This review is an attempt to indicate which sets of phantoms are optimal for specific applications, and provide links to studies that characterize main phantom material properties and recipes...
  61. ncbi request reprint Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
    Subhadra Srinivasan
    Department of Biomedical Engineering, Thayer School of Engineering, Dartmouth College, P O Box 8000, Hanover, New Hampshire 03755, USA
    Appl Opt 44:1858-69. 2005
    ..Accurate quantification was obtained with a mean error of 7.7% for oxygen saturation and 6.2% for total hemoglobin, with minimal cross talk between different parameters...
  62. ncbi request reprint Effects of refractive index on near-infrared tomography of the breast
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755 8000, USA
    Appl Opt 44:1870-8. 2005
    ..The results suggest that provided the refractive index of breast tissue is approximately 1.3-1.4, their exclusion will have minimal effect on the reconstructed images...
  63. ncbi request reprint Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth
    Dax S Kepshire
    Thayer School of Engineering, Dartmouth College, New Hampshire 03755, USA
    Appl Opt 46:1669-78. 2007
    ..However, increases in tissue curvature and/or the addition of prior information are expected to improve the linearity of the response. The potential for this type of imaging technique to serve as a surgical guide is highlighted...
  64. ncbi request reprint Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 34:2085-98. 2007
    ....
  65. ncbi request reprint Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model
    Bin Chen
    Thayer School of Engineering, 80000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
    Clin Cancer Res 11:720-7. 2005
    ....
  66. ncbi request reprint Absorption and scattering imaging of tissue with steady-state second-differential spectral-analysis tomography
    Heng Xu
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 29:2043-5. 2004
    ..The steady-state broadband CCD system has the potential to provide accurate chromophore imaging without the technological complexity of time- or frequency-domain systems...
  67. pmc Automated classification of breast pathology using local measures of broadband reflectance
    Ashley M Laughney
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 15:066019. 2010
    ..The increased sensitivity of this technique may render it useful to guide the surgeon or pathologist where to sample pathology for microscopic assessment...

Research Grants2

  1. Micro CT/NIR Molecular Imaging of Cancer
    Brian Pogue; Fiscal Year: 2007
    ....
  2. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..