Nadeem Khan

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen
    Nadeem Khan
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    J Neurosci Methods 204:111-7. 2012
  2. pmc Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 172:592-7. 2009
  3. pmc Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 73:878-85. 2009
  4. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
  5. pmc The evaluation of new and isotopically labeled isoindoline nitroxides and an azaphenalene nitroxide for EPR oximetry
    Nadeem Khan
    EPR Centre for Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Magn Reson 211:170-7. 2011
  6. ncbi request reprint Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005
  7. ncbi request reprint The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiat Res 168:218-25. 2007
  8. pmc Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonators
    Huagang Hou
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, United States
    J Magn Reson 214:22-8. 2012
  9. ncbi request reprint Synergistic combination of hyperoxygenation and radiotherapy by repeated assessments of tumor pO2 with EPR oximetry
    Huagang Hou
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    J Radiat Res 52:568-74. 2011
  10. pmc Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutants
    Jiangang Shen
    EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biophys J 84:1291-8. 2003

Detail Information

Publications31

  1. pmc Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen
    Nadeem Khan
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    J Neurosci Methods 204:111-7. 2012
    ..Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2)...
  2. pmc Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 172:592-7. 2009
    ..This multimodal approach could be used to enhance the outcome of radiotherapy. Furthermore, tumor pO2 could be a potential marker of therapeutic response...
  3. pmc Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 73:878-85. 2009
    ..3 Gy of radiation and carbogen inhalation on orthotopic 9L and C6 gliomas and on the contralateral brain pO(2) in rats using a new and potentially widely useful method, multisite in vivo electron paramagnetic resonance oximetry...
  4. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
    ..We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy...
  5. pmc The evaluation of new and isotopically labeled isoindoline nitroxides and an azaphenalene nitroxide for EPR oximetry
    Nadeem Khan
    EPR Centre for Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Magn Reson 211:170-7. 2011
    ..The active ester nitroxide showed approximately 6% intracellular localization and low cytotoxicity. The EPR spectra of TMAO nitroxide indicated an increased rigidity in the nitroxide ring, due to dibenzo-annulation...
  6. ncbi request reprint Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005
    ..Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors...
  7. ncbi request reprint The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiat Res 168:218-25. 2007
    ..This is the first study to demonstrate the ability of efaproxiral to increase tumor oxygenation and to increase the tumor growth inhibition of radiotherapy over 5 days of treatment...
  8. pmc Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonators
    Huagang Hou
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, United States
    J Magn Reson 214:22-8. 2012
    ..We report a recently developed electron paramagnetic resonance (EPR) oximetry approach with multiple probe implantable resonators (IRs) that allow repeated measurements of oxygen in tissue at depths of greater than 10mm...
  9. ncbi request reprint Synergistic combination of hyperoxygenation and radiotherapy by repeated assessments of tumor pO2 with EPR oximetry
    Huagang Hou
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    J Radiat Res 52:568-74. 2011
    ..Repeated tumor pO(2) measurements by EPR oximetry can provide temporal information that could be used to improve therapeutic outcomes by scheduling doses at times of improved tumor oxygenation...
  10. pmc Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutants
    Jiangang Shen
    EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biophys J 84:1291-8. 2003
    ..The results are consistent with our earlier findings suggesting that such oxygen gradients may be a general phenomenon found in most or all cell systems under appropriate conditions...
  11. ncbi request reprint Spin traps: in vitro toxicity and stability of radical adducts
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Free Radic Biol Med 34:1473-81. 2003
    ..It then should be feasible to select the spin trap(s) best suited for the proposed study...
  12. pmc Tumor pO₂ as a surrogate marker to identify therapeutic window during metronomic chemotherapy of 9L gliomas
    Sriram Mupparaju
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Adv Exp Med Biol 701:107-13. 2011
    ..In vivo EPR oximetry is currently being tested for repeated pO(2) measurements in patients with superficial tumors...
  13. ncbi request reprint Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 25:1413-23. 2004
    ....
  14. pmc Repeated tumor pO(2) measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapy
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
    Radiother Oncol 91:126-31. 2009
    ..To investigate the temporal effects of single or fractionated radiotherapy on subcutaneous RIF-1 tumor pO(2) and to determine the therapeutic outcomes when the timing of fractionations is guided by tumor pO(2)...
  15. pmc Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomas
    Sriram Mupparaju
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Oncol Rep 26:281-6. 2011
    ..This vital information could also be used to schedule radiotherapy to enhance therapeutic outcome...
  16. pmc Clinical electron paramagnetic resonance (EPR) oximetry using India ink
    Benjamin B Williams
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:149-56. 2010
    ..These studies demonstrate the feasibility of EPR oximetry in a clinical setting and the potential for more widespread use in the treatment of these and other oxygen-dependent diseases...
  17. ncbi request reprint "Distant spin trapping": a method for expanding the availability of spin trapping measurements
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, 7785 Vail, Room 702, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biochem Biophys Methods 62:125-30. 2005
    ..This should significantly expand the ability to use spin trapping in biology and medicine...
  18. ncbi request reprint Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 59:834-43. 2004
    ....
  19. pmc Assessment of the Changes in 9L and C6 Glioma pO2 by EPR Oximetry as a Prognostic Indicator of Differential Response to Radiotherapy
    Huagang Hou
    a EPR Center for Viable Systems, Department of Radiology, and
    Radiat Res 179:343-51. 2013
    ..We propose that the repeated measurement of the oxygen levels in the tumors during radiotherapy can be used to identify responders and to design tumor oxygen guided treatment plans to improve the outcome...
  20. pmc Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 173:651-8. 2010
    ..5% BN formulation led to a significant growth inhibition. EPR oximetry provided dynamic information on the changes in tumor pO(2), which could be used to identify responders and non-responders and schedule therapy during the experiments...
  21. ncbi request reprint Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 26:203-13. 2005
    ..26 to 0.95 (carbogen) were similar by the two methods and (4) in some rats breathing carbogen, absolute values of PtO(2) were above the sensitive range of the OxyLite method...
  22. pmc Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1169-82. 2007
    ..We are confident that in vivo EPR oximetry will play a crucial role in the understanding and clinical management of various pathologies in the years to come...
  23. doi request reprint Cerebral oxygenation of the cortex and striatum following normobaric hyperoxia and mild hypoxia in rats by EPR oximetry using multi-probe implantable resonators
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Adv Exp Med Biol 701:61-7. 2011
    ..In addition, the ability to simultaneously measure the pO(2) in several areas of the brain provides important information that could potentially help differentiate the pO(2) changes that can occur due to global or local mechanisms...
  24. ncbi request reprint Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 42:23-9. 2003
    ..The results indicate that the concentration of cholesterol in the plasma membrane can be an important factor for the magnitude of the oxygen gradient observed across the cell membrane...
  25. ncbi request reprint Clinical applications of EPR: overview and perspectives
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    NMR Biomed 17:335-51. 2004
    ....
  26. pmc Use of electron paramagnetic resonance spectroscopy to evaluate the redox state in vivo
    Harold M Swartz
    Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1757-71. 2007
    ..It seems likely that the use of in vivo EPR to measure redox processes will become an increasingly utilized and valuable tool...
  27. ncbi request reprint In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation
    Harold M Swartz
    EPR Center for Viable Systems, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Radiat Prot Dosimetry 120:163-70. 2006
    ....
  28. ncbi request reprint Impact of mouse strain differences in innate hindlimb collateral vasculature
    Armin Helisch
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Arterioscler Thromb Vasc Biol 26:520-6. 2006
    ..To assess the importance of genetic background for collateral artery development...
  29. pmc Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy
    Zrinka Abramovic
    Laboratory of Biophysics, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Adv Exp Med Biol 701:75-82. 2011
    ..This approach can be potentially used to enhance radiotherapeutic outcome by scheduling radiation doses when an increase in tumor pO(2) is observed after topical applications of BN formulations...
  30. pmc Application of in vivo EPR for tissue pO2 and redox measurements
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Methods Mol Biol 559:131-9. 2009
    ..In this chapter, we describe the procedure for in vivo pO(2) and redox measurements in animal models...
  31. ncbi request reprint Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopy
    Nadeem Khan
    EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Cell Biochem 234:341-57. 2002
    ..The current state of the art for these and other measurements is discussed, especially in relationship to experiments that are likely to be useful for studies of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS)...

Research Grants7

  1. Development of EPR and NIR Oximetry for Diabetic Foot
    Mohammad Khan; Fiscal Year: 2007
    ..If the promise of these techniques is fulfilled, clinicians will have a new powerful tool for management of peripheral vascular disease, based on fundamental pathophysiology. ..
  2. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Mohammad Khan; Fiscal Year: 2007
    ....
  3. Monitoring Oxygen Repeatedly for Hypoxic Tumor Therapy
    Mohammad Khan; Fiscal Year: 2007
    ..The proposed approach to modulate tumor hypoxia will avoid possible complications and toxicity arising due to oral or injections of drugs. If successful, this approach potentially could be immediately extended for clinical applications. ..
  4. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Nadeem Khan; Fiscal Year: 2010
    ....