DEAN MADDEN

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint The structure and function of glutamate receptor ion channels
    Dean R Madden
    Ion Channel Structure Research Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Rev Neurosci 3:91-101. 2002
  2. ncbi request reprint The inner workings of the AMPA receptors
    Dean R Madden
    Department of Biochemistry, Vail Building 7200, Dartmouth Medical School, Hanover, NH 03755, USA
    Curr Opin Drug Discov Devel 5:741-8. 2002
  3. pmc Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors
    Amanda Birdsey-Benson
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurosci 30:1463-70. 2010
  4. ncbi request reprint Solution X-ray scattering evidence for agonist- and antagonist-induced modulation of cleft closure in a glutamate receptor ligand-binding domain
    Dean R Madden
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 280:23637-42. 2005
  5. pmc Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists
    Avinash Gill
    Departments of Biochemistry and Physiology, Dartmouth Medical School, 7200 Vail Building, Hanover, New Hampshire 03755, USA
    Biochemistry 47:13831-41. 2008
  6. ncbi request reprint The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain
    Stefan Reinelt
    Ion Channel Structure Group, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Biol Chem 278:39189-96. 2003
  7. ncbi request reprint The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly
    Willem Tichelaar
    Ion Channel Structure Group, Max Planck Institute for Medical Research, Jahnstr 29, D 69120 Heidelberg, Germany
    J Mol Biol 344:435-42. 2004
  8. pmc Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection
    Avinash Gill
    Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:831-5. 2008
  9. doi request reprint The quaternary structure of a calcium-permeable AMPA receptor: conservation of shape and symmetry across functionally distinct subunit assemblies
    Charles R Midgett
    Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA
    J Mol Biol 382:578-84. 2008
  10. ncbi request reprint Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach
    Michael Wolde
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 282:8099-109. 2007

Collaborators

  • Leslie Henderson
  • Keiko Hirose
  • William B Guggino
  • D F Mierke
  • Patrice Vachette
  • Holger Stark
  • Dietmar J Manstein
  • Markus Zweckstetter
  • Jennifer M Bomberger
  • Avinash Gill
  • Charles R Midgett
  • Amanda Birdsey-Benson
  • Abigail Fellows
  • Andrea Piserchio
  • Stefan Reinelt
  • James Féthière
  • Willem Tichelaar
  • Christopher D Bahl
  • Bruce A Stanton
  • Patrick R Cushing
  • Madhumati Sevvana
  • Michael Wolde
  • Michael Bott
  • Kari Keinanen
  • Arja Pasternack
  • Boris Klockow
  • Christophe Morisseau
  • Bruce D Hammock
  • GEORGE A O'TOOLE
  • Stefan Becker
  • George M Sheldrick
  • Prisca Boisguerin
  • Christian Griesinger
  • Daniel Villone
  • Vinesh Vijayan
  • Regine Herbst-Irmer
  • Brian L Jones
  • Jie Cheng
  • Katherine Karlson
  • Aleksandr Kivenson
  • Bonita Coutermarsh
  • Laleh Talebian
  • Bettina Bottcher
  • David Venzke
  • Markus Safferling
  • Sarah K Coleman
  • Tanja Gerharz
  • Jean Pierre Lecaer
  • Eckhard Hofmann
  • Jean Rossier
  • Michael Pasternack
  • Toshihiko Akiba
  • Hartmut H Niemann

Detail Information

Publications20

  1. ncbi request reprint The structure and function of glutamate receptor ion channels
    Dean R Madden
    Ion Channel Structure Research Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Rev Neurosci 3:91-101. 2002
    ....
  2. ncbi request reprint The inner workings of the AMPA receptors
    Dean R Madden
    Department of Biochemistry, Vail Building 7200, Dartmouth Medical School, Hanover, NH 03755, USA
    Curr Opin Drug Discov Devel 5:741-8. 2002
    ..Recent biomedical and structural research has greatly expanded our understanding of the chemistry of iGluR agonist binding, and of the subsequent molecular changes that drive channel gating and desensitization...
  3. pmc Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors
    Amanda Birdsey-Benson
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurosci 30:1463-70. 2010
    ....
  4. ncbi request reprint Solution X-ray scattering evidence for agonist- and antagonist-induced modulation of cleft closure in a glutamate receptor ligand-binding domain
    Dean R Madden
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 280:23637-42. 2005
    ..Addition of peptide moieties that connect the core domain to the other functional domains in each channel subunit appears to constrain the conformational equilibrium in favor of the open state...
  5. pmc Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists
    Avinash Gill
    Departments of Biochemistry and Physiology, Dartmouth Medical School, 7200 Vail Building, Hanover, New Hampshire 03755, USA
    Biochemistry 47:13831-41. 2008
    ..Furthermore, the GluR4 subunit exhibits a different correlation between receptor activation and LBD cleft closure than does GluR2...
  6. ncbi request reprint The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain
    Stefan Reinelt
    Ion Channel Structure Group, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Biol Chem 278:39189-96. 2003
    ..These secondary structure elements thus provide a potential conformational link between the periplasmic ligand binding site and the cytoplasmic signaling domains of the receptor...
  7. ncbi request reprint The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly
    Willem Tichelaar
    Ion Channel Structure Group, Max Planck Institute for Medical Research, Jahnstr 29, D 69120 Heidelberg, Germany
    J Mol Biol 344:435-42. 2004
    ..Internal cavities located along the longitudinal axis may represent components of the ion conduction pathway...
  8. pmc Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection
    Avinash Gill
    Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:831-5. 2008
    ..Together, these crystals lay the foundation for a structural comparison of LBD-agonist interactions in distinct AMPA-R subunits...
  9. doi request reprint The quaternary structure of a calcium-permeable AMPA receptor: conservation of shape and symmetry across functionally distinct subunit assemblies
    Charles R Midgett
    Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA
    J Mol Biol 382:578-84. 2008
    ....
  10. ncbi request reprint Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach
    Michael Wolde
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 282:8099-109. 2007
    ..Taken together, our data establish CAL as a candidate therapeutic target for correction of post-maturational trafficking defects in cystic fibrosis...
  11. pmc The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling
    Patrick R Cushing
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 47:10084-98. 2008
    ..The relatively weak affinity of the CAL:CFTR interaction may provide a pharmacological window for stabilizing rescued DeltaF508-CFTR in patients with cystic fibrosis...
  12. pmc The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes
    Boris Klockow
    Department of Biophysics, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    EMBO J 21:240-50. 2002
    ..Nucleotide-dependent changes observed with the unmodified and modified protein support a mechanochemical action of dynamin, in which tightening and stretching of a helix contribute to membrane fission...
  13. ncbi request reprint Breaking the bottleneck: eukaryotic membrane protein expression for high-resolution structural studies
    Charles R Midgett
    Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA
    J Struct Biol 160:265-74. 2007
    ..Here, we summarize the major expression systems available, and highlight technical advances that should facilitate more systematic screening of expression conditions for this physiologically important class of targets...
  14. pmc Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor
    Christopher D Bahl
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 192:1785-95. 2010
    ..A reassessment of the structural and functional consequences of the H269A mutation suggests that Cif's effect on host-cell CFTR expression requires the hydrolysis of an extended endogenous epoxide substrate...
  15. ncbi request reprint Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor
    Dean R Madden
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 43:15838-44. 2004
    ....
  16. ncbi request reprint Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain
    Arja Pasternack
    Viikki Biocenter, Department of Biosciences Division of Biochemistry, Viikinkaari 5D, FIN 00014 University of Helsinki, Finland
    J Neurochem 84:1184-92. 2003
    ....
  17. doi request reprint A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA
    Madhumati Sevvana
    Department of Structural Chemistry, University of Gottingen, Tammannstrasse 4, 37077 Gottingen, Germany
    J Mol Biol 377:512-23. 2008
    ..A comparison of the two structures shows that ligand binding causes a considerable contraction of the sensor domain. This contraction may represent the molecular switch that activates transmembrane signaling in the receptor...
  18. ncbi request reprint Association of the cystic fibrosis transmembrane regulator with CAL: structural features and molecular dynamics
    Andrea Piserchio
    Department of Molecular Pharmacology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 44:16158-66. 2005
    ....
  19. ncbi request reprint Peripheral stator of the yeast V-ATPase: stoichiometry and specificity of interaction between the EG complex and subunits C and H
    James Féthière
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Biochemistry 44:15906-14. 2005
    ..The EGC complex can be formed in vitro by combining equimolar amounts of subunit C and the EG subcomplex and results most likely from the initial interaction between subunits E and C...
  20. ncbi request reprint New light on an open-and-shut case
    Dean R Madden
    Nat Chem Biol 1:317-9. 2005

Research Grants3

  1. Keeping CFTR in its Place: An Integrated Small-Molecule Approach
    DEAN MADDEN; Fiscal Year: 2009
    ..Lay summary: In CF, genetic mutation prevents the CFTR protein from functioning correctly, leading to chronic lung infection and death. We seek chemicals that can correct this functional defect. ..
  2. Keeping CFTR in its Place: An Integrated Small-Molecule Approach
    Dean R Madden; Fiscal Year: 2010
    ..Lay summary: In CF, genetic mutation prevents the CFTR protein from functioning correctly, leading to chronic lung infection and death. We seek chemicals that can correct this functional defect. ..