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Genomes and Genes | Patricia A PioliSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
TGF-beta regulation of human macrophage scavenger receptor CD163 is Smad3-dependentPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Leukoc Biol 76:500-8. 2004..This promoter was inhibited by TGF-beta, and suppression was dependent on Smad3 expression. These results define a novel function for TGF-beta and implicate an important role for CD163 in the host response to inflammation...
Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tractPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 72:5799-806. 2004..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...- Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2Patricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 176:6647-55. 2006..These data indicate dynamic immunologic interaction between uterine macrophages and epithelial cells and implicate a role for estradiol in the modulation of the immune response... - Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxinMark P Yeager
Department of Anesthesiology and Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Crit Care Med 37:2727-32. 2009.... - Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptorsLehn K Weaver
Department of Microbiology and Immunology, Dartmouth Medical School, HB7700, Lebanon, NH 03756, USA
J Leukoc Biol 81:663-71. 2007..Thus, surface CD163 expression on mononuclear phagocytes is a carefully regulated component of the innate immune response to infection... - Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production by human peripheral blood monocytesPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 179:6284-90. 2007..These results implicate a role for estradiol in the modulation of the immune response, and may lead to an enhanced understanding of gender-based differences in inflammatory control mechanisms... - IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cellsTodd M Schaefer
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 175:6509-16. 2005.... - Functional expression of pattern recognition receptors in tissues of the human female reproductive tractKevin M Hart
Department of Immunology and Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Reprod Immunol 80:33-40. 2009..Results of these studies indicate that PRRs are functionally expressed in FRT tissues, and suggest that these receptors mediate microbial recognition and immune defense in the reproductive tract... - Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPsSatarupa Basu
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 61:52-61. 2009..In the human endometrium, uterine natural killer (uNK) cells and uterine macrophages are present in significant numbers and in close proximity, yet how they cooperatively respond to infectious challenge is poorly understood... - Pivotal advance: activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163Lehn K Weaver
Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
J Leukoc Biol 80:26-35. 2006..These data demonstrate that the soluble HbSR is released from monocytic cells in response to TLR signaling as an acute innate immune response to extracellular pathogen infections... - Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophagesAmy J Murphy
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
PLoS ONE 4:e5539. 2009..However, relatively little is known about the ability of E2 to regulate isoform expression of estrogen receptors (ERs) in these cells... - Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophagesAmy J Murphy
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 184:5029-37. 2010..These findings are significant in that they are the first to demonstrate that estradiol represses NF-kappaB activation through the induction of kappaB-Ras2, a key inhibitor of NF-kappaB signaling... - In vivo exposure to high or low cortisol has biphasic effects on inflammatory response pathways of human monocytesMark P Yeager
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA
Anesth Analg 107:1726-34. 2008..Since some GC effects on inflammation are stimulatory, we hypothesized that acute in vivo GC depletion would decrease inflammatory responses of human monocytes... - Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163Katharine A Hintz
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire, USA
J Leukoc Biol 72:711-7. 2002..As hemoglobin can bind LPS and enhance its toxicity, it will be important to determine how cell surface and soluble CD163 influence inflammatory processes during sepsis... - Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163Timothy H Sulahian
Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
J Leukoc Biol 76:271-7. 2004..This may be particularly important in disease states in which immune complexes and high levels of free Hb are present, such as in autoimmune hemolytic anemia, transfusion reactions, or infections by hemolytic bacteria... - PILAR is a novel modulator of human T-cell expansionEduardo Huarte
Department ofMicrobiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA
Blood 112:1259-68. 2008..Our results indicate that PILAR plays a central role in modulating the extent of T-cell expansion. Manipulation of PILAR signaling may be important for treatment of autoimmune diseases and cancer... - Estradiol regulates MICA expression in human endometrial cellsSatarupa Basu
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Clin Immunol 129:325-32. 2008..Thus, estrogens regulate expression of MICA. These data suggest hormonal regulation of innate immunity and NKG2D-mediated recognition in other tissues and diseases where estrogen may be involved... - A subset of human uterine endometrial macrophages is alternatively activatedAmy L Jensen
Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Am J Reprod Immunol 68:374-86. 2012..Although macrophages comprise a significant portion of leukocytes within the uterine endometrium, the activation profile and functional response of these cells to endotoxin are unknown... - Innate and adaptive immunity in female genital tract: cellular responses and interactionsCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Immunol Rev 206:306-35. 2005..By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health... - Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1Patricia A Pioli
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Biol Chem 277:35738-45. 2002..The interaction between LDH and AUF1 is direct as it can be demonstrated in vitro with purified proteins. Collectively these data implicate a role for LDH in the post-transcriptional regulation of gene expression...