Margaret R Karagas

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
  2. pmc Evidence on the human health effects of low-level methylmercury exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Environ Health Perspect 120:799-806. 2012
  3. pmc SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 131:453-61. 2012
  4. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
  5. pmc CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer
    Marleen M Welsh
    Department of Environmental Health, Harvard School of Public Health, Boston University School of Public Health, Boston, Massachusetts, USA
    Cancer Res 69:6158-63. 2009
  6. ncbi request reprint XPA, haplotypes, and risk of basal and squamous cell carcinoma
    Katie L Miller
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 27:1670-5. 2006
  7. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
  8. pmc Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Environ Health Perspect 114:1193-8. 2006
  9. pmc Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    BMJ 341:c2986. 2010
  10. ncbi request reprint A population-based case-control study of the XRCC1 Arg399Gln polymorphism and susceptibility to bladder cancer
    Karl T Kelsey
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Building 1, Room 607, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1337-41. 2004

Detail Information

Publications81

  1. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
    ..Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC)...
  2. pmc Evidence on the human health effects of low-level methylmercury exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Environ Health Perspect 120:799-806. 2012
    ..Despite its global relevance, synthesis of the available literature on low-level MeHg exposure has been limited...
  3. pmc SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 131:453-61. 2012
    ..03). Our findings suggest novel variants that may influence risk of arsenic-associated bladder cancer and those who may be at greatest risk from this widespread exposure...
  4. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
    ..01). Haplotype analysis confirmed the association of the XRCC3 241. Thus, double-strand break repair genotype may enhance arsenic associated bladder cancer susceptibility in the U.S. population...
  5. pmc CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer
    Marleen M Welsh
    Department of Environmental Health, Harvard School of Public Health, Boston University School of Public Health, Boston, Massachusetts, USA
    Cancer Res 69:6158-63. 2009
    ..In conclusion, genetic variation at the CTLA4 locus may be etiologically important in NMSC, the most prevalent malignancy in the United States...
  6. ncbi request reprint XPA, haplotypes, and risk of basal and squamous cell carcinoma
    Katie L Miller
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 27:1670-5. 2006
    ..The common G allele of the A23G polymorphism was associated with an increased risk of BCC and SCC and this polymorphism appeared to be the determining polymorphism in XPA that alters cancer susceptibility...
  7. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
    ..8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use...
  8. pmc Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Environ Health Perspect 114:1193-8. 2006
    ....
  9. pmc Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    BMJ 341:c2986. 2010
    ..To investigate the association between genus beta human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population...
  10. ncbi request reprint A population-based case-control study of the XRCC1 Arg399Gln polymorphism and susceptibility to bladder cancer
    Karl T Kelsey
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Building 1, Room 607, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1337-41. 2004
    ....
  11. ncbi request reprint Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Epidemiology 18:776-84. 2007
    ..It is also not known whether subgroups of individuals are at greater risk, eg, those with radiation sensitivity or high ultraviolet radiation exposure...
  12. ncbi request reprint Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Carcinogenesis 27:1030-7. 2006
    ..These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and emphasize the need for a multifaceted statistical approach to identify gene-gene and gene-environment interactions...
  13. ncbi request reprint Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damage
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Epidemiol 165:719-26. 2007
    ..Findings suggest that cumulative, but not intermittent, measures of sun exposure derived from a personal interview appear to reflect a person's exposure history based on histologic evidence...
  14. pmc Oral contraceptives: a risk factor for squamous cell carcinoma?
    Katie M Applebaum
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
    J Invest Dermatol 129:2760-5. 2009
    ..03). These findings lead us to hypothesize a potential relationship between OCs and SCC risk, and that this could involve DNA repair pathways...
  15. pmc Cutaneous alpha, beta and gamma human papillomaviruses in relation to squamous cell carcinoma of the skin: a population-based study
    Shohreh F Farzan
    Department of Community and Family Medicine and the Norris Cotton Cancer Center, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH 03756, USA
    Int J Cancer 133:1713-20. 2013
    ..Overall, the association between cutaneous HPVs and skin cancers appears to be specific to SCC and to genus beta HPVs in a general US population. ..
  16. pmc A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions
    Marleen M Welsh
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:1950-4. 2008
    ..0004). In conclusion, our findings are a first step in determining the genetic underpinnings of UV immune suppression and have identified important new genetic interactions contributing to the etiology of skin cancer...
  17. ncbi request reprint Occupation and keratinocyte cancer risk: a population-based case-control study
    Josh Marehbian
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Cancer Causes Control 18:895-908. 2007
    ..The aim of our study was to identify occupations associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)...
  18. pmc Exposure profiles and human papillomavirus infection in skin cancer: an analysis of 25 genus beta-types in a population-based study
    Anita S Patel
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Invest Dermatol 128:2888-93. 2008
    ..These data highlight the potential importance of various genus beta-HPV types, in particular genus beta-species 1 in SCC, and support the hypothesis of a behavioral difference of the virus within the two major histological skin cancers...
  19. ncbi request reprint The XPC poly-AT polymorphism in non-melanoma skin cancer
    Heather H Nelson
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Lett 222:205-9. 2005
    ..These results require further confirmation...
  20. pmc Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer: a population-based case-control study
    Dorothea C Torti
    Section of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Am Acad Dermatol 65:304-12. 2011
    ..Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially chemopreventive...
  21. pmc Associations between toenail arsenic concentration and dietary factors in a New Hampshire population
    Joann F Gruber
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Nutr J 11:45. 2012
    ..However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown...
  22. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
    ..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality...
  23. pmc Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study
    Anita S Patel
    Department of Environmental Health, Harvard School of Public Health, Boston, MA
    Int J Cancer 122:2377-9. 2008
    ..7, 95% CI 1.1-2.7]. These data provide evidence for a role of genetic variation in the EVER2 gene in beta-HPV infection and risk of SCC, shedding light on the link between HPVs and skin cancers...
  24. ncbi request reprint Carcinogen exposure and gene promoter hypermethylation in bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:112-6. 2006
    ..These results, from human bladder tumors, add to the body of animal and in vitro evidence that suggests a role in epigenetic alterations for bladder carcinogens...
  25. ncbi request reprint Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire
    Margaret R Karagas
    Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Causes Control 15:465-72. 2004
    ..To examine the effects of lower levels of arsenic exposure on bladder cancer incidence, we conducted a case-control study in New Hampshire, USA where levels above 10 micro/l are commonly found in private wells...
  26. pmc DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 65:105-18. 2008
    ..These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway...
  27. ncbi request reprint Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study
    Margaret R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    Int J Hyg Environ Health 208:321-7. 2005
    ..12 for MTHFR 1298A>C). Thus, our findings do not support the presence of a main gene effect. The possibility that MTHFR polymorphism affects susceptibility to environmental exposures warrants further consideration...
  28. ncbi request reprint Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 65:7081-5. 2005
    ..02) controlled for TP53 staining intensity and other survival-associated factors. Classifying tumors based on SFRP methylation status and TP53 protein staining intensity may be a clinically powerful predictor of invasive, deadly disease...
  29. pmc Tea consumption and basal cell and squamous cell skin cancer: results of a case-control study
    Judy R Rees
    Department of Community and Family Medicine Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH, USA
    J Am Acad Dermatol 56:781-5. 2007
    ..Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models...
  30. ncbi request reprint Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin
    Margaret R Karagas
    Department of Community and Family Medicine, Center for Environmental Health Sciences, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Natl Cancer Inst 98:389-95. 2006
    ....
  31. ncbi request reprint Body mass and smoking are modifiable risk factors for recurrent bladder cancer
    Asaf Wyszynski
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire Program in Experimental and Molecular Medicine, Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
    Cancer 120:408-14. 2014
    ..Recurrences frequently occur, and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed...
  32. ncbi request reprint The association of physical activity and body mass index with the risk of large bowel polyps
    Kristin Wallace
    Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 14:2082-6. 2005
    ..After the second study colonoscopy, we asked subjects questions about their leisure time physical activity. Seven hundred eighty-seven subjects completed at least part of the physical activity questionnaire...
  33. pmc A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire
    Corina Lesseur
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Toxicol Lett 210:100-6. 2012
    ....
  34. pmc Selenium and risk of bladder cancer: a population-based case-control study
    Kristin Wallace
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Prev Res (Phila) 2:70-3. 2009
    ..g., p53 positive) or within certain subsets of a population (e.g., women or moderate smokers)...
  35. pmc Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Cancer Epidemiol Biomarkers Prev 21:1293-302. 2012
    ....
  36. ncbi request reprint Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Lett 219:63-9. 2005
    ..Recent work further suggests that susceptibility to the carcinogenic effects of tobacco on the bladder may differ among men and women...
  37. pmc Photosensitizing agents and the risk of non-melanoma skin cancer: a population-based case-control study
    Sarah N Robinson
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA
    J Invest Dermatol 133:1950-5. 2013
    ....
  38. pmc Rice consumption and urinary arsenic concentrations in U.S. children
    Matthew A Davis
    Institute for Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03756, USA
    Environ Health Perspect 120:1418-24. 2012
    ..In adult populations, emerging evidence indicates that humans are exposed to arsenic by ingestion of contaminated foods such as rice, grains, and juice; yet little is known about arsenic exposure among children...
  39. pmc A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis
    Jiang Gui
    Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 70:219-25. 2010
    ..The results suggest that our proposed method performs similarly, but is more computationally efficient. We then apply this new method to an analysis of a population-based bladder cancer study in New Hampshire...
  40. pmc Which fish should I eat? Perspectives influencing fish consumption choices
    Emily Oken
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 120:790-8. 2012
    ..Diverse perspectives have influenced fish consumption choices...
  41. ncbi request reprint Allelic loss at Drosophila patched gene is highly prevalent in Basal and squamous cell carcinomas of the skin
    Hadi Danaee
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Invest Dermatol 126:1152-8. 2006
    ..08). Thus, in our large, population-based sample, 9q22 loss, including PTCH, was highly prevalent in both BCC and SCC. Overall, these data support the hypothesis that PTCH loss is a common, early lesion for SCC and BCC...
  42. pmc Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA
    Environ Health Perspect 121:971-7. 2013
    ..Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations, specifically by altering patterns of DNA methylation...
  43. ncbi request reprint Carcinogen exposure and epigenetic silencing in bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Ann N Y Acad Sci 1076:810-21. 2006
    ..01). These results from human bladder tumors, add to the body of animal and in vitro evidence that suggests bladder carcinogens play a crucial role in the induction of important epigenetic alterations...
  44. pmc Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions
    E Andres Houseman
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
    BMC Bioinformatics 9:365. 2008
    ..Model-based cluster analysis is often used to identify DNA methylation subgroups in data, but it is unclear how to cluster DNA methylation data from arrays in a scalable and reliable manner...
  45. ncbi request reprint Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer
    Shuya Hirao
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 104:1918-23. 2005
    ..Although alteration of p53 has been strongly associated with invasive stage disease, the prognostic significance of 9q loss of heterozygosity (LOH) and the relations between these alterations are less well defined...
  46. ncbi request reprint Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Urol 178:1196-200; discussion 1200. 2007
    ..In a large, nonselected population of patients with bladder cancer we rated all incident tumors using each system and compared long-term patient survival...
  47. pmc Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population
    Angeline S Andrew
    Dartmouth Medical School Section of Biostatistics and Epidemiology, 7927 Rubin 860, One Medical Center Dr, Lebanon, NH 03756, USA
    Environ Health Perspect 116:524-31. 2008
    ....
  48. ncbi request reprint Effect of calcium supplementation on the risk of large bowel polyps
    Kristin Wallace
    Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Natl Cancer Inst 96:921-5. 2004
    ..However, few studies have examined the effect of calcium on the risk of different types of colorectal lesions or dietary determinants of this effect...
  49. pmc A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis
    Jiang Gui
    Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Hum Genet 129:101-10. 2011
    ....
  50. pmc EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
    Rebecca A Mason
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Carcinogenesis 30:1155-60. 2009
    ..Understanding these genetic influences on increased bladder cancer susceptibility and survival may help in cancer prevention, drug development and choice of therapeutic regimen...
  51. ncbi request reprint Early-onset Basal cell carcinoma and indoor tanning: a population-based study
    Margaret R Karagas
    Children s Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, New Hampshire Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Geisel School of Medicine, Hanover, New Hampshire
    Pediatrics 134:e4-e12. 2014
    ..Therefore, we sought to address these issues in a population-based case-control study from New Hampshire...
  52. ncbi request reprint Pregnancy history and incidence of melanoma in women: a pooled analysis
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, 7927 Rubin Bldg, One Medical Center Drive, Hanover, Lebanon, New Hampshire, 03756 0001, USA
    Cancer Causes Control 17:11-9. 2006
    ..g., <5 live births) (pOR 0.33, 95% CI 0.14-0.75). The results are compatible with an effect of reproductive history-related factors on melanoma risk, but also could reflect differences in other factors, such as sun exposure history...
  53. ncbi request reprint Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer
    Anita S Patel
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1868-70. 2007
    ..Given the large numbers of individuals on immunosuppressive drug therapy for inflammatory disease, these findings have important implications for NMSC screening and prevention...
  54. ncbi request reprint Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water
    Angeline S Andrew
    Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 104:263-8. 2003
    ..Although our findings need verification in a larger study group, they are consistent with the hypothesis that inhibition of DNA repair capacity is a potential mechanism for the co-carcinogenic activity of arsenic...
  55. doi request reprint Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water
    Kathryn L Cottingham
    Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
    Nutr J 12:149. 2013
    ..Foods known to be high in arsenic, including rice and seafood, were of particular interest...
  56. pmc HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer
    Angeline S Andrew
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
    PLoS ONE 7:e51301. 2012
    ..This biologic process-based analysis suggests candidate susceptibility markers and supports the theory that disrupted hormone regulation plays a role in bladder carcinogenesis...
  57. pmc Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Scand J Urol Nephrol 42:237-42. 2008
    ..This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States...
  58. ncbi request reprint A system-level pathway-phenotype association analysis using synthetic feature random forest
    Qinxin Pan
    Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America
    Genet Epidemiol 38:209-19. 2014
    ..The bladder cancer associated pathways we found are both consistent with existing biological knowledge and reveal novel and plausible hypotheses for future biological validations. ..
  59. pmc A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA
    Diane Gilbert-Diamond
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA
    Environ Health Perspect 121:1154-60. 2013
    ..However, little is known about the carcinogenicity of arsenic at levels commonly observed in the United States...
  60. ncbi request reprint Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Res 66:10621-9. 2006
    ....
  61. ncbi request reprint The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction
    Heather H Nelson
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:152-5. 2002
    ..These data, using the classic skin carcinogenesis model, provide new insight on the role of the XRCC1 399 polymorphism in neoplasia and may help explain the conflicting results relating this polymorphism to cancer risk at various sites...
  62. pmc Rice consumption contributes to arsenic exposure in US women
    Diane Gilbert-Diamond
    Children s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:20656-60. 2011
    ..Our findings along with others indicate that rice consumption should be considered when designing arsenic reduction strategies in the United States...
  63. pmc Arsenic, organic foods, and brown rice syrup
    Brian P Jackson
    Trace Element Analysis Core Laboratory, Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Environ Health Perspect 120:623-6. 2012
    ..Organic brown rice syrup (OBRS) is used as a sweetener in organic food products as an alternative to high-fructose corn syrup. We hypothesized that OBRS introduces As into these products...
  64. pmc A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility
    Jiang Gui
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Ann Hum Genet 75:20-8. 2011
    ..We show that there is no loss of success rate when this is not the case. We then apply the RMDR method to the detection of gene-gene interactions in genotype data from a population-based study of bladder cancer in New Hampshire...
  65. pmc Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA
    Mod Pathol 27:145-55. 2014
    ..1, P=0.004) exhibited a methylation profile similar to right-colon adenomas. In summary, our results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon. ..
  66. ncbi request reprint Toenail mercury and dietary fish consumption
    Judy R Rees
    Dartmouth College Center for Environmental Health Sciences, Department of Community and Family Medicine Biostatistics and Epidemiology and Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    J Expo Sci Environ Epidemiol 17:25-30. 2007
    ..48, P=0.012). Multivariate models confirmed that toenail total mercury concentration was best predicted by total finfish and shellfish consumption...
  67. pmc A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction
    Kristine A Pattin
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Genet Epidemiol 33:87-94. 2009
    ..We then demonstrate this new method by applying it to a genetic epidemiology study of bladder cancer susceptibility that was previously analyzed using MDR and assessed using a 1,000-fold permutation test...
  68. pmc In utero and early life arsenic exposure in relation to long-term health and disease
    Shohreh F Farzan
    Children s Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH 03755, USA Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
    Toxicol Appl Pharmacol 272:384-90. 2013
    ..There is a growing body of evidence that prenatal and early childhood exposure to arsenic from drinking water can have serious long-term health implications...
  69. pmc In utero arsenic exposure and infant infection in a United States cohort: a prospective study
    Shohreh F Farzan
    Children s Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH 03755, USA Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
    Environ Res 126:24-30. 2013
    ..3; 95% CI=1.0, 5.2). Our results provide initial evidence that in utero As exposure may be related to infant infection and infection severity and provide insight into the early life impacts of fetal As exposure. ..
  70. ncbi request reprint Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community
    Joel B Wickre
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA
    Arch Environ Health 59:400-9. 2004
    ..Fingernail analysis helped to identify differential exposure pathways in children and adults. Mercury and arsenic uptake via soil exposure in children warrants further consideration...
  71. pmc Genetic population structure analysis in New Hampshire reveals Eastern European ancestry
    Chantel D Sloan
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 4:e6928. 2009
    ..To our knowledge, this is the first time such an investigation has uncovered a strong link between genetic structure and ancestry in what would otherwise be considered a homogenous US population...
  72. ncbi request reprint Normal neonatal microbiome variation in relation to environmental factors, infection and allergy
    Juliette C Madan
    Division of Neonatology, Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH 03753, USA
    Curr Opin Pediatr 24:753-9. 2012
    ....
  73. pmc Cancer heterogeneity: origins and implications for genetic association studies
    Davnah Urbach
    Institute for Quantitative Biomedical Sciences, The Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, NH 03756, USA
    Trends Genet 28:538-43. 2012
    ....
  74. ncbi request reprint Bladder cancer risk and personal hair dye use
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 109:581-6. 2004
    ..In light of the prevalence of hair dye use, further studies are needed that address the effects of specific colors and types of hair dyes along with the possible role of individual susceptibility...
  75. pmc Diabetes and risk of bladder cancer: evidence from a case-control study in New England
    Todd MacKenzie
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 037756, USA
    Cancer 117:1552-6. 2011
    ....
  76. pmc Characterizing genetic interactions in human disease association studies using statistical epistasis networks
    Ting Hu
    Department of Genetics, Dartmouth Medical School, Dartmouth College, Lebanon, NH, USA
    BMC Bioinformatics 12:364. 2011
    ....
  77. ncbi request reprint Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study
    Kristin Wallace
    Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Cancer Epidemiol Biomarkers Prev 12:464-7. 2003
    ..50 for total selenium and P for trend = 0.20 for bound selenium). Thus, our findings do not indicate a clear association between serum selenium concentrations and adenoma recurrence...
  78. pmc Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies
    Richard Cowper-Sal Lari
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH, USA
    Wiley Interdiscip Rev Syst Biol Med 3:513-26. 2011
    ..This will give GWAS re-analysis efforts the most current and relevant substrates, and root them firmly on our knowledge of human disease...
  79. pmc Using Bayesian networks to discover relations between genes, environment, and disease
    Chengwei Su
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    BioData Min 6:6. 2013
    ....
  80. ncbi request reprint Assessment of cancer risk and environmental levels of arsenic in New Hampshire
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, 7927 Rubin 462M 3, One Medical Center Drive, Lebanon, NH 03756 001, USA
    Int J Hyg Environ Health 205:85-94. 2002
    ..Lastly, our data suggest that use of a biologic marker along with alternative statistical approaches may aid detection of the levels at which arsenic may affect cancer occurrence in the US...
  81. pmc Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors
    Dennis Liang Fei
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 70:1981-8. 2010
    ..Thus, we provide an important insight into the etiology of arsenic-induced human carcinogenesis, which may be relevant to millions of people exposed to high levels of arsenic worldwide...