A L Howell
Affiliation: Dartmouth Medical School
- HIV-1 infection of the female reproductive tractAlexandra L Howell
VA Medical Center, 215 North Main Street, White River Junction, VT 05009, USA
Curr HIV/AIDS Rep 2:35-8. 2005..This indicates that several mechanisms for viral infection and transmission are present throughout the FRT...
- Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female reproductive tractA L Howell
Department of Veterans Affairs, White River Junction, Vermont 05009, USA
J Virol 71:3498-506. 1997....
- Human immunodeficiency virus-specific and CD3-redirected cytotoxic T lymphocyte activity in the human female reproductive tract: lack of correlation between mucosa and peripheral bloodH D White
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Infect Dis 183:977-83. 2001..Thus, CTL activity in PBMC may fail to correlate with mucosal activity. The finding of CTL activity in the FRT of patient 872 represents the first description of CTL in upper and lower FRT tissues of an HIV-positive woman...
- Increased potency of Fc-receptor-targeted antigensP M Guyre
Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Cancer Immunol Immunother 45:146-8. 1997..Overall, these studies suggest that targeting antigens to CD64 represents an effective approach to enhancing the effectiveness of vaccines in vivo...
- Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivitySusana N Asin
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Infect Dis 187:1522-33. 2003..These data demonstrated that HIV-1 infects human epithelial cells of upper reproductive tract origin and that productive viral infection of epithelial cells may be an important mechanism of transmission of HIV-1 infection in women...
- Estradiol and progesterone regulate HIV type 1 replication in peripheral blood cellsSusana N Asin
V A Medical Center, White River Junction, Vermont 05009, USA
AIDS Res Hum Retroviruses 24:701-16. 2008..An additional indirect mechanism of sex hormone regulation of cytokine and chemokine secretion cannot be excluded...
- HIV type 1 infection in women: increased transcription of HIV type 1 in ectocervical tissue explantsSusana N Asin
Veterans Affairs Medical Center, 215 N Main Street, White River Junction, VT 05009, USA
J Infect Dis 200:965-72. 2009..Mucosal surfaces of the female reproductive tract are the main routes of heterosexual transmission of human immunodeficiency virus type 1 (HIV-1), but the contribution of each of the reproductive sites to mucosal transmission is unknown...
- Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblastsSusana N Asin
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Infect Dis 190:236-45. 2004..These data suggest that uterine cells are targets for productive infection with X4-tropic strains and release unmodified R5-tropic viruses that would then be able to infect submucosal target cells, including T cells and macrophages...
- Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infectionGrant R Yeaman
Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA
Immunology 109:137-46. 2003..In addition, these studies provide evidence that the uterus, and potentially the entire upper reproductive tract, are important sites for the initial events involved in HIV infection...
- Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus-type IGrant R Yeaman
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA
Immunology 113:524-33. 2004..These findings are important to define potential targets of HIV-1 infection within the FRT, and for the future design of approaches to reduce the susceptibility of women to infection by HIV-1...