T W McAllister

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Evaluation and treatment of psychosis after traumatic brain injury
    Thomas W McAllister
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:357-68. 2002
  2. pmc Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes
    T W McAllister
    Department of Psychiatry, Dartmouth Medical School, Lebanon
    Neurology 78:1777-84. 2012
  3. pmc Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 05756, USA
    J Neurotrauma 29:1111-8. 2012
  4. pmc Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: altered working memory and BOLD response
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Psychophysiol 82:107-14. 2011
  5. doi request reprint Maximum principal strain and strain rate associated with concussion diagnosis correlates with changes in corpus callosum white matter indices
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Ann Biomed Eng 40:127-40. 2012
  6. ncbi request reprint Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 6:364-71. 2004
  7. ncbi request reprint Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756
    Am J Psychiatry 162:1749-51. 2005
  8. ncbi request reprint Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics
    Thomas W McAllister
    Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurotrauma 23:1450-67. 2006
  9. pmc Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Brain Inj 22:705-14. 2008
  10. doi request reprint Psychopharmacological issues in the treatment of TBI and PTSD
    Thomas W McAllister
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Clin Neuropsychol 23:1338-67. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Evaluation and treatment of psychosis after traumatic brain injury
    Thomas W McAllister
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:357-68. 2002
    ..Anticonvulsant, antidepressant or other drugs may also be needed in some cases. Medication approaches must be adjusted for the particular characteristics and vulnerabilities of the patient with a TBI...
  2. pmc Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes
    T W McAllister
    Department of Psychiatry, Dartmouth Medical School, Lebanon
    Neurology 78:1777-84. 2012
    ..To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes...
  3. pmc Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 05756, USA
    J Neurotrauma 29:1111-8. 2012
    ..Polymorphisms in BDNF influence cognitive performance shortly after mTBI. The results raise the possibility that a functional polymorphism other than rs6265 may contribute to memory function after mTBI...
  4. pmc Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: altered working memory and BOLD response
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Psychophysiol 82:107-14. 2011
    ..On guanfacine the MTBI group showed increased activation within a WM task-specific region of interest. Findings are consistent with the hypothesis that alterations in WM after MTBI may be improved with the alpha-2 agonist guanfacine...
  5. doi request reprint Maximum principal strain and strain rate associated with concussion diagnosis correlates with changes in corpus callosum white matter indices
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Ann Biomed Eng 40:127-40. 2012
    ..80, p = 0.006) but change in FA did not (ρ = 0.18, p = 0.62). These results provide preliminary confirmation that model-predicted strain and strain rate in the CC correlate with changes in indices of white matter integrity...
  6. ncbi request reprint Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 6:364-71. 2004
    ..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described...
  7. ncbi request reprint Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756
    Am J Psychiatry 162:1749-51. 2005
    ..The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury...
  8. ncbi request reprint Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics
    Thomas W McAllister
    Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurotrauma 23:1450-67. 2006
    ..We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI...
  9. pmc Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Brain Inj 22:705-14. 2008
    ....
  10. doi request reprint Psychopharmacological issues in the treatment of TBI and PTSD
    Thomas W McAllister
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Clin Neuropsychol 23:1338-67. 2009
    ..General principles are suggested and particular attention is directed to situations where the use of medication for one condition might exacerbate symptoms of the other disorder. Directions for future research are suggested...
  11. pmc Neurobiological consequences of traumatic brain injury
    Thomas W McAllister
    Departments of Psychiatry and Neurology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Dialogues Clin Neurosci 13:287-300. 2011
    ..This paper reviews our current understanding of the neuropathophysiology of TBI and how this relates to the common clinical presentation of neurobehavioral difficulties seen after an injury...
  12. pmc Effects of psychological and biomechanical trauma on brain and behavior
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Ann N Y Acad Sci 1208:46-57. 2010
    ..This paper reviews the literature on the neural substrate of biomechanical and psychological injury and discusses the implications for evaluation and treatment of the neuropsychiatric sequelae of these processes...
  13. doi request reprint Genetic factors modulating outcome after neurotrauma
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    PM R 2:S241-52. 2010
    ..Polymorphisms reported to influence outcome after traumatic brain injury that illustrate important underlying mechanisms are emphasized...
  14. doi request reprint Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: altered working memory and BOLD response
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH, USA
    J Neuropsychiatry Clin Neurosci 23:277-86. 2011
    ..On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine...
  15. ncbi request reprint Working memory deficits after traumatic brain injury: catecholaminergic mechanisms and prospects for treatment -- a review
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry and the Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
    Brain Inj 18:331-50. 2004
    ..Current knowledge gaps and research needs are identified...
  16. ncbi request reprint Evaluation and treatment of postconcussive symptoms
    Thomas W McAllister
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:265-83. 2002
    ....
  17. ncbi request reprint Neuroimaging findings in mild traumatic brain injury
    T W McAllister
    Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Clin Exp Neuropsychol 23:775-91. 2001
    ..It is, therefore, important to be aware of the advantages and limitations of the various available imaging modalities. This paper selectively reviews the pertinent literature on the structural and functional imaging in mild TBI...
  18. ncbi request reprint Evaluation and treatment of neurobehavioral complications of traumatic brain injury--have we made any progress?
    Thomas W McAllister
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:263-4. 2002
  19. ncbi request reprint Apathy
    T W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, New Hampshire Hospital, Lebanon, NH 03756, USA
    Semin Clin Neuropsychiatry 5:275-82. 2000
    ..Catecholaminergic systems, particularly the mesolimbic dopaminergic system, are key modulators of motivated behaviors. Treatment thus involves the use of catecholaminergic agents...
  20. ncbi request reprint Genetic polymorphisms in the expression and treatment of neuropsychiatric disorders
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 5:400-9. 2003
    ....
  21. ncbi request reprint Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study
    T W McAllister
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neurology 53:1300-8. 1999
    ..To assess patterns of regional brain activation in response to varying working memory loads shortly after mild traumatic brain injury (MTBI)...
  22. ncbi request reprint Differential working memory load effects after mild traumatic brain injury
    T W McAllister
    Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neuroimage 14:1004-12. 2001
    ..This suggests that injury-related changes in ability to activate or modulate WM processing resources might underlie some of the memory complaints after MTBI...
  23. ncbi request reprint Brain activation on fMRI and verbal memory ability: functional neuroanatomic correlates of CVLT performance
    S C Johnson
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Int Neuropsychol Soc 7:55-62. 2001
    ....
  24. ncbi request reprint Smaller brain size associated with unawareness of illness in patients with schizophrenia
    L A Flashman
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Psychiatry 157:1167-9. 2000
    ..Although several neuropsychological studies have supported the notion of frontal and parietal lobe involvement in unawareness of illness in schizophrenia, neuroanatomic differences have not been examined...
  25. pmc Apathy and the processing of novelty in schizophrenia
    Robert M Roth
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, New Hampshire, 03756 0001, USA
    Schizophr Res 98:232-8. 2008
    ..The present findings indicate that schizophrenia is associated with slowed information processing, but do not support the hypothesis that apathy in schizophrenia is associated with abnormal processing of novelty...
  26. ncbi request reprint Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele
    H A Wishart
    Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH 03756 0001, USA
    Neurology 67:1221-4. 2006
    ..To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele...
  27. ncbi request reprint Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study
    L A Flashman
    Department of Psychiatry Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuropsychiatry Clin Neurosci 13:255-7. 2001
    ..Significant inverse correlations were seen between unawareness and bilateral middle frontal gyrus volume and between symptom misattribution and superior frontal gyrus volume...
  28. ncbi request reprint Functional magnetic resonance imaging: emerging clinical applications
    Heather A Wishart
    Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, Hanover, NH 03756, USA
    Curr Psychiatry Rep 4:338-45. 2002
    ..Future research will address integrating fMRI with other emerging neuroimaging techniques...
  29. ncbi request reprint Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficits
    Robert M Roth
    Department of Psychiatry, Dartmouth Medical School and New Hampshire Hospital, Lebanon 03756 0001, USA
    Am J Psychiatry 161:157-9. 2004
    ..Apathy is a common negative symptom in schizophrenia. The authors investigated neuropsychological performance and regional brain volumes in schizophrenia patients with high versus low levels of apathy...
  30. ncbi request reprint Neuropsychiatric syndromes in adults with intellectual disability: issues in assessment and treatment
    Richard B Ferrell
    Neuropsychiatry Service, Dartmouth Medical School at New Hampshire Hospital, 36 Clinton Street, Concord, NH 03301, USA
    Curr Psychiatry Rep 6:380-90. 2004
    ..Community-based models of support with neuropsychiatric intervention can be a potent therapeutic combination in the management of challenging behaviors in individuals with ID...
  31. ncbi request reprint Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele
    Heather A Wishart
    Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Am J Psychiatry 163:1603-10. 2006
    ..The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults...
  32. ncbi request reprint Apathy and its treatment
    Robert M Roth
    Laura A Flashman, PhD Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Treat Options Neurol 9:363-70. 2007
    ..In the interim, careful evaluation of possible psychosocial and biological contributors to apathy in any given patient is suggested, with treatment planning based accordingly...
  33. ncbi request reprint Lack of awareness and its impact in traumatic brain injury
    Laura A Flashman
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:285-96. 2002
    ..Finally, a review of the literature studying lack of awareness in TBI, its relationship to injury severity, the impact of lack of awareness on outcome, and intervention approaches is presented...
  34. pmc Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates
    Laura A Flashman
    Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, and New Hampshire Hospital, Lebanon, NH, USA
    Psychiatry Res 154:147-55. 2007
    ..CSP, while prevalent, was not more frequent in our sample of patients with schizophrenia, and had few associations with symptom severity or neuropsychological deficits...
  35. doi request reprint Depression and cognitive complaints following mild traumatic brain injury
    Jonathan M Silver
    Department of Psychiatry, New York University, New Yourk, NY, USA
    Am J Psychiatry 166:653-61. 2009
    ..This article discusses the clinical approach to treating an individual with depression and cognitive complaints following mild TBI. Recommendations regarding the diagnosis, evaluation, and treatment of these problems are offered...
  36. pmc Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes
    Chantel D Sloan
    Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010
    ..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints...
  37. doi request reprint Nonclinical obsessive-compulsive symptoms and executive functions in schizophrenia
    Sheba R Kumbhani
    Dartmouth Medical School, Department of Psychiatry, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    J Neuropsychiatry Clin Neurosci 22:304-12. 2010
    ..Performance-based scores showed few correlations with OCS. Findings indicate that severity of nonclinical OCS subtypes contributes to the heterogeneity of executive functions in schizophrenia...
  38. pmc Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study
    Julie A Dumas
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
    Menopause 17:852-9. 2010
    ....
  39. ncbi request reprint The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting
    David B Arciniegas
    Neuropsychiatry Service, Department of Psychiatry, University of Colorado School of Medicine, Denver, Colorado 80211, USA
    CNS Spectr 10:1-14; quiz 15-6. 2005
    ..The material presented in this monograph will help clinicians better recognize, diagnose, and treat PBA, and will form a foundation for understanding and interpreting future studies of this condition...
  40. pmc Lack of relationship between psychological denial and unawareness of illness in schizophrenia-spectrum disorders
    Carrie L Kruck
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Psychiatry Res 169:33-8. 2009
    ..The patient group and the healthy comparison group did not differ in their use of self-deception. The current results do not support the psychological denial theory of unawareness of illness in schizophrenia-spectrum disorders...
  41. ncbi request reprint Complex partial seizures and depression
    Brian A Greenlee
    Department of Psychiatry, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 5:410-6. 2003
    ..Surgical resection of seizure foci may lead to psychiatric improvement for some individuals, but can also have psychiatric complications...
  42. pmc Nicotinic versus muscarinic blockade alters verbal working memory-related brain activity in older women
    Julie A Dumas
    Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Am J Geriatr Psychiatry 16:272-82. 2008
    ..This approach simulates the effects of age- or disease-related neuroreceptor or neuronal loss by temporarily blocking pre- and postsynaptic muscarinic and nicotinic cholinergic receptors...
  43. ncbi request reprint Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury
    Deborah L Warden
    Defense and Veterans Brain Injury Center, Department of Neurology and Neurosurgery, Walter Reed Army Medical Center, USA
    J Neurotrauma 23:1468-501. 2006
    ..There is a clear need for well-designed randomized controlled trials in the treatment of these common problems after TBI in order to establish definitive treatment standards for this patient population...

Research Grants22

  1. Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student
    Thomas McAllister; Fiscal Year: 2009
    ..Impact parameters will be directly measured using helmet-based accelerometer units. ..
  2. RCT Methylphenidate & Memory/Attention Training in Traumatic Brain Injury
    Thomas McAllister; Fiscal Year: 2010
    ..Further, it will help to clarify underlying neural mechanisms and suggest additional treatment possibilities. ..
  3. Effect of Biomechanical Force Exposure on Cognition and Brain Activation in TBI
    Thomas McAllister; Fiscal Year: 2010
    ....
  4. Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student
    Thomas McAllister; Fiscal Year: 2007
    ..Impact parameters will be directly measured using helmet-based accelerometer units. ..
  5. Effect of Biomechanical Force Exposure on Cognition and Brain Activation in TBI
    Thomas McAllister; Fiscal Year: 2007
    ....
  6. DOPAMINERGIC MODULATION WORKING MEMORY TBI--FMRI STUDY
    Thomas McAllister; Fiscal Year: 2003
    ..Performance and fMRI visualized activation of WM circuitry will be characterized at baseline (on placebo) and following administration of a dopamine agonist. ..
  7. Role of Candidate Alleles in Cognitive Outcome After TBI
    Thomas McAllister; Fiscal Year: 2007
    ....
  8. RCT Methylphenidate & Memory/Attention Training in Traumatic Brain Injury
    Thomas McAllister; Fiscal Year: 2009
    ..Further, it will help to clarify underlying neural mechanisms and suggest additional treatment possibilities. ..