Patricia A Pioli

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages
    Amy J Murphy
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 4:e5539. 2009
  2. ncbi request reprint TGF-beta regulation of human macrophage scavenger receptor CD163 is Smad3-dependent
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Leukoc Biol 76:500-8. 2004
  3. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004
  4. ncbi request reprint Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 176:6647-55. 2006
  5. pmc Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin
    Mark P Yeager
    Department of Anesthesiology and Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Crit Care Med 37:2727-32. 2009
  6. ncbi request reprint Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors
    Lehn K Weaver
    Department of Microbiology and Immunology, Dartmouth Medical School, HB7700, Lebanon, NH 03756, USA
    J Leukoc Biol 81:663-71. 2007
  7. pmc A subset of human uterine endometrial macrophages is alternatively activated
    Amy L Jensen
    Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Am J Reprod Immunol 68:374-86. 2012
  8. ncbi request reprint IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:6509-16. 2005
  9. ncbi request reprint Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production by human peripheral blood monocytes
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 179:6284-90. 2007
  10. ncbi request reprint Pivotal advance: activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163
    Lehn K Weaver
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 80:26-35. 2006

Collaborators

Detail Information

Publications21

  1. pmc Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages
    Amy J Murphy
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 4:e5539. 2009
    ..However, relatively little is known about the ability of E2 to regulate isoform expression of estrogen receptors (ERs) in these cells...
  2. ncbi request reprint TGF-beta regulation of human macrophage scavenger receptor CD163 is Smad3-dependent
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Leukoc Biol 76:500-8. 2004
    ..This promoter was inhibited by TGF-beta, and suppression was dependent on Smad3 expression. These results define a novel function for TGF-beta and implicate an important role for CD163 in the host response to inflammation...
  3. pmc Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 72:5799-806. 2004
    ..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
  4. ncbi request reprint Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 176:6647-55. 2006
    ..These data indicate dynamic immunologic interaction between uterine macrophages and epithelial cells and implicate a role for estradiol in the modulation of the immune response...
  5. pmc Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin
    Mark P Yeager
    Department of Anesthesiology and Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Crit Care Med 37:2727-32. 2009
    ....
  6. ncbi request reprint Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors
    Lehn K Weaver
    Department of Microbiology and Immunology, Dartmouth Medical School, HB7700, Lebanon, NH 03756, USA
    J Leukoc Biol 81:663-71. 2007
    ..Thus, surface CD163 expression on mononuclear phagocytes is a carefully regulated component of the innate immune response to infection...
  7. pmc A subset of human uterine endometrial macrophages is alternatively activated
    Amy L Jensen
    Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Am J Reprod Immunol 68:374-86. 2012
    ..Although macrophages comprise a significant portion of leukocytes within the uterine endometrium, the activation profile and functional response of these cells to endotoxin are unknown...
  8. ncbi request reprint IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:6509-16. 2005
    ....
  9. ncbi request reprint Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production by human peripheral blood monocytes
    Patricia A Pioli
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 179:6284-90. 2007
    ..These results implicate a role for estradiol in the modulation of the immune response, and may lead to an enhanced understanding of gender-based differences in inflammatory control mechanisms...
  10. ncbi request reprint Pivotal advance: activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163
    Lehn K Weaver
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 80:26-35. 2006
    ..These data demonstrate that the soluble HbSR is released from monocytic cells in response to TLR signaling as an acute innate immune response to extracellular pathogen infections...
  11. pmc Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs
    Satarupa Basu
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 61:52-61. 2009
    ..In the human endometrium, uterine natural killer (uNK) cells and uterine macrophages are present in significant numbers and in close proximity, yet how they cooperatively respond to infectious challenge is poorly understood...
  12. pmc Functional expression of pattern recognition receptors in tissues of the human female reproductive tract
    Kevin M Hart
    Department of Immunology and Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Reprod Immunol 80:33-40. 2009
    ..Results of these studies indicate that PRRs are functionally expressed in FRT tissues, and suggest that these receptors mediate microbial recognition and immune defense in the reproductive tract...
  13. ncbi request reprint Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163
    Timothy H Sulahian
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    J Leukoc Biol 76:271-7. 2004
    ..This may be particularly important in disease states in which immune complexes and high levels of free Hb are present, such as in autoimmune hemolytic anemia, transfusion reactions, or infections by hemolytic bacteria...
  14. pmc Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages
    Amy J Murphy
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 184:5029-37. 2010
    ..These findings are significant in that they are the first to demonstrate that estradiol represses NF-kappaB activation through the induction of kappaB-Ras2, a key inhibitor of NF-kappaB signaling...
  15. pmc In vivo exposure to high or low cortisol has biphasic effects on inflammatory response pathways of human monocytes
    Mark P Yeager
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Anesth Analg 107:1726-34. 2008
    ..Since some GC effects on inflammation are stimulatory, we hypothesized that acute in vivo GC depletion would decrease inflammatory responses of human monocytes...
  16. ncbi request reprint Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163
    Katharine A Hintz
    Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire, USA
    J Leukoc Biol 72:711-7. 2002
    ..As hemoglobin can bind LPS and enhance its toxicity, it will be important to determine how cell surface and soluble CD163 influence inflammatory processes during sepsis...
  17. pmc PILAR is a novel modulator of human T-cell expansion
    Eduardo Huarte
    Department ofMicrobiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA
    Blood 112:1259-68. 2008
    ..Our results indicate that PILAR plays a central role in modulating the extent of T-cell expansion. Manipulation of PILAR signaling may be important for treatment of autoimmune diseases and cancer...
  18. pmc Estradiol regulates MICA expression in human endometrial cells
    Satarupa Basu
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Clin Immunol 129:325-32. 2008
    ..Thus, estrogens regulate expression of MICA. These data suggest hormonal regulation of innate immunity and NKG2D-mediated recognition in other tissues and diseases where estrogen may be involved...
  19. pmc The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer
    Kim Tran
    Department of Pharmacology or Medicine, Dartmouth Medical School, Hanover, NH 03755, USA
    Carcinogenesis 34:199-210. 2013
    ..These studies suggest that both SAHA and triterpenoids effectively delay tumorigenesis, thereby demonstrating a promising, novel drug combination for chemoprevention...
  20. ncbi request reprint Innate and adaptive immunity in female genital tract: cellular responses and interactions
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunol Rev 206:306-35. 2005
    ..By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health...
  21. ncbi request reprint Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1
    Patricia A Pioli
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 277:35738-45. 2002
    ..The interaction between LDH and AUF1 is direct as it can be demonstrated in vitro with purified proteins. Collectively these data implicate a role for LDH in the post-transcriptional regulation of gene expression...