Research Topics
Species | WILLIAM NORTHSummaryAffiliation: Dartmouth Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
Targeting the neurophysin-related cell surface antigen on small cell lung cancer cells using a monoclonal antibody against the glycopeptide region (MAG-1) of provasopressinBrendan P Keegan
Departments of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Mol Cancer Ther 1:1153-9. 2002..This is the first study to demonstrate that a mAb directed to the VAG region of the pro-VP protein has the potential for development into an in vivo diagnostic and therapeutic tool that targets plasma membrane-incorporated NRSA...- Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinomaW G North
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Peptides 18:985-93. 1997.... 
Breast cancer expresses functional NMDA receptorsWilliam G North
Dartmouth Medical School, Lebanon, NH 03756, USA
Breast Cancer Res Treat 122:307-14. 2010..All of these data point to active NMDAR receptors being expressed by most breast cancers, and having an important influence on their survival...- Immunohistochemical detection of NRSA on small cell lung cancer with a monoclonal antibody (MAG-1) that recognizes the carboxyl terminus of provasopressinWilliam G North
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03755, USA
Appl Immunohistochem Mol Morphol 13:363-6. 2005.... - Native MAG-1 antibody almost destroys human breast cancer xenograftsWilliam G North
Departments of Physiology and Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
Breast Cancer Res Treat 127:631-7. 2011..Pathological examination of such tumors revealed they had undergone very extensive (>66%) necrosis... - Gene regulation of vasopressin and vasopressin receptors in cancerW G North
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
Exp Physiol 85:27S-40S. 2000..By extrapolation, similar mechanisms might also be responsible for the expression of additional features that characterize the 'neuroendocrine' profile of these cancers... - MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2RW G North
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Peptides 20:837-42. 1999..Western analysis revealed that all three normal mRNAs gave rise to proteins of sizes compatible with them being functional receptors. The abnormal V2 receptor mRNA also gave rise to proteins... - Key peptide processing enzymes are expressed by a variant form of small-cell carcinoma of the lungW G North
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Peptides 19:1743-7. 1998..Our findings therefore demonstrate that key enzymes involved in the generation of active neuropeptides, unlike the marker enzymes NSE and DDC, continue to be expressed by variant SCCL... - Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS)William G North
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
Endocr Pathol 14:257-62. 2003..Our results suggest that products of vasopressin gene expression are not markers of cellular proliferation in the breast, and might rather represent an early part of the carcinogenic process in this tissue... - Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategiesBrendan P Keegan
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Breast Cancer Res Treat 95:265-77. 2006..Thus, strategies for targeting proAVP should be examined for their effectiveness in diagnosing and treating breast cancer...
Research Grants
- NEUROPEPTIDES AND SMALL CELL CARCINOMAWILLIAM NORTH; Fiscal Year: 2002..The information obtained is expected to result in effective chemotherapeutic and immunotherapeutic interventions for all patients with limited and extensive SCCL. ..
- GRSA Proteins in the Diagnosis of Breast CancerWILLIAM NORTH; Fiscal Year: 2002..These methods could be applicable to all patients with breast cancer or suspected breast cancer. ..
- VP peptides and receptors in diagnosis of breast cancer.WILLIAM NORTH; Fiscal Year: 2006..Another successful end-point would be the finding that these same methods can successfully monitor current treatments, and potentially lead to new and more effective ones. ..
- THE ROLE OF HORMONES IN HEALTH AND DISEASEWILLIAM NORTH; Fiscal Year: 2007..The ETP also provides a center for improved teaching and health delivery for Northern New England. ..
- THE ROLE OF HORMONES IN HEALTH AND DISEASEWILLIAM NORTH; Fiscal Year: 2007..The ETP alsoprovides acenter for improved teaching and health delivery for Northern New England. ..
- NEUROPEPTIDES AND SMALL CELL CARCINOMAWILLIAM NORTH; Fiscal Year: 1991..The formation gained could possibly by applied to antibody-directed therapy, and the proposed studies should lead to more effective treatments for SCCL...
- NEUROPEPTIDES AND SMALL CELL CARCINOMAWILLIAM NORTH; Fiscal Year: 1993..The information obtained is expected to result in more effective chemotherapeutic and immunotherapeutic interventions...
- ECTOPIC HORMONES IN SMALL CELL CARCINOMA OF THE LUNGWILLIAM NORTH; Fiscal Year: 1980..Knowledge gained in these studies should lead us to a better understanding of the pathophysiology of small cell carcinoma and possibly to a more rational approach to therapy. ..