Mary Jo Mulligan-Kehoe

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Anti-angiogenic activity of rPAI-1(23) and vasa vasorum regression
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Section, The Geisel School of Medicine at Dartmouth, Borwell 530E, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Trends Cardiovasc Med 23:114-20. 2013
  2. pmc Micro computed tomography for vascular exploration
    Lyubomir Zagorchev
    INSERM U828, Plateforme d Innovation Biotechnologique de Xavier Arnozan, , Pessac, France
    J Angiogenes Res 2:7. 2010
  3. pmc The vasa vasorum in diseased and nondiseased arteries
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Section, Dartmouth Medical School, Borwell 530E, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Physiol Heart Circ Physiol 298:H295-305. 2010
  4. ncbi request reprint Inhibition of cytoplasmic antigen, glucose- 6-phosphate dehydrogenase, by VH-CH1, an intracellular Fd fragment antibody derived from a semisynthetic Fd fragment phage display library
    M J Mulligan-Kehoe
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Mol Biol 289:41-55. 1999
  5. ncbi request reprint A truncated plasminogen activator inhibitor-1 protein blocks the availability of heparin-binding vascular endothelial growth factor A isoforms
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Surgery Section, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    J Biol Chem 277:49077-89. 2002
  6. ncbi request reprint A truncated plasminogen activator inhibitor-1 protein induces and inhibits angiostatin (kringles 1-3), a plasminogen cleavage product
    M J Mulligan-Kehoe
    Division of Vascular Surgery, Department of Surgery, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    J Biol Chem 276:8588-96. 2001
  7. pmc The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque
    Mary Drinane
    Angiogenesis Research, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 104:337-45. 2009
  8. pmc Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism
    Jessica Mollmark
    Department of Surgery, Vascular Section, Dartmouth Medical School, Borwell 530 E, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Circ Res 108:1419-28. 2011
  9. ncbi request reprint Antiangiogenic plasma activity in patients with systemic sclerosis
    Mary Jo Mulligan-Kehoe
    Angiogenesis Research Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Arthritis Rheum 56:3448-58. 2007
  10. ncbi request reprint The anti-angiogenic activity of rPAI-1(23) inhibits fibroblast growth factor-2 functions
    Mary Drinane
    Department of Surgery, Vascular Section, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Biol Chem 281:33336-44. 2006

Research Grants

  1. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2003
  2. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2004
  3. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2005
  4. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2006
  5. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2009
  6. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2010
  7. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
  8. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2010

Collaborators

  • Michael Simons
  • Richard J Powell
  • R Wagner
  • Peter Carmeliet
  • Fredrick M Wigley
  • Jai Pal Singh
  • Robert Tomanek
  • Hynda K Kleinman
  • Laura K Hummers
  • Arie Horowitz
  • MARY MULLIGAN KEHOE
  • Mary J Mulligan Kehoe
  • Jessica Mollmark
  • Mary Drinane
  • Lyubomir Zagorchev
  • Jessica I Mollmark
  • L Zagorchev
  • Baiming Sun
  • Samantha Shipman
  • Karen Moodie
  • Zhen W Zhuang
  • Thomas W Chittenden
  • Richard R Proia
  • Andrew J H Park
  • Lyubomir G Zagorchev
  • Samantha L Shipman
  • Sarah Katzenell
  • Justin Kim
  • Thomas Z Wang
  • Maarten Buitendijk
  • Saranya Ravi
  • Pierre Oses
  • Mary Jo Mulligan Kehoe
  • Thierry Couffinhal
  • Amy Hall
  • Peter Morganelli
  • Filip Claes
  • Monica Autiero
  • Eugene V Tkachenko
  • Weiming Li
  • Jannine Walsh
  • Karen L Moodie
  • Michael Westmore
  • Carmen Ruiz de Almodovar
  • Robert T Palac
  • Eduard Dedkov
  • Anthony A Lanahan
  • Arye Elfenbein
  • Peter R Nelson
  • Arthur J Kehas

Detail Information

Publications16

  1. pmc Anti-angiogenic activity of rPAI-1(23) and vasa vasorum regression
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Section, The Geisel School of Medicine at Dartmouth, Borwell 530E, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Trends Cardiovasc Med 23:114-20. 2013
    ..This mechanism contributes significantly to vasa vasorum regression/collapse and is discussed as a model of regression...
  2. pmc Micro computed tomography for vascular exploration
    Lyubomir Zagorchev
    INSERM U828, Plateforme d Innovation Biotechnologique de Xavier Arnozan, , Pessac, France
    J Angiogenes Res 2:7. 2010
    ..This review highlights the capabilities of micro-CT for vascular exploration, describes the current state of imaging protocols, and offers guidelines and suggestions aimed at making micro-CT more accurate, replicable, and robust...
  3. pmc The vasa vasorum in diseased and nondiseased arteries
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Section, Dartmouth Medical School, Borwell 530E, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Physiol Heart Circ Physiol 298:H295-305. 2010
    ..Atherosclerosis is a multifactorial disease. There is increasing evidence that factors, produced in response to changes in the arterial wall, collaborate with the vasa vasorum to enhance the disease process...
  4. ncbi request reprint Inhibition of cytoplasmic antigen, glucose- 6-phosphate dehydrogenase, by VH-CH1, an intracellular Fd fragment antibody derived from a semisynthetic Fd fragment phage display library
    M J Mulligan-Kehoe
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Mol Biol 289:41-55. 1999
    ....
  5. ncbi request reprint A truncated plasminogen activator inhibitor-1 protein blocks the availability of heparin-binding vascular endothelial growth factor A isoforms
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Surgery Section, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    J Biol Chem 277:49077-89. 2002
    ..This insight into anti-angiogenic functions related to PAI-1 conformational changes could provide potential intervention points in angiogenesis associated with atherosclerotic plaques and cancer...
  6. ncbi request reprint A truncated plasminogen activator inhibitor-1 protein induces and inhibits angiostatin (kringles 1-3), a plasminogen cleavage product
    M J Mulligan-Kehoe
    Division of Vascular Surgery, Department of Surgery, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    J Biol Chem 276:8588-96. 2001
    ..In a second mechanism, rPAI-1(23) can bind uPA and/or plasminogen to reduce the number of uPA and plasminogen interactions, hence reducing the amount of plasmin that is produced...
  7. pmc The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque
    Mary Drinane
    Angiogenesis Research, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 104:337-45. 2009
    ....
  8. pmc Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism
    Jessica Mollmark
    Department of Surgery, Vascular Section, Dartmouth Medical School, Borwell 530 E, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Circ Res 108:1419-28. 2011
    ....
  9. ncbi request reprint Antiangiogenic plasma activity in patients with systemic sclerosis
    Mary Jo Mulligan-Kehoe
    Angiogenesis Research Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Arthritis Rheum 56:3448-58. 2007
    ..The aim of this study was to investigate the presence of antiangiogenic factors in patients with SSc...
  10. ncbi request reprint The anti-angiogenic activity of rPAI-1(23) inhibits fibroblast growth factor-2 functions
    Mary Drinane
    Department of Surgery, Vascular Section, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Biol Chem 281:33336-44. 2006
    ..The rPAI-1(23) anti-angiogenic activity inhibits FGF2 pro-angiogenic functions by blocking FGF2 signaling through FGF receptor 1 and syndecan-4 and downstream effectors p-Akt, p-JNK, and p-c-Jun...
  11. ncbi request reprint Current concepts in normal and defective angiogenesis: implications for systemic sclerosis
    Mary Jo Mulligan-Kehoe
    Section of Cardiology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Rheumatol Rep 9:173-9. 2007
    ..In this review, we summarize the current knowledge of the angiogenic imbalance in systemic sclerosis...
  12. pmc Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice
    Jessica I Mollmark
    Department of Surgery, Vascular Section, Dartmouth Medical School, Borwell 530 E 1 Medical Center Dr, Lebanon, NH 03756, USA
    Arterioscler Thromb Vasc Biol 32:2644-51. 2012
    ..FGF-2 seems to play a role in the formation of a distinct vasa vasorum network. This study examined the vasa vasorum structure and its relationship to FGF-2...
  13. ncbi request reprint The effect of endothelial cell overexpression of plasminogen activator inhibitor-1 on smooth muscle cell migration
    Richard R Proia
    Department of Surgery, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Vasc Surg 36:164-71. 2002
    ..Plasminogen activator inhibitor-1 (PAI-1), a known inhibitor of plasminogen activators, may regulate smooth muscle cell migration (SMC) through alteration in matrix metalloproteinase (MMP) activity...
  14. ncbi request reprint Selective regulation of arterial branching morphogenesis by synectin
    Thomas W Chittenden
    Angiogenesis Research Center, Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 10:783-95. 2006
    ..We conclude that synectin is involved in selective regulation of arterial, but not venous, growth and branching morphogenesis and that Rac1 plays an important role in this process...
  15. doi request reprint Vascular disease in scleroderma: angiogenesis and vascular repair
    Mary Jo Mulligan-Kehoe
    Angiogenesis Research Center, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Borwell 530 E, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Rheum Dis Clin North Am 34:73-9; vi. 2008
    ..Although most aspects of vascular injury in scleroderma are poorly understood, certain biologic themes are beginning to emerge that are important in understanding scleroderma-related vascular disease...
  16. pmc Advances in imaging angiogenesis and inflammation in atherosclerosis
    L Zagorchev
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    Thromb Haemost 105:820-7. 2011
    ....

Research Grants9

  1. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2003
    ....
  2. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2004
    ....
  3. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2005
    ....
  4. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2006
    ....
  5. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2009
    ....
  6. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2010
    ....
  7. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ....
  8. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2010
    ....