Eugene Nattie

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. doi request reprint Respiration and autonomic regulation and orexin
    Eugene Nattie
    Department of Physiology and Neurobiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Prog Brain Res 198:25-46. 2012
  2. ncbi request reprint Multiple central chemoreceptor sites: cell types and function in vivo
    Gene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:343-7. 2008
  3. pmc Do muscle blood flow detectors link breathing to oxygen consumption in exercise?
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03755, USA
    J Physiol 569:714. 2005
  4. pmc The retrotrapezoid nucleus and the 'drive' to breathe
    Eugene E Nattie
    Department of Physiology, Darthmouth Medical School, Lebanon, NH 03755, USA
    J Physiol 572:311. 2006
  5. ncbi request reprint Central chemoreception 2005: a brief review
    Eugene Nattie
    Department of Physiology, Borwell Bldg, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Auton Neurosci 126:332-8. 2006
  6. ncbi request reprint Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Appl Physiol 100:1746-7. 2006
  7. ncbi request reprint Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Appl Physiol 101:1596-606. 2006
  8. ncbi request reprint Do medullary serotonin neurones modulate the ventilatory response to hypoxia?
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Acta Physiol (Oxf) 193:309. 2008
  9. doi request reprint Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 164:394-400. 2008
  10. pmc Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Appl Physiol 108:1417-24. 2010

Research Grants

  1. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2007
  2. CSF and the central chemical control of breathing.
    Eugene Edward Nattie; Fiscal Year: 2010

Collaborators

Detail Information

Publications43

  1. doi request reprint Respiration and autonomic regulation and orexin
    Eugene Nattie
    Department of Physiology and Neurobiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Prog Brain Res 198:25-46. 2012
    ..Orexin-mediated processes may operate at two levels: (1) in sleep-wake and circadian states and (2) in stress, for example, the defense or "fight-or-flight" response and panic-anxiety syndrome...
  2. ncbi request reprint Multiple central chemoreceptor sites: cell types and function in vivo
    Gene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:343-7. 2008
    ..They affect physiological control systems in many ways, perhaps not all measurable, via the study of the steady-state CO2 response...
  3. pmc Do muscle blood flow detectors link breathing to oxygen consumption in exercise?
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03755, USA
    J Physiol 569:714. 2005
  4. pmc The retrotrapezoid nucleus and the 'drive' to breathe
    Eugene E Nattie
    Department of Physiology, Darthmouth Medical School, Lebanon, NH 03755, USA
    J Physiol 572:311. 2006
  5. ncbi request reprint Central chemoreception 2005: a brief review
    Eugene Nattie
    Department of Physiology, Borwell Bldg, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Auton Neurosci 126:332-8. 2006
    ....
  6. ncbi request reprint Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Appl Physiol 100:1746-7. 2006
  7. ncbi request reprint Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Appl Physiol 101:1596-606. 2006
    ..NK1R-ir neurons in the ventral medulla are essential for normal central chemoreception, provide a drive to breathe, and modulate the peripheral chemoreceptor responses. These effects are not state dependent...
  8. ncbi request reprint Do medullary serotonin neurones modulate the ventilatory response to hypoxia?
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Acta Physiol (Oxf) 193:309. 2008
  9. doi request reprint Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 164:394-400. 2008
    ....
  10. pmc Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Appl Physiol 108:1417-24. 2010
    ..We comment on the organization of this distributed central chemoreceptor system and suggest that interactions among sites are synergistic and not additive, which is an important aspect of its normal function...
  11. pmc Julius H. Comroe, Jr., distinguished lecture: central chemoreception: then ... and now
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon New Hampshire 03756 0001, USA
    J Appl Physiol 110:1-8. 2011
    ..Emphasis is placed on the importance of data derived from studies performed in the absence of anesthesia...
  12. pmc Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Physiol 556:235-53. 2004
    ..001; two-way ANOVA; P < 0.05, Tukey's post hoc test). We conclude that separate populations of serotonergic and adjacent NK1R-expressing neurones in the medulla are both involved in central chemoreception in vivo...
  13. pmc The cartography of breathing
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 548:665. 2003
  14. ncbi request reprint Central chemoreception in the region of the ventral respiratory group in the rat
    E E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Appl Physiol 81:1987-95. 1996
    ....
  15. ncbi request reprint Central chemosensitivity, sleep, and wakefulness
    E E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol 129:257-68. 2001
    ..1978. Science 201, 16-22). The presence of a number of chemosensitive sites with varying thresholds, sensitivity, and arousal dependence provides finely tuned control and stability for breathing...
  16. ncbi request reprint CO2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Appl Physiol 92:2119-30. 2002
    ..Central chemoreceptors in the NTS affect breathing in both sleep and wakefulness. The threshold for arousal in caudal NTS is greater than that for the stimulation of breathing...
  17. ncbi request reprint Bicuculline dialysis in the retrotrapezoid nucleus (RTN) region stimulates breathing in the awake rat
    E Nattie
    Department of Physiology, Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol 124:179-93. 2001
    ..The lack of effect on the response to systemic hypercapnia suggests that the RTN provides an ongoing endogenous drive to respiration by a process that is independent of its role in chemoreception...
  18. ncbi request reprint Ventral medulla pHi measured in vivo by 31P NMR is not regulated during hypercapnia in anesthetized rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, 706E Borwell Building, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 130:139-49. 2002
    ..Regional differences in pHi regulation between cortex and ventral medulla may be due to both chemosensitive and non-chemosensitive neurons...
  19. pmc Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity
    Eugene E Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756 0001, USA
    J Physiol 544:603-16. 2002
    ..We conclude that neurons with NK1R-ir somata or processes in the RTN/Ppy region are either chemosensitive or they modulate chemosensitivity. They also provide a tonic drive to breathe and may affect arousal...
  20. ncbi request reprint Multiple sites for central chemoreception: their roles in response sensitivity and in sleep and wakefulness
    E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol 122:223-35. 2000
    ..For example, some sites are more important in wakefulness; others in sleep. Proof for these hypotheses depends critically on obtaining accurate measures of stimulus intensity at each chemoreceptor site in vivo...
  21. ncbi request reprint Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat
    E Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Appl Physiol 89:153-62. 2000
    ..In the awake rat, the RTN region provides a portion of the tonic drive to breathe, as well as a portion of the response to hypercapnia...
  22. pmc The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 170:96-102. 2010
    ..We conclude that OX(1)R in the rostral medullary raphe contribute to the hypercapnic chemoreflex in wakefulness, during the dark period in rats...
  23. ncbi request reprint Inhibition of medullary raphe serotonergic neurons has age-dependent effects on the CO2 response in newborn piglets
    Michelle L Messier
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Appl Physiol 96:1909-19. 2004
    ..Inhibition of serotonergic medullary raphé and extra-raphé neurons decreases ventilatory CO2 sensitivity and alters cardiovascular variables and sleep cycling, which may contribute to the sudden infant death syndrome...
  24. pmc Focal microdialysis of CO₂ in the perifornical-hypothalamic area increases ventilation during wakefulness but not NREM sleep
    Ningjing Li
    Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 185:349-55. 2013
    ..These results suggest that PF-LHA functions as a central chemoreceptor site in the central nervous system in a vigilant state dependent manner with predominant effects in wakefulness...
  25. ncbi request reprint Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats
    Natalie C Taylor
    Department of Physiology, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 153:203-16. 2006
    ..In the Cool condition the ventilatory response to hypoxia is inhibited but appropriately so for the lower VO2 ...
  26. pmc Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 570:385-96. 2006
    ..We conclude that CA neurones (1) promote wakefulness, (2) participate in central respiratory chemoreception, (3) stimulate breathing frequency, and (4) minimize breathing variability in REM sleep...
  27. pmc Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons
    Kevin J Cummings
    Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1783-96. 2009
    ..007). Within the first two postnatal weeks, the medullary 5-HT system plays an important role in cardiorespiratory control, mitigating spontaneous bradycardia, stabilizing the breathing pattern, and dampening the hypercapnic Ve response...
  28. ncbi request reprint Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:371-6. 2008
    ..Conclusions: Central CA neurons have a net excitatory effect on breathing and chemoreception but a net inhibitory effect on blood pressure...
  29. pmc Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats
    Aihua Li
    Department of Physiology, Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 577:307-18. 2006
    ..These effects of caudal MR serotonergic neurons could be at a chemoreceptor site, e.g. the RTN, or at 'downstream' sites involved in rhythm and pattern generation...
  30. ncbi request reprint CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat
    Aihua Li
    Department of Physiology, Dartmouth Medical School, 706E Borwell Building, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 133:11-22. 2002
    ..9 (0.7) Torr (N=5), which may inhibit other chemoreceptor sites. Multiple chemoreceptor sites may interact to provide high sensitivity in systemic hypercapnia and stability during heterogeneous stimulation and inhibition...
  31. pmc Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 586:2321-9. 2008
    ..This genetic model allows examination of the role of excess 5-HT in ECF in the development of the control of breathing and central chemoreception, which may be pertinent to SIDS...
  32. ncbi request reprint The retrotrapezoid nucleus (RTN): local cytoarchitecture and afferent connections
    Carlos Cream
    Department of Physiology, 706E Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 130:121-37. 2002
    ..Other sources of input include the Kölliker-fuse nucleus, subceruleus, A5 region, and the paralemniscal zone...
  33. doi request reprint Serotonin transporter null male mouse pups have lower ventilation in air and 5% CO2 at postnatal ages P15 and P25
    Eliana Penatti
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 177:61-5. 2011
    ..Physiol. 586.9, 2321-2329, 2008) appears to have origins in early postnatal life (P15) when ventilation in both air and 5% CO(2) is reduced...
  34. pmc Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats
    Natalie C Taylor
    Department of Physiology, Dartmouth Medical Sshool, Lebanon, NH 03756, USA
    J Physiol 566:543-57. 2005
    ..We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT1A receptors are also involved in thermoregulation and arousal...
  35. ncbi request reprint Acoustic plethysmography measures breathing in unrestrained neonatal mice
    J Andrew Daubenspeck
    Physiology Department, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Appl Physiol 104:262-8. 2008
    ..In addition, this approach should be useful to study unrestrained neonatal mice under conditions where body temperature approaches environmental temperature and barometric plethysmography cannot be used...
  36. ncbi request reprint Muscimol inhibition of medullary raphé neurons decreases the CO2 response and alters sleep in newborn piglets
    Michelle L Messier
    Department of Physiology, Dartmouth Medical School, Borwell Building, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 133:197-214. 2002
    ..Disturbances of medullary raphé function can alter central chemoreception and normal sleep architecture, which may contribute to the pathogenesis of SIDS...
  37. ncbi request reprint Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2
    Natalie C Taylor
    Department of Physiology, Dartmouth Medical Center, Borwell Bldg, Lebanon, NH 03756 000, USA
    J Appl Physiol 97:1763-73. 2004
    ..Chronic fluoxetine treatment in the medullary raphe increases the ventilatory response to hypercapnia in an unanesthetized rat model, an effect that may be due to facilitation of chemosensitive serotonergic neurons...
  38. pmc Antagonism of rat orexin receptors by almorexant attenuates central chemoreception in wakefulness in the active period of the diurnal cycle
    Aihua Li
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Physiol 588:2935-44. 2010
    ..The results support our hypothesis that the orexin system participates importantly in central chemoreception in a vigilance-state- and diurnal-cycle-dependent manner and indicate a role for orexin in the important process of sighing...
  39. pmc Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 587:2059-67. 2009
    ..We conclude that projections of orexin-containing neurons to the RTN contribute, via OX(1)Rs in the region, to the hypercapnic chemoreflex control during wakefulness and to a lesser extent, non-rapid eye movement sleep...
  40. pmc Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks
    Kevin J Cummings
    Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03766, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1333-42. 2010
    ....
  41. doi request reprint Sudden infant death syndrome and serotonin: animal models
    Eugene Nattie
    Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Bioessays 31:130-3. 2009
    ..Nevertheless, the description of an animal model with serotonin defects that has autonomic dysfunction and spontaneous mortality at a young age is an exciting finding of possible importance for understanding SIDS...
  42. doi request reprint Central chemoreceptors: locations and functions
    Eugene Nattie
    Dartmouth Medical School, Department of Physiology, Lebanon, New Hampshire, USA
    Compr Physiol 2:221-54. 2012
    ....
  43. pmc Breathing: rhythmicity, plasticity, chemosensitivity
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Annu Rev Neurosci 26:239-66. 2003
    ..Neurons with appropriate chemosensitivity are spread throughout the brainstem; their individual properties and collective role are just beginning to be understood...

Research Grants4

  1. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2007
    ....
  2. CSF and the central chemical control of breathing.
    Eugene Edward Nattie; Fiscal Year: 2010
    ..Abnormal central chemoreception is a key defect in the congenital central hypoventilation syndrome and is hypothesized to play a role in the Sudden Infant Death Syndrome. ..