WILLIAM NORTH

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Targeting the neurophysin-related cell surface antigen on small cell lung cancer cells using a monoclonal antibody against the glycopeptide region (MAG-1) of provasopressin
    Brendan P Keegan
    Departments of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Mol Cancer Ther 1:1153-9. 2002
  2. ncbi request reprint Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Peptides 18:985-93. 1997
  3. doi request reprint Breast cancer expresses functional NMDA receptors
    William G North
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 122:307-14. 2010
  4. ncbi request reprint Immunohistochemical detection of NRSA on small cell lung cancer with a monoclonal antibody (MAG-1) that recognizes the carboxyl terminus of provasopressin
    William G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03755, USA
    Appl Immunohistochem Mol Morphol 13:363-6. 2005
  5. doi request reprint Native MAG-1 antibody almost destroys human breast cancer xenografts
    William G North
    Departments of Physiology and Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 127:631-7. 2011
  6. ncbi request reprint Gene regulation of vasopressin and vasopressin receptors in cancer
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Exp Physiol 85:27S-40S. 2000
  7. ncbi request reprint MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Peptides 20:837-42. 1999
  8. ncbi request reprint Key peptide processing enzymes are expressed by a variant form of small-cell carcinoma of the lung
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Peptides 19:1743-7. 1998
  9. ncbi request reprint Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS)
    William G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Endocr Pathol 14:257-62. 2003
  10. ncbi request reprint Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies
    Brendan P Keegan
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 95:265-77. 2006

Research Grants

  1. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 2002
  2. GRSA Proteins in the Diagnosis of Breast Cancer
    WILLIAM NORTH; Fiscal Year: 2002
  3. VP peptides and receptors in diagnosis of breast cancer.
    WILLIAM NORTH; Fiscal Year: 2006
  4. THE ROLE OF HORMONES IN HEALTH AND DISEASE
    WILLIAM NORTH; Fiscal Year: 2007
  5. THE ROLE OF HORMONES IN HEALTH AND DISEASE
    WILLIAM NORTH; Fiscal Year: 2007
  6. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 1991
  7. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 1993
  8. ECTOPIC HORMONES IN SMALL CELL CARCINOMA OF THE LUNG
    WILLIAM NORTH; Fiscal Year: 1980

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Targeting the neurophysin-related cell surface antigen on small cell lung cancer cells using a monoclonal antibody against the glycopeptide region (MAG-1) of provasopressin
    Brendan P Keegan
    Departments of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Mol Cancer Ther 1:1153-9. 2002
    ..This is the first study to demonstrate that a mAb directed to the VAG region of the pro-VP protein has the potential for development into an in vivo diagnostic and therapeutic tool that targets plasma membrane-incorporated NRSA...
  2. ncbi request reprint Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Peptides 18:985-93. 1997
    ....
  3. doi request reprint Breast cancer expresses functional NMDA receptors
    William G North
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 122:307-14. 2010
    ..All of these data point to active NMDAR receptors being expressed by most breast cancers, and having an important influence on their survival...
  4. ncbi request reprint Immunohistochemical detection of NRSA on small cell lung cancer with a monoclonal antibody (MAG-1) that recognizes the carboxyl terminus of provasopressin
    William G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03755, USA
    Appl Immunohistochem Mol Morphol 13:363-6. 2005
    ....
  5. doi request reprint Native MAG-1 antibody almost destroys human breast cancer xenografts
    William G North
    Departments of Physiology and Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 127:631-7. 2011
    ..Pathological examination of such tumors revealed they had undergone very extensive (>66%) necrosis...
  6. ncbi request reprint Gene regulation of vasopressin and vasopressin receptors in cancer
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Exp Physiol 85:27S-40S. 2000
    ..By extrapolation, similar mechanisms might also be responsible for the expression of additional features that characterize the 'neuroendocrine' profile of these cancers...
  7. ncbi request reprint MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Peptides 20:837-42. 1999
    ..Western analysis revealed that all three normal mRNAs gave rise to proteins of sizes compatible with them being functional receptors. The abnormal V2 receptor mRNA also gave rise to proteins...
  8. ncbi request reprint Key peptide processing enzymes are expressed by a variant form of small-cell carcinoma of the lung
    W G North
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Peptides 19:1743-7. 1998
    ..Our findings therefore demonstrate that key enzymes involved in the generation of active neuropeptides, unlike the marker enzymes NSE and DDC, continue to be expressed by variant SCCL...
  9. ncbi request reprint Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS)
    William G North
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Endocr Pathol 14:257-62. 2003
    ..Our results suggest that products of vasopressin gene expression are not markers of cellular proliferation in the breast, and might rather represent an early part of the carcinogenic process in this tissue...
  10. ncbi request reprint Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies
    Brendan P Keegan
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Breast Cancer Res Treat 95:265-77. 2006
    ..Thus, strategies for targeting proAVP should be examined for their effectiveness in diagnosing and treating breast cancer...

Research Grants30

  1. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 2002
    ..The information obtained is expected to result in effective chemotherapeutic and immunotherapeutic interventions for all patients with limited and extensive SCCL. ..
  2. GRSA Proteins in the Diagnosis of Breast Cancer
    WILLIAM NORTH; Fiscal Year: 2002
    ..These methods could be applicable to all patients with breast cancer or suspected breast cancer. ..
  3. VP peptides and receptors in diagnosis of breast cancer.
    WILLIAM NORTH; Fiscal Year: 2006
    ..Another successful end-point would be the finding that these same methods can successfully monitor current treatments, and potentially lead to new and more effective ones. ..
  4. THE ROLE OF HORMONES IN HEALTH AND DISEASE
    WILLIAM NORTH; Fiscal Year: 2007
    ..The ETP also provides a center for improved teaching and health delivery for Northern New England. ..
  5. THE ROLE OF HORMONES IN HEALTH AND DISEASE
    WILLIAM NORTH; Fiscal Year: 2007
    ..The ETP alsoprovides acenter for improved teaching and health delivery for Northern New England. ..
  6. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 1991
    ..The formation gained could possibly by applied to antibody-directed therapy, and the proposed studies should lead to more effective treatments for SCCL...
  7. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 1993
    ..The information obtained is expected to result in more effective chemotherapeutic and immunotherapeutic interventions...
  8. ECTOPIC HORMONES IN SMALL CELL CARCINOMA OF THE LUNG
    WILLIAM NORTH; Fiscal Year: 1980
    ..Knowledge gained in these studies should lead us to a better understanding of the pathophysiology of small cell carcinoma and possibly to a more rational approach to therapy. ..