Research Topics
| Frederic LeblondSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Detail Information
Publications
Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub-surface imagingF Leblond
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
Phys Med Biol 56:6823-37. 2011..These results suggest that depth assessment of fluorescence contrast can be achieved in fluorescence-guided surgery to allow improved intra-operative delineation of tumor margins...
Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerationsFrederic Leblond
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover New Hampshire 03755, USA
J Opt Soc Am A Opt Image Sci Vis 26:1444-57. 2009..5 to 2.5 mm) separated by less than 1.5 mm...- Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applicationsFrederic Leblond
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
J Photochem Photobiol B 98:77-94. 2010.... - Toward whole-body optical imaging of rats using single-photon counting fluorescence tomographyFrederic Leblond
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
Opt Lett 36:3723-5. 2011.... - Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)David W Roberts
Dartmouth Medical School, Hanover, NH, USA
Neurosurg Clin N Am 23:371-7. 2012..These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development... 
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgeryPablo A Valdes
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 16:116007. 2011..Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients...- Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic valueBrian W Pogue
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Philos Trans A Math Phys Eng Sci 369:4531-57. 2011..Most beneficial inclusion of prior information has been in the inversion/reconstruction process, because it solves the mathematical intractability. However, it is not clear that this is always the most beneficial stage... - Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image qualityRobert W Holt
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 37:2559-61. 2012.... - Dual-tracer background subtraction approach for fluorescent molecular tomographyKenneth M Tichauer
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 18:16003. 2013..The approach is demonstrated in simulations, a phantom study, and in a mouse glioma imaging study, demonstrating substantial improvement over conventional and homogenous background subtraction image reconstruction approaches... - Quantitative, spectrally-resolved intraoperative fluorescence imagingPablo A Valdes
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Sci Rep 2:798. 2012..The wide-field qFI technique has broad implications for intraoperative surgical guidance because it provides near real-time quantitative assessment of multiple fluorescent biomarkers across the operative field... - A microcomputed tomography guided fluorescence tomography system for small animal molecular imagingDax Kepshire
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Rev Sci Instrum 80:043701. 2009..This multimodality imaging system will have a wide range of applications in preclinical cancer research ranging from studies of the tumor microenvironment and treatment efficacy for emerging cancer therapeutics... - Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarkerPablo A Valdes
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
J Neurosurg 115:11-7. 2011..The authors show that diagnostically significant but visually imperceptible concentrations of PpIX can be quantitatively measured in vivo and used to discriminate normal from neoplastic brain tissue across a range of tumor histologies... - Automatic exposure control and estimation of effective system noise in diffuse fluorescence tomographyDax L Kepshire
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
Opt Express 17:23272-83. 2009..This fluorophore has very low fluorescence yield, but high biological relevance for tumor imaging, given that it is produced in the mitochondria, and upregulated in many tumor types... - Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence dataKenneth M Tichauer
Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
Appl Opt 50:3962-72. 2011.... - Computationally efficient methods for incorporation of spectral priors in 3-d optical tomographySubhadra Srinivasan
Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
Conf Proc IEEE Eng Med Biol Soc . 2006.... - Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical articleDavid W Roberts
Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
J Neurosurg 114:595-603. 2011.... - Radiologic and near-infrared/optical spectroscopic imaging: where is the synergy?Brian W Pogue
Dartmouth College, Hanover, New Hampshire 03755, USA
AJR Am J Roentgenol 195:321-32. 2010..Examples of clinical systems under research and development are shown...