Brian W Pogue

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Image analysis methods for diffuse optical tomography
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:33001. 2006
  2. ncbi Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
  3. ncbi In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 13:195-202. 2006
  4. ncbi Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
    Subhadra Srinivasan
    Department of Biomedical Engineering, Thayer School of Engineering, Dartmouth College, P O Box 8000, Hanover, New Hampshire 03755, USA
    Appl Opt 44:1858-69. 2005
  5. pmc MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 17:271-6. 2010
  6. ncbi Spectral priors improve near-infrared diffuse tomography more than spatial priors
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 30:1968-70. 2005
  7. ncbi Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 9:541-52. 2004
  8. pmc Implementation of a computationally efficient least-squares algorithm for highly under-determined three-dimensional diffuse optical tomography problems
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:1682-97. 2008
  9. pmc Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:76011. 2013
  10. pmc Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy
    Venkataramanan Krishnaswamy
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 14:014004. 2009

Collaborators

Detail Information

Publications96

  1. ncbi Image analysis methods for diffuse optical tomography
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:33001. 2006
    ..Each of these three major areas of image interpretation and analysis are reviewed in the context of medical imaging as well as how they are used to quantify the performance of diffuse optical imaging of tissue...
  2. ncbi Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
    ....
  3. ncbi In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 13:195-202. 2006
    ....
  4. ncbi Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
    Subhadra Srinivasan
    Department of Biomedical Engineering, Thayer School of Engineering, Dartmouth College, P O Box 8000, Hanover, New Hampshire 03755, USA
    Appl Opt 44:1858-69. 2005
    ..Accurate quantification was obtained with a mean error of 7.7% for oxygen saturation and 6.2% for total hemoglobin, with minimal cross talk between different parameters...
  5. pmc MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 17:271-6. 2010
    ..This report demonstrates the diagnostic potential of magnetic resonance imaging (MRI)-coupled fluorescence molecular tomography (FMT) to determine epidermal growth factor receptor (EGFR) status in brain cancer...
  6. ncbi Spectral priors improve near-infrared diffuse tomography more than spatial priors
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 30:1968-70. 2005
    ..When both spatial and spectral priors were applied in a healthy volunteer, glandular tissue showed a higher [Hb(T)], water fraction, and scattering power compared to adipose tissue...
  7. ncbi Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 9:541-52. 2004
    ....
  8. pmc Implementation of a computationally efficient least-squares algorithm for highly under-determined three-dimensional diffuse optical tomography problems
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:1682-97. 2008
    ..Use of these new alternative forms becomes effective when the ratio of the number of imaging property parameters exceeds the number of measurements by a factor greater than 2...
  9. pmc Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:76011. 2013
    ....
  10. pmc Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy
    Venkataramanan Krishnaswamy
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 14:014004. 2009
    ....
  11. pmc Noninvasive measurement of aminolevulinic acid-induced protoporphyrin IX fluorescence allowing detection of murine glioma in vivo
    Summer L Gibbs-Strauss
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 14:014007. 2009
    ..The red light bleaching is found to increase the ability to accurately quantify PpIX fluorescence in vivo, but decreases the specificity of detection between tumor-bearing and nontumor-bearing groups...
  12. ncbi A boundary element approach for image-guided near-infrared absorption and scatter estimation
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 34:4545-57. 2007
    ..With simpler and faster meshing schemes required for surface grids as compared with volume grids, BEM offers a powerful and potentially more feasible alternative for high-resolution 3D image-guided NIR spectroscopy...
  13. pmc Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:8828-33. 2006
    ..Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images...
  14. ncbi Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure
    Ben Brooksby
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051504. 2005
    ..This approach is expected to improve recovery of abnormalities within the breast, as the inclusion of structural information increases the accuracy of recovery of embedded heterogeneities, at least in phantom studies...
  15. pmc Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data
    Jia Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 13:041305. 2008
    ..The system and algorithms developed here should provide an optimal way to quantify regions with the goal of image-guided breast tissue spectroscopy within the MRI...
  16. ncbi Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part II--Experimental interpretation
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:764-72. 2002
    ..Precalibration of the algorithm through statistical evaluation of phantom studies may provide a better measure of the image accuracy than that implied by minimization of the standard objective function...
  17. ncbi Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051704. 2005
    ....
  18. ncbi Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    Technol Cancer Res Treat 4:513-26. 2005
    ..These changes represent potential diagnostic indicators, which can be assessed to characterize breast tumors...
  19. pmc MR water quantitative priors improves the accuracy of optical breast imaging
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 30:159-68. 2011
    ..In addition, it is shown that these techniques can improve the ability of MRI to quantify water in the presence of bias in the Dixon water/fat separation...
  20. ncbi Breast deformation modelling for image reconstruction in near infrared optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 49:1131-45. 2004
    ..Finally, assuming a non-deformed breast shape for image reconstruction is shown to lead to poor quality images since the geometry of the breast is greatly altered, whereas using the correct deformed geometry produces the best images...
  21. pmc Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 100:12349-54. 2003
    ..These breast constituents vary significantly between individuals and can be altered because of changes in breast physiology or pathological state...
  22. pmc Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 15:061703. 2010
    ..The method provides potentially complementary information to DCE-MRI for tumor characterization...
  23. pmc Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy
    Kimberley S Samkoe
    Geisel School of Medicine at Dartmouth College, Department of Surgery, Lebanon, New Hampshire 03756bDartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755
    J Biomed Opt 18:120504. 2013
    ..The use of contrast-enhanced MR imaging shows promise as a method for treatment planning and photosensitizer dosimetry in human photodynamic therapy (PDT) of pancreas cancer...
  24. pmc Projection imaging of photon beams by the Čerenkov effect
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Med Phys 40:012101. 2013
    ..A novel technique for beam profiling of megavoltage photon beams was investigated for the first time by capturing images of the induced Čerenkov emission in water, as a potential surrogate for the imparted dose in irradiated media...
  25. pmc Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment
    Ashley M Laughney
    Thayer School of Engineering, Dartmouth College Hanover, Lebanon, New Hampshire, USA
    Clin Cancer Res 18:6315-25. 2012
    ....
  26. pmc High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas
    Kimberley S Samkoe
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Mol Imaging Biol 14:472-9. 2012
    ..Here, the in vivo delivery and binding kinetics of epidermal growth factor receptor (EGFR) was determined for normal pancreas and AsPC-1 orthotopic pancreatic tumors known to overexpress EGFR...
  27. ncbi Receiver operating characteristic and location analysis of simulated near-infrared tomography images
    Xiaomei Song
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 12:054013. 2007
    ..Interobserver variance performance in detecting objects in these images was low, suggesting that because of the low spatial resolution, detection tasks with NIR tomography is likely consistent between human observers...
  28. ncbi Magnetic-resonance-imaging-coupled broadband near-infrared tomography system for small animal brain studies
    Heng Xu
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 44:2177-88. 2005
    ....
  29. pmc Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models
    Kimberley S Samkoe
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 76:251-9. 2010
    ....
  30. ncbi Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model
    Bin Chen
    Thayer School of Engineering, 80000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
    Clin Cancer Res 11:720-7. 2005
    ....
  31. ncbi Improved quantification of small objects in near-infrared diffuse optical tomography
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 9:1161-71. 2004
    ..The algorithm is successfully applied to clinical data from a subject with a breast abnormality to yield quantitatively increased absorption coefficients, which enhances the contrast to 3.8 compared to 1.23 previously...
  32. pmc Diagnostic detection of diffuse glioma tumors in vive with molecular fluorescent probe-based transmission spectroscopy
    Summer L Gibbs-Strauss
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755 8000, USA
    Med Phys 36:974-83. 2009
    ..Optical transmitted fluorescent signal may add significant benefit for clinical cases of diffuse infiltrative growth pattern glioma tumors given sufficient optimization of the signal acquisition for each patient...
  33. ncbi Automated region detection based on the contrast-to-noise ratio in near-infrared tomography
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 43:1053-62. 2004
    ..4. A new linear convolution method of CNR calculation was developed for automated region of interest (ROI) detection...
  34. pmc A digital x-ray tomosynthesis coupled near infrared spectral tomography system for dual-modality breast imaging
    Venkataramanan Krishnaswamy
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Opt Express 20:19125-36. 2012
    ..The quantitative accuracy of the system can be further improved with independent measurements of scattering properties through integration of frequency or time domain data...
  35. ncbi Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth
    Dax S Kepshire
    Thayer School of Engineering, Dartmouth College, New Hampshire 03755, USA
    Appl Opt 46:1669-78. 2007
    ..However, increases in tissue curvature and/or the addition of prior information are expected to improve the linearity of the response. The potential for this type of imaging technique to serve as a surgical guide is highlighted...
  36. pmc Broadband frequency-domain near-infrared spectral tomography using a mode-locked Ti:sapphire laser
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D198-207. 2009
    ..Simulations and tissue phantom experiments were used to quantify this improvement in image accuracy for recovery of tissue hemoglobin and oxygen saturation...
  37. pmc Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D262-72. 2009
    ..Specifically, fluorescence measurements are favorable if background drug concentrations are below 135-200 nM for LuTex and 25-50 nM for ICG, while absorption measurements are more sensitive above these ranges...
  38. ncbi Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 32:933-5. 2007
    ..Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography...
  39. pmc Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors
    Scott C Davis
    Dartmouth College, Thayer School of Engineering, HB 8000, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:051602. 2010
    ..Bulk fluorescence spectroscopy techniques performed as well as most imaging techniques, suggesting that complex imaging algorithms may be unnecessary to diagnose EGFR status in these tissue volumes...
  40. ncbi Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1143-56. 2007
    ..The MRI-guided NIR images of oxygen saturation provide higher resolution and superior SNR and will likely be used in the future to study and characterize specific tissue volumes...
  41. ncbi Protoporphyrin IX level correlates with number of mitochondria, but increase in production correlates with tumor cell size
    Summer L Gibbs
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 82:1334-41. 2006
    ..The study indicates that use of L1 in tumors with a lower innate production of PpIX with ALA alone may be the most productive approach to this combined delivery...
  42. pmc Video-rate near infrared tomography to image pulsatile absorption properties in thick tissue
    Zhiqiu Li
    Thayer School of Engineering, Dartmouth College, Hanover NH 0375, USA
    Opt Express 17:12043-56. 2009
    ..The ability to image thick tissue and the capacity to image periodic changes in absorption makes this design well suited for tracking thick tissue hemodynamics in vivo during MR or CT imaging...
  43. pmc Pulsed-light imaging for fluorescence guided surgery under normal room lighting
    Kristian Sexton
    Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 38:3249-52. 2013
    ..Resection of orthotopic brain tumors in mice also suggests that the pulsed-light system provides superior sensitivity in vivo...
  44. pmc Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 110:9025-30. 2013
    ..3 ± 0.5 nM (n = 5), consistent with values estimated in comparative invasive imaging and ex vivo studies...
  45. pmc Dual-tracer background subtraction approach for fluorescent molecular tomography
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:16003. 2013
    ..The approach is demonstrated in simulations, a phantom study, and in a mouse glioma imaging study, demonstrating substantial improvement over conventional and homogenous background subtraction image reconstruction approaches...
  46. ncbi Video-rate near-infrared optical tomography using spectrally encoded parallel light delivery
    Daqing Piao
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 30:2593-5. 2005
    ..35 mm diameter inclusion with an absorption coefficient of 0.01 mm(-1) and a reduced scattering coefficient of 1.5 mm(-1) that is moving along a circular path inside a 1% Intralipid solution...
  47. ncbi Absorption and scattering imaging of tissue with steady-state second-differential spectral-analysis tomography
    Heng Xu
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 29:2043-5. 2004
    ..The steady-state broadband CCD system has the potential to provide accurate chromophore imaging without the technological complexity of time- or frequency-domain systems...
  48. ncbi The effects of internal refractive index variation in near-infrared optical tomography: a finite element modelling approach
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Phys Med Biol 48:2713-27. 2003
    ....
  49. pmc Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Photochem Photobiol 86:471-5. 2010
    ..These results indicate that iron chelation therapy could significantly increase delta-ALA-induced PpIX fluorescence in malignant gliomas, pointing to a potential role of iron chelation therapy for more effective FGR of brain tumors...
  50. ncbi Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy
    Bin Chen
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 61:1216-26. 2005
    ..The sequence of photosensitizer and light delivery can influence the effect of combined treatments...
  51. ncbi Effects of refractive index on near-infrared tomography of the breast
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755 8000, USA
    Appl Opt 44:1870-8. 2005
    ..The results suggest that provided the refractive index of breast tissue is approximately 1.3-1.4, their exclusion will have minimal effect on the reconstructed images...
  52. ncbi Analysis of sampling volume and tissue heterogeneity on the in vivo detection of fluorescence
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:41206. 2005
    ..In summary, sampling fiber size affects the fluorescence intensities detected and use of multiple region microscopic sampling could provide better information about the distribution of values that occur...
  53. pmc Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 35:82-4. 2010
    ..Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid...
  54. ncbi Pretreatment photosensitizer dosimetry reduces variation in tumor response
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 64:1211-20. 2006
    ..Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency...
  55. pmc Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?
    Marius G Pakalniskis
    Department of Pathology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiology 259:365-74. 2011
    ..To investigate if changes in tumor angiogenesis associated with complete pathologic response (pCR) or partial pathologic response (pPR) to treatment can be demonstrated by using diffuse optical spectroscopic (DOS) tomography...
  56. pmc System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues
    Ashley M Laughney
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:036012. 2013
    ..SFDI could potentially reduce the high secondary excision rate associated with breast conserving surgery; its clinical translation further requires reduced image reconstruction time and smart inking strategies...
  57. ncbi Blood flow dynamics after photodynamic therapy with verteporfin in the RIF-1 tumor
    Bin Chen
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Radiat Res 160:452-9. 2003
    ..These results support the hypothesis that temporal pharmacokinetic changes in the distribution of the photosensitizer between the tumor parenchyma and blood vessels can significantly alter the tumor target of PDT...
  58. pmc Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation
    Rongxiao Zhang
    Dartmouth College, Department of Physics and Astronomy, Hanover, NH 03755, USA
    J Biomed Opt 18:50503. 2013
    ..Translating this approach to the clinic could facilitate direct sensing of pO(2) during radiotherapy...
  59. pmc Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure
    Sason Torosean
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire, USA
    Nanomedicine 9:151-8. 2013
    ..Imaging of these parameters in vivo can lead to better individual noninvasive methods to assess drug penetration in situ...
  60. pmc In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging
    Kenneth M Tichauer
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Mol Imaging Biol 14:584-92. 2012
    ..A dual-reporter methodology capable of quantifying available receptor binding potential of tumors in vivo within a clinically relevant time scale is presented...
  61. pmc Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 37:1193-5. 2012
    ..This observation has the potential to significantly increase the value of Cherenkov emission spectroscopy during radiation therapy to monitor tissue molecular events...
  62. pmc Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breast
    Zhiqiu Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 35:3964-6. 2010
    ..A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue...
  63. pmc Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Philos Trans A Math Phys Eng Sci 369:4531-57. 2011
    ..Most beneficial inclusion of prior information has been in the inversion/reconstruction process, because it solves the mathematical intractability. However, it is not clear that this is always the most beneficial stage...
  64. ncbi Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the Dunning rat prostate tumor
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 82:1348-57. 2006
    ..This study presents a method to systematically analyze micro-heterogeneity as well as possible methods to increase delivery and homogeneity of photosensitizer within tumor tissue...
  65. pmc In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 37:3715-24. 2010
    ..A NIR tomography system that combines frequency domain (FD) and continuous wave (CW) measurements was used to image normal and malignant breast tissues...
  66. ncbi Peptide-induced inflammatory increase in vascular permeability improves photosensitizer delivery and intersubject photodynamic treatment efficacy
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Radiat Res 168:299-307. 2007
    ..There was also a significant reduction in the interindividual variability in with substance P plus PDT from 64% to 13%. The resulting treatment was therefore more effective and there was less variability in dose between subjects...
  67. ncbi Estimation of subcellular particle size histograms with electron microscopy for prediction of optical scattering in breast tissue
    Matthew Bartek
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:064007. 2006
    ..The ability to image reduced scattering coefficient spectra of bulk breast tissues exists, and so this data provides insight into how bulk imaging may be mapped over to predict factors related to the tissue ultrastructure...
  68. pmc Sensitivity of hemoglobin concentration on optical probe positioning in image-guided near infrared spectroscopy
    Subhadra Srinivasan
    Dartmouth College, Hanover, NH 03755 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:1994-6. 2009
    ..Image guidance is necessary for accurate positioning, and multi-plane acquisition can improve this accuracy...
  69. pmc Fluorescence tomography characterization for sub-surface imaging with protoporphyrin IX
    Dax Kepshire
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Opt Express 16:8581-93. 2008
    ....
  70. pmc Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Radiology 252:551-60. 2009
    ....
  71. pmc Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D130-6. 2009
    ..No statistically valid correlations were found between the applied pressure and the changes in tissue oxygen saturation (S(t)O(2)) or water percentage (H(2)O) across the range of BMI values studied...
  72. pmc Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Rev Sci Instrum 79:064302. 2008
    ..A pilot murine study using an orthotopic glioma tumor model demonstrates optical-MRI imaging of an epidermal growth factor receptor targeted fluorescent probe in vivo...
  73. pmc Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced magnetic resonance image contrast but has higher diagnostic accuracy
    Kimberley S Samkoe
    Dartmouth College, Thayer School of Engineering, Hanover New Hampshire 03755, USA
    J Biomed Opt 16:096008. 2011
    ..This study indicates that gadolinium contrast enhanced MR images can predict the presence of diffuse tumors, but PpIX fluorescence is a better predictor regardless of tumor vascularity...
  74. ncbi Comparisons of three alternative breast modalities in a common phantom imaging experiment
    Dun Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 30:2194-205. 2003
    ..Future work includes the minimization of bias (artifacts) on the periphery of electrical impedance spectroscopy images to improve cross modality correlation and implementation of the multimodality diagnosis for breast cancer detection...
  75. ncbi Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagus
    Chao Sheng
    Thayer School of Engineering, Dartmouth College, Harvard Medical School, Boston, MA, USA
    Photochem Photobiol 83:738-48. 2007
    ..This detection system and rodent model can be used for prospective dosimetry studies that focus on optimization of esophageal PDT...
  76. pmc A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging
    Dax Kepshire
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Rev Sci Instrum 80:043701. 2009
    ..This multimodality imaging system will have a wide range of applications in preclinical cancer research ranging from studies of the tumor microenvironment and treatment efficacy for emerging cancer therapeutics...
  77. ncbi Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041102. 2006
    ..This review is an attempt to indicate which sets of phantoms are optimal for specific applications, and provide links to studies that characterize main phantom material properties and recipes...
  78. ncbi Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 34:2085-98. 2007
    ....
  79. ncbi Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 8:308-15. 2003
    ....
  80. ncbi Spectral derivative based image reconstruction provides inherent insensitivity to coupling and geometric errors
    Heng Xu
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 30:2912-4. 2005
    ....
  81. pmc Automatic exposure control and estimation of effective system noise in diffuse fluorescence tomography
    Dax L Kepshire
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Opt Express 17:23272-83. 2009
    ..This fluorophore has very low fluorescence yield, but high biological relevance for tumor imaging, given that it is produced in the mitochondria, and upregulated in many tumor types...
  82. ncbi Computationally efficient methods for incorporation of spectral priors in 3-d optical tomography
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ....
  83. pmc Image-guided Raman spectroscopic recovery of canine cortical bone contrast in situ
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    Opt Express 16:12190-200. 2008
    ..Considerably less contrast was found without the CT image to guide recovery. This study presents the first known IG-RS results from tissue and indicates that intrinsically high contrasts (on the order of a hundred fold) are available...
  84. ncbi Spectrally resolved bioluminescence optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 31:365-7. 2006
    ..The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity...
  85. pmc Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College Hanover, NH 03755, USA
    Opt Express 16:17903-14. 2008
    ..These concepts are demonstrated with 3D data sets using Volview software online...
  86. ncbi Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 42:135-45. 2003
    ....
  87. ncbi Three-dimensional optical tomography: resolution in small-object imaging
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 42:3117-28. 2003
    ..Furthermore, the accuracy of quantitative imaging is increased to almost 100% of the target values when a priori information regarding the internal structure of imaging domain is utilized...
  88. ncbi Strategies for absolute calibration of near infrared tomographic tissue imaging
    Troy O McBride
    Thayer School of Engineering, 8000 Cummings Hall, Dartmouth College, Hanover, New Hampshire 03755, USA
    Adv Exp Med Biol 530:85-99. 2003
    ..They have allowed demonstration of a prototype imaging system that has the ability to quantitatively reconstruct heterogeneous images of hemoglobin concentrations within a highly scattering medium with no a priori information...
  89. ncbi Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:755-63. 2002
    ..Increasing measurement noise causes a need to constrain the minimum regularization parameter to higher values in order to achieve a minimum in the overall image MSE...
  90. pmc Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover New Hampshire 03755, USA
    J Opt Soc Am A Opt Image Sci Vis 26:1444-57. 2009
    ..5 to 2.5 mm) separated by less than 1.5 mm...
  91. ncbi Analysis of effective molecular diffusion rates for verteporfin in subcutaneous versus orthotopic Dunning prostate tumors
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Photochem Photobiol 79:323-31. 2004
    ....
  92. ncbi Contrast-detail analysis characterizing diffuse optical fluorescence tomography image reconstruction
    Scott C Davis
    J Biomed Opt 10:050501. 2005
    ..Contrast-detail analysis using human detection of lower contrast limits provides fundamentally important information about the performance of reconstruction algorithms, and can be used to compare imaging performance of different systems...
  93. pmc Noninvasive Raman tomographic imaging of canine bone tissue
    Matthew V Schulmerich
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109 1055, USA
    J Biomed Opt 13:020506. 2008
    ..Diffuse emission tomography reconstruction was used, and the location that was recovered has been confirmed by micro-computed tomography (micro-CT) images...
  94. pmc Assessing the future of diffuse optical imaging technologies for breast cancer management
    Bruce J Tromberg
    Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, USA
    Med Phys 35:2443-51. 2008
    ....
  95. ncbi Rapid near-infrared diffuse tomography for hemodynamic imaging using a low-coherence wideband light source
    Daqing Piao
    Oklahoma State University, School of Electrical and Computer Engineering, Stillwater, Oklahoma 74078 5032, USA
    J Biomed Opt 12:014016. 2007
    ....
  96. ncbi Endoscopic, rapid near-infrared optical tomography
    Daqing Piao
    School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma, USA
    Opt Lett 31:2876-8. 2006
    ..This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation...