M R Karagas

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Associations between toenail arsenic concentration and dietary factors in a New Hampshire population
    Joann F Gruber
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Nutr J 11:45. 2012
  2. pmc Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study
    Dennis Liang Fei
    Department of Surgery, Molecular Oncology Program, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Environ Health 12:58. 2013
  3. pmc Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study
    Joan Fortuny
    Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research IMIM, 08003 Barcelona, Catalonia, Spain
    BMC Urol 7:13. 2007
  4. ncbi request reprint Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Epidemiology 18:776-84. 2007
  5. ncbi request reprint Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire
    Margaret R Karagas
    Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Causes Control 15:465-72. 2004
  6. ncbi request reprint Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damage
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Epidemiol 165:719-26. 2007
  7. pmc Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    BMJ 341:c2986. 2010
  8. ncbi request reprint Pregnancy history and incidence of melanoma in women: a pooled analysis
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, 7927 Rubin Bldg, One Medical Center Drive, Hanover, Lebanon, New Hampshire, 03756 0001, USA
    Cancer Causes Control 17:11-9. 2006
  9. ncbi request reprint Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin
    Margaret R Karagas
    Department of Community and Family Medicine, Center for Environmental Health Sciences, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Natl Cancer Inst 98:389-95. 2006
  10. ncbi request reprint Assessment of cancer risk and environmental levels of arsenic in New Hampshire
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, 7927 Rubin 462M 3, One Medical Center Drive, Lebanon, NH 03756 001, USA
    Int J Hyg Environ Health 205:85-94. 2002

Detail Information

Publications70

  1. pmc Associations between toenail arsenic concentration and dietary factors in a New Hampshire population
    Joann F Gruber
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Nutr J 11:45. 2012
    ..However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown...
  2. pmc Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study
    Dennis Liang Fei
    Department of Surgery, Molecular Oncology Program, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Environ Health 12:58. 2013
    ....
  3. pmc Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study
    Joan Fortuny
    Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research IMIM, 08003 Barcelona, Catalonia, Spain
    BMC Urol 7:13. 2007
    ..Use of phenacetin and other analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) potentially influences bladder cancer incidence, but epidemiologic evidence is limited...
  4. ncbi request reprint Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Epidemiology 18:776-84. 2007
    ..It is also not known whether subgroups of individuals are at greater risk, eg, those with radiation sensitivity or high ultraviolet radiation exposure...
  5. ncbi request reprint Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire
    Margaret R Karagas
    Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Causes Control 15:465-72. 2004
    ..To examine the effects of lower levels of arsenic exposure on bladder cancer incidence, we conducted a case-control study in New Hampshire, USA where levels above 10 micro/l are commonly found in private wells...
  6. ncbi request reprint Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damage
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Epidemiol 165:719-26. 2007
    ..Findings suggest that cumulative, but not intermittent, measures of sun exposure derived from a personal interview appear to reflect a person's exposure history based on histologic evidence...
  7. pmc Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    BMJ 341:c2986. 2010
    ..To investigate the association between genus beta human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population...
  8. ncbi request reprint Pregnancy history and incidence of melanoma in women: a pooled analysis
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, 7927 Rubin Bldg, One Medical Center Drive, Hanover, Lebanon, New Hampshire, 03756 0001, USA
    Cancer Causes Control 17:11-9. 2006
    ..g., <5 live births) (pOR 0.33, 95% CI 0.14-0.75). The results are compatible with an effect of reproductive history-related factors on melanoma risk, but also could reflect differences in other factors, such as sun exposure history...
  9. ncbi request reprint Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin
    Margaret R Karagas
    Department of Community and Family Medicine, Center for Environmental Health Sciences, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Natl Cancer Inst 98:389-95. 2006
    ....
  10. ncbi request reprint Assessment of cancer risk and environmental levels of arsenic in New Hampshire
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, 7927 Rubin 462M 3, One Medical Center Drive, Lebanon, NH 03756 001, USA
    Int J Hyg Environ Health 205:85-94. 2002
    ..Lastly, our data suggest that use of a biologic marker along with alternative statistical approaches may aid detection of the levels at which arsenic may affect cancer occurrence in the US...
  11. pmc A pooled analysis of 10 case-control studies of melanoma and oral contraceptive use
    M R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine Dartmouth Medical School, 7927 Rubin 462M 3, One Medical Center Drive, Lebanon, New Hampshire, NH 03756 0001, USA
    Br J Cancer 86:1085-92. 2002
    ..In aggregate, our findings do not suggest a major role of oral contraceptive use on women's risk of melanoma...
  12. ncbi request reprint Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    Am J Epidemiol 152:84-90. 2000
    ..08 (p = 0.31) among those with concentrations below 1 microg/liter (overall r = 0.46, p < 0.001). Our data suggest that toenail samples provide a useful biologic marker for quantifying low-level arsenic exposure...
  13. ncbi request reprint Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Epidemiol 153:559-65. 2001
    ....
  14. ncbi request reprint Increase in incidence rates of basal cell and squamous cell skin cancer in New Hampshire, USA. New Hampshire Skin Cancer Study Group
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    Int J Cancer 81:555-9. 1999
    ..Studies of BCC and SCC occurrence are needed to identify possible behavioral and environmental factors and to assess possible changes in diagnostic practices that might account for the rise in incidence of these common malignancies...
  15. pmc Design of an epidemiologic study of drinking water arsenic exposure and skin and bladder cancer risk in a U.S. population
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    Environ Health Perspect 106:1047-50. 1998
    ..Based on our projected sample size, we expect at least 80% power to detect a 2-fold risk of basal cell or squamous cell skin cancer or bladder cancer among individuals with the highest 5% toenail concentrations of arsenic...
  16. ncbi request reprint Markers of low level arsenic exposure for evaluating human cancer risks in a US population
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Occup Med Environ Health 14:171-5. 2001
    ..Our data suggest that biologic markers may provide reliable estimates of internal dose of low level arsenic exposure that can be used to assess cancer risk...
  17. pmc Non-melanoma skin cancers and glucocorticoid therapy
    M R Karagas
    Departments of Community and Family Medicine, Medicine, Pharmacology and Toxicology, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, 03756, USA
    Br J Cancer 85:683-6. 2001
    ..We hypothesize that immunosuppression induced by oral glucocorticoids may allow these cancers to emerge from immunosurveillance...
  18. ncbi request reprint Occupation and keratinocyte cancer risk: a population-based case-control study
    Josh Marehbian
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Cancer Causes Control 18:895-908. 2007
    ..The aim of our study was to identify occupations associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)...
  19. pmc Parity, early menopause and the incidence of bladder cancer in women: a case-control study and meta-analysis
    K Dietrich
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Eur J Cancer 47:592-9. 2011
    ..Incidence rates of bladder cancer are notably higher in men than in women. While there is evidence that reproductive and hormonal risk factors may influence risk of bladder cancer, data are inconclusive...
  20. ncbi request reprint Two-stage methods for the analysis of pooled data
    T A Stukel
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, NH 03755 3863, USA
    Stat Med 20:2115-30. 2001
    ..The results are applied to a study of reproductive history and cutaneous melanoma risk in women using data from ten large case-control studies...
  21. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
    ..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality...
  22. pmc Glucocorticoid therapy and risk of bladder cancer
    K Dietrich
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Br J Cancer 101:1316-20. 2009
    ....
  23. pmc Tea consumption and basal cell and squamous cell skin cancer: results of a case-control study
    Judy R Rees
    Department of Community and Family Medicine Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH, USA
    J Am Acad Dermatol 56:781-5. 2007
    ..Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models...
  24. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
    ..01). Haplotype analysis confirmed the association of the XRCC3 241. Thus, double-strand break repair genotype may enhance arsenic associated bladder cancer susceptibility in the U.S. population...
  25. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
    ..8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use...
  26. ncbi request reprint Toenail mercury and dietary fish consumption
    Judy R Rees
    Dartmouth College Center for Environmental Health Sciences, Department of Community and Family Medicine Biostatistics and Epidemiology and Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    J Expo Sci Environ Epidemiol 17:25-30. 2007
    ..48, P=0.012). Multivariate models confirmed that toenail total mercury concentration was best predicted by total finfish and shellfish consumption...
  27. pmc Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Environ Health Perspect 114:1193-8. 2006
    ....
  28. ncbi request reprint Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Carcinogenesis 27:1030-7. 2006
    ..These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and emphasize the need for a multifaceted statistical approach to identify gene-gene and gene-environment interactions...
  29. pmc Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population
    Angeline S Andrew
    Dartmouth Medical School Section of Biostatistics and Epidemiology, 7927 Rubin 860, One Medical Center Dr, Lebanon, NH 03756, USA
    Environ Health Perspect 116:524-31. 2008
    ....
  30. ncbi request reprint Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water
    Angeline S Andrew
    Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 104:263-8. 2003
    ..Although our findings need verification in a larger study group, they are consistent with the hypothesis that inhibition of DNA repair capacity is a potential mechanism for the co-carcinogenic activity of arsenic...
  31. ncbi request reprint Bladder cancer risk and personal hair dye use
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 109:581-6. 2004
    ..In light of the prevalence of hair dye use, further studies are needed that address the effects of specific colors and types of hair dyes along with the possible role of individual susceptibility...
  32. pmc DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 65:105-18. 2008
    ..These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway...
  33. ncbi request reprint Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community
    Joel B Wickre
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA
    Arch Environ Health 59:400-9. 2004
    ..Fingernail analysis helped to identify differential exposure pathways in children and adults. Mercury and arsenic uptake via soil exposure in children warrants further consideration...
  34. pmc Diabetes and risk of bladder cancer: evidence from a case-control study in New England
    Todd MacKenzie
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 037756, USA
    Cancer 117:1552-6. 2011
    ....
  35. ncbi request reprint Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study
    Margaret R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    Int J Hyg Environ Health 208:321-7. 2005
    ..12 for MTHFR 1298A>C). Thus, our findings do not support the presence of a main gene effect. The possibility that MTHFR polymorphism affects susceptibility to environmental exposures warrants further consideration...
  36. ncbi request reprint Use of tanning devices and risk of basal cell and squamous cell skin cancers
    Margaret R Karagas
    Department of Community and Family Medicine and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Natl Cancer Inst 94:224-6. 2002
    ..They highlight the need to further evaluate the potential risks of BCC and SCC that are associated with tanning lamp exposure and the appropriate public health response...
  37. ncbi request reprint Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Urol 178:1196-200; discussion 1200. 2007
    ..In a large, nonselected population of patients with bladder cancer we rated all incident tumors using each system and compared long-term patient survival...
  38. ncbi request reprint Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Lett 219:63-9. 2005
    ..Recent work further suggests that susceptibility to the carcinogenic effects of tobacco on the bladder may differ among men and women...
  39. pmc EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
    Rebecca A Mason
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Carcinogenesis 30:1155-60. 2009
    ..Understanding these genetic influences on increased bladder cancer susceptibility and survival may help in cancer prevention, drug development and choice of therapeutic regimen...
  40. doi request reprint Hearing loss and heavy metal toxicity in a Nicaraguan mining community: audiological results and case reports
    J E Saunders
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Audiol Neurootol 18:101-13. 2013
    ..Several young individuals with high metal levels reported neurological symptoms and had poor hearing. The data suggest that metal levels in artisanal mining communities present a significant public health problem and may affect hearing...
  41. ncbi request reprint The epidemiology of peripheral fractures
    J A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, NH 03755 3861, USA
    Bone 18:209S-213S. 1996
    ..In each limb, the most proximal fractures tend to have the most pronounced age-related increases in risk...
  42. pmc Genetic population structure analysis in New Hampshire reveals Eastern European ancestry
    Chantel D Sloan
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 4:e6928. 2009
    ..To our knowledge, this is the first time such an investigation has uncovered a strong link between genetic structure and ancestry in what would otherwise be considered a homogenous US population...
  43. pmc Selenium and risk of bladder cancer: a population-based case-control study
    Kristin Wallace
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Prev Res (Phila) 2:70-3. 2009
    ..g., p53 positive) or within certain subsets of a population (e.g., women or moderate smokers)...
  44. pmc A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction
    Kristine A Pattin
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Genet Epidemiol 33:87-94. 2009
    ..We then demonstrate this new method by applying it to a genetic epidemiology study of bladder cancer susceptibility that was previously analyzed using MDR and assessed using a 1,000-fold permutation test...
  45. ncbi request reprint Effect of calcium supplementation on the risk of large bowel polyps
    Kristin Wallace
    Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Natl Cancer Inst 96:921-5. 2004
    ..However, few studies have examined the effect of calcium on the risk of different types of colorectal lesions or dietary determinants of this effect...
  46. pmc Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors
    Dennis Liang Fei
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 70:1981-8. 2010
    ..Thus, we provide an important insight into the etiology of arsenic-induced human carcinogenesis, which may be relevant to millions of people exposed to high levels of arsenic worldwide...
  47. ncbi request reprint Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study
    Kristin Wallace
    Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Cancer Epidemiol Biomarkers Prev 12:464-7. 2003
    ..50 for total selenium and P for trend = 0.20 for bound selenium). Thus, our findings do not indicate a clear association between serum selenium concentrations and adenoma recurrence...
  48. pmc Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Scand J Urol Nephrol 42:237-42. 2008
    ..This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States...
  49. pmc A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions
    Marleen M Welsh
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:1950-4. 2008
    ..0004). In conclusion, our findings are a first step in determining the genetic underpinnings of UV immune suppression and have identified important new genetic interactions contributing to the etiology of skin cancer...
  50. ncbi request reprint The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction
    Heather H Nelson
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:152-5. 2002
    ..These data, using the classic skin carcinogenesis model, provide new insight on the role of the XRCC1 399 polymorphism in neoplasia and may help explain the conflicting results relating this polymorphism to cancer risk at various sites...
  51. pmc Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study
    Anita S Patel
    Department of Environmental Health, Harvard School of Public Health, Boston, MA
    Int J Cancer 122:2377-9. 2008
    ..7, 95% CI 1.1-2.7]. These data provide evidence for a role of genetic variation in the EVER2 gene in beta-HPV infection and risk of SCC, shedding light on the link between HPVs and skin cancers...
  52. pmc Disinfection byproducts in drinking water and skin cancer? A hypothesis
    Margaret R Karagas
    Cancer Causes Control 19:547-8. 2008
  53. ncbi request reprint The XPC poly-AT polymorphism in non-melanoma skin cancer
    Heather H Nelson
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Lett 222:205-9. 2005
    ..These results require further confirmation...
  54. ncbi request reprint Carcinogen exposure and gene promoter hypermethylation in bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:112-6. 2006
    ..These results, from human bladder tumors, add to the body of animal and in vitro evidence that suggests a role in epigenetic alterations for bladder carcinogens...
  55. ncbi request reprint Allelic loss at Drosophila patched gene is highly prevalent in Basal and squamous cell carcinomas of the skin
    Hadi Danaee
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Invest Dermatol 126:1152-8. 2006
    ..08). Thus, in our large, population-based sample, 9q22 loss, including PTCH, was highly prevalent in both BCC and SCC. Overall, these data support the hypothesis that PTCH loss is a common, early lesion for SCC and BCC...
  56. ncbi request reprint XPA, haplotypes, and risk of basal and squamous cell carcinoma
    Katie L Miller
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 27:1670-5. 2006
    ..The common G allele of the A23G polymorphism was associated with an increased risk of BCC and SCC and this polymorphism appeared to be the determining polymorphism in XPA that alters cancer susceptibility...
  57. ncbi request reprint XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review
    Maurizio Manuguerra
    Section of Epidemiology, ISI Foundation, Torino, Italy
    Am J Epidemiol 164:297-302. 2006
    ....
  58. ncbi request reprint A population-based case-control study of the XRCC1 Arg399Gln polymorphism and susceptibility to bladder cancer
    Karl T Kelsey
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Building 1, Room 607, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1337-41. 2004
    ....
  59. ncbi request reprint Carcinogen exposure and epigenetic silencing in bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Ann N Y Acad Sci 1076:810-21. 2006
    ..01). These results from human bladder tumors, add to the body of animal and in vitro evidence that suggests bladder carcinogens play a crucial role in the induction of important epigenetic alterations...
  60. ncbi request reprint Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer
    Anita S Patel
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1868-70. 2007
    ..Given the large numbers of individuals on immunosuppressive drug therapy for inflammatory disease, these findings have important implications for NMSC screening and prevention...
  61. ncbi request reprint Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer
    Carlotta Sacerdote
    Unità di epidemiologia dei tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO Piemonte, Torino, Italy
    Mutagenesis 22:281-5. 2007
    ..This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms...
  62. ncbi request reprint Skin cancers and non-hodgkin lymphoma among users of systemic glucocorticoids: a population-based cohort study
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    J Natl Cancer Inst 96:709-11. 2004
    ..68, 95% CI = 1.16 to 5.29). Our data suggest that use of glucocorticoids may be a shared risk factor for certain skin cancers and lymphomas...
  63. ncbi request reprint Reported use of photosensitizing medications and basal cell and squamous cell carcinoma of the skin: results of a population-based case-control study
    Margaret R Karagas
    J Invest Dermatol 127:2901-3. 2007
  64. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
    ..Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC)...
  65. ncbi request reprint Chronic diseases requiring hospitalization and risk of non-melanoma skin cancers--a population based study from Denmark
    Annette Ø Jensen
    Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark
    J Invest Dermatol 128:926-31. 2008
    ..JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article please go to http://network.nature.com/group/jidclub...
  66. ncbi request reprint Anthropometric factors and risk of melanoma in women: a pooled analysis
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD, Australia
    Int J Cancer 122:1100-8. 2008
    ..In aggregate, data from these studies suggest that greater height and weight gain may be risk factors for cutaneous melanoma in women...
  67. ncbi request reprint Selenium and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724 5024, USA
    J Natl Cancer Inst 96:1669-75. 2004
    ..Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association...
  68. ncbi request reprint Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Res 66:10621-9. 2006
    ....
  69. ncbi request reprint Promoter hypermethylation is associated with current smoking, age, gender and survival in bladder cancer
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Carcinogenesis 28:1745-51. 2007
    ....
  70. ncbi request reprint Microsatellite instability at tetranucleotide repeats in skin and bladder cancer
    Hadi Danaee
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:4894-9. 2002
    ..Hence, EMAST likely reflects a particular pattern of somatic events that are interactive with p53 mutation, particularly common in skin cancer and limited to non-invasive disease in bladder cancer...