Research Topics
| Shudong JiangSummaryAffiliation: Dartmouth Medical School Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changesShudong Jiang
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
Radiology 252:551-60. 2009....
Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantomShudong Jiang
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 8:308-15. 2003....- Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imagingShudong Jiang
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Appl Opt 48:D130-6. 2009..No statistically valid correlations were found between the applied pressure and the changes in tissue oxygen saturation (S(t)O(2)) or water percentage (H(2)O) across the range of BMI values studied... - In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstructionSubhadra Srinivasan
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Acad Radiol 13:195-202. 2006.... - Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomographyXin Wang
Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
J Biomed Opt 11:041106. 2006.... - Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changesBrian W Pogue
Thayer School of Engineering, Dartmouth College, 800 Cummings Hall, Hanover, New Hampshire 03755, USA
J Biomed Opt 9:541-52. 2004.... - Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstructionSubhadra Srinivasan
Department of Biomedical Engineering, Thayer School of Engineering, Dartmouth College, P O Box 8000, Hanover, New Hampshire 03755, USA
Appl Opt 44:1858-69. 2005..Accurate quantification was obtained with a mean error of 7.7% for oxygen saturation and 6.2% for total hemoglobin, with minimal cross talk between different parameters... - Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part II--Experimental interpretationXiaomei Song
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
IEEE Trans Med Imaging 21:764-72. 2002..Precalibration of the algorithm through statistical evaluation of phantom studies may provide a better measure of the image accuracy than that implied by minimization of the standard objective function... - Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstructionSubhadra Srinivasan
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
Technol Cancer Res Treat 4:513-26. 2005..These changes represent potential diagnostic indicators, which can be assessed to characterize breast tumors... - Spectral priors improve near-infrared diffuse tomography more than spatial priorsBen Brooksby
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
Opt Lett 30:1968-70. 2005..When both spatial and spectral priors were applied in a healthy volunteer, glandular tissue showed a higher [Hb(T)], water fraction, and scattering power compared to adipose tissue... - Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomographyBen Brooksby
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 103:8828-33. 2006..Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images... - Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomographySubhadra Srinivasan
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 100:12349-54. 2003..These breast constituents vary significantly between individuals and can be altered because of changes in breast physiology or pathological state... - Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivoXin Wang
Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
J Biomed Opt 10:051704. 2005.... - Improved quantification of small objects in near-infrared diffuse optical tomographySubhadra Srinivasan
Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
J Biomed Opt 9:1161-71. 2004..The algorithm is successfully applied to clinical data from a subject with a breast abnormality to yield quantitatively increased absorption coefficients, which enhances the contrast to 3.8 compared to 1.23 previously... - Receiver operating characteristic and location analysis of simulated near-infrared tomography imagesXiaomei Song
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 12:054013. 2007..Interobserver variance performance in detecting objects in these images was low, suggesting that because of the low spatial resolution, detection tasks with NIR tomography is likely consistent between human observers... - Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer sizeColin M Carpenter
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 32:933-5. 2007..Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography... - Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral dataJia Wang
Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
J Biomed Opt 13:041305. 2008..The system and algorithms developed here should provide an optimal way to quantify regions with the goal of image-guided breast tissue spectroscopy within the MRI... - Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structureBen Brooksby
Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
J Biomed Opt 10:051504. 2005..This approach is expected to improve recovery of abnormalities within the breast, as the inclusion of structural information increases the accuracy of recovery of embedded heterogeneities, at least in phantom studies... - Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomographySubhadra Srinivasan
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Antioxid Redox Signal 9:1143-56. 2007..The MRI-guided NIR images of oxygen saturation provide higher resolution and superior SNR and will likely be used in the future to study and characterize specific tissue volumes... 
MR water quantitative priors improves the accuracy of optical breast imagingColin M Carpenter
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
IEEE Trans Med Imaging 30:159-68. 2011..In addition, it is shown that these techniques can improve the ability of MRI to quantify water in the presence of bias in the Dixon water/fat separation...- Breast deformation modelling for image reconstruction in near infrared optical tomographyHamid Dehghani
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Phys Med Biol 49:1131-45. 2004..Finally, assuming a non-deformed breast shape for image reconstruction is shown to lead to poor quality images since the geometry of the breast is greatly altered, whereas using the correct deformed geometry produces the best images... - Automated region detection based on the contrast-to-noise ratio in near-infrared tomographyXiaomei Song
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Appl Opt 43:1053-62. 2004..4. A new linear convolution method of CNR calculation was developed for automated region of interest (ROI) detection... - Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurementJia Wang
Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 35:82-4. 2010..Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid... - Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?Marius G Pakalniskis
Department of Pathology, Dartmouth Medical School, Hanover, NH 03755, USA
Radiology 259:365-74. 2011..To investigate if changes in tumor angiogenesis associated with complete pathologic response (pCR) or partial pathologic response (pPR) to treatment can be demonstrated by using diffuse optical spectroscopic (DOS) tomography... - Broadband frequency-domain near-infrared spectral tomography using a mode-locked Ti:sapphire laserJia Wang
Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
Appl Opt 48:D198-207. 2009..Simulations and tissue phantom experiments were used to quantify this improvement in image accuracy for recovery of tissue hemoglobin and oxygen saturation... - In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomographyJia Wang
Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
Med Phys 37:3715-24. 2010..A NIR tomography system that combines frequency domain (FD) and continuous wave (CW) measurements was used to image normal and malignant breast tissues... - Multispectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breastTroy O McBride
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 7:72-9. 2002.... - Video-rate near-infrared optical tomography using spectrally encoded parallel light deliveryDaqing Piao
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 30:2593-5. 2005..35 mm diameter inclusion with an absorption coefficient of 0.01 mm(-1) and a reduced scattering coefficient of 1.5 mm(-1) that is moving along a circular path inside a 1% Intralipid solution... - Comparisons of three alternative breast modalities in a common phantom imaging experimentDun Li
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Med Phys 30:2194-205. 2003..Future work includes the minimization of bias (artifacts) on the periphery of electrical impedance spectroscopy images to improve cross modality correlation and implementation of the multimodality diagnosis for breast cancer detection... - Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot studyColin M Carpenter
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 15:036026. 2010..This study presents a methodology to quantitatively analyze inspired gas changes in human breast tumors, and demonstrates this technique in a pilot patient population... - Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breastZhiqiu Li
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 35:3964-6. 2010..A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue... - Spectrally resolved bioluminescence optical tomographyHamid Dehghani
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 31:365-7. 2006..The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity... - In vivo near-infrared spectral detection of pressure-induced changes in breast tissueShudong Jiang
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Opt Lett 28:1212-4. 2003..In addition, the technique provides a unique approach to measuring tissue elastic changes in vivo in the female breast and may offer a new method for dynamic contrast imaging based on elasto-optical measurements... - Statistical analysis of nonlinearly reconstructed near-infrared tomographic images: Part I--Theory and simulationsBrian W Pogue
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
IEEE Trans Med Imaging 21:755-63. 2002..Increasing measurement noise causes a need to constrain the minimum regularization parameter to higher values in order to achieve a minimum in the overall image MSE... - Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopyMichael A Mastanduno
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Biomed Opt Express 3:2339-52. 2012..Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast... - Remote positioning optical breast magnetic resonance coil for slice-selection during image-guided near-infrared spectroscopy of breast cancerMichael A Mastanduno
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 16:066001. 2011..This interface allows improved volumetric imaging with interactive and accurate slice selection to quantify targeted suspicious lesions...
Research Grants
- Pressure-enhanced near-infrared breast cancer imagingShudong Jiang; Fiscal Year: 2007....