Eugene Nattie

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. doi request reprint Central chemoreceptors: locations and functions
    Eugene Nattie
    Dartmouth Medical School, Department of Physiology, Lebanon, New Hampshire, USA
    Compr Physiol 2:221-54. 2012
  2. doi request reprint Sudden infant death syndrome and serotonin: animal models
    Eugene Nattie
    Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Bioessays 31:130-3. 2009
  3. pmc The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 170:96-102. 2010
  4. doi request reprint Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 164:394-400. 2008
  5. doi request reprint Respiration and autonomic regulation and orexin
    Eugene Nattie
    Department of Physiology and Neurobiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Prog Brain Res 198:25-46. 2012
  6. pmc Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats
    Aihua Li
    Department of Physiology, Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 577:307-18. 2006
  7. ncbi request reprint Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:371-6. 2008
  8. ncbi request reprint Do medullary serotonin neurones modulate the ventilatory response to hypoxia?
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Acta Physiol (Oxf) 193:309. 2008
  9. pmc Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 570:385-96. 2006
  10. pmc Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Appl Physiol (1985) 108:1417-24. 2010

Collaborators

  • Aihua Li
  • Eliana Penatti
  • Mirela Barros Dias
  • Kevin J Cummings
  • Alexis Barina
  • Koren Schram
  • Evan S Deneris

Detail Information

Publications19

  1. doi request reprint Central chemoreceptors: locations and functions
    Eugene Nattie
    Dartmouth Medical School, Department of Physiology, Lebanon, New Hampshire, USA
    Compr Physiol 2:221-54. 2012
    ....
  2. doi request reprint Sudden infant death syndrome and serotonin: animal models
    Eugene Nattie
    Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Bioessays 31:130-3. 2009
    ..Nevertheless, the description of an animal model with serotonin defects that has autonomic dysfunction and spontaneous mortality at a young age is an exciting finding of possible importance for understanding SIDS...
  3. pmc The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 170:96-102. 2010
    ..We conclude that OX(1)R in the rostral medullary raphe contribute to the hypercapnic chemoreflex in wakefulness, during the dark period in rats...
  4. doi request reprint Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 164:394-400. 2008
    ....
  5. doi request reprint Respiration and autonomic regulation and orexin
    Eugene Nattie
    Department of Physiology and Neurobiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Prog Brain Res 198:25-46. 2012
    ..Orexin-mediated processes may operate at two levels: (1) in sleep-wake and circadian states and (2) in stress, for example, the defense or "fight-or-flight" response and panic-anxiety syndrome...
  6. pmc Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats
    Aihua Li
    Department of Physiology, Borwell Building, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 577:307-18. 2006
    ..These effects of caudal MR serotonergic neurons could be at a chemoreceptor site, e.g. the RTN, or at 'downstream' sites involved in rhythm and pattern generation...
  7. ncbi request reprint Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Adv Exp Med Biol 605:371-6. 2008
    ..Conclusions: Central CA neurons have a net excitatory effect on breathing and chemoreception but a net inhibitory effect on blood pressure...
  8. ncbi request reprint Do medullary serotonin neurones modulate the ventilatory response to hypoxia?
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Acta Physiol (Oxf) 193:309. 2008
  9. pmc Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 570:385-96. 2006
    ..We conclude that CA neurones (1) promote wakefulness, (2) participate in central respiratory chemoreception, (3) stimulate breathing frequency, and (4) minimize breathing variability in REM sleep...
  10. pmc Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Appl Physiol (1985) 108:1417-24. 2010
    ..We comment on the organization of this distributed central chemoreceptor system and suggest that interactions among sites are synergistic and not additive, which is an important aspect of its normal function...
  11. ncbi request reprint Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Appl Physiol (1985) 101:1596-606. 2006
    ..NK1R-ir neurons in the ventral medulla are essential for normal central chemoreception, provide a drive to breathe, and modulate the peripheral chemoreceptor responses. These effects are not state dependent...
  12. doi request reprint Serotonin transporter null male mouse pups have lower ventilation in air and 5% CO2 at postnatal ages P15 and P25
    Eliana Penatti
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 177:61-5. 2011
    ..Physiol. 586.9, 2321-2329, 2008) appears to have origins in early postnatal life (P15) when ventilation in both air and 5% CO(2) is reduced...
  13. pmc Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia
    Aihua Li
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 586:2321-9. 2008
    ..This genetic model allows examination of the role of excess 5-HT in ECF in the development of the control of breathing and central chemoreception, which may be pertinent to SIDS...
  14. ncbi request reprint Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Appl Physiol 100:1746-7. 2006
  15. ncbi request reprint Central chemoreception 2005: a brief review
    Eugene Nattie
    Department of Physiology, Borwell Bldg, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Auton Neurosci 126:332-8. 2006
    ....
  16. pmc Antagonism of rat orexin receptors by almorexant attenuates central chemoreception in wakefulness in the active period of the diurnal cycle
    Aihua Li
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Physiol 588:2935-44. 2010
    ..The results support our hypothesis that the orexin system participates importantly in central chemoreception in a vigilance-state- and diurnal-cycle-dependent manner and indicate a role for orexin in the important process of sighing...
  17. pmc The cartography of breathing
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 548:665. 2003
  18. ncbi request reprint CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat
    Aihua Li
    Department of Physiology, Dartmouth Medical School, 706E Borwell Building, Lebanon, NH 03756 0001, USA
    Respir Physiol Neurobiol 133:11-22. 2002
    ..9 (0.7) Torr (N=5), which may inhibit other chemoreceptor sites. Multiple chemoreceptor sites may interact to provide high sensitivity in systemic hypercapnia and stability during heterogeneous stimulation and inhibition...
  19. pmc Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks
    Kevin J Cummings
    Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03766, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1333-42. 2010
    ....