Carmen J Marsit

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA
    Environ Health Perspect 121:971-7. 2013
  2. pmc Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research
    David A Armstrong
    2Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, 7650 Remsen, Hanover, NH 03755, USA
    FASEB J 28:2088-97. 2014
  3. pmc In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta
    Charlotte S Wilhelm-Benartzi
    Department of Epidemiology, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, USA
    Environ Health Perspect 120:296-302. 2012
  4. pmc Epigenomics in environmental health
    Brock C Christensen
    Section on Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School Hanover, NH, USA
    Front Genet 2:84. 2011
  5. pmc DNA methylation arrays as surrogate measures of cell mixture distribution
    Eugene Andres Houseman
    College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA
    BMC Bioinformatics 13:86. 2012
  6. doi request reprint Blood-derived DNA methylation markers of cancer risk
    Carmen Marsit
    Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, USA
    Adv Exp Med Biol 754:233-52. 2013
  7. pmc Placenta-imprinted gene expression association of infant neurobehavior
    Carmen J Marsit
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH, USA
    J Pediatr 160:854-860.e2. 2012
  8. pmc Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome
    Carmen J Marsit
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e33794. 2012
  9. pmc Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Carcinogenesis 30:416-22. 2009
  10. pmc Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
    Brock C Christensen
    Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA
    Cancer Res 70:5686-94. 2010

Collaborators

Detail Information

Publications65

  1. pmc Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA
    Environ Health Perspect 121:971-7. 2013
    ..Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations, specifically by altering patterns of DNA methylation...
  2. pmc Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research
    David A Armstrong
    2Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, 7650 Remsen, Hanover, NH 03755, USA
    FASEB J 28:2088-97. 2014
    ..Armstrong, D. A., Lesseur, C., Conradt, E., Lester, B. M., Marsit, C. J. Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. ..
  3. pmc In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta
    Charlotte S Wilhelm-Benartzi
    Department of Epidemiology, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, USA
    Environ Health Perspect 120:296-302. 2012
    ..Environmental insults in utero may lead to changes in epigenetic mechanisms potentially affecting fetal development...
  4. pmc Epigenomics in environmental health
    Brock C Christensen
    Section on Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School Hanover, NH, USA
    Front Genet 2:84. 2011
    ....
  5. pmc DNA methylation arrays as surrogate measures of cell mixture distribution
    Eugene Andres Houseman
    College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA
    BMC Bioinformatics 13:86. 2012
    ..Emerging research demonstrates that DNA methylation is responsible for cellular differentiation, and when measured in whole peripheral blood, serves to distinguish cancer cases from controls...
  6. doi request reprint Blood-derived DNA methylation markers of cancer risk
    Carmen Marsit
    Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, USA
    Adv Exp Med Biol 754:233-52. 2013
    ..This chapter highlights the existing research linking the environment, blood-derived DNA methylation alterations, and cancer risk, and points out how these epigenetic alterations may be contributing fundamentally to carcinogenesis...
  7. pmc Placenta-imprinted gene expression association of infant neurobehavior
    Carmen J Marsit
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH, USA
    J Pediatr 160:854-860.e2. 2012
    ..To identify links between altered gene imprinting in the placenta and infant neurobehavioral profiles...
  8. pmc Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome
    Carmen J Marsit
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e33794. 2012
    ....
  9. pmc Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Carcinogenesis 30:416-22. 2009
    ..We found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study...
  10. pmc Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
    Brock C Christensen
    Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA
    Cancer Res 70:5686-94. 2010
    ..Our findings define a strong association between global genetic and global epigenetic dysregulation in mesothelioma, rather than a discrete, local coordination of gene inactivation...
  11. pmc Identification of methylated genes associated with aggressive bladder cancer
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e12334. 2010
    ..Methylation of these genes may be useful as clinical markers of the disease and may point to genes and pathways worthy of additional examination as novel targets for therapeutic treatment...
  12. pmc Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Cancer Epidemiol Biomarkers Prev 21:1293-302. 2012
    ....
  13. pmc DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    J Natl Cancer Inst 103:143-53. 2011
    ....
  14. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
    ..01). Haplotype analysis confirmed the association of the XRCC3 241. Thus, double-strand break repair genotype may enhance arsenic associated bladder cancer susceptibility in the U.S. population...
  15. pmc Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma
    Gretchen V Gee
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Int J Cancer 127:2859-69. 2010
    ..This research points to novel approaches using miRNAs whose decreased expression is unique to mesothelioma as potentially suitable for rapid diagnosis and reveals prospective new targets for the treatment of this deadly disease...
  16. pmc Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA
    Clin Cancer Res 16:3713-20. 2010
    ..A polymorphism in the MIR196A2 locus has shown associations with lung, breast, esophageal, and gastric tumors but has not been examined in head and neck cancers, which share similar pathology and etiology to these diseases...
  17. pmc DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer
    Carmen J Marsit
    Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    J Clin Oncol 29:1133-9. 2011
    ..We sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility...
  18. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
    ..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality...
  19. pmc Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome
    Brock C Christensen
    Department of Community Health, Center for Environmental Health and Technology, Brown University, 70 Ship Street, Providence, RI 02903, USA
    Cancer Res 69:227-34. 2009
    ..Importantly, these findings hold great promise for using epigenetic profiling in the diagnosis and prognosis of human cancers...
  20. pmc Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted
    Graham M Poage
    Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e9651. 2010
    ....
  21. pmc Copy number variation has little impact on bead-array-based measures of DNA methylation
    E Andres Houseman
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Bioinformatics 25:1999-2005. 2009
    ..However, copy number variation may bias the measurement of DNA methylation. To investigate possible bias, we analyzed integrated data obtained from 19 head and neck squamous cell carcinoma (HNSCC) tumors and 23 mesothelioma tumors...
  22. pmc Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS Genet 6:e1001043. 2010
    ..0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns...
  23. pmc Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study
    Scott M Langevin
    Department of Epidemiology, Brown University, Providence, RI, USA
    Epigenetics 7:291-9. 2012
    ..This profile demonstrates the potential of DNA methylation measured in blood for development of non-invasive applications for detection of head and neck cancer...
  24. pmc The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood
    Scott M Langevin
    Department of Community Health, Brown University, Providence, RI, USA
    Epigenetics 6:908-19. 2011
    ....
  25. pmc Association of secondhand smoke exposures with DNA methylation in bladder carcinomas
    Charlotte S Wilhelm-Benartzi
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
    Cancer Causes Control 22:1205-13. 2011
    ..Epigenetic alterations in bladder tumors have been linked to primary cigarette smoking and could add to the biological plausibility of an association between SHS exposure and bladder cancer...
  26. pmc Biomarkers of HPV in head and neck squamous cell carcinoma
    Caihua Liang
    Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA
    Cancer Res 72:5004-13. 2012
    ....
  27. pmc Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer
    Graham M Poage
    Departments of Molecular Pharmacology and Physiology, Community Health Center for Environmental Health and Technology, and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
    Clin Cancer Res 17:3579-89. 2011
    ..The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas...
  28. pmc Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    PLoS Genet 5:e1000602. 2009
    ..Collectively we reveal key issues to consider both in the construction of reference and disease-related epigenomes and in the interpretation of potentially pathologically important alterations...
  29. pmc Semi-supervised recursively partitioned mixture models for identifying cancer subtypes
    Devin C Koestler
    Department of Community Health, Section for Biostatistics, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Bioinformatics 26:2578-85. 2010
    ..We propose a method called semi-supervised recursively partitioned mixture models (SS-RPMM) that utilizes array-based genetic and patient-level clinical data for finding cancer subtypes that are associated with patient survival...
  30. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
    ..8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use...
  31. pmc Patterning in placental 11-B hydroxysteroid dehydrogenase methylation according to prenatal socioeconomic adversity
    Allison A Appleton
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
    PLoS ONE 8:e74691. 2013
    ..Therefore, we hypothesized that prenatal socioeconomic adversity would be associated with less HSD11B2 methylation...
  32. pmc Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors
    Corina Lesseur
    Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, 7650 Remsen, Hanover, NH 03755, USA Electronic address
    Mol Cell Endocrinol 381:160-7. 2013
    ..05). These results suggest that LEP epigenetic control may be influenced by perinatal factors including: maternal obesity, infant growth, genotype and gender in a tissue-specific manner and may have multigenerational implications. ..
  33. pmc Placental miRNA expression profiles are associated with measures of infant neurobehavioral outcomes
    Matthew A Maccani
    Division of Behavioral Genetics, Rhode Island Hospital, Providence, RI, USA
    Pediatr Res 74:272-8. 2013
    ..Our study aimed to identify the relationships between placental miRNA expression and newborn neurobehavior...
  34. pmc MicroRNA expression in head and neck cancer associates with alcohol consumption and survival
    Michele Avissar
    Department of Pathology and Laboratory Medicine, Brown University, Box G E5, Providence, RI 02912, USA
    Carcinogenesis 30:2059-63. 2009
    ..77) in a model controlled for patient age, gender and tumor stage. Together, these data suggest that alterations in miRNA expression are related to exposures causal in head and neck cancer and may be useful biomarkers of patient outcome...
  35. pmc Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Stat Appl Genet Mol Biol 12:225-40. 2013
    ....
  36. pmc Body mass and smoking are modifiable risk factors for recurrent bladder cancer
    Asaf Wyszynski
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire Program in Experimental and Molecular Medicine, Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
    Cancer 120:408-14. 2014
    ..Recurrences frequently occur, and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed...
  37. pmc Bisphenol A exposure leads to specific microRNA alterations in placental cells
    Michele Avissar-Whiting
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States
    Reprod Toxicol 29:401-6. 2010
    ..Overall, these results suggest that BPA can alter miRNA expression in placental cells, a potentially novel mode of BPA toxicity...
  38. pmc Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma
    Katie M Applebaum
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Int J Cancer 124:2690-6. 2009
    ..There was no relationship between XRCC1 and HPV16-related HNSCC, regardless of smoking. Our findings underscore the importance of accounting for HPV16 exposure even when studying susceptibility to HNSCC...
  39. pmc Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta
    Matthew A Maccani
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Epigenetics 5:583-9. 2010
    ..These results suggest that miR-146a is particularly responsive to exposures, and that smoking may elicit some of its downstream effects through alteration of miRNA expression...
  40. pmc Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm
    Sara E Pacheco
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 6:e20280. 2011
    ..We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function...
  41. pmc A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire
    Corina Lesseur
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Toxicol Lett 210:100-6. 2012
    ....
  42. pmc Gene-environment interactions of novel variants associated with head and neck cancer
    Caihua Liang
    Department of Community Health, Brown University, Providence, Rhode Island, USA
    Head Neck 34:1111-8. 2012
    ..We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk...
  43. pmc Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma
    Michele Avissar-Whiting
    Department of Pathology, Brown University, Providence, RI, USA
    Epigenetics 6:703-9. 2011
    ..This work contributes to our understanding of how repressive marks on DNA and chromatin are dysregulated in carcinogenesis, knowledge that might aid the development of therapies or preventive strategies for human malignancies...
  44. pmc LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese
    Haley L Cash
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
    Int J Cancer 130:1151-9. 2012
    ..006). Further research is needed to understand the relationships between methyl group availability and LINE-1 methylation in relation to bladder cancer risk...
  45. pmc Implications of LINE1 methylation for bladder cancer risk in women
    Charlotte S Wilhelm
    Department of Community Health Center for Environmental Health, Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Clin Cancer Res 16:1682-9. 2010
    ....
  46. pmc MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma
    Michele Avissar
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Clin Cancer Res 15:2850-5. 2009
    ..We sought to identify microRNAs altered in head and neck squamous cell carcinoma (HNSCC) and to determine whether microRNA expression is predictive of disease...
  47. pmc Endocrine disruptors, environmental oxygen, epigenetics and pregnancy
    Jared C Robins
    Division of Reproductive Endocrinology and Infertility, Women and Infants Hospital of Rhode Island, Providence, RI, USA
    Front Biosci (Elite Ed) 3:690-700. 2011
    ....
  48. pmc A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Carcinogenesis 30:1003-7. 2009
    ..7; 95% CI, 1.4-5.3). These data demonstrate that cases with the KRAS-LCS6 variant have significantly reduced survival time and suggest that this variant may alter the phenotype or therapeutic response of this disease...
  49. pmc Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas
    Carolyn E Banister
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Epigenetics 6:920-7. 2011
    ....
  50. pmc Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta
    Amanda C Filiberto
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Epigenetics 6:566-72. 2011
    ..Our work is one of the first to link infant growth as a measure of the intrauterine environment and epigenetic alterations to the GR and suggests that DNA methylation may be a critical determinant of placental function...
  51. pmc SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 131:453-61. 2012
    ..03). Our findings suggest novel variants that may influence risk of arsenic-associated bladder cancer and those who may be at greatest risk from this widespread exposure...
  52. pmc Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma
    Scott M Langevin
    Department of Epidemiology, Brown University, Providence, RI 02912, USA
    Cancer Epidemiol Biomarkers Prev 22:1061-8. 2013
    ..This condition is believed to be a risk factor for development of laryngopharyngeal squamous cell carcinoma (LPSCC), although the literature is conflicting...
  53. pmc Hypermethylation of E-cadherin is an independent predictor of improved survival in head and neck squamous cell carcinoma
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Cancer 113:1566-71. 2008
    ....
  54. pmc HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer
    Angeline S Andrew
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
    PLoS ONE 7:e51301. 2012
    ..This biologic process-based analysis suggests candidate susceptibility markers and supports the theory that disrupted hormone regulation plays a role in bladder carcinogenesis...
  55. pmc Epigenetics in the placenta
    Matthew A Maccani
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Am J Reprod Immunol 62:78-89. 2009
    ..Thus, epigenetic alterations may aid in disease diagnosis and prognosis as well as in targeting new treatment and prevention strategies...
  56. pmc Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders
    Haley L Cash
    Department of Pathology and Laboratory Medicine, International Health Institute, Public Health Program, Brown University, Providence, RI, USA
    Epigenetics 6:1257-64. 2011
    ....
  57. pmc Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Scand J Urol Nephrol 42:237-42. 2008
    ..This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States...
  58. pmc Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior
    Corina Lesseur
    Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, 7650 Remsen, Hanover, NH 03755, USA Electronic address
    Psychoneuroendocrinology 40:1-9. 2014
    ..Recent evidence has suggested a role for LEP in behavioral development. In this study, we investigated associations between profiles of human newborn neurobehavior and placental LEP DNA methylation...
  59. pmc Allergies and risk of head and neck cancer
    Dominique S Michaud
    Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA
    Cancer Causes Control 23:1317-22. 2012
    ..Inverse associations have been reported among individuals with allergies and risk of brain and pancreatic cancers...
  60. pmc miR-16 and miR-21 expression in the placenta is associated with fetal growth
    Matthew A Maccani
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 6:e21210. 2011
    ..We hypothesized that aberrant expression of miRNA in the placenta is associated with fetal growth, a measurable phenotype resulting from a number of intrauterine factors, and one which is significantly predictive of later life outcomes...
  61. pmc A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis
    Jiang Gui
    Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Hum Genet 129:101-10. 2011
    ....
  62. pmc Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles
    Brock C Christensen
    Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA
    Cancer Res 69:6315-21. 2009
    ..Methylation profile-based differentiation of lung adenocarcinoma and mesothelioma is highly accurate, informs on the distinct etiologies of these diseases, and holds promise for clinical application...
  63. pmc Epigenetic basis for the development of depression in children
    Barry M Lester
    Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University and Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA
    Clin Obstet Gynecol 56:556-65. 2013
    ..Implications of this approach to the study of mental health disorders for preventive interventions are discussed. ..
  64. pmc Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA
    Mod Pathol 27:145-55. 2014
    ..1, P=0.004) exhibited a methylation profile similar to right-colon adenomas. In summary, our results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon. ..
  65. pmc Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation
    Bijesh K Biswal
    Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e53003. 2012
    ..Low-dose 5-aza therapy may be a general strategy to treat those tumors that are sustained by cells with embryonic stem-like properties.GEO NUMBER FOR THE MICROARRAY DATA: GSE42647...