Shudong Jiang

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:76011. 2013
  2. pmc Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Radiology 252:551-60. 2009
  3. ncbi request reprint Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 8:308-15. 2003
  4. pmc Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D130-6. 2009
  5. ncbi request reprint In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 13:195-202. 2006
  6. ncbi request reprint Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
  7. ncbi request reprint Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 9:541-52. 2004
  8. ncbi request reprint Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
    Subhadra Srinivasan
    Department of Biomedical Engineering, Thayer School of Engineering, Dartmouth College, P O Box 8000, Hanover, New Hampshire 03755, USA
    Appl Opt 44:1858-69. 2005
  9. ncbi request reprint Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part II--Experimental interpretation
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:764-72. 2002
  10. ncbi request reprint Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    Technol Cancer Res Treat 4:513-26. 2005

Research Grants

Detail Information

Publications39

  1. pmc Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:76011. 2013
    ....
  2. pmc Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Radiology 252:551-60. 2009
    ....
  3. ncbi request reprint Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 8:308-15. 2003
    ....
  4. pmc Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D130-6. 2009
    ..No statistically valid correlations were found between the applied pressure and the changes in tissue oxygen saturation (S(t)O(2)) or water percentage (H(2)O) across the range of BMI values studied...
  5. ncbi request reprint In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 13:195-202. 2006
    ....
  6. ncbi request reprint Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041106. 2006
    ....
  7. ncbi request reprint Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 9:541-52. 2004
    ....
  8. ncbi request reprint Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
    Subhadra Srinivasan
    Department of Biomedical Engineering, Thayer School of Engineering, Dartmouth College, P O Box 8000, Hanover, New Hampshire 03755, USA
    Appl Opt 44:1858-69. 2005
    ..Accurate quantification was obtained with a mean error of 7.7% for oxygen saturation and 6.2% for total hemoglobin, with minimal cross talk between different parameters...
  9. ncbi request reprint Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part II--Experimental interpretation
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:764-72. 2002
    ..Precalibration of the algorithm through statistical evaluation of phantom studies may provide a better measure of the image accuracy than that implied by minimization of the standard objective function...
  10. ncbi request reprint Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    Technol Cancer Res Treat 4:513-26. 2005
    ..These changes represent potential diagnostic indicators, which can be assessed to characterize breast tumors...
  11. ncbi request reprint Spectral priors improve near-infrared diffuse tomography more than spatial priors
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 30:1968-70. 2005
    ..When both spatial and spectral priors were applied in a healthy volunteer, glandular tissue showed a higher [Hb(T)], water fraction, and scattering power compared to adipose tissue...
  12. pmc Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography
    Ben Brooksby
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:8828-33. 2006
    ..Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images...
  13. pmc Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 100:12349-54. 2003
    ..These breast constituents vary significantly between individuals and can be altered because of changes in breast physiology or pathological state...
  14. ncbi request reprint Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo
    Xin Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051704. 2005
    ....
  15. ncbi request reprint Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomography
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1143-56. 2007
    ..The MRI-guided NIR images of oxygen saturation provide higher resolution and superior SNR and will likely be used in the future to study and characterize specific tissue volumes...
  16. ncbi request reprint Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure
    Ben Brooksby
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 10:051504. 2005
    ..This approach is expected to improve recovery of abnormalities within the breast, as the inclusion of structural information increases the accuracy of recovery of embedded heterogeneities, at least in phantom studies...
  17. pmc Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data
    Jia Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 13:041305. 2008
    ..The system and algorithms developed here should provide an optimal way to quantify regions with the goal of image-guided breast tissue spectroscopy within the MRI...
  18. ncbi request reprint Receiver operating characteristic and location analysis of simulated near-infrared tomography images
    Xiaomei Song
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 12:054013. 2007
    ..Interobserver variance performance in detecting objects in these images was low, suggesting that because of the low spatial resolution, detection tasks with NIR tomography is likely consistent between human observers...
  19. ncbi request reprint Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 32:933-5. 2007
    ..Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography...
  20. ncbi request reprint Improved quantification of small objects in near-infrared diffuse optical tomography
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 9:1161-71. 2004
    ..The algorithm is successfully applied to clinical data from a subject with a breast abnormality to yield quantitatively increased absorption coefficients, which enhances the contrast to 3.8 compared to 1.23 previously...
  21. ncbi request reprint Automated region detection based on the contrast-to-noise ratio in near-infrared tomography
    Xiaomei Song
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 43:1053-62. 2004
    ..4. A new linear convolution method of CNR calculation was developed for automated region of interest (ROI) detection...
  22. ncbi request reprint Breast deformation modelling for image reconstruction in near infrared optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 49:1131-45. 2004
    ..Finally, assuming a non-deformed breast shape for image reconstruction is shown to lead to poor quality images since the geometry of the breast is greatly altered, whereas using the correct deformed geometry produces the best images...
  23. pmc MR water quantitative priors improves the accuracy of optical breast imaging
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 30:159-68. 2011
    ..In addition, it is shown that these techniques can improve the ability of MRI to quantify water in the presence of bias in the Dixon water/fat separation...
  24. ncbi request reprint Multispectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast
    Troy O McBride
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 7:72-9. 2002
    ....
  25. pmc Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?
    Marius G Pakalniskis
    Department of Pathology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiology 259:365-74. 2011
    ..To investigate if changes in tumor angiogenesis associated with complete pathologic response (pCR) or partial pathologic response (pPR) to treatment can be demonstrated by using diffuse optical spectroscopic (DOS) tomography...
  26. pmc Broadband frequency-domain near-infrared spectral tomography using a mode-locked Ti:sapphire laser
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D198-207. 2009
    ..Simulations and tissue phantom experiments were used to quantify this improvement in image accuracy for recovery of tissue hemoglobin and oxygen saturation...
  27. pmc Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 35:82-4. 2010
    ..Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid...
  28. pmc In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 37:3715-24. 2010
    ..A NIR tomography system that combines frequency domain (FD) and continuous wave (CW) measurements was used to image normal and malignant breast tissues...
  29. pmc Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study
    Colin M Carpenter
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:036026. 2010
    ..This study presents a methodology to quantitatively analyze inspired gas changes in human breast tumors, and demonstrates this technique in a pilot patient population...
  30. ncbi request reprint Video-rate near-infrared optical tomography using spectrally encoded parallel light delivery
    Daqing Piao
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 30:2593-5. 2005
    ..35 mm diameter inclusion with an absorption coefficient of 0.01 mm(-1) and a reduced scattering coefficient of 1.5 mm(-1) that is moving along a circular path inside a 1% Intralipid solution...
  31. ncbi request reprint Comparisons of three alternative breast modalities in a common phantom imaging experiment
    Dun Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 30:2194-205. 2003
    ..Future work includes the minimization of bias (artifacts) on the periphery of electrical impedance spectroscopy images to improve cross modality correlation and implementation of the multimodality diagnosis for breast cancer detection...
  32. pmc Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breast
    Zhiqiu Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 35:3964-6. 2010
    ..A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue...
  33. ncbi request reprint Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulations
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:755-63. 2002
    ..Increasing measurement noise causes a need to constrain the minimum regularization parameter to higher values in order to achieve a minimum in the overall image MSE...
  34. ncbi request reprint Spectrally resolved bioluminescence optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 31:365-7. 2006
    ..The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity...
  35. ncbi request reprint In vivo near-infrared spectral detection of pressure-induced changes in breast tissue
    Shudong Jiang
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 28:1212-4. 2003
    ..In addition, the technique provides a unique approach to measuring tissue elastic changes in vivo in the female breast and may offer a new method for dynamic contrast imaging based on elasto-optical measurements...
  36. doi request reprint Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging
    Fadi El-Ghussein
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 19:011010. 2014
    ..The current system is being utilized in a clinical trial imaging suspected breast cancer tumors as detected by contrast MRI scans...
  37. doi request reprint Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI
    Michael A Mastanduno
    Thayer School of Engineering, Dartmouth College, 14 Engineering Dr, Hanover, NH 03755 Electronic address
    Acad Radiol 21:141-50. 2014
    ....
  38. pmc Remote positioning optical breast magnetic resonance coil for slice-selection during image-guided near-infrared spectroscopy of breast cancer
    Michael A Mastanduno
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 16:066001. 2011
    ..This interface allows improved volumetric imaging with interactive and accurate slice selection to quantify targeted suspicious lesions...
  39. pmc Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
    Michael A Mastanduno
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Biomed Opt Express 3:2339-52. 2012
    ..Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast...

Research Grants2

  1. Pressure-enhanced near-infrared breast cancer imaging
    Shudong Jiang; Fiscal Year: 2007
    ....